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Article ; Online: Acute infectious aortitis presenting as pyelonephritis.

Rimac, Goran / Lafleur, Alexandre

The American journal of emergency medicine

2018 Volume 36, Issue 9, Page(s) 1722.e5–1722.e7

Abstract: A 65-years-old man with poorly controlled type 2 diabetes presented to the emergency department in sepsis with a 2-week history of new-onset fever, abdominal pain and pyuria. A Computed Tomography without contrast ruled out nephrolithiasis and ... ...

Abstract	A 65-years-old man with poorly controlled type 2 diabetes presented to the emergency department in sepsis with a 2-week history of new-onset fever, abdominal pain and pyuria. A Computed Tomography without contrast ruled out nephrolithiasis and hydronephrosis, but showed infiltration around the infra-renal aorta (5 x 1 cm) and several retroperitoneal lymph nodes. The periaortic infiltration raised suspicion for acute infectious aortitis. Aortic CT angiography confirmed an aortic pseudo-aneurysm in the infra-renal aorta without signs of impending aortic rupture. A Positron Emission Tomography-Computed Tomography confirmed abnormal 18F-FDG uptake adjacent to the right posterolateral aortic wall. The patient underwent abdominal aortic reconstruction with cryopreserved arterial allograft. Infectious aortitis is a rare but lethal cause of sepsis. Males over 50 years old with diabetes mellitus and peripheral vascular atherosclerotic disease are considered at higher risk. The diagnosis should be considered when a septic patient has vascular risk factors, abdominal pain, bacteremia and suggestive imaging. A CT without contrast showing infiltration around the aorta should, in some context, be promptly followed by Aortic CTA to search for acute aortitis among other less urgent differentials. Antibiotic therapy and involvement of vascular surgeons should be initiated in the emergency department.
MeSH term(s)	Acute Disease ; Aged ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/surgery ; Aortitis/diagnosis ; Aortitis/diagnostic imaging ; Aortitis/microbiology ; Computed Tomography Angiography ; Humans ; Male ; Positron-Emission Tomography ; Pyelonephritis/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-06-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2018.06.018
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Article ; Online: Severity of Left Ventricular Dysfunction in Patients With Tachycardia-Induced Cardiomyopathy: Impacts on Remodeling After Atrial Flutter Ablation.

De Larochellière, Hugo / Brouillette, François / Lévesque, Patrick / Dognin, Nicolas / St-Germain, Raphaël / Rimac, Goran / Lemay, Sylvain / Philippon, François / Sénéchal, Mario

The American journal of cardiology

2023 Volume 213, Page(s) 132–139

Abstract: Tachycardia-induced cardiomyopathy is defined as a reversible left ventricular (LV) systolic dysfunction (SeD) resulting from a sustained fast heart rate. LV remodeling in patients with severe LV dysfunction at diagnosis remains poorly understood. In ... ...

Abstract	Tachycardia-induced cardiomyopathy is defined as a reversible left ventricular (LV) systolic dysfunction (SeD) resulting from a sustained fast heart rate. LV remodeling in patients with severe LV dysfunction at diagnosis remains poorly understood. In this retrospective cohort study, we described LV remodeling in 50 patients who underwent atrial flutter ablation. These patients were divided into severe LV SeD (LV ejection fraction [EF] ≤30%) and LV nonsevere SeD (LVEF 31% to 50%) at baseline. All continuous variables are expressed as median and interquartile range. LVEF was 18% (13 to 25) and 38% (34 to 41) in the SeD (n = 29) and LV nonsevere SeD (n = 21) groups, respectively. At baseline, patients with SeD had higher LV end-diastolic diameter (56 [54 to 59] vs 49 mm [47 to 52], p <0.01), LV end-systolic diameter (48 [43 to 51] vs 36 mm [34 to 41], p <0.01), LV end-diastolic volume (71 [64 to 85] vs 56 ml/m
MeSH term(s)	Humans ; Atrial Flutter/complications ; Atrial Flutter/surgery ; Retrospective Studies ; Cardiomyopathies/complications ; Ventricular Dysfunction, Left/etiology ; Ventricular Function, Left ; Stroke Volume ; Tachycardia ; Catheter Ablation ; Ventricular Remodeling/physiology
Language	English
Publishing date	2023-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.11.072
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Article ; Online: Effect of concomitant surgical atrial fibrillation ablation in patients with reduced left ventricle ejection fraction: A propensity-score matching analysis.

Rimac, Goran / Lauzon, Nicolas / Sénéchal, Mario / Dagenais, François / Jacques, Frédéric / Philippon, François / Voisine, Pierre

Journal of cardiac surgery

2022 Volume 37, Issue 11, Page(s) 3598–3606

Abstract: Background: Atrial fibrillation (AF) is common in patients with reduced left ventricle ejection fraction (RLVEF). The impact of concomitant surgical atrial fibrillation ablation (SAFA) in patients with RLVEF is uncertain. The purpose of this study was ... ...

Abstract	Background: Atrial fibrillation (AF) is common in patients with reduced left ventricle ejection fraction (RLVEF). The impact of concomitant surgical atrial fibrillation ablation (SAFA) in patients with RLVEF is uncertain. The purpose of this study was to assess the outcomes of concomitant SAFA in patients with RLVEF undergoing heart surgery on heart failure (HF) rehospitalization and mortality. Methods: Using a local registry and electronic health records linked with provincial civil register survival data from July 2002 to April 2019, we analyzed treatment and outcomes in a cohort of patients with AF and HF defined by left ventricle ejection fraction (LVEF) ≤40%. Health records were used to collect treatment and International Classification of Diseases (ICD 10) codes to determine outcomes. A negative binomial model was used to compare outcomes such as all-cause mortality and rehospitalization for heart failure. Results: The cohort included 682 patients with RLVEF and AF who underwent coronary artery bypass graft and/or valve surgery. A total of 196 patients (29%) underwent concomitant SAFA. After matching, 132 patients with concomitant SAFA were compared to 159 patients who did not undergo concomitant SAFA. At 6.0 ± 3.7 years of follow-up, concomitant SAFA was not associated with lower all-cause mortality (p = .9861) and reduction in rehospitalizations for heart failure decompensation (p = .31) compared to patients who did not have concomitant SAFA performed. Postoperatively, concomitant SAFA might be associated with less vasopressor and mechanical support use (p = .01). Conclusions: Concomitant SAFA during index cardiac surgery is safe but does not reduce mortality or rehospitalizations for HF. The effects of concomitant SAFA in the context of RLVEF need to be better studied with prospective trials.
MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Heart Failure/surgery ; Heart Ventricles/surgery ; Humans ; Prospective Studies ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.16927
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Article ; Online: When a delayed cardiology consultation leads to a massive left ventricle pseudoaneurysm: collateral effects of the COVID-19 pandemic.

Rimac, Goran / Marzouk, Mohammed / Dumont, Éric / Paradis, Jean-Michel

European heart journal

2020 Volume 41, Issue 32, Page(s) 3102

MeSH term(s)	Aneurysm, False/diagnosis ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Betacoronavirus ; COVID-19 ; Cardiac Surgical Procedures/methods ; Coronary Angiography ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Echocardiography ; Female ; Heart Diseases/diagnosis ; Heart Diseases/etiology ; Heart Diseases/surgery ; Heart Ventricles/diagnostic imaging ; Humans ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehaa480
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Article ; Online: The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.

Bojić, Mirza / Kondža, Martin / Rimac, Hrvoje / Benković, Goran / Maleš, Željan

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 17

Abstract: Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to ... ...

Abstract	Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to which humans are exposed through everyday diet. In the previous study, selected flavonoid aglycones showed inhibition of CYP3A4 enzyme. Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes. For this purpose, the
MeSH term(s)	Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Substrate Specificity/drug effects
Chemical Substances	Flavonoids ; Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2019-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24173174
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Article: When a delayed cardiology consultation leads to a massive left ventricle pseudoaneurysm: collateral effects of the COVID-19 pandemic

Rimac, Goran / Marzouk, Mohammed / Dumont, Éric / Paradis, Jean-Michel

Eur Heart J

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #526487
Database	COVID19

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Article ; Online: New Perspective in Cardiac Sarcoidosis: The Potential Role of a Dedicated Clinic and the Importance of Collaboration Among Different Specialties.

Lemay, Sylvain / Beaudoin, Jonathan / Philippon, François / Rimac, Goran / Lalancette, Jean-Simon / De Larochellière, Hugo / Gleeton, Guylaine / Charbonneau, Éric / Dion, Geneviève / Trottier, Mikaël / Albert, Alexandra / Fortin, Sophie / Laliberté, Claudine / Komlosy, Marie-Ève / Toma, Mustafa / Nery, Pablo / Birnie, David / Sénéchal, Mario

The Canadian journal of cardiology

2023 Volume 39, Issue 7, Page(s) 981–984

MeSH term(s)	Humans ; Myocarditis ; Sarcoidosis/diagnosis ; Sarcoidosis/therapy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2023.04.007
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Article ; Online: When a delayed cardiology consultation leads to a massive left ventricle pseudoaneurysm

Rimac, Goran / Marzouk, Mohammed / Dumont, Éric / Paradis, Jean-Michel

European Heart Journal

collateral effects of the COVID-19 pandemic

2020 Volume 41, Issue 32, Page(s) 3102–3102

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehaa480
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Article ; Online: The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity

Mirza Bojić / Martin Kondža / Hrvoje Rimac / Goran Benković / Željan Maleš

Molecules, Vol 24, Iss 17, p

2019 Volume 3174

Abstract	Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to which humans are exposed through everyday diet. In the previous study, selected flavonoid aglycones showed inhibition of CYP3A4 enzyme. Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes. For this purpose, the O -deethylation reaction of phenacetin was used for monitoring CYP1A2 enzyme activity, coumarin 7-hydroxylation for CYP2A6 enzyme activity, 6-α-hydroxylation of paclitaxel for CYP2C8 enzyme activity, and dextromethorphan O -demethylation for CYP2D6 enzyme activity. The generated metabolites were monitored by high-performance liquid chromatography coupled with diode array detection. Hesperetin, pinocembrin, chrysin, isorhamnetin, and morin inhibited CYP1A2 activity; apigenin, tangeretin, galangin, and isorhamnetin inhibited CYP2A6 activity; and chrysin, chrysin-dimethylether, and galangin inhibited CYP2C8. None of the analyzed flavonoids showed inhibition of CYP2D6. The flavonoids in this study were mainly reversible inhibitors of CYP1A2 and CYP2A6, while the inhibition of CYP2C8 was of mixed type (reversible and irreversible). The most prominent reversible inhibitor of CYP1A2 was chrysin, and this was confirmed by the docking study.
Keywords	flavonoids ; CYP1A2 ; CYP2A6 ; CYP2C8 ; CYP2D6 ; inhibition ; Organic chemistry ; QD241-441
Subject code	572
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Survival, ventricular arrhythmia, and implantable cardioverter-defibrillator usefulness in toxic cardiomyopathy due to substance abuse.

Dognin, Nicolas / Rimac, Goran / Domain, Guillaume / Cinq-Mars, Alexandre / Massot, Montse / Turgeon, Pierre Yves / Dubois-Sénéchal, Sacha-Michelle / Bourgault, Christine / Morin, Joëlle / Bernier, Mathieu / Beaudoin, Jonathan / Laflamme, Maxime / Charbonneau, Eric / Strubé, Camille / Voisine, Pierre / Philippon, François / Belzile, David / Sénéchal, Mario

Pacing and clinical electrophysiology : PACE

2023 Volume 46, Issue 7, Page(s) 645–656

Abstract: Background: Toxic dilated cardiomyopathy (T-DCM) due to substance abuse is now recognized as a potential cause of severe left ventricular dysfunction. The burden of ventricular arrhythmias (VA) and the role of a prophylactic implantable cardioverter- ... ...

Abstract	Background: Toxic dilated cardiomyopathy (T-DCM) due to substance abuse is now recognized as a potential cause of severe left ventricular dysfunction. The burden of ventricular arrhythmias (VA) and the role of a prophylactic implantable cardioverter-defibrillator (ICD) are not well documented in this population. We aim to assess the usefulness of ICD implantation in a T-DCM cohort. Methods: Patients younger than 65 years with a left ventricular ejection fraction (LVEF) < 35% followed at a tertiary center heart failure (HF) clinic between January 2003 and August 2019 were screened for inclusion. The diagnosis of T-DCM was confirmed after excluding other etiologies, and substance abuse was established according to the DSM-5 criteria. The composite primary endpoints were arrhythmic syncope, sudden cardiac death (SCD), or death of unknown cause. The secondary endpoints were the occurrence of sustained VA and/or appropriate therapies in ICD carriers. Results: Thirty-eight patients were identified, and an ICD was implanted in 19 (50%) of these patients, only one for secondary prevention. The primary outcome was similar between the two groups (ICD vs. non-ICD; p = 1.00). After a mean follow-up of 33 ± 36 months, only two VA episodes were reported in the ICD group. Three patients received inappropriate ICD therapies. One ICD implantation was complicated with cardiac tamponade. Twenty-three patients (61%) had an LVEF ≥35% at 12 months. Conclusion: VA are infrequent in the T-DCM population. The prophylactic ICD benefit was not observed in our cohort. The ideal timing for potential prophylactic ICD implantation in this population needs further studies.
MeSH term(s)	Humans ; Defibrillators, Implantable/adverse effects ; Stroke Volume ; Ventricular Function, Left ; Arrhythmias, Cardiac/complications ; Cardiomyopathies/therapy ; Cardiomyopathies/complications ; Death, Sudden, Cardiac/etiology ; Cardiomyopathy, Dilated/therapy ; Substance-Related Disorders/complications ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14720
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