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Article ; Online: Epidemiología de campo en tiempos de COVID-19: retos para los servicios de salud pública. Informe SESPAS 2022.

Zurriaga-Carda, Rocío / Aginagalde Llorente, Adrián Hugo / Álvarez-Vaca, Daniel

2022 Volume 36 Suppl 1, Page(s) S76–S81

Abstract: During the COVID-19 crisis, local epidemiology units have been forced to manage an increasing number of cases, contacts and outbreaks for which they were not previously prepared or staffed. Under normal circumstances, the efficient study and control of ... ...

Title translation	Field epidemiology in times of COVID-19: challenges for public health services. SESPAS Report 2022.
Abstract	During the COVID-19 crisis, local epidemiology units have been forced to manage an increasing number of cases, contacts and outbreaks for which they were not previously prepared or staffed. Under normal circumstances, the efficient study and control of outbreaks and public health alerts requires human and material resources, situation analysis to identify possible causes and present recommendations, coordination with other health system structures, as well as the providing a written report including control and prevention measures implemented and their results or other recommendations. The field study of outbreaks has been systematized in a way that has made it possible to implement quick and effective measures, for the interruption of transmission chains and management of risk situations. To achieve this, a rapid and extraordinary exercise of digital integration, staff mobilization and creation of ad hoc structures needed to be carried out. Solidarity and cooperation between professionals from different administrations has been the pillar that has sustained the surveillance systems. Despite this, obstacles have been found as a result of the lack of coordination, social inequalities, and later, pandemic fatigue, which have reduced adherence and effectiveness of the implemented measures. It has also come to light the need to properly staff these units with trained professionals, and match working conditions and salaries with other health services.
MeSH term(s)	COVID-19/epidemiology ; Disease Outbreaks/prevention & control ; Health Services ; Humans ; Pandemics ; United States
Language	Spanish
Publishing date	2022-04-20
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1038713-4
ISSN	1578-1283 ; 0213-9111
ISSN (online)	1578-1283
ISSN	0213-9111
DOI	10.1016/j.gaceta.2022.02.009
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Article ; Online: Epidemiología de campo en tiempos de COVID-19

Rocío Zurriaga-Carda / Adrián Hugo Aginagalde Llorente / Daniel Álvarez-Vaca

Gaceta Sanitaria, Vol 36, Iss , Pp S76-S

retos para los servicios de salud pública. Informe SESPAS 2022

2022 Volume 81

Abstract: Resumen: Durante la crisis por la COVID-19, las unidades periféricas de epidemiología se han visto obligadas a gestionar un volumen de casos, contactos y brotes para el que no estaban dimensionadas ni dotadas. En situaciones ordinarias, el estudio y el ... ...

Abstract	Resumen: Durante la crisis por la COVID-19, las unidades periféricas de epidemiología se han visto obligadas a gestionar un volumen de casos, contactos y brotes para el que no estaban dimensionadas ni dotadas. En situaciones ordinarias, el estudio y el control eficiente de los brotes y de las alertas requieren recursos humanos y materiales, análisis de la situación para identificar causas y emitir recomendaciones, coordinación con otras estructuras del sistema sanitario, así como la devolución de los resultados y las actuaciones en un informe y una propuesta de actuaciones. El estudio de brotes sobre el terreno ha evolucionado, alcanzando un grado de sistematización que ha permitido implementar de forma generalizada medidas rápidas y eficaces, para la interrupción de las cadenas de transmisión y la gestión de las situaciones de riesgo. Para conseguirlo, se ha tenido que realizar un ejercicio rápido y extraordinario de integración informática, de movilización de personal y de creación de estructuras ad hoc. La solidaridad y la cooperación entre profesionales de distintas Administraciones ha sido el pilar que ha sostenido el sistema de vigilancia. A pesar de ello, se han detectado obstáculos fruto de la falta de coordinación, las desigualdades sociales en salud y, posteriormente, la fatiga pandémica, que han disminuido la adherencia y la efectividad de las medidas. A su vez, se ha puesto de manifiesto la necesidad de redimensionar estas unidades, dotarlas de profesionales con formación y equiparar las condiciones de trabajo y de remuneración con los servicios de salud. Abstract: During the COVID-19 crisis, local epidemiology units have been forced to manage an increasing number of cases, contacts and outbreaks for which they were not previously prepared or staffed. Under normal circumstances, the efficient study and control of outbreaks and public health alerts requires human and material resources, situation analysis to identify possible causes and present recommendations, coordination with other health system ...
Keywords	Epidemiology ; Communicable diseases control ; COVID-19 ; Disease outbreaks ; Contact tracing ; Health workforce ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Masa auricular como complicación después de intervención coronaria percutánea compleja

Luis Nieto-Roca / Rocío Carda Barrio / Marta Tomás-Mallebrera / José Antonio Esteban-Chapel / María Luisa Martín-Mariscal

REC: Interventional Cardiology, Vol 5, Iss 2, Pp 160-

2023 Volume 161

Abstract: Se presenta el caso de un varón de 75 años a quien se realiza una coronariografía por disnea de nueva aparición y bloqueo de rama izquierda con lesión larga, difusa y fuertemente calcificada y estenosis máxima del 90% en coronaria derecha dominante. Se ... ...

Abstract	Se presenta el caso de un varón de 75 años a quien se realiza una coronariografía por disnea de nueva aparición y bloqueo de rama izquierda con lesión larga, difusa y fuertemente calcificada y estenosis máxima del 90% en coronaria derecha dominante. Se le sometió a una intervención coronaria percutánea (ICP) compleja (técnica de doble guía, ambas hidrofílicas, catéter guía telescopado y dilataciones con balones distensibles y semidistensibles) y se implantaron con éxito 3 stents farmacoactivos en sentido distal a proximal. A las pocas horas, el paciente empezó a quejarse de dolor torácico pleurítico, aunque seguía hemodinámicamente estable y con una exploración física normal. Las pruebas de laboratorio mostraron niveles de troponina I de 8 ng/ml (valores de referencia < 0,012 ng/ml). El ecocardiograma no mostró signos de movimiento regional anómalo, pero sí la presencia de una masa en la aurícula izquierda de 55,3 × 29 mm emergiendo de la pared auricular posterior que casi taponaba por completo la cavidad auricular sin disfunción protésica mitral asociada ni flujo transmitral comprometido. También se confirmó la presencia de derrame pericárdico sugestivo de hemopericardio (figura 1A; vídeo 1 del material adicional). Ante la sospecha de hematoma intramural auricular izquierdo (HIAI) se realizó una.
Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents.

Pla-López, Alberto / Castillo, Raquel / Cejudo-Marín, Rocío / García-Pedrero, Olaya / Bakir-Laso, Mariam / Falomir, Eva / Carda, Miguel

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically evaluated as multitarget ... ...

Abstract	Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically evaluated as multitarget inhibitors of VEGFR-2, PD-L1 and c-Myc proteins. The antiproliferative activity of these molecules on several tumor cell lines (HT-29, A-549, and MCF-7) and on the non-tumor cell line HEK-293 was determined. The effects on the abovementioned biological targets were evaluated for some selected compounds. Compound
MeSH term(s)	Antineoplastic Agents ; B7-H1 Antigen ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Proto-Oncogene Proteins c-myc/metabolism ; Structure-Activity Relationship ; Triazoles/pharmacology ; Vascular Endothelial Growth Factor A/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Antineoplastic Agents ; B7-H1 Antigen ; Proto-Oncogene Proteins c-myc ; Triazoles ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137049
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Article ; Online: Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents

Alberto Pla-López / Raquel Castillo / Rocío Cejudo-Marín / Olaya García-Pedrero / Mariam Bakir-Laso / Eva Falomir / Miguel Carda

International Journal of Molecular Sciences, Vol 23, Iss 7049, p

2022 Volume 7049

Abstract	Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically evaluated as multitarget inhibitors of VEGFR-2, PD-L1 and c-Myc proteins. The antiproliferative activity of these molecules on several tumor cell lines (HT-29, A-549, and MCF-7) and on the non-tumor cell line HEK-293 was determined. The effects on the abovementioned biological targets were evaluated for some selected compounds. Compound 23 , bearing a p -chlorophenyl group, showed better results than sorafenib in regard to the downregulation of VEGFR-2 and a similar effect to BMS-8 on both PD-L1 and c-Myc proteins. The antiangiogenic and antivascular activities of chloro derivatives were also established by endothelial microtube formation assay on Matrigel ® .
Keywords	PD-L1 ; VEGFR-2 ; c-Myc ; multitarget inhibitors ; immunomodulation ; angiogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic value of initial QRS analysis in anterior STEMI: Correlation with left ventricular systolic dysfunction, serum biomarkers, and cardiac outcomes.

López-Castillo, Marta / Aceña, Álvaro / Pello-Lázaro, Ana M / Viegas, Vanessa / Merchán Muñoz, Beatriz / Carda, Rocío / Franco-Peláez, Juan / Martín-Mariscal, Maria Luisa / Briongos-Figuero, Sem / Tuñón, Jose

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

2020 Volume 26, Issue 1, Page(s) e12791

Abstract: Background: The presence of pathologic Q waves on admission electrocardiogram (ECG) in patients with anterior ST-elevated myocardial infarction (STEMI) has been related to adverse cardiac outcomes. Our study evaluates the prognostic value of QRS complex ...

Abstract	Background: The presence of pathologic Q waves on admission electrocardiogram (ECG) in patients with anterior ST-elevated myocardial infarction (STEMI) has been related to adverse cardiac outcomes. Our study evaluates the prognostic value of QRS complex and Q waves in patients with STEMI undergoing percutaneous coronary intervention. Methods: We prospectively analyzed the specific characteristics of QRS complex and pathologic Q waves on admission and on discharge ECG in 144 patients hospitalized for anterior STEMI. We correlated these findings with the development of left ventricular systolic dysfunction (LVSD), appearance of heart failure (HF) or death during follow-up, and levels of several biomarkers obtained 6 months after the index event. Results: Multivariate logistic regression analysis showed that QRS width (odds ratios [OR] 1.05, p = .001) on admission ECG and the sum of Q-wave depth (OR 1.06, p = .002) on discharge ECG were independent predictors of LVSD development. Moreover, QRS width on admission ECG was related to an increased risk of HF or death (OR 1.03, p = .026). Regarding biomarkers, QRS width on admission ECG revealed a statistically significant relationship with the levels of NT-pro-BNP at 6 months (0.29, p = .004); the sum of Q-wave depth (0.27, p = .012) and width (0.25, p = .021) on admission ECG was related to the higher levels of hs-cTnI; the sum of the voltages in precordial leads both on admission ECG (-0.26, p = .011) and discharge ECG (0.24, p = .046) was related to the lower levels of parathormone. Conclusions: Assessment of QRS complex width and pathologic Q waves on admission and discharge ECGs aids in predicting long-term prognosis in patients with STEMI.
MeSH term(s)	Biomarkers/blood ; Electrocardiography/methods ; Female ; Heart/physiopathology ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prognosis ; Prospective Studies ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/physiopathology ; Troponin I/blood ; Ventricular Dysfunction, Left/blood ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/physiopathology
Chemical Substances	Biomarkers ; Peptide Fragments ; Troponin I ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1325530-7
ISSN	1542-474X ; 1082-720X
ISSN (online)	1542-474X
ISSN	1082-720X
DOI	10.1111/anec.12791
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Article: Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome.

Franco-Peláez, Juan Antonio / Martín-Reyes, Roberto / Pello-Lázaro, Ana María / Aceña, Álvaro / Lorenzo, Óscar / Martín-Ventura, José Luis / Blanco-Colio, Luis / González-Casaus, María Luisa / Hernández-González, Ignacio / Carda, Rocío / Martín-Mariscal, María Luisa / Egido, Jesús / Tuñón, José

Journal of clinical medicine

2020 Volume 9, Issue 9

Abstract: Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients ... ...

Abstract	Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an acute coronary syndrome 6 months before. Plasma levels of several biomarkers were assessed, and patients were followed during a median of 5.35 (3.88-6.65) years. Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = (1.35-3.76) for each increase of 100 pg/mL,
Language	English
Publishing date	2020-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9093037
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Article ; Online: Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome

Juan Antonio Franco-Peláez / Roberto Martín-Reyes / Ana María Pello-Lázaro / Álvaro Aceña / Óscar Lorenzo / José Luis Martín-Ventura / Luis Blanco-Colio / María Luisa González-Casaus / Ignacio Hernández-González / Rocío Carda / María Luisa Martín-Mariscal / Jesús Egido / José Tuñón

Journal of Clinical Medicine, Vol 9, Iss 3037, p

2020 Volume 3037

Abstract	Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an acute coronary syndrome 6 months before. Plasma levels of several biomarkers were assessed, and patients were followed during a median of 5.35 (3.88–6.65) years. Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = (1.35–3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor of CAE, whereas mineral metabolism markers or proprotein convertase subtilisin/kexin type 9 were not. Moreover, CAE was a strong predictor of AAT during follow-up after adjustment for other clinically relevant variables (HR = 2.67, 95%CI = (1.22–5.82), p = 0.013). This is the first report showing that MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery disease may share pathogenic mechanisms. Furthermore, CAE was associated with an increased incidence of AAT.
Keywords	coronary artery ectasia ; monocyte chemoattractant protein-1 ; low-density lipoprotein ; acute atherotrombotic events ; coronary artery disease ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of 3 Predictive Clinical Risk Scores in 603 Patients with Stable Coronary Artery Disease.

Aceña, Álvaro / Martín-Mariscal, Maria Luisa / Tarín, Nieves / Cristóbal, Carmen / Huelmos, Ana / Pello, Ana / Carda, Rocío / Alonso, Joaquín / Lorenzo, Óscar / Mahíllo-Fernández, Ignacio / Tuñón, José

Texas Heart Institute journal

2017 Volume 44, Issue 4, Page(s) 239–244

Abstract: No clinical risk score is universally accepted for coronary artery disease. In 603 patients (mean age, 61.2 ± 12.3 yr) with stable coronary artery disease, we investigated the predictive power of clinical risk scores derived from the Framingham, the Long- ...

Abstract	No clinical risk score is universally accepted for coronary artery disease. In 603 patients (mean age, 61.2 ± 12.3 yr) with stable coronary artery disease, we investigated the predictive power of clinical risk scores derived from the Framingham, the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID), and the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) studies. Secondary outcomes were the recurrence of an acute thrombotic event (coronary events, strokes, or transient ischemic attacks), or heart failure or death. The primary outcome was the combination of secondary outcomes. During follow-up (duration, 2.08 ± 0.97 yr), 42 patients had an acute thrombotic event; 22, heart failure or death; and 60, the primary outcome. The Framingham score predicted acute thrombotic events: hazard ratio (HR)=1.05; 95% confidence interval (CI), 1.01-1.08;
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	604761-0
ISSN	1526-6702 ; 0730-2347
ISSN (online)	1526-6702
ISSN	0730-2347
DOI	10.14503/THIJ-15-5643
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Zs.A 1452: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives.

Martí-Centelles, Rosa / Cejudo-Marín, Rocío / Falomir, Eva / Murga, Juan / Carda, Miguel / Marco, J Alberto

Bioorganic & medicinal chemistry

2013 Volume 21, Issue 11, Page(s) 3010–3015

Abstract: We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine ... ...

Abstract	We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives downregulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells.
MeSH term(s)	Angiogenesis Inhibitors/chemical synthesis ; Angiogenesis Inhibitors/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Aorta/cytology ; Aorta/drug effects ; Aorta/metabolism ; Cattle ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Inhibitory Concentration 50 ; Stilbenes/chemical synthesis ; Stilbenes/pharmacology ; Structure-Activity Relationship
Chemical Substances	Angiogenesis Inhibitors ; Antineoplastic Agents ; Stilbenes ; resveratrol (Q369O8926L)
Language	English
Publishing date	2013-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2013.03.072
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