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  1. Article ; Online: COVID-19 vaccine hesitancy and patient self-advocacy: a statistical analysis of those who can and can't get vaccinated.

    Ashwell, Douglas / Cullinane, Joanna / Croucher, Stephen M

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1296

    Abstract: Background: This study applies the Patient Self-Advocacy scale to investigate vaccine hesitancy in New Zealand. Due to New Zealand's very limited tertiary hospital system and vulnerable populations, the Government's strategy to address COVID-19 has been ...

    Abstract Background: This study applies the Patient Self-Advocacy scale to investigate vaccine hesitancy in New Zealand. Due to New Zealand's very limited tertiary hospital system and vulnerable populations, the Government's strategy to address COVID-19 has been to prevent the virus from entering the nation and to eliminate it when it does cross the border. Therefore, there is no opportunity for the nation to generate any acquired immunity through exposure. To transition from closed borders, New Zealand will need to run a highly successful national vaccination programme and this needs to have the ability to drive influential public health messaging to the targeted places within the communities where vaccine hesitancy most exists.
    Methods: This study employed statistical methods. A nationally representative survey of adults in New Zealand (n = 1852) was collected via Qualtrics. Independent samples t-tests, and multiple regression were used to explore the research questions.
    Results: Those who identify as medically able to be vaccinated expressed significantly higher confidence in the COVID-19 vaccine than those who identified as unable to be vaccinated. Patient-self advocacy had a positive effect on vaccine confidence. Individuals who identify as able to be vaccinated have less hesitancy. Demographics had various effects on vaccine hesitancy.
    Conclusion: The research highlights particularly important insights into vaccine hesitancy related to patient self-advocacy behaviours, and various demographic variables such as political affiliation. In addition, the research adds further clarity on how and why New Zealanders have responded to the COVID-vaccine. Finally, the importance of vaccine literacy is discussed.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Parents ; Vaccination ; Vaccination Hesitancy ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-13661-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When being positive might be negative: An analysis of Australian and New Zealand newspaper framing of vaccination post Australia's No Jab No Pay legislation.

    Ashwell, Douglas / Murray, Niki

    Vaccine

    2020  Volume 38, Issue 35, Page(s) 5627–5633

    Abstract: Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider ... ...

    Abstract Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider public is via the use of the news media. Communication agenda-setting and framing theory generally hold that the news media sets the issues of importance to society and also tells us how we should think about those issues. Emphasis framing theory however, would suggest that positively-framed statements in the media may actually be viewed as persuasive in a coercing way, leading to resistance to the messages. Further, this theory claims that negative news media is viewed as more credible and therefore, more easily accepted. We were interested to explore the framing of news reports about vaccination and the potential effects this framing may have had on the wider public over the years 2016-2017 in both Australia and New Zealand (when changes in vaccination policy and publicity respectively were on the agenda). We undertook a content analysis of 197 articles and emphasis frame, type of message, and other variables recorded. In both Australia and New Zealand, the news media messages were predominately positively framed and yet the vaccination rates of New Zealand particularly (where no policy changes mandating vaccination took place) have been decreasing. We suggest the media emphasis on positive vaccination reporting may be having the opposite effect of engendering resistance to vaccination within those who are vaccine-hesitant.
    MeSH term(s) Australia ; Mass Media ; New Zealand ; Persuasive Communication ; Vaccination
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.06.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The challenges of science journalism: The perspectives of scientists, science communication advisors and journalists from New Zealand.

    Ashwell, Douglas James

    Public understanding of science (Bristol, England)

    2016  Volume 25, Issue 3, Page(s) 379–393

    Abstract: The news media play an important role in informing the public about scientific and technological developments. Some argue that restructuring and downsizing result in journalists coming under increased pressure to produce copy, leading them to use more ... ...

    Abstract The news media play an important role in informing the public about scientific and technological developments. Some argue that restructuring and downsizing result in journalists coming under increased pressure to produce copy, leading them to use more public relations material to meet their deadlines. This article explores science journalism in the highly commercialised media market of New Zealand. Using semi-structured interviews with scientists, science communication advisors and journalists, the study finds communication advisors and scientists believe most media outlets, excluding public service media, report science poorly. Furthermore, restructuring and staff cuts have placed the journalists interviewed under increasing pressure. While smaller newspapers appear to be printing press releases verbatim, metropolitan newspaper journalists still exercise control over their use of such material. The results suggest these journalists will continue to resist increasing their use of public relations material for some time to come.
    MeSH term(s) Information Dissemination/methods ; Journalism/standards ; Mass Media ; New Zealand ; Public Relations ; Science
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421272-9
    ISSN 1361-6609 ; 0963-6625
    ISSN (online) 1361-6609
    ISSN 0963-6625
    DOI 10.1177/0963662514556144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: When being positive might be negative: An analysis of Australian and New Zealand newspaper framing of vaccination post Australia's No Jab No Pay legislation

    Ashwell, Douglas / Murray, Niki

    Vaccine. 2020 July 31, v. 38, no. 35

    2020  

    Abstract: Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider ... ...

    Abstract Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider public is via the use of the news media. Communication agenda-setting and framing theory generally hold that the news media sets the issues of importance to society and also tells us how we should think about those issues. Emphasis framing theory however, would suggest that positively-framed statements in the media may actually be viewed as persuasive in a coercing way, leading to resistance to the messages. Further, this theory claims that negative news media is viewed as more credible and therefore, more easily accepted. We were interested to explore the framing of news reports about vaccination and the potential effects this framing may have had on the wider public over the years 2016–2017 in both Australia and New Zealand (when changes in vaccination policy and publicity respectively were on the agenda). We undertook a content analysis of 197 articles and emphasis frame, type of message, and other variables recorded. In both Australia and New Zealand, the news media messages were predominately positively framed and yet the vaccination rates of New Zealand particularly (where no policy changes mandating vaccination took place) have been decreasing. We suggest the media emphasis on positive vaccination reporting may be having the opposite effect of engendering resistance to vaccination within those who are vaccine-hesitant.
    Keywords herd immunity ; issues and policy ; laws and regulations ; society ; vaccination ; vaccines ; Australia ; New Zealand
    Language English
    Dates of publication 2020-0731
    Size p. 5627-5633.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.06.070
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: When being positive might be negative: An analysis of Australian and New Zealand newspaper framing of vaccination post Australia's No Jab No Pay legislation

    Ashwell, Douglas / Murray, Niki

    Vaccine

    Abstract: Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider ... ...

    Abstract Vaccination rates are an ongoing global concern. Many developing and developed countries have rates of vaccination below rates required for herd immunity, for differing reasons. One way in which to communicate information about vaccination to the wider public is via the use of the news media. Communication agenda-setting and framing theory generally hold that the news media sets the issues of importance to society and also tells us how we should think about those issues. Emphasis framing theory however, would suggest that positively-framed statements in the media may actually be viewed as persuasive in a coercing way, leading to resistance to the messages. Further, this theory claims that negative news media is viewed as more credible and therefore, more easily accepted. We were interested to explore the framing of news reports about vaccination and the potential effects this framing may have had on the wider public over the years 2016-2017 in both Australia and New Zealand (when changes in vaccination policy and publicity respectively were on the agenda). We undertook a content analysis of 197 articles and emphasis frame, type of message, and other variables recorded. In both Australia and New Zealand, the news media messages were predominately positively framed and yet the vaccination rates of New Zealand particularly (where no policy changes mandating vaccination took place) have been decreasing. We suggest the media emphasis on positive vaccination reporting may be having the opposite effect of engendering resistance to vaccination within those who are vaccine-hesitant.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #635831
    Database COVID19

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  6. Article: Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.

    Sabatucci, Joseph P / Ashwell, Mark A / Trybulski, Eugene / O'Donnell, Mary-Margaret / Moore, William J / Harnish, Douglas C / Chadwick, Christopher C

    Bioorganic & medicinal chemistry letters

    2006  Volume 16, Issue 4, Page(s) 854–858

    Abstract: The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional ... ...

    Abstract The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional activity but are devoid of conventional estrogenic activity.
    MeSH term(s) Animals ; Cell Line ; Ligands ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Receptors, Estrogen/drug effects ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Sulfonamides/pharmacology
    Chemical Substances Ligands ; NF-kappa B ; Receptors, Estrogen ; Sulfonamides
    Language English
    Publishing date 2006-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2005.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Control of chronic inflammation with pathway selective estrogen receptor ligands.

    Steffan, Robert J / Matelan, Edward / Ashwell, Mark A / Moore, William J / Solvibile, William R / Trybulski, Eugene / Chadwick, Christopher C / Chippari, Susan / Kenney, Thomas / Winneker, Richard C / Eckert, Amy / Borges-Marcucci, Lisa / Adelman, Steven J / Xu, Zhang / Mosyak, Lydia / Harnish, Douglas C

    Current topics in medicinal chemistry

    2006  Volume 6, Issue 2, Page(s) 103–111

    Abstract: The discovery of novel intervention points in the inflammatory pathway has been a focus of drug development in recent years. We have identified pathway selective ligands for the estrogen receptor (ER) that inhibit NF-kappaB mediated inflammatory gene ... ...

    Abstract The discovery of novel intervention points in the inflammatory pathway has been a focus of drug development in recent years. We have identified pathway selective ligands for the estrogen receptor (ER) that inhibit NF-kappaB mediated inflammatory gene expression causing a reduction of cytokines, chemokines, adhesion molecules and inflammatory enzymes. SAR development of a series of 4-(Indazol-3-yl)-phenols has led to the identification of WAY-169916 an orally active non-steroidal ligand with the potential use in the treatment of inflammatory diseases without the classical proliferative effects associated with non-selective estrogens.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Chronic Disease ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Ligands ; Molecular Structure ; Pyrazoles/therapeutic use ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/immunology ; Structure-Activity Relationship
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Ligands ; Pyrazoles ; Receptors, Estrogen ; WAY-169916
    Language English
    Publishing date 2006-01-04
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802606775270279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.

    Chadwick, Christopher C / Chippari, Susan / Matelan, Edward / Borges-Marcucci, Lisa / Eckert, Amy M / Keith, James C / Albert, Leo M / Leathurby, Yelena / Harris, Heather A / Bhat, Ramesh A / Ashwell, Mark / Trybulski, Eugene / Winneker, Richard C / Adelman, Steven J / Steffan, Robert J / Harnish, Douglas C

    Proceedings of the National Academy of Sciences of the United States of America

    2005  Volume 102, Issue 7, Page(s) 2543–2548

    Abstract: Inflammation is now recognized as a key component in a number of diseases such as atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. The transcription factor NF-kappaB has been shown to be involved in both the early and late stages of ...

    Abstract Inflammation is now recognized as a key component in a number of diseases such as atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. The transcription factor NF-kappaB has been shown to be involved in both the early and late stages of the inflammatory-proliferative process. In this report, we describe the identification of the pathway-selective estrogen receptor (ER) ligand, WAY-169916, that inhibits NF-kappaB transcriptional activity but is devoid of conventional estrogenic activity. This pathway-selective ligand does not promote the classic actions of estrogens such as stimulation of uterine proliferation or ER-mediated gene expression, but is a potent antiinflammatory agent, as demonstrated in the HLA-B27 transgenic rat model of inflammatory bowel disease. Our results indicate the potential utility of pathway-selective ER ligands such as WAY-169916 in the treatment of chronic inflammatory diseases.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Line ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Female ; HLA-B27 Antigen/genetics ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/metabolism ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/antagonists & inhibitors ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrazoles/pharmacology ; Rats ; Receptors, Estrogen/metabolism ; Transcription, Genetic/drug effects ; Uterus/drug effects ; Uterus/metabolism
    Chemical Substances Estrogen Receptor alpha ; Estrogen Receptor beta ; HLA-B27 Antigen ; Ligands ; NF-kappa B ; Pyrazoles ; Receptors, Estrogen ; WAY-169916
    Language English
    Publishing date 2005-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0405841102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.

    Steffan, Robert J / Matelan, Edward / Ashwell, Mark A / Moore, William J / Solvibile, William R / Trybulski, Eugene / Chadwick, Christopher C / Chippari, Susan / Kenney, Thomas / Eckert, Amy / Borges-Marcucci, Lisa / Keith, James C / Xu, Zhang / Mosyak, Lydia / Harnish, Douglas C

    Journal of medicinal chemistry

    2004  Volume 47, Issue 26, Page(s) 6435–6438

    Abstract: Pathway-selective ligands for the estrogen receptor (ER) inhibit NF-kappaB-mediated inflammatory gene expression causing a reduction of cytokines, chemokines, adhesion molecules, and inflammatory enzymes. SAR development of a series of 4-(indazol-3-yl) ... ...

    Abstract Pathway-selective ligands for the estrogen receptor (ER) inhibit NF-kappaB-mediated inflammatory gene expression causing a reduction of cytokines, chemokines, adhesion molecules, and inflammatory enzymes. SAR development of a series of 4-(indazol-3-yl)phenols has led to the identification of WAY-169916 an orally active nonsteroidal ligand with the potential use in the treatment of rheumatoid arthritis without the classical proliferative effects associated with estrogens.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/drug therapy ; Cell Line ; Estrogen Receptor alpha/chemistry ; Estrogen Receptor alpha/drug effects ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/chemistry ; Estrogen Receptor beta/drug effects ; Estrogen Receptor beta/metabolism ; Humans ; Indazoles/chemical synthesis ; Indazoles/chemistry ; Indazoles/pharmacology ; Ligands ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; NF-kappa B/biosynthesis ; NF-kappa B/genetics ; Phenols/chemical synthesis ; Phenols/chemistry ; Phenols/pharmacology ; Rats ; Rats, Inbred Lew ; Receptors, Estrogen/chemistry ; Receptors, Estrogen/drug effects ; Receptors, Estrogen/metabolism ; Structure-Activity Relationship
    Chemical Substances Anti-Inflammatory Agents ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Indazoles ; Ligands ; NF-kappa B ; Phenols ; Receptors, Estrogen
    Language English
    Publishing date 2004-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm049194+
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Third Report on Chicken Genes and Chromosomes 2015.

    Schmid, Michael / Smith, Jacqueline / Burt, David W / Aken, Bronwen L / Antin, Parker B / Archibald, Alan L / Ashwell, Chris / Blackshear, Perry J / Boschiero, Clarissa / Brown, C Titus / Burgess, Shane C / Cheng, Hans H / Chow, William / Coble, Derrick J / Cooksey, Amanda / Crooijmans, Richard P M A / Damas, Joana / Davis, Richard V N / de Koning, Dirk-Jan /
    Delany, Mary E / Derrien, Thomas / Desta, Takele T / Dunn, Ian C / Dunn, Matthew / Ellegren, Hans / Eöry, Lél / Erb, Ionas / Farré, Marta / Fasold, Mario / Fleming, Damarius / Flicek, Paul / Fowler, Katie E / Frésard, Laure / Froman, David P / Garceau, Valerie / Gardner, Paul P / Gheyas, Almas A / Griffin, Darren K / Groenen, Martien A M / Haaf, Thomas / Hanotte, Olivier / Hart, Alan / Häsler, Julien / Hedges, S Blair / Hertel, Jana / Howe, Kerstin / Hubbard, Allen / Hume, David A / Kaiser, Pete / Kedra, Darek / Kemp, Stephen J / Klopp, Christophe / Kniel, Kalmia E / Kuo, Richard / Lagarrigue, Sandrine / Lamont, Susan J / Larkin, Denis M / Lawal, Raman A / Markland, Sarah M / McCarthy, Fiona / McCormack, Heather A / McPherson, Marla C / Motegi, Akira / Muljo, Stefan A / Münsterberg, Andrea / Nag, Rishi / Nanda, Indrajit / Neuberger, Michael / Nitsche, Anne / Notredame, Cedric / Noyes, Harry / O'Connor, Rebecca / O'Hare, Elizabeth A / Oler, Andrew J / Ommeh, Sheila C / Pais, Helio / Persia, Michael / Pitel, Frédérique / Preeyanon, Likit / Prieto Barja, Pablo / Pritchett, Elizabeth M / Rhoads, Douglas D / Robinson, Charmaine M / Romanov, Michael N / Rothschild, Max / Roux, Pierre-François / Schmidt, Carl J / Schneider, Alisa-Sophia / Schwartz, Matthew G / Searle, Steve M / Skinner, Michael A / Smith, Craig A / Stadler, Peter F / Steeves, Tammy E / Steinlein, Claus / Sun, Liang / Takata, Minoru / Ulitsky, Igor / Wang, Qing / Wang, Ying / Warren, Wesley C / Wood, Jonathan M D / Wragg, David / Zhou, Huaijun

    Cytogenetic and genome research

    2015  Volume 145, Issue 2, Page(s) 78–179

    MeSH term(s) Animals ; Chickens/classification ; Chickens/genetics ; Chickens/physiology ; Chromosome Mapping ; Chromosomes/genetics ; DNA Methylation ; Evolution, Molecular ; Female ; Gene Expression Profiling ; Genetic Variation ; Genomics/methods ; In Situ Hybridization, Fluorescence/methods ; Male ; Molecular Sequence Annotation ; Phylogeny
    Language English
    Publishing date 2015-07-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2087824-2
    ISSN 1424-859X ; 1424-8581
    ISSN (online) 1424-859X
    ISSN 1424-8581
    DOI 10.1159/000430927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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