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  1. AU=Roesch Saskia
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  1. Article ; Conference proceedings: Stromale und intratumorale T-Zellinfiltration in Plattenepithelkarzinome des Kopf-Hals-Bereichs

    Krum, David / Rösch, Saskia / Dyckhoff, Gerhard / Warta, Rolf / Plinkert, Peter-Karl / Herold-Mende, Christel

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766555
    Database Thieme publisher's database

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  2. Article ; Conference proceedings: Stromal and intratumoral T cell infiltration in head and neck squamous cell carcinoma

    Krum, David / Rösch, Saskia / Dyckhoff, Gerhard / Warta, Rolf / Plinkert, Peter-Karl / Herold-Mende, Christel

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767152
    Database Thieme publisher's database

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  3. Article: Ketogenic diet for treating alopecia in BCS1l-related mitochondrial disease (Bjornstad syndrome).

    Della Marina, Adela / Leiendecker, Baerbel / Roesch, Sebastian / Wortmann, Saskia B

    JIMD reports

    2020  Volume 53, Issue 1, Page(s) 10–11

    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2672872-2
    ISSN 2192-8312 ; 2192-8304
    ISSN (online) 2192-8312
    ISSN 2192-8304
    DOI 10.1002/jmd2.12109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Gold(I) complexes based on six-membered phosphorus heterocycles as bio-active molecules against brain cancer.

    Roesch, Saskia / Fermi, Valentina / Rominger, Frank / Herold-Mende, Christel / Romero-Nieto, Carlos

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 95, Page(s) 15088

    Abstract: ... molecules against brain cancer' by Saskia Roesch et al., Chem. Commun., 2020, DOI: 10.1039/d0cc05761d. ...

    Abstract Correction for 'Gold(i) complexes based on six-membered phosphorus heterocycles as bio-active molecules against brain cancer' by Saskia Roesch et al., Chem. Commun., 2020, DOI: 10.1039/d0cc05761d.
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc90495c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mitochondrial Disease and Hearing Loss in Children: A Systematic Review.

    Roesch, Sebastian / O'Sullivan, Anna / Zimmermann, Georg / Mair, Alois / Lipuš, Cvetka / Mayr, Johannes A / Wortmann, Saskia B / Rasp, Gerd

    The Laryngoscope

    2022  Volume 132, Issue 12, Page(s) 2459–2472

    Abstract: Objectives: Hearing loss is a clinical symptom, frequently mentioned in the context of mitochondrial disease. With no cure available for mitochondrial disease, supportive treatment of clinical symptoms like hearing loss is of the utmost importance. The ... ...

    Abstract Objectives: Hearing loss is a clinical symptom, frequently mentioned in the context of mitochondrial disease. With no cure available for mitochondrial disease, supportive treatment of clinical symptoms like hearing loss is of the utmost importance. The aim of this study was to summarize current knowledge on hearing loss in genetically proven mitochondrial disease in children and deduce possible and necessary consequences in patient care.
    Methods: Systematic literature review, including Medline, Embase, and Cochrane library. Review protocol was established and registered prior to conduction (International prospective register of systematic reviews-PROSPERO: CRD42020165356). Conduction of this review was done in accordance with MOOSE criteria.
    Results: A total of 23 articles, meeting predefined criteria and providing sufficient information on 75 individuals with childhood onset hearing loss was included for analysis. Both cochlear and retro-cochlear origin of hearing loss can be identified among different types of mitochondrial disease. Analysis was hindered by inhomogeneous reporting and methodical limitations.
    Conclusion: Overall, the findings do not allow for a general statement on hearing loss in children with mitochondrial disease. Retro-cochlear hearing loss seems to be found more often than expected. A common feature appears to be progression of hearing loss over time. However, hearing loss in these patients shows manifold characteristics. Therefore, awareness of mitochondrial disease as a possible causative background is important for otolaryngologists. Future attempts rely on standardized reporting and long-term follow-up.
    Level of evidence: NA Laryngoscope, 132:2459-2472, 2022.
    MeSH term(s) Humans ; Hearing Loss/diagnosis ; Deafness ; Hearing Loss, Sensorineural ; Mitochondrial Diseases/complications
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gold(i) complexes based on six-membered phosphorus heterocycles as bio-active molecules against brain cancer.

    Roesch, Saskia / Fermi, Valentina / Rominger, Frank / Herold-Mende, Christel / Romero-Nieto, Carlos

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 93, Page(s) 14593–14596

    Abstract: π-Systems based on six-membered phosphorus heterocycles possess structural and electronic characteristics that clearly distinguish them from the rest of the organophosphorus molecules. However, their use in cancer therapy has been uninvestigated. In ... ...

    Abstract π-Systems based on six-membered phosphorus heterocycles possess structural and electronic characteristics that clearly distinguish them from the rest of the organophosphorus molecules. However, their use in cancer therapy has been uninvestigated. In particular, glioblastoma is one of the most lethal brain tumors. The development of novel and more efficient drugs for the treatment of glioblastoma is thus crucial to battle this aggressive disease. Herein, we report a new family of gold(i) complexes based on six-membered phosphorus heterocycles as a promising tool to investigate brain cancer. We discovered that the latter complexes inhibit the proliferation, sensitize to apoptosis and hamper the migration of not only conventional but also stem-like glioblastoma cells. Our results unveil thus new research opportunities for the treatment of glioblastoma.
    MeSH term(s) Apoptosis ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Glioblastoma/pathology ; Gold/chemistry ; Heterocyclic Compounds/chemistry ; Humans ; Phosphorus/chemistry
    Chemical Substances Heterocyclic Compounds ; Phosphorus (27YLU75U4W) ; Gold (7440-57-5)
    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc05761d
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  7. Book ; Online ; Thesis: Identifizierung Tumorstroma-assoziierter T-Zellantigene in Plattenepithelkarzinomen des oberen Aerodigestivtrakts

    Rösch, Saskia [Verfasser] / Beckhove, Philipp [Akademischer Betreuer]

    2018  

    Author's details Saskia Rösch ; Betreuer: Philipp Beckhove
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

    Saskia Roesch / Carmen Rapp / Steffen Dettling / Christel Herold-Mende

    International Journal of Molecular Sciences, Vol 19, Iss 2, p

    2018  Volume 436

    Abstract: As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell ... ...

    Abstract As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells.
    Keywords microglia ; glioma-associated microglia/macrophages ; GAMs ; glioma ; glioblastoma ; GBM ; tumor microenvironment ; TME ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma.

    Roesch, Saskia / Rapp, Carmen / Dettling, Steffen / Herold-Mende, Christel

    International journal of molecular sciences

    2018  Volume 19, Issue 2

    Abstract: As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell ... ...

    Abstract As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells.
    MeSH term(s) Animals ; Brain/immunology ; Brain/metabolism ; Brain/pathology ; Brain Neoplasms/immunology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cytokines/immunology ; Cytokines/metabolism ; Glioma/immunology ; Glioma/metabolism ; Glioma/pathology ; Humans ; Macrophages/immunology ; Macrophages/pathology ; Microglia/immunology ; Microglia/pathology ; Models, Immunological ; Tumor Microenvironment/immunology
    Chemical Substances Cytokines
    Language English
    Publishing date 2018-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19020436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molekulare und funktionale Abklärung hereditärer Schwerhörigkeiten am Beispiel des SLC26A4-Gens.

    Roesch, Sebastian / Bernardinelli, Emanuele / Wortmann, Saskia / Mayr, Johannes A / Bader, Ingrid / Schweighofer-Zwink, Gregor / Rasp, Gerd / Dossena, Silvia

    Laryngo- rhino- otologie

    2020  Volume 99, Issue 12, Page(s) 853–862

    Abstract: Due to development of molecular techniques at hand, the number of genomic sequence variants detected in patient investigations is rising constantly. The number of potentially involved genes in hereditary hearing loss is rising simultaneously.In this ... ...

    Title translation Molecular and functional testing in case of hereditary hearing loss associated with the SLC26A4 gene.
    Abstract Due to development of molecular techniques at hand, the number of genomic sequence variants detected in patient investigations is rising constantly. The number of potentially involved genes in hereditary hearing loss is rising simultaneously.In this overview, current methods for diagnostic workup on a molecular and functional level for variants of the
    MeSH term(s) Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/genetics ; Humans ; Membrane Transport Proteins/genetics ; Mutation ; Sulfate Transporters/genetics ; Vestibular Aqueduct
    Chemical Substances Membrane Transport Proteins ; SLC26A4 protein, human ; Sulfate Transporters
    Language German
    Publishing date 2020-12-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-1190-4173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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