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  1. Book ; Online ; Thesis: Der konjunktivale Provokationstest als zuverlässiger Biomarker für die allergenspezifische Immuntherapie

    Schröder, Julian / Mösges, Ralph / Hunzelmann, Nicolas

    ein Überblick

    2021  

    Institution Universität zu Köln / Institut für Medizinische Statistik und Bioinformatik
    Author's details vorgelegt von Julian Schröder ; 1. Gutachter: Universitätsprofessor Dr. med. R W. Mösges, 2. Gutachter: Professor Dr. med. N. Hunzelmann ; aus dem Institut für Medizinische Statistik und Bioinformatik der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 1 Online-Ressource (55 Seiten)
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache ; Open Acces
    HBZ-ID HT021199104
    DOI 10.4126/FRL01-006431127
    Database Repository for Life Sciences

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  2. Book ; Thesis: Der konjunktivale Provokationstest als zuverlässiger Biomarker für die allergenspezifische Immuntherapie

    Schröder, Julian / Mösges, Ralph / Hunzelmann, Nicolas

    ein Überblick

    2021  

    Institution Universität zu Köln / Institut für Medizinische Statistik und Bioinformatik
    Author's details vorgelegt von Julian Schröder ; 1. Gutachter: Universitätsprofessor Dr. med. R W. Mösges, 2. Gutachter: Professor Dr. med. N. Hunzelmann ; aus dem Institut für Medizinische Statistik und Bioinformatik der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 56 Seiten
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT021296921
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 136 order for loan Magazin

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  3. Article ; Online: Bone health and the masters runner.

    Raiser, Sara N / Schroeder, Allison N / Lawley, Richard J / Tenforde, Adam S

    PM & R : the journal of injury, function, and rehabilitation

    2024  Volume 16, Issue 4, Page(s) 363–373

    Abstract: Masters runners are often defined as those ages 35 years and older who train and compete in running events. These runners represent a growing population of the overall running community and experience running-related injuries including bone stress ... ...

    Abstract Masters runners are often defined as those ages 35 years and older who train and compete in running events. These runners represent a growing population of the overall running community and experience running-related injuries including bone stress injuries (BSIs). Similar to younger runners, health considerations in masters runners include the goal to optimize bone health with focus on mitigating age-associated loss of bone strength and preventing BSIs through a combination of ensuring appropriate physical activity, optimizing nutrition, and correcting faulty biomechanics. Importantly, BSIs in masters runners may include characteristics of both overuse injury from insufficient recovery and failure of bone weakened by age-related loss of bone (insufficiency fractures). This narrative review covers the limited available research on strategies to optimize bone health in masters runners. Applying knowledge on masters athletes and extrapolating from other populations, we propose strategies on treatment and prevention of BSIs. Finally, the review highlights gaps in knowledge that require further age-specific discoveries to advance treatment and prevention.
    MeSH term(s) Humans ; Bone Density ; Cumulative Trauma Disorders ; Fractures, Stress/diagnosis ; Fractures, Stress/etiology ; Fractures, Stress/therapy ; Running/injuries
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1002/pmrj.13175
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  4. Article ; Online: Validity of mortality risk prediction scores in critically ill patients with secondary pulmonary embolism.

    Ryll, Martin J / Weingarten, Toby N / Schroeder, Darrel R / Sprung, Juraj

    Biomolecules & biomedicine

    2024  

    Abstract: Herein, we assess the use of the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV) and pulmonary embolism (PE)-specific risk scores to predict mortality among intensive care unit (ICU) patients who developed secondary PE. This retrospective ... ...

    Abstract Herein, we assess the use of the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV) and pulmonary embolism (PE)-specific risk scores to predict mortality among intensive care unit (ICU) patients who developed secondary PE. This retrospective cohort study used information from 208 United States critical care units recorded in the eICU Collaborative Research Database during 2014 and 2015. We calculated APACHE-IV, Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and ICU-sPESI scores and compared their predicting performance using the area under the receiver operating characteristic (AUROC) curve. Of 812 patients included in our study, 150 died (mortality, 18.5% [95% CI, 15.8%-21.1%]). Compared to survivors, non-survivors had higher APACHE-IV (86 vs 52, P<0.001), PESI (170 vs 129, P<0.001), sPESI (2 vs 2, P<0.001), and ICU-sPESI (4 vs 2, P<0.001) scores. AUROCs were 0.790 (APACHE-IV); 0.737 (PESI); 0.726 (ICU-sPESI); and 0.620 (sPESI). APACHE-IV performed significantly better than all 3 PE-specific mortality scores (APACHE-IV vs PESI, P=0.041; APACHE-IV vs sPESI, P=0.001; and APACHE-IV vs ICU-sPESI, P=0.021). Both the PESI and ICU-sPESI outperformed the sPESI (PESI vs sPESI, P=0.001; ICU-sPESI vs sPESI, P<0.001). APACHE-IV score was found to be the best instrument for predicting mortality risk, but PESI and ICU-sPESI scores may be used when APACHE-IV is unavailable. sPESI AUROC suggests absence of sufficient discriminative value to be used as a predictor of mortality in patients with secondary PE.
    Language English
    Publishing date 2024-02-28
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2024.10202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effect of Fluopyram on

    Han, Jaeyeong / Ficca, Alyson / Kleczewski, Nathan / Schroeder, Nathan

    Plant disease

    2024  Volume 108, Issue 2, Page(s) 342–347

    Abstract: The effects of a fluopyram seed treatment on lesion nematodes ( ...

    Abstract The effects of a fluopyram seed treatment on lesion nematodes (
    MeSH term(s) Animals ; Zea mays ; Benzamides/pharmacology ; Pyridines/pharmacology ; Tylenchoidea
    Chemical Substances N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide (F0VT7K5302) ; Benzamides ; Pyridines
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-04-23-0725-RE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  6. Article ; Online: Evaluation of a Rubric to Assess Pharmacy Student Performance in a Telehealth Simulation Exercise.

    Schroeder, Michelle N / Lengel, Aaron J

    American journal of pharmaceutical education

    2021  Volume 86, Issue 8, Page(s) ajpe8778

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Students, Pharmacy ; Education, Pharmacy/methods ; Educational Measurement/methods ; Reproducibility of Results ; Pharmacists ; Telemedicine
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.5688/ajpe8778
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 924: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Optimizing Combination Hyaluronic Acid and Platelet-Rich Plasma Injections: Does Composition of Hyaluronic Acid Product Matter?

    Schroeder, Allison N / Jelsing, Elena J

    Current sports medicine reports

    2021  Volume 20, Issue 5, Page(s) 233–235

    MeSH term(s) Humans ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/therapeutic use ; Injections, Intra-Articular ; Osteoarthritis, Knee ; Platelet-Rich Plasma ; Treatment Outcome ; Viscosupplements
    Chemical Substances Viscosupplements ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2080040-X
    ISSN 1537-8918 ; 1537-890X
    ISSN (online) 1537-8918
    ISSN 1537-890X
    DOI 10.1249/JSR.0000000000000836
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5922: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Pluripotent Stem Cells for Cell Therapy.

    Schroeder, Insa S

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2269, Page(s) 25–33

    Abstract: In an increasingly geriatric population, in which elderly people frequently face chronic diseases and degenerative conditions, cell therapies as part of novel regenerative medicine approaches are of great interest. Even though today's cell therapies ... ...

    Abstract In an increasingly geriatric population, in which elderly people frequently face chronic diseases and degenerative conditions, cell therapies as part of novel regenerative medicine approaches are of great interest. Even though today's cell therapies mostly rely on adult stem cells like the mesenchymal stem cells or primary somatic cells, pluripotent stem cells represent an enormously versatile cell model to explore possible new avenues in the field of regenerative medicine due to their capacity to grow indefinitely and to differentiate into the desired cell types. The discovery of reprogramming somatic cells into induced pluripotent stem cells augmented the pool of applicable cell entities so that researchers nowadays can resort to embryonic stem cells, but also to a plethora of patient- and disease-specific induced pluripotent stem cells. The ease of targeted genome engineering is an additional benefit that allows using pluripotent stem cells for disease modeling, drug discovery, and the development of cell therapies. However, the task is still demanding as the generation of subpopulations and a sufficient cell maturation for some cell entities have yet to be achieved. Likewise, even though for some applications the cells of interest can be produced in the large-scale dimensions and purity that are required for clinical purposes, proper integration, and function in the host tissue remain challenging. Nonetheless, the immense progress that has been made over the last decades warrants the prominent role of pluripotent stem cells in regenerative medicine as in vitro models to broaden our knowledge of disease onset/progression and treatment as well as in vivo as a substitution of damaged/aged tissue.
    MeSH term(s) Animals ; Cell- and Tissue-Based Therapy ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Regenerative Medicine
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1225-5_2
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  9. Article ; Conference proceedings: Percutaneous MitraClip Implantation in an Adult with Functionally Univentricular Physiology

    Kanaan, M. / Ostermayer, S. / Lebherz, C. / Schröder, J. / Marx, N. / Herberg, U.

    The Thoracic and Cardiovascular Surgeon

    2024  Volume 72, Issue S 02

    Event/congress 56th Annual Meeting of the German Society for Pediatric Cardiology (DGPK), Congress Center Hamburg, 2024-02-17
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0044-1780727
    Database Thieme publisher's database

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    Uk I Zs.186: Show issues Location:
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  10. Article ; Online: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans.

    Fox, Bennett W / Helf, Maximilian J / Burkhardt, Russell N / Artyukhin, Alexander B / Curtis, Brian J / Palomino, Diana Fajardo / Schroeder, Allen F / Chaturbedi, Amaresh / Tauffenberger, Arnaud / Wrobel, Chester J J / Zhang, Ying K / Lee, Siu Sylvia / Schroeder, Frank C

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1520

    Abstract: Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression, but the ... ...

    Abstract Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression, but the underlying mechanisms have remained unclear. Here, we show that endogenous and microbiota-dependent small molecule signals promote lipid desaturation via the nuclear receptor NHR-49/PPARα in C. elegans. Untargeted metabolomics of a β-oxidation mutant, acdh-11, in which expression of the stearoyl-CoA desaturase FAT-7/SCD1 is constitutively increased, revealed accumulation of a β-cyclopropyl fatty acid, becyp#1, that potently activates fat-7 expression via NHR-49. Biosynthesis of becyp#1 is strictly dependent on expression of cyclopropane synthase by associated bacteria, e.g., E. coli. Screening for structurally related endogenous metabolites revealed a β-methyl fatty acid, bemeth#1, which mimics the activity of microbiota-dependent becyp#1 but is derived from a methyltransferase, fcmt-1, that is conserved across Nematoda and likely originates from bacterial cyclopropane synthase via ancient horizontal gene transfer. Activation of fat-7 expression by these structurally similar metabolites is controlled by distinct mechanisms, as microbiota-dependent becyp#1 is metabolized by a dedicated β-oxidation pathway, while the endogenous bemeth#1 is metabolized via α-oxidation. Collectively, we demonstrate that evolutionarily related biosynthetic pathways in metazoan host and associated microbiota converge on NHR-49/PPARα to regulate fat desaturation.
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; PPAR alpha/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fatty Acids/metabolism ; Cyclopropanes/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; PPAR alpha ; Fatty Acids ; Cyclopropanes
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45782-2
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