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  1. Article ; Online: What the stock market tells us about the post-COVID-19 world.

    Wagner, Alexander F

    Nature human behaviour

    2020  Volume 4, Issue 5, Page(s) 440

    MeSH term(s) Betacoronavirus ; COVID-19 ; Commerce/economics ; Coronavirus ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Cost of Illness ; Disease Outbreaks/economics ; Global Burden of Disease/economics ; Humans ; Investments/economics ; Pandemics/economics ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Uncertainty
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-020-0869-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What the stock market tells us about the post-COVID-19 world

    Wagner, Alexander F.

    Nature Human Behaviour

    2020  Volume 4, Issue 5, Page(s) 440–440

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ISSN 2397-3374
    DOI 10.1038/s41562-020-0869-y
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Concept for the Real-Time Monitoring of Molecular Configurations during Manipulation with a Scanning Probe Microscope.

    Scheidt, Joshua / Diener, Alexander / Maiworm, Michael / Müller, Klaus-Robert / Findeisen, Rolf / Driessens, Kurt / Tautz, F Stefan / Wagner, Christian

    The journal of physical chemistry. C, Nanomaterials and interfaces

    2023  Volume 127, Issue 28, Page(s) 13817–13836

    Abstract: A bold vision in nanofabrication is the assembly of functional molecular structures using a scanning probe microscope (SPM). This approach requires continuous monitoring of the molecular configuration during manipulation. Until now, this has been ... ...

    Abstract A bold vision in nanofabrication is the assembly of functional molecular structures using a scanning probe microscope (SPM). This approach requires continuous monitoring of the molecular configuration during manipulation. Until now, this has been impossible because the SPM tip cannot simultaneously act as an actuator and an imaging probe. Here, we implement configuration monitoring using experimental data other than images collected during the manipulation process. We model the manipulation as a partially observable Markov decision process (POMDP) and approximate the actual configuration in real time using a particle filter. To achieve this, the models underlying the POMDP are precomputed and organized in the form of a finite-state automaton, allowing the use of complex atomistic simulations. We exemplify the configuration monitoring process and reveal structural motifs behind measured force gradients. The proposed methodology marks an important step toward the piece-by-piece creation of supramolecular structures in a robotic and possibly automated manner.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ISSN 1932-7447
    ISSN 1932-7447
    DOI 10.1021/acs.jpcc.3c02072
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  5. Article: Feverish Stock Price Reactions to COVID-19

    Ramelli, Stefano / Wagner, Alexander F.

    The Review of Corporate Finance Studies

    Abstract: Market reactions to the 2019 novel coronavirus disease (COVID-19) provide new insights into how real shocks and financial policies drive firm value Initially, internationally oriented firms, especially those more exposed to trade with China, ... ...

    Abstract Market reactions to the 2019 novel coronavirus disease (COVID-19) provide new insights into how real shocks and financial policies drive firm value Initially, internationally oriented firms, especially those more exposed to trade with China, underperformed As the virus spread to Europe and the United States, corporate debt and cash holdings emerged as important value drivers, relevant even after the Fed intervened in the bond market The content and tone of conference calls mirror this development over time Overall, the results illustrate how anticipated real effects from the health crisis, a rare disaster, were amplified through financial channels
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #636886
    Database COVID19

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  6. Article: Hip MRI in flexion abduction external rotation for assessment of the ischiofemoral interval in patients with hip pain-a feasibility study.

    Heimann, Alexander F / Walther, Jonas / Tannast, Moritz / Schwab, Joseph M / Wagner, Moritz / Brunner, Alexander / Lerch, Till D / Steppacher, Simon D / Vavron, Peter / Schmaranzer, Ehrenfried / Schmaranzer, Florian

    Insights into imaging

    2023  Volume 14, Issue 1, Page(s) 172

    Abstract: Objectives: To assess the feasibility of flexion-abduction-external rotation (FABER) magnetic resonance imaging (MRI) of the hip to visualize changes in the ischiofemoral interval and ability to provoke foveal excursion over the acetabular rim.: ... ...

    Abstract Objectives: To assess the feasibility of flexion-abduction-external rotation (FABER) magnetic resonance imaging (MRI) of the hip to visualize changes in the ischiofemoral interval and ability to provoke foveal excursion over the acetabular rim.
    Methods: IRB-approved retrospective single-center study. Patients underwent non-contrast 1.5-T hip MRI in the neutral and FABER position. Two readers measured the ischiofemoral interval at three levels: proximal/distal intertrochanteric distance and ischiofemoral space. Subgroup analysis was performed for hips with/without high femoral torsion, or quadratus femoris muscle edema (QFME), respectively. A receiver operating curve with calculation of the area under the curve (AUC) for the prediction of QFME was calculated. The presence of foveal excursion in both positions was assessed.
    Results: One hundred ten patients (121 hips, mean age 34 ± 11 years, 67 females) were evaluated. FABER-MRI led to narrowing (both p < .001) of the ischiofemoral interval which decreased more at the proximal (mean decrease by 26 ± 7 mm) than at the distal (6 ± 7 mm) intertrochanteric ridge. With high femoral torsion/ QFME, the ischiofemoral interval was significantly narrower at all three measurement locations compared to normal torsion/no QFME (p < .05). Accuracy for predicting QFME was high with an AUC of .89 (95% CI .82-.94) using a threshold of ≤ 7 mm for the proximal intertrochanteric distance. With FABER-MRI foveal excursion was more frequent in hips with QFME (63% vs 25%; p = .021).
    Conclusion: Hip MRI in the FABER position is feasible, visualizes narrowing of the ischiofemoral interval, and can provoke foveal excursion.
    Critical relevance statement: FABER MRI may be helpful in diagnosing ischiofemoral impingement and detecting concomitant hip instability by overcoming shortcomings of static MR protocols that do not allow visualization of dynamic changes in the ischiofemoral interval and thus may improve surgical decision making.
    Key points: • FABER MRI enables visualization of narrowing of the ischiofemoral interval proximal to the lesser trochanter. • Proximal intertrochanteric distance of ≤ 7 mm accurately predicts quadratus femoris muscle edema. • Foveal excursion was more frequent in hips with quadratus femoris muscle edema.
    Language English
    Publishing date 2023-10-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-023-01524-4
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  7. Article ; Online: Repeat crossclamp after failed initial degenerative mitral valve repair is safe and successful.

    Wagner, Catherine M / Fu, Whitney W / Brescia, Alexander A / Hawkins, Robert B / Romano, Matthew A / Ailawadi, Gorav / Bolling, Steven F

    JTCVS open

    2023  Volume 16, Page(s) 209–217

    Abstract: Objective: Surgical risk and long-term outcomes when re-crossclamp is required during degenerative mitral valve repair are unknown. We examined the outcomes of patients who required re-crossclamp for mitral valve reintervention.: Methods: Adults ... ...

    Abstract Objective: Surgical risk and long-term outcomes when re-crossclamp is required during degenerative mitral valve repair are unknown. We examined the outcomes of patients who required re-crossclamp for mitral valve reintervention.
    Methods: Adults undergoing mitral valve repair for degenerative mitral valve disease at a single center from 2007 to 2021 who required more than 1 crossclamp for mitral valve reintervention were included. Outcomes including major morbidity and 30-day mortality were collected. Kaplan-Meier analysis characterized survival and freedom from recurrent mitral regurgitation.
    Results: A total of 69 patients required re-crossclamp for mitral valve reintervention. Of those, 72% (n = 50) underwent successful re-repair and the remaining underwent mitral valve replacement (28%, n = 19). Major morbidity occurred in 23% (n = 16). There was no 30-day mortality, and median long-term survival was 10.9 years for those undergoing re-repair and 7.2 years for those undergoing replacement (
    Conclusions: Patients requiring re-crossclamp for residual mitral regurgitation had low perioperative morbidity and no mortality. Most patients underwent successful re-repair (vs mitral valve replacement) with excellent valve function and long-term survival. In the event of unsatisfactory repair at the time of mitral valve repair, attempt at re-repair is safe and successful with the appropriate valvar anatomy.
    Language English
    Publishing date 2023-09-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.08.021
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  8. Article ; Online: A Multimodal Phantom for Visualization and Assessment of Histotripsy Treatments on Ultrasound and X-Ray Imaging.

    Kutlu, Ayca Z / Laeseke, Paul F / Zeighami Salimabad, Mehdi / Minesinger, Grace M / Periyasamy, Sarvesh / Pieper, Alexander A / Hall, Timothy J / Wagner, Martin G

    Ultrasound in medicine & biology

    2023  Volume 49, Issue 6, Page(s) 1401–1407

    Abstract: Objective: Histotripsy is an emerging non-invasive, non-ionizing and non-thermal focal tumor therapy. Although histotripsy targeting is currently based on ultrasound (US), other imaging modalities such as cone-beam computed tomography (CBCT) have ... ...

    Abstract Objective: Histotripsy is an emerging non-invasive, non-ionizing and non-thermal focal tumor therapy. Although histotripsy targeting is currently based on ultrasound (US), other imaging modalities such as cone-beam computed tomography (CBCT) have recently been proposed to enable the treatment of tumors not visible on ultrasound. The objective of this study was to develop and evaluate a multi-modality phantom to facilitate the assessment of histotripsy treatment zones on both US and CBCT imaging.
    Methods: Fifteen red blood cell phantoms composed of alternating layers with and without barium were manufactured. Spherical 25-mm histotripsy treatments were performed, and treatment zone size and location were measured on CBCT and ultrasound. Sound speed, impedance and attenuation were measured for each layer type.
    Results: The average ± standard deviation signed difference between measured treatment diameters was 0.29 ± 1.25 mm. The Euclidean distance between measured treatment centers was 1.68 ± 0.63 mm. The sound speed in the different layers ranged from 1491 to 1514 m/s and was within typically reported soft tissue ranges (1480-1560 m/s). In all phantoms, histotripsy resulted in sharply delineated treatment zones, allowing segmentation in both modalities.
    Conclusion: These phantoms will aid in the development and validation of X-ray-based histotripsy targeting techniques, which promise to expand the scope of treatable lesions beyond only those visible on ultrasound.
    MeSH term(s) Humans ; X-Rays ; Ultrasonography ; Phantoms, Imaging ; High-Intensity Focused Ultrasound Ablation/methods ; Cone-Beam Computed Tomography ; Neoplasms
    Language English
    Publishing date 2023-03-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2023.01.019
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  9. Article ; Online: Feverish Stock Price Reactions to COVID-19*

    Ramelli, Stefano / Wagner, Alexander F

    The Review of Corporate Finance Studies

    2020  Volume 9, Issue 3, Page(s) 622–655

    Abstract: Abstract Market reactions to the 2019 novel coronavirus disease (COVID-19) provide new insights into how real shocks and financial policies drive firm value. Initially, internationally oriented firms, especially those more exposed to trade with China, ... ...

    Abstract Abstract Market reactions to the 2019 novel coronavirus disease (COVID-19) provide new insights into how real shocks and financial policies drive firm value. Initially, internationally oriented firms, especially those more exposed to trade with China, underperformed. As the virus spread to Europe and the United States, corporate debt and cash holdings emerged as important value drivers, relevant even after the Fed intervened in the bond market. The content and tone of conference calls mirror this development over time. Overall, the results illustrate how anticipated real effects from the health crisis, a rare disaster, were amplified through financial channels. (JEL G01, G12, G14, G32, F14) Received: May 27, 2020; editorial decision June 16, 2020 by Editor Andrew Ellul. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2650556-3
    ISSN 2046-9136 ; 2046-9128
    ISSN (online) 2046-9136
    ISSN 2046-9128
    DOI 10.1093/rcfs/cfaa012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Connecting the dots: Motor and default mode network crossroads in post-stroke motor learning deficits.

    Dahms, Christiane / Noll, Alexander / Wagner, Franziska / Schmidt, Alexander / Brodoehl, Stefan / Klingner, Carsten M

    NeuroImage. Clinical

    2024  Volume 42, Page(s) 103601

    Abstract: Background: Strokes frequently result in long-term motor deficits, imposing significant personal and economic burdens. However, our understanding of the underlying neural mechanisms governing motor learning in stroke survivors remains limited - a fact ... ...

    Abstract Background: Strokes frequently result in long-term motor deficits, imposing significant personal and economic burdens. However, our understanding of the underlying neural mechanisms governing motor learning in stroke survivors remains limited - a fact that poses significant challenges to the development and optimisation of therapeutic strategies.
    Objective: This study investigates the diversity in motor learning aptitude and its associated neurological mechanisms. We hypothesised that stroke patients exhibit compromised overall motor learning capacity, which is associated with altered activity and connectivity patterns in the motor- and default-mode-network in the brain.
    Methods: We assessed a cohort of 40 chronic-stage, mildly impaired stroke survivors and 39 age-matched healthy controls using functional Magnetic Resonance Imaging (fMRI) and connectivity analyses. We focused on neural activity and connectivity patterns during an unilateral motor sequence learning task performed with the unimpaired or non-dominant hand. Primary outcome measures included task-induced changes in neural activity and network connectivity.
    Results: Compared to controls, stroke patients showed significantly reduced motor learning capacity, associated with diminished cerebral lateralization. Task induced activity modulation was reduced in the motor network but increased in the default mode network. The modulated activation strength was associated with an opposing trend in task-induced functional connectivity, with increased connectivity in the motor network and decreased connectivity in the DMN.
    Conclusions: Stroke patients demonstrate altered neural activity and connectivity patterns during motor learning with their unaffected hand, potentially contributing to globally impaired motor learning skills. The reduced ability to lateralize cerebral activation, along with the enhanced connectivity between the right and left motor cortices in these patients, may signify maladaptive neural processes that impede motor adaptation, possibly affecting long-term rehabilitation post-stroke. The contrasting pattern of activity modulation and connectivity alteration in the default mode network suggests a nuanced role of this network in post-stroke motor learning. These insights could have significant implications for the development of customised rehabilitation strategies for stroke patients.
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2024.103601
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