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  1. Article ; Online: Appraisal as a unifying theory of response shift: continuing the conversation.

    Mayo, Nancy E

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2019  Volume 28, Issue 10, Page(s) 2635–2636

    MeSH term(s) Communication ; Humans ; Quality of Life
    Language English
    Publishing date 2019-09-10
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-019-02270-1
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    Zs.A 3796: Show issues Location:
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  2. Article ; Online: Medication utilization patterns in patients with post-COVID syndrome (PCS): Implications for polypharmacy and drug-drug interactions.

    Michael, Henry Ukachukwu / Brouillette, Marie-Josée / Fellows, Lesley K / Mayo, Nancy E

    Journal of the American Pharmacists Association : JAPhA

    2024  , Page(s) 102083

    Abstract: Background: Post-COVID syndrome (PCS) causes lasting symptoms like fatigue and cognitive issues. PCS treatment is nonspecific, focusing on symptom management, potentially increasing the risk of polypharmacy.: Objectives: To describe medication use ... ...

    Abstract Background: Post-COVID syndrome (PCS) causes lasting symptoms like fatigue and cognitive issues. PCS treatment is nonspecific, focusing on symptom management, potentially increasing the risk of polypharmacy.
    Objectives: To describe medication use patterns among patients with Post-COVID Syndrome (PCS) and estimate the prevalence of polypharmacy, potential drug-drug interactions, and anticholinergic/sedative burden.
    Methods: A cross-sectional analysis of baseline data from the Quebec Action for Post-COVID cohort, consisting of individuals self-identifying with persistent COVID-19 symptoms beyond 12 weeks. Medications were categorized using Anatomical Therapeutic Classification (ATC) codes. Polypharmacy was defined as using 5 or more concurrent medications. The Anticholinergic and Sedative Burden Catalog assessed anticholinergic and sedative loads. The Lexi-Interact checker identified potential drug-drug interactions, which were categorized into 3 severity tiers.
    Results: Out of 414 respondents, 154 (average age 47.7 years) were prescribed medications related to persistent COVID-19 symptoms. Drugs targeting the nervous system were predominant at 54.5%. The median number of medications was 2, while 11.7% reported polypharmacy. Over half of the participants prescribed medications used at least 1 anticholinergic or sedative medication, and 25% had the potential risk for clinically significant drug-drug interactions, primarily needing therapy monitoring.
    Conclusions: Our study reveals prescription patterns for PCS, underscoring the targeted management of nervous system symptoms. The risks associated with polypharmacy, potential drug-drug interactions, and anticholinergic/sedative burden stress the importance of judicious prescribing. While limitations like recall bias and a regional cohort are present, the findings underscore the imperative need for vigilant PCS symptom management.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2024.102083
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  3. Article ; Online: Thoughts on human geriatric rehabilitation from a geriatric greyhound: lessons learned from the rehabilitation given to an aged dog.

    Mayo, Nancy E

    Clinical rehabilitation

    2017  Volume 31, Issue 7, Page(s) 855–856

    MeSH term(s) Aged ; Aged, 80 and over ; Aging/physiology ; Animals ; Dogs ; Geriatric Assessment/methods ; Humans ; Program Development ; Program Evaluation ; Rehabilitation/organization & administration ; Species Specificity
    Language English
    Publishing date 2017-06-21
    Publishing country England
    Document type Editorial
    ZDB-ID 639276-3
    ISSN 1477-0873 ; 0269-2155
    ISSN (online) 1477-0873
    ISSN 0269-2155
    DOI 10.1177/0269215517709053
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  4. Article ; Online: The Patient Generated Index (PGI) as an early-warning system for predicting brain health challenges: a prospective cohort study for people living with Human Immunodeficiency Virus (HIV).

    Humayun, Muhammad Mustafa / Brouillette, Marie-Josée / Fellows, Lesley K / Mayo, Nancy E

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2023  Volume 32, Issue 12, Page(s) 3439–3452

    Abstract: Purpose: In research people are often asked to fill out questionnaires about their health and functioning and some of the questions refer to serious health concerns. Typically, these concerns are not identified until the statistician analyses the data. ... ...

    Abstract Purpose: In research people are often asked to fill out questionnaires about their health and functioning and some of the questions refer to serious health concerns. Typically, these concerns are not identified until the statistician analyses the data. An alternative is to use an individualized measure, the Patient Generated Index (PGI) where people are asked to self-nominate areas of concern which can then be dealt with in real-time. This study estimates the extent to which self-nominated areas of concern related to mood, anxiety and cognition predict the presence or occurrence of brain health outcomes such as depression, anxiety, psychological distress, or cognitive impairment among people aging with HIV at study entry and for successive assessments over 27 months.
    Methods: The data comes from participants enrolled in the Positive Brain Health Now (+ BHN) cohort (n = 856). We analyzed the self-nominated areas that participants wrote on the PGI and classified them into seven sentiment groups according to the type of sentiment expressed: emotional, interpersonal, anxiety, depressogenic, somatic, cognitive and positive sentiments. Tokenization was used to convert qualitative data into quantifiable tokens. A longitudinal design was used to link these sentiment groups to the presence or emergence of brain health outcomes as assessed using standardized measures of these constructs: the Hospital Anxiety and Depression Scale (HADS), the Mental Health Index (MHI) of the RAND-36, the Communicating Cognitive Concerns Questionnaire (C3Q) and the Brief Cognitive Ability Measure (B-CAM). Logistic regressions were used to estimate the goodness of fit of each model using the c-statistic.
    Results: Emotional sentiments predicted all of the brain health outcomes at all visits with adjusted odds ratios (OR) ranging from 1.61 to 2.00 and c-statistics > 0.73 (good to excellent prediction). Nominating an anxiety sentiment was specific to predicting anxiety and psychological distress (OR 1.65 & 1.52); nominating a cognitive concern was specific to predicting self-reported cognitive ability (OR 4.78). Positive sentiments were predictive of good cognitive function (OR 0.36) and protective of depressive symptoms (OR 0.55).
    Conclusions: This study indicates the value of using this semi-qualitative approach as an early-warning system in predicting brain health outcomes.
    MeSH term(s) Humans ; HIV ; Prospective Studies ; Quality of Life/psychology ; Anxiety/diagnosis ; Brain ; HIV Infections ; Depression/therapy
    Language English
    Publishing date 2023-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-023-03475-1
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    Zs.A 3796: Show issues Location:
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  5. Article ; Online: Admission and discharge profiles of people with MS accessing in-patient rehabilitation in Canada.

    Mate, Kedar K V / Ow, Nikki / Hum, Stanley / Mayo, Nancy E

    Multiple sclerosis and related disorders

    2023  Volume 79, Page(s) 105008

    Abstract: Background: Rehabilitation is the mainstay of management for people with disabilities of neurological origin to maximize function and reduce disability. Access to in-patient rehabilitation is usually reserved for people after crises or those who are ... ...

    Abstract Background: Rehabilitation is the mainstay of management for people with disabilities of neurological origin to maximize function and reduce disability. Access to in-patient rehabilitation is usually reserved for people after crises or those who are discharged from acute care such as in stroke or trauma. Access to people with Multiple Sclerosis (MS) differs across countries and unknown for Canada. With the progression of MS, quality of life (QOL) becomes more closely coupled with independence and hence timely access to rehabilitation is important. The objectives of this paper are (i) to characterize the disability profiles of people with MS admitted to in-patient rehabilitation in Canada; and (ii) to estimate the extent to which disability profiles differ from admission to discharge.
    Methods: A longitudinal study of a rehabilitation admission-to-discharge cohort of 3500 people with MS was conducting using latent class analysis on the five Functional Independence Measure (FIM) subscales for Self-care, Transfers, Locomotion, Bladder/Bowel, and Cognition. The extent to which age, sex, and calendar time was associated with latent class membership, at both admission and discharge, was estimated using ordinal logistic regression, and proportional odds model was calculated for each age and sex.
    Results: At admission five classes were identified. The two most prevalent classes included people with total or moderate dependency in all FIM subscales except cognition (n = 1205 and n = 1099). The third most common was dependent in ambulation only (n = 523), followed by dependence in ambulation with varying degree of limitation in self-care and transfers (n = 465, and n = 208). At discharge four classes were identified with the largest class comprising of people dependent in ambulation and to a lesser degree in transfers (n = 1010). The second most prevalent class was no dependency (n = 946), followed by two classes with varying dependency in all subscales but cognition (n = 678 and n = 771).
    Conclusion: Overall 62.3% of admissions transitioned to a more functional class by discharge. By discharge 28% of the population was characterized by no dependencies; however, 23% remained with dependencies in all areas. Those in the most dependent classes showed the greatest probability of transitioning to a better class at discharge highlighting the importance of reserving scarce rehabilitation services to those with more disability.
    MeSH term(s) Humans ; Patient Discharge ; Quality of Life ; Longitudinal Studies ; Recovery of Function ; Canada ; Retrospective Studies
    Language English
    Publishing date 2023-09-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.105008
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  6. Article ; Online: Stroke Rehabilitation at Home: Lessons Learned and Ways Forward.

    Mayo, Nancy E

    Stroke

    2016  Volume 47, Issue 6, Page(s) 1685–1691

    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.116.011309
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    Zs.A 448: Show issues Location:
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  7. Article ; Online: The prototype of a preference-based index of weight-related quality of life: demonstrating the possibilities.

    Moga, Ana M / Twells, Laurie K / Mayo, Nancy E

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2022  Volume 31, Issue 10, Page(s) 3061–3075

    Abstract: Purpose: Evidence for comparative and cost-effectiveness of weight-loss interventions is lacking as there are no obesity-specific measures fit for this purpose. This study aimed to estimate the extent to which a prototype of a brief, multi-dimensional ... ...

    Abstract Purpose: Evidence for comparative and cost-effectiveness of weight-loss interventions is lacking as there are no obesity-specific measures fit for this purpose. This study aimed to estimate the extent to which a prototype of a brief, multi-dimensional obesity-specific Preference-Based Index of Weight-Related Quality of Life (PBI-WRQL) could fill this gap.
    Methods: Longitudinal data from a Canadian bariatric cohort was used. Forty-eight items from the IWQoL-Lite, EQ-5D-3L, and SF-12V2 were mapped onto the WHO ICF domains, and one item was chosen for the dimension based on fit to the Rasch model. Individuals' health ratings (0-100) were regressed on each dimension, and the regression coefficients for the response options were used as weights to generate a total score. Generalized estimation equations were used to compare measure parameters across groups and levels of converging constructs.
    Results: Pre-surgery data were available on 201 people (Women: 82%; BMI: 48.8 ± 6.7 kg/m
    Conclusion: This study demonstrates that a brief, 7-dimension index weighted by health impact performed as well as the 31-item IWQoL-Lite and better than the EQ-5D-3L. These findings demonstrate the potential value of the brief PB-WRQL prototype index and support its further development using preference weights to reflect the current generation's needs and concerns.
    MeSH term(s) Adult ; Bariatric Surgery/methods ; Canada ; Female ; Humans ; Middle Aged ; Obesity/surgery ; Quality of Life/psychology ; Surveys and Questionnaires ; Weight Loss
    Language English
    Publishing date 2022-05-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-022-03156-5
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  8. Article ; Online: Health-related quality of life scores of typically developing children and adolescents around the world: a meta-analysis with meta-regression.

    Ow, Nikki / Mayo, Nancy E

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2020  Volume 29, Issue 9, Page(s) 2311–2332

    Abstract: Purpose: In the context of identifying consequences and evaluating interventions for rare diseases, health-related quality of life (HRQL) measures are often used. Conclusions about HRQL are difficult to make as the participants are likely drawn from ... ...

    Abstract Purpose: In the context of identifying consequences and evaluating interventions for rare diseases, health-related quality of life (HRQL) measures are often used. Conclusions about HRQL are difficult to make as the participants are likely drawn from different countries. A global estimate of HRQL with estimates of variation would permit pooling of data from diverse sources. The aim was to estimate a global HRQL score of typically developing children and adolescents on the Pediatric Quality of Life Inventory (PedsQL™) and to identify sources of variation across studies.
    Methods: A systematic search was conducted in December 2018 on four databases: MEDLINE, EMBASE, CINAHL and PsycINFO. Inclusion criteria were all population health studies or validation studies using the self-report version of the PedsQL™ for typically developing children aged 5 to 18 years. Quality appraisal was conducted using the Appraisal Tool for Cross-Sectional Studies. Meta-analysis and meta-regression were conducted.
    Results: A total of 66 studies with a sample size of 67,805 participants were included in this analysis. The average QOL score across all studies was 80.9 (CI 78.6-83.2). Univariate analyses showed that region, minimum age of sample and income of country, was associated with the total HRQL score. Subgroup analysis showed that there was an effect of age and region on HRQL scores.
    Conclusion: Results of this review provide ranges of pediatric HRQL across personal factors and regions that can be used for normative comparisons of HRQL. Interpretation of scores on generic measures should always take into consideration the contextual influences in the child's life.
    Registration: PROSPERO, CRD42019128313 https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019128313 .
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Health Status ; Humans ; Male ; Quality of Life/psychology
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-020-02519-0
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  9. Article ; Online: Components of a Behavior Change Model Drive Quality of Life in Community-Dwelling Older Persons.

    Mayo, Nancy E / Mate, Kedar / Akinrolie, Olayinka / Chan, Hong / Salbach, Nancy M / Webber, Sandra C / Barclay, Ruth

    Journal of aging and physical activity

    2023  Volume 31, Issue 3, Page(s) 506–514

    Abstract: This study aimed to inform a measurement approach for older persons who wish to engage in active living such as participating in a walking program. The Patient Generated Index, an individualized measurement approach, and directed and summative content ... ...

    Abstract This study aimed to inform a measurement approach for older persons who wish to engage in active living such as participating in a walking program. The Patient Generated Index, an individualized measurement approach, and directed and summative content analyses were carried out. A sample size of 204 participants (mean age 75 years; 62% women) was recruited; it generated 934 text threads mapped to 460 unique categories within 45 domains with similarities and differences for women and men. The Capability, Opportunity, Motivation, and Behaviors Model best linked the domains. The results suggest that older persons identify the need to overcome impaired capacity, low motivation, and barriers to engagement to live actively. These are all areas that active living programs could address. How to measure the outcomes of these programs remains elusive.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Independent Living ; Quality of Life ; Motivation
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 1543-267X
    ISSN (online) 1543-267X
    DOI 10.1123/japa.2022-0076
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  10. Article ; Online: Residual respiratory disability after successful treatment of pulmonary tuberculosis: a systematic review and meta-analysis.

    Taylor, Joshua / Bastos, Mayara Lisboa / Lachapelle-Chisholm, Sophie / Mayo, Nancy E / Johnston, James / Menzies, Dick

    EClinicalMedicine

    2023  Volume 59, Page(s) 101979

    Abstract: Background: Pulmonary tuberculosis (PTB) can result in long-term health consequences, even after successful treatment. We conducted a systematic review and meta-analysis to estimate the occurrence of respiratory impairment, other disability states, and ... ...

    Abstract Background: Pulmonary tuberculosis (PTB) can result in long-term health consequences, even after successful treatment. We conducted a systematic review and meta-analysis to estimate the occurrence of respiratory impairment, other disability states, and respiratory complications following successful PTB treatment.
    Methods: We identified studies from January 1, 1960, to December 6, 2022, describing populations of all ages that successfully completed treatment for active PTB and had been assessed for at least one of the following outcomes: occurrence of respiratory impairment, other disability states, or respiratory complications following PTB treatment. Studies were excluded if they reported on participants with self-reported TB, extra-pulmonary TB, inactive TB, latent TB, or if participants had been selected on the basis of having more advanced disease. Study characteristics and outcome-related data were abstracted. Meta-analysis was performed using a random effects model. We adapted the Newcastle Ottawa Scale to evaluate the methodological quality of the included studies. Heterogeneity was assessed using the I
    Findings: 61 studies with 41,014 participants with PTB were included. In 42 studies reporting post-treatment lung function measurements, 59.1% (I
    Interpretation: The occurrence of post-PTB respiratory impairment, other disability states, and respiratory complications is high, adding to the potential benefits of disease prevention, and highlighting the need for optimised management after successful treatment.
    Funding: Canadian Institutes of Health Research Foundation Grant.
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.101979
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