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Article ; Online: Evidence for a multidomain clinical assessment of mild traumatic brain injury in older adults.

Sherry, Natalie S / Kissinger-Knox, Alicia / Manderino, Lisa / Eagle, Shawn / Mucha, Anne / Collins, Michael W / Kontos, Anthony P

Applied neuropsychology. Adult

2023 , Page(s) 1–8

Abstract: Background: There are few guidelines on the appropriate clinical tools to evaluate mTBI in older adults.: Objective: We aimed to investigate the utility of a multidomain assessment to differentiate older adults with mTBI from controls.: Methods: ... ...

Abstract	Background: There are few guidelines on the appropriate clinical tools to evaluate mTBI in older adults. Objective: We aimed to investigate the utility of a multidomain assessment to differentiate older adults with mTBI from controls. Methods: Participants included 68 older adults (37% male) aged 60-76 ( Results: The mTBI group endorsed significantly more symptoms of concussion ( Discussion: The current findings support a multidomain assessment model of care for evaluating mTBI in older adults.
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2023.2218512
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Article ; Online: Evaluating Recovery After Two and Three Repeated Concussions Using Growth Curves.

Preszler, Jonathan / Manderino, Lisa / Eagle, Shawn R / Trbovich, Alicia / Kissinger-Knox, Alicia / Feder, Abigail / Mehmel, Bindal / Collins, Michael W / Kontos, Anthony P

Journal of neurotrauma

2024

Abstract: The results of prior research concerning the effects of repeated concussions have been mixed. The aim of this study was to evaluate how concussion outcomes and presentation changed within patients who were evaluated at a concussion specialty clinic ... ...

Abstract	The results of prior research concerning the effects of repeated concussions have been mixed. The aim of this study was to evaluate how concussion outcomes and presentation changed within patients who were evaluated at a concussion specialty clinic multiple times with a concussion. Subjects included 202 patients (54% male) aged 10-21 years (M = 13.17) who presented to a specialty concussion clinic for two and three concussions (77% sport-related) and were followed through formal clearance. First, growth curve models were estimated to determine recovery time and initial symptom burden across the multiple injuries. Second, covariates were added to these models to evaluate which demographic, risk factor, or injury variables predicted any change that did occur in evaluation or outcome variables. Models indicated that each subsequent concussion linearly resulted in significantly fewer days to recovery (-4.62 days,
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0148
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Article ; Online: Lower post-injury psychological resilience is associated with increased recovery time and symptom burden following sport-related concussion.

Ernst, Nathan / Eagle, Shawn / Trbovich, Alicia / Kissinger-Knox, Alicia / Bitzer, Hannah / Kontos, Anthony P

Applied neuropsychology. Child

2021 Volume 11, Issue 4, Page(s) 781–788

Abstract: The purpose of this study was to compare athletes with high and low resilience scores on concussion outcomes, and identify significant predictors associated with protracted recovery (>30 days). Forty-five adolescent and young adult athletes (28 males; ... ...

Abstract	The purpose of this study was to compare athletes with high and low resilience scores on concussion outcomes, and identify significant predictors associated with protracted recovery (>30 days). Forty-five adolescent and young adult athletes (28 males; aged 15.13 ± 2.74; range of 11-22) were diagnosed with an SRC within 14 days of injury (M = 4.9 days) and grouped as high or low resilience based on score on the Connor-Davidson Resilience Scale-10 (CD-RISC-10). Primary dependent measures included days to full clearance, Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT), Depression Anxiety and Stress Scale-21 (DASS-21), and Vestibular/Ocular Motor Screening (VOMS). The low resilience group (
MeSH term(s)	Adolescent ; Athletes ; Athletic Injuries/diagnosis ; Brain Concussion/diagnosis ; Humans ; Male ; Neuropsychological Tests ; Post-Concussion Syndrome/complications ; Post-Concussion Syndrome/diagnosis ; Resilience, Psychological ; Sports ; Young Adult
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673759-0
ISSN	2162-2973 ; 2162-2965
ISSN (online)	2162-2973
ISSN	2162-2965
DOI	10.1080/21622965.2021.1964966
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Article ; Online: Does time since concussion alter the factor structure of a multidomain assessment in adolescents?

Kissinger-Knox, Alicia M / Eagle, Shawn R / Jennings, Sabrina / Collins, Michael W / Kontos, Anthony P

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

2021 Volume 27, Issue 8, Page(s) 1104–1116

Abstract: The utilization of principal component analysis (PCA) approaches to concussion is beneficial to inform the interpretation of clinical outcome data in adolescent patients. While researchers have identified factors using post-concussive symptom scales and ... ...

Abstract	The utilization of principal component analysis (PCA) approaches to concussion is beneficial to inform the interpretation of clinical outcome data in adolescent patients. While researchers have identified factors using post-concussive symptom scales and cognitive testing, there has yet to be a PCA that incorporates vestibular or oculomotor outcomes, or that focuses exclusively on adolescents. Moreover, the role of time since injury has not been examined in relation to concussion factors in this at-risk population. PCA methods were applied to two independent samples of 237 adolescents who presented to an outpatient concussion clinic: 1) ≤7 days (n = 145), and 2) 8 days-1 month (n = 92). The two separate PCAs included nine clinical assessments comprised of: a) four symptoms factors (cognitive/fatigue/migraine, affective, somatic, sleep), b) memory and speeded cognitive performance, c) near point of convergence (NPC), d) oculomotor, and e) vestibular outcomes. A three-component model including 1) symptoms, 2) cognitive, and 3) vestibular/oculomotor factors that accounted for 69.2% of the variance was supported for the ≤7 days sample. All items except somatic symptoms loaded. A different three-component model was supported for the 8 days-1 month sample, including 1) vestibulo-ocular migraine, 2) visuo-cognitive, and 3) affective-sleep that accounted for 72.1% of the variance, with all items loading. The findings supported two different concussion factor models that highlight the influence of time since injury and importance of considering vestibular and oculomotor outcomes in adolescents. Clinicians should evaluate these different factors using a comprehensive, multi domain approach to better inform assessment and monitor recovery in adolescent patients following concussion.
MeSH term(s)	Adolescent ; Athletic Injuries ; Brain Concussion/diagnosis ; Humans ; Neuropsychological Tests ; Post-Concussion Syndrome/diagnosis
Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1262599-1
ISSN	1744-4136 ; 0929-7049
ISSN (online)	1744-4136
ISSN	0929-7049
DOI	10.1080/09297049.2021.1936475
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Article: What's really '

Knox, Shawn / Moghadam, Steven / Patrick, Kenny / Phan, Anh / Choo, Kim-Kwang Raymond

Computers & security

2020 Volume 94, Page(s) 101833

Abstract: With today's world revolving around online interaction, dating applications (apps) are a prime example of how people are able to discover and converse with others that may share similar interests or lifestyles, including during the recent COVID-19 ... ...

Abstract	With today's world revolving around online interaction, dating applications (apps) are a prime example of how people are able to discover and converse with others that may share similar interests or lifestyles, including during the recent COVID-19 lockdowns. To connect the users, geolocation is often utilized. However, with each new app comes the possibility of criminal exploitation. For example, while apps with geolocation feature are intended for users to provide personal information that drive their search to meet someone, that same information can be used by hackers or forensic analysts to gain access to personal data,
Keywords	covid19
Language	English
Publishing date	2020-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2001917-8
ISSN	0167-4048
ISSN	0167-4048
DOI	10.1016/j.cose.2020.101833
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Article ; Online: The Emerging Role of Telehealth for Concussion Clinical Care During the Coronavirus (COVID-19) Pandemic.

Womble, Melissa N / Reynolds, Erin / Kissinger-Knox, Alicia / Collins, Michael W / Kontos, Anthony P / West, Robin V / Eagle, Shawn / Elbin, R J

The Journal of head trauma rehabilitation

2021 Volume 37, Issue 2, Page(s) E49–E54

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has substantially altered the delivery of healthcare for providers and their patients. Patients have been reticent to seek care for many diseases and injuries including concussion due to fears of potential ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has substantially altered the delivery of healthcare for providers and their patients. Patients have been reticent to seek care for many diseases and injuries including concussion due to fears of potential exposure to COVID-19. Moreover, because of social distancing recommendations and stay-at-home orders, patient screening, evaluation, and delivery of care have become less efficient or impossible to perform via in-person clinic visits. Consequently, there was a sudden need to shift healthcare delivery from primarily in-person visits to telehealth. This sudden shift in healthcare delivery brings with it both challenges and opportunities for clinical concussion care. This article is designed to discuss these challenges and opportunities and provide an experiential-based framework for providing concussion care via telehealth. We first provide an overview of a clinical concussion model utilized at concussion specialty clinics from 3 geographically disparate healthcare systems for in-person service delivery prior to COVID-19. We then discuss the creation of new clinical workflows to facilitate the continued provision of concussion specialty care using telehealth. Finally, we examine lessons learned during this healthcare delivery shift including limitations and potential barriers for telehealth for concussion care, as well as opportunities for expansion of concussion care in rural and underserved areas. We also discuss the need to empirically evaluate the comparative efficacy of telehealth and in-person concussion care moving forward.
MeSH term(s)	Brain Concussion/diagnosis ; Brain Concussion/therapy ; COVID-19 ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639221-0
ISSN	1550-509X ; 0885-9701
ISSN (online)	1550-509X
ISSN	0885-9701
DOI	10.1097/HTR.0000000000000713
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Article ; Online: Temporal Differences in Concussion Symptom Factors in Adolescents following Sports-Related Concussion.

Eagle, Shawn R / Kissinger-Knox, Alicia M / Feder, Abigail / Manderino, Lisa / Preszler, Jonathan / Womble, Melissa N / Elbin, Robert J / Collins, Michael / Kontos, Anthony P

The Journal of pediatrics

2022 Volume 245, Page(s) 89–94

Abstract: Objective: To evaluate temporal differences in concussion symptoms up to 30 days following a sports-related concussion.: Study design: Adolescent and young adult athletes (n = 782) were separated based on time since injury at presentation as Early (0- ...

Abstract	Objective: To evaluate temporal differences in concussion symptoms up to 30 days following a sports-related concussion. Study design: Adolescent and young adult athletes (n = 782) were separated based on time since injury at presentation as Early (0-7 days; n = 321, age: 15.4 ± 1.9 years, 51.7% female), Middle (8-14 days; n = 281, age: 15.8 ± 2.2 years, 54.8% female), and Late (15-30 days; n = 180, age: 15.6 ± 1.8 years, 52.8% female). All participants completed the 22-item Post-Concussion Symptom Scale at first visit. A confirmatory factor analysis was completed separately for each time since injury cohort using a 4-component model reported previously. Results: The confirmatory factor analysis model fit was acceptable for Early, Middle, and Late (using cognitive-migraine-fatigue, affective, sleep, and somatic factors). Both affective (change = 0.30; P = .01; Cohen d = 0.30) and sleep (change = 0.51; P ≤ .001; Cohen d = 0.47) factors were significantly greater in the Late group compared with the Early, but not Middle, groups. The previously reported 4-factor symptom model, including cognitive-migraine-fatigue, affective, somatic, and sleep factors, was appropriate for adolescents up to 30 days' postinjury. However, adolescents who presented between 15 and 30 days' postinjury reported greater affective and sleep symptoms than those who presented within 1 week. Conclusions: Clinicians should consider these temporal differences when evaluating concussion symptoms in adolescents, as greater affective and sleep symptoms can be predictive of prolonged recovery/persistent complications.
MeSH term(s)	Adolescent ; Athletic Injuries/complications ; Athletic Injuries/diagnosis ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Fatigue/complications ; Female ; Humans ; Male ; Migraine Disorders ; Neuropsychological Tests ; Post-Concussion Syndrome/complications ; Post-Concussion Syndrome/diagnosis ; Young Adult
Language	English
Publishing date	2022-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2022.02.013
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Article ; Online: The impact of dose of FSH (Folltropin) containing LH (Lutropin) on follicular development, estrus and ovulation responses in prepubertal gilts.

Breen, Shawn M / Knox, Robert V

Animal reproduction science

2012 Volume 132, Issue 3-4, Page(s) 193–200

Abstract: FSH is favored over chorionic gonadotropins for induction of estrus in various species, yet little data are available for its effects on follicle development and fertility for use in pigs. For Experiment 1, prepubertal gilts (n = 36) received saline, 100 ...

Abstract	FSH is favored over chorionic gonadotropins for induction of estrus in various species, yet little data are available for its effects on follicle development and fertility for use in pigs. For Experiment 1, prepubertal gilts (n = 36) received saline, 100 mg FSH, or FSH with 0.5 mg LH. Treatments were divided into six injections given every 8 h on Days 0 and 1. Proportions of gilts developing medium follicles were increased for FSH and FSH-LH (P < 0.05) compared to saline, but follicles were not sustained and fewer hormone-treated gilts developed large follicles (P < 0.05). No gilts expressed estrus and few ovulated. Experiment 2 tested FSH preparations with greater LH content. Prepubertal gilts (n = 56) received saline, FSH-hCG (100 mg FSH with 200 IU hCG), FSH-LH5 (FSH with 5 mg LH), FSH-LH10 (FSH with 10 mg LH), or FSH-LH20 (FSH with 20 mg LH). FSH-LH was administered as previously described, while 100 IU of hCG was given at 0 h and 24 h. Hormone treated gilts showed increased (P < 0.05) medium and large follicle development, estrus (>70%), ovulation (100%), and ovulation rate (>30 CL) compared to saline. There was an increase (P < 0.05) in the proportion of hormone-treated gilts with follicular cysts at Day 5, but these did not persist to Day 22. These gilts also showed an increase in poorly formed CL (P < 0.05). FSH alone or with small amounts of LH can induce medium follicle growth but greater amounts of LH at the same time is needed to sustain medium follicles, stimulate development of large follicles and induce estrus and ovulation in prepubertal gilts.
MeSH term(s)	Animals ; Dose-Response Relationship, Drug ; Estrus/drug effects ; Estrus/physiology ; Female ; Fertility Agents, Female/administration & dosage ; Fertility Agents, Female/pharmacology ; Follicle Stimulating Hormone/administration & dosage ; Follicle Stimulating Hormone/pharmacology ; Luteinizing Hormone/administration & dosage ; Luteinizing Hormone/pharmacology ; Ovarian Follicle/drug effects ; Ovarian Follicle/physiology ; Ovulation/drug effects ; Ovulation/physiology ; Sexual Maturation/drug effects ; Swine
Chemical Substances	Fertility Agents, Female ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2012-06
Publishing country	Netherlands
Document type	Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2012.05.013
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Article ; Online: Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma.

British journal of cancer

2023 Volume 128, Issue 10, Page(s) 1916–1921

Abstract: Background: Systemic inflammatory scores may aid prognostication and patient selection for trials. We compared five scores in advanced pancreatic adenocarcinoma (PDAC).: Methods: Unresectable/metastatic PDAC patients enrolled in the Comprehensive ... ...

Abstract	Background: Systemic inflammatory scores may aid prognostication and patient selection for trials. We compared five scores in advanced pancreatic adenocarcinoma (PDAC). Methods: Unresectable/metastatic PDAC patients enrolled in the Comprehensive Molecular Characterisation of Advanced Pancreatic Ductal Adenocarcinoma for Better Treatment Selection trial (NCT02750657) were included. Patients had pre-treatment biopsies for whole genome and RNA sequencing. CD8 immunohistochemistry was available in a subset. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, Prognostic Nutritional Index, Gustave Roussy Immune Score (GRIm-S), and Memorial Sloan Kettering Prognostic Score (MPS) were calculated. Overall survival (OS) was estimated using Kaplan-Meier methods. Associations between inflammatory scores, clinical/genomic characteristics, and OS were analysed. Results: We analysed 263 patients. High-risk NLR, GRIm-S and MPS were poorly prognostic. The GRIm-S had the highest predictive ability: median OS 6.4 vs. 10 months for high risk vs. low-risk (P < 0.001); HR 2.26 (P < 0.001). ECOG ≥ 1, the basal-like subtype, and low-HRDetect were additional poor prognostic factors (P < 0.01). Inflammatory scores did not associate with RNA-based classifiers or homologous recombination repair deficiency genotypes. High-risk MPS (P = 0.04) and GRIm-S (P = 0.02) patients had lower median CD8 + tumour-infiltrating lymphocytes. Conclusions: Inflammatory scores incorporating NLR have prognostic value in advanced PDAC. Understanding immunophenotypes of poor-risk patients and using these scores in trials will advance the field.
MeSH term(s)	Humans ; Pancreatic Neoplasms/pathology ; Prognosis ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Lymphocytes/pathology ; Neutrophils/pathology ; Retrospective Studies
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02214-0
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Article ; Online: Early onset cardiovascular disease related to methamphetamine use is most striking in individuals under 30: A retrospective chart review.

Batra, Vinita / Murnane, Kevin S / Knox, Brianne / Edinoff, Amber N / Ghaffar, Yahya / Nussdorf, Laura / Petersen, Murray / Kaufman, Sarah E / Jiwani, Sania / Casey, Christopher A / Terhoeve, Stephanie / Alfrad Nobel Bhuiyan, Mohammad / Dominic, Paari / McNeil, Shawn / Patterson, James

Addictive behaviors reports

2022 Volume 15, Page(s) 100435

Abstract: Introduction: The illicit use of methamphetamine (MA), a dangerous psychostimulant has become a global epidemic. Studies have demonstrated a link between illicit substance use and cardiovascular consequences. The objective of this study was to assess ... ...

Abstract	Introduction: The illicit use of methamphetamine (MA), a dangerous psychostimulant has become a global epidemic. Studies have demonstrated a link between illicit substance use and cardiovascular consequences. The objective of this study was to assess whether MA use is associated with an early onset of cardiovascular diseases (CVD). Methods: Retrospective analysis was conducted using data collected from 1376 individuals at Louisiana State University Health Sciences Center - Shreveport between 2011 and 2020. Cardiovascular patients with and without a history of MA use were divided into the MA and Control groups. The age of CVD onset was assessed. Descriptive statistics for patient characteristics, Two Samples T-Test for continuous and Pearson's χ^2- tests for categorical variables were calculated. Hazard ratios (HR) and time ratios (TR) were calculated. Results: The age of CVD onset in patients with prior MA use occurred on average 8 year earlier than the age of CVD onset (mean age ± SD = 44 ± 12.04) in controls (mean age ± SD = 52 ± 10.70) (unpaired Conclusions: MA use likely accelerates early onset of CVD and contributes to CVD complications in young adults.
Language	English
Publishing date	2022-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831558-3
ISSN	2352-8532 ; 2352-8532
ISSN (online)	2352-8532
ISSN	2352-8532
DOI	10.1016/j.abrep.2022.100435
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