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  1. Article ; Online: What the lung has taught us about latent TGF-beta activation.

    Aluwihare, Poshala / Munger, John S

    American journal of respiratory cell and molecular biology

    2008  Volume 39, Issue 5, Page(s) 499–502

    MeSH term(s) Animals ; Antigens, Neoplasm/metabolism ; Homeostasis ; Humans ; Integrins/metabolism ; Lung/immunology ; Lung/metabolism ; Transforming Growth Factor beta/immunology ; Transforming Growth Factor beta/metabolism
    Chemical Substances Antigens, Neoplasm ; Integrins ; Transforming Growth Factor beta ; integrin alphavbeta6
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2008-0003ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  2. Article: Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice.

    Aluwihare, Poshala / Mu, Zhenyu / Zhao, Zhicheng / Yu, Dawen / Weinreb, Paul H / Horan, Gerald S / Violette, Shelia M / Munger, John S

    Journal of cell science

    2008  Volume 122, Issue Pt 2, Page(s) 227–232

    Abstract: The arginine-glycine-aspartate (RGD)-binding integrins alphavbeta6 and alphavbeta8 activate latent TGFbeta1 and TGFbeta3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins alphavbeta5 and alphavbeta3 activate these TGFbeta ...

    Abstract The arginine-glycine-aspartate (RGD)-binding integrins alphavbeta6 and alphavbeta8 activate latent TGFbeta1 and TGFbeta3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins alphavbeta5 and alphavbeta3 activate these TGFbeta isoforms. To define the combined role of alphavbeta6- and alphavbeta8-integrin in TGFbeta activation, we analyzed mice lacking function of both integrins by means of gene deletion and/or pharmacologic inhibition. Most Itgb6-/-;Itgb8-/- embryos die at mid-gestation; those that survive develop cleft palate-as observed in Tgfb3-/- mice. Itgb8-/- mice treated with an anti-alphavbeta6-integrin antibody develop severe autoimmunity and lack Langerhans cells-similar to Tgfb1-null mice. These results support a model in which TGFbeta3-mediated palate fusion and TGFbeta1-mediated suppression of autoimmunity and generation of Langerhans cells require integrins alphavbeta6 and alphavbeta8 but not other RGD-binding integrins as TGFbeta activators.
    MeSH term(s) Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Autoimmunity/genetics ; Autoimmunity/immunology ; Cleft Palate/genetics ; Cleft Palate/immunology ; Cleft Palate/metabolism ; Integrins/genetics ; Integrins/immunology ; Integrins/metabolism ; Kaplan-Meier Estimate ; Langerhans Cells/immunology ; Mice ; Mice, Knockout ; Oligopeptides/metabolism ; Palate/abnormalities ; Palate/immunology ; Palate/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/immunology ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta3/genetics ; Transforming Growth Factor beta3/immunology ; Transforming Growth Factor beta3/metabolism
    Chemical Substances Antigens, Neoplasm ; Integrins ; Oligopeptides ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta3 ; integrin alphavbeta6 ; integrin alphavbeta8 ; arginyl-glycyl-aspartic acid (78VO7F77PN)
    Language English
    Publishing date 2008-12-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.035246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MG 14: Show issues

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  3. Article: Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

    Aluwihare, Poshala / Mu, Zhenyu / Zhao, Zhicheng / Yu, Dawen / Weinreb, Paul H / Horan, Gerald S / Violette, Shelia M / Munger, John S

    Journal of cell science. 2009 Jan. 15, v. 122, no. 2

    2009  

    Abstract: The arginine-glycine-aspartate (RGD)-binding integrins αvβ6 and αvβ8 activate latent TGFβ1 and TGFβ3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins αvβ5 and αvβ3 activate these TGFβ isoforms. To define the combined ... ...

    Abstract The arginine-glycine-aspartate (RGD)-binding integrins αvβ6 and αvβ8 activate latent TGFβ1 and TGFβ3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins αvβ5 and αvβ3 activate these TGFβ isoforms. To define the combined role of αvβ6- and αvβ8-integrin in TGFβ activation, we analyzed mice lacking function of both integrins by means of gene deletion and/or pharmacologic inhibition. Most Itgb6⁻/⁻;Itgb8⁻/⁻ embryos die at mid-gestation; those that survive develop cleft palate-as observed in Tgfb3⁻/⁻ mice. Itgb8⁻/⁻ mice treated with an anti-αvβ6-integrin antibody develop severe autoimmunity and lack Langerhans cells-similar to Tgfb1-null mice. These results support a model in which TGFβ3-mediated palate fusion and TGFβ1-mediated suppression of autoimmunity and generation of Langerhans cells require integrins αvβ6 and αvβ8 but not other RGD-binding integrins as TGFβ activators.
    Language English
    Dates of publication 2009-0115
    Size p. 227-232.
    Publishing place The Company of Biologists Limited
    Document type Article
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    Database NAL-Catalogue (AGRICOLA)

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