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Article: Effects of fresh and anaerobically digested algae (G. salicornia) as soil amendments on yield and nutrient concentrations of Pak Choy

Reppun, Frederick / Deenik, Jonathan / Martin, Jay / Hoy, Casey

Agroecology and sustainable food systems. 2021 Oct. 21, v. 45, no. 9

2021

Abstract: ... evaluated the use of fresh and anaerobically digested G. salicornia as soil amendments at lower ...

Abstract	Gracilaria salicornia, a common invasive algal species found in Kāneʻohe Bay, Hawaiʻi and around the world, is a potential potassium fertilizer source, but requires high application rates. This study evaluated the use of fresh and anaerobically digested G. salicornia as soil amendments at lower application rates than those required to provide complete plant nutrition to determine whether they increase pak choy growth and the efficiency of fish bone meal fertilizer. Fresh algae reduced the yield gap between low and high fish bone meal rates; however, these effects were only observed on one of two soil types tested.
Keywords	Brassica rapa subsp. chinensis ; Gracilaria ; agroecology ; algae ; anaerobic digestion ; bone meal ; fish ; plant nutrition ; potassium fertilizers
Language	English
Dates of publication	2021-1021
Size	p. 1270-1299.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2687596-2
ISSN	2168-3573 ; 2168-3565
ISSN (online)	2168-3573
ISSN	2168-3565
DOI	10.1080/21683565.2021.1917470
Database	NAL-Catalogue (AGRICOLA)

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Article: Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study.

Leininger-Muller, Brigitte / Hoy, Aline / Herbeth, Bernard / Pfister, Michèle / Serot, Jean Marie / Stavljenic-Rukavina, Marina / Massana, Luis / Passmore, P / Siest, Gérard / Visvikis, Sophie

Neuroscience letters

2003 Volume 349, Issue 2, Page(s) 95–98

Abstract: ... the genetic structure of the population. We investigated MPO G-463A and apoE polymorphism in 265 cases and 246 controls ... allele. In conclusion, the G-463A polymorphism of MPO was statistically associated with AD in a gender ... linkage disequilibrium between the MPO G-463A gene polymorphism and another functional variant involved in AD. ...

Abstract	Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Epidemiological and molecular genetic studies have shown the existence of several genes associated with increased risk of AD, the major genetic susceptibility locus coding for apolipoprotein E (apoE). A polymorphism in the myeloperoxidase gene (MPO) has previously been associated with AD susceptibility. However, results in the literature are controversial and seem to be dependent on several factors such as gender, apoE polymorphism or the genetic structure of the population. We investigated MPO G-463A and apoE polymorphism in 265 cases and 246 controls from the ApoEurope Study. In females, we found a significant association between MPO genotype and AD (P=0.034), GG genotype frequency being lower in cases (52.4%) as compared to controls (64.2%). In men, there was no significant effect of MPO polymorphism. No interaction was found between MPO polymorphism and apoE epsilon 4 allele. In conclusion, the G-463A polymorphism of MPO was statistically associated with AD in a gender-specific manner. However, given the low significance of P value we suggest no causal effect of the MPO gene in AD, as also evidenced in a recent meta-analysis. Our results support the hypothesis of a possible linkage disequilibrium between the MPO G-463A gene polymorphism and another functional variant involved in AD.
MeSH term(s)	Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Europe ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Peroxidase/genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length
Chemical Substances	Apolipoprotein E4 ; Apolipoproteins E ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2003-08-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/s0304-3940(03)00795-x
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Article: Real-time development of data acquisition and analysis software for hands-on physiology education in neuroscience: G-PRIME.

Lott, Gus K / Johnson, Bruce R / Bonow, Robert H / Land, Bruce R / Hoy, Ronald R

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2009 Volume 2009, Page(s) 2019–2021

Abstract: ... analysis environment, "g-PRIME." The software was developed from week to week in response to curriculum ...

Abstract	We report on the real-time creation of an application for hands-on neurophysiology in an advanced undergraduate teaching laboratory. Enabled by the rapid software development tools included in the Matlab technical computing environment (The Mathworks, Natick, MA), a team, consisting of a neurophysiology educator and a biophysicist trained as an electrical engineer, interfaced to a course of approximately 15 students from engineering and biology backgrounds. The result is the powerful freeware data acquisition and analysis environment, "g-PRIME." The software was developed from week to week in response to curriculum demands, and student feedback. The program evolved from a simple software oscilloscope, enabling RC circuit analysis, to a suite of tools supporting analysis of neuronal excitability and synaptic transmission analysis in invertebrate model systems. The program has subsequently expanded in application to university courses, research, and high school projects in the US and abroad as free courseware.
MeSH term(s)	Computational Biology/education ; Curriculum ; Education, Graduate/statistics & numerical data ; Education, Professional ; Equipment Design ; Humans ; Neurophysiology/education ; Neurosciences/education ; Software ; Teaching/methods ; Universities ; User-Computer Interface
Language	English
Publishing date	2009-12-05
Publishing country	United States
Document type	Journal Article
ISSN	2375-7477
ISSN	2375-7477
DOI	10.1109/IEMBS.2009.5334424
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Article ; Online: Amubarvimab/Romlusevimab: First Approval.

Hoy, Sheridan M

Drugs

2022 Volume 82, Issue 12, Page(s) 1327–1331

Abstract: Amubarvimab /romlusevimab is a combination of two neutralizing recombinant human IgG1 monoclonal antibodies (amubarvimab and romlusevimab) against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of ... ...

Abstract	Amubarvimab /romlusevimab is a combination of two neutralizing recombinant human IgG1 monoclonal antibodies (amubarvimab and romlusevimab) against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Jointly developed by Brii Biosciences, Tsinghua University and the Third People's Hospital of Shenzhen, it has been approved (in December 2021) by the National Medical Products Administration of China for the treatment of mild COVID-19 in patients aged ≥ 18 years, and those aged 12-17 years with a bodyweight of ≥ 40 kg (conditional approval) who are at high risk of progressing to severe disease, including hospitalization or death. An Emergency Use Authorization application for amubarvimab/romlusevimab is currently under review in the USA. This article summarizes the milestones in the development of amubarvimab/romlusevimab leading to this first approval for the treatment of COVID-19.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Neutralizing ; COVID-19/drug therapy ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-08-23
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.1007/s40265-022-01759-3
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Article ; Online: Ruxolitinib Cream 1.5%: A Review in Mild to Moderate Atopic Dermatitis.

Hoy, Sheridan M

American journal of clinical dermatology

2022 Volume 24, Issue 1, Page(s) 143–151

Abstract: ... emergent adverse events indicative of skin tolerability issues (e.g. stinging/burning sensation) were ... agents (e.g. corticosteroids and calcineurin inhibitors) for the treatment of mild to moderate AD ...

Abstract	Ruxolitinib cream 1.5% (OPZELURA™) is a topical formulation of ruxolitinib, a potent, selective inhibitor of Janus kinase (JAK)1 and JAK2. The targeting of these kinases is associated with therapeutic benefits in patients with atopic dermatitis (AD). In two identically designed, multinational, phase III studies in patients aged ≥ 12 years with mild to moderate AD, ruxolitinib cream 1.5% improved measures of disease severity, pruritus and sleep disturbance relative to vehicle cream when applied twice daily for 8 weeks. Disease severity was controlled for the next 44 weeks when applied as needed to active lesions. Ruxolitinib cream 1.5% was well tolerated in this patient population; its safety profile was similar to that of vehicle cream over the short term, with the types of treatment-emergent adverse events typical of those seen in the vehicle-controlled period over the longer term. Moreover, application site treatment-emergent adverse events indicative of skin tolerability issues (e.g. stinging/burning sensation) were infrequent and no safety findings suggestive of systemic JAK inhibition were identified. Although further longer-term data would be of use, ruxolitinib cream 1.5% provides an alternative to established topical agents (e.g. corticosteroids and calcineurin inhibitors) for the treatment of mild to moderate AD in adults and adolescents.
MeSH term(s)	Adult ; Adolescent ; Humans ; Dermatitis, Atopic/drug therapy ; Nitriles/therapeutic use ; Pyrimidines/therapeutic use ; Emollients/therapeutic use ; Treatment Outcome ; Double-Blind Method ; Randomized Controlled Trials as Topic
Chemical Substances	ruxolitinib (82S8X8XX8H) ; Nitriles ; Pyrimidines ; Emollients
Language	English
Publishing date	2022-12-20
Publishing country	New Zealand
Document type	Review ; Journal Article
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-022-00748-2
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Article ; Online: Tezepelumab: First Approval.

Hoy, Sheridan M

Drugs

2022 Volume 82, Issue 4, Page(s) 461–468

Abstract: ... with severe asthma in the USA; it is the only biologic approved for severe asthma with no phenotype (e.g ...

Abstract	Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine implicated in the pathogenesis of asthma. Tezepelumab (tezepelumab-ekko; TEZSPIRE™) is a first-in-class human IgG2λ monoclonal antibody that inhibits the action of TSLP. Administered subcutaneously, it is being developed by Amgen and AstraZeneca for the treatment of asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis with nasal polyps (CRSwNP), chronic spontaneous urticaria and eosinophilic oesophagitis. Tezepelumab received its first approval on 17 December 2021 as an add-on maintenance treatment for patients aged ≥ 12 years with severe asthma in the USA; it is the only biologic approved for severe asthma with no phenotype (e.g. eosinophilic or allergic) or biomarker limitations. A regulatory assessment of tezepelumab for the treatment of asthma is currently underway in the EU and Japan. Tezepelumab received orphan drug designation for the treatment of eosinophilic oesophagitis in October 2021 in the USA, and is undergoing clinical development for the treatment of COPD, CRSwNP and chronic spontaneous urticaria. This article summarizes the milestones in the development of tezepelumab leading to this first approval for the add-on maintenance treatment of patients aged ≥ 12 years with severe asthma.
MeSH term(s)	Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized/adverse effects ; Asthma/drug therapy ; Child ; Chronic Disease ; Eosinophilia/drug therapy ; Humans ; Nasal Polyps/drug therapy
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; tezepelumab (RJ1IW3B4QX)
Language	English
Publishing date	2022-02-03
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.1007/s40265-022-01679-2
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Article: g-PRIME: A Free, Windows Based Data Acquisition and Event Analysis Software Package for Physiology in Classrooms and Research Labs.

Lott, Gus K / Johnson, Bruce R / Bonow, Robert H / Land, Bruce R / Hoy, Ronald R

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience

2009 Volume 8, Issue 1, Page(s) A50–4

Abstract: We present g-PRIME, a software based tool for physiology data acquisition, analysis, and stimulus ... and strongly influenced by instructor and student feedback. g-PRIME is a free, stand-alone, windows ... application coded and "compiled" in Matlab (does not require a Matlab license). g-PRIME supports ...

Abstract	We present g-PRIME, a software based tool for physiology data acquisition, analysis, and stimulus generation in education and research. This software was developed in an undergraduate neurophysiology course and strongly influenced by instructor and student feedback. g-PRIME is a free, stand-alone, windows application coded and "compiled" in Matlab (does not require a Matlab license). g-PRIME supports many data acquisition interfaces from the PC sound card to expensive high throughput calibrated equipment. The program is designed as a software oscilloscope with standard trigger modes, multi-channel visualization controls, and data logging features. Extensive analysis options allow real time and offline filtering of signals, multi-parameter threshold-and-window based event detection, and two-dimensional display of a variety of parameters including event time, energy density, maximum FFT frequency component, max/min amplitudes, and inter-event rate and intervals. The software also correlates detected events with another simultaneously acquired source (event triggered average) in real time or offline. g-PRIME supports parameter histogram production and a variety of elegant publication quality graphics outputs. A major goal of this software is to merge powerful engineering acquisition and analysis tools with a biological approach to studies of nervous system function.
Language	English
Publishing date	2009-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2577251-X
ISSN	1544-2896
ISSN	1544-2896
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Article ; Online: Quantitative skills in undergraduate neuroscience education in the age of big data.

Hoy, Ronald R

Neuroscience letters

2021 Volume 759, Page(s) 136074

Abstract: ... to enroll in the Data Science courses that are required in the social sciences (e.g., economics ...

Abstract	For over a half-Century, the mathematics requirement for graduation at most undergraduate colleges and universities has been one year of calculus and a semester of statistics. Many universities and colleges offer a neuroscience major that may or may not add additional mathematics, statistics, or data science requirements. Today in the age of Big Data and Systems Neuroscience, many students are ill-equipped for the future without the tools of computational competency that are necessary to tackle the large data sets generated by contemporary neuroscience research. Required courses in statistics still focus on parametric statistics based on the normal distribution and do not provide the computational tools required to analyze big data sets. Undergraduates in STEM fields including neuroscience need to enroll in the Data Science courses that are required in the social sciences (e.g., economics, political science and psychology). Contemporary systems neuroscience is routinely done by interdisciplinary research teams of statisticians, engineers, and physical scientists. Emerging "NeuroX-omics" such as connectomics have emerged along with genomics, proteomics, and transcriptomics, all of which deploy systems analysis techniques based on mathematical graph theory. Connectomics is the 21st Century's functional neuroanatomy. Whole brain connectome research appears almost monthly in the Drosphila, zebra fish, and mouse literature, and human brain connectomics is not far behind. The techniques for connectomics rely on the tools of data science. Undergraduate neuroscience students are already squeezed for credit hours given the high-prescribed science curriculum for biology majors and premedical students, in addition to required courses in social sciences and humanities. However, additional training in mathematics, statistics, computer science, and/or data science is urgently needed for undergraduate neuroscience majors just to understand the contemporary research literature. Undoubtedly, the faculty who teach neuroscience courses are acutely aware of the problem and most of them freely acknowledge the importance of quantitative analytical skills for their students. However, some faculty members may feel that their own math and statistics knowledge or other analytical skills have atrophied beyond recall or were never fulfilled in the first place. In this commentary I suggest that this problem can be ameliorated, though not solved, through organizing workshops, journal clubs, or independent studies courses in which the students and the instructors learn and teach each other in short-course format. In addition, web-available teaching materials such as targeted video clips are plentifully available on the internet. To attract and maintain student interest, qauntitative instruction and learning should occur in neuroscience context.
MeSH term(s)	Big Data ; Humans ; Neurosciences/education
Language	English
Publishing date	2021-06-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2021.136074
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Article: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.

Gromada, J / Høy, M / Buschard, K / Salehi, A / Rorsman, P

The Journal of physiology

2001 Volume 535, Issue Pt 2, Page(s) 519–532

Abstract: ... was mimicked by intracellular dialysis with specific antibodies to G(i1/2) and by antisense ... oligonucleotides against G proteins of the subtype G(i2). 4. Somatostatin lacked inhibitory action when applied ... We propose that somatostatin receptors associate with L-type Ca(2+) channels and couple to G(i2) proteins ...

Abstract	1. Measurements of cell capacitance were used to investigate the molecular mechanisms by which somatostatin inhibits Ca(2+)-induced exocytosis in single rat glucagon-secreting pancreatic alpha-cells. 2. Somatostatin decreased the exocytotic responses elicited by voltage-clamp depolarisations by 80 % in the presence of cyclic AMP-elevating agents such as isoprenaline and forskolin. Inhibition was time dependent and half-maximal within 22 s. 3. The inhibitory action of somatostatin was concentration dependent with an IC(50) of 68 nM and prevented by pretreatment of the cells with pertussis toxin. The latter effect was mimicked by intracellular dialysis with specific antibodies to G(i1/2) and by antisense oligonucleotides against G proteins of the subtype G(i2). 4. Somatostatin lacked inhibitory action when applied in the absence of forskolin or in the presence of the L-type Ca(2+) channel blocker nifedipine. The size of the omega-conotoxin-sensitive and forskolin-independent component of exocytosis was limited to 60 fF. By contrast, somatostatin abolished L-type Ca(2+) channel-dependent exocytosis in alpha-cells exposed to forskolin. The magnitude of the latter pool amounted to 230 fF. 5. The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and was prevented by pretreatment with cyclosporin A and deltamethrin or intracellularly applied calcineurin autoinhibitory peptide. Experiments using the stable ATP analogue AMP-PCP indicate that somatostatin acts by depriming of granules. 6. We propose that somatostatin receptors associate with L-type Ca(2+) channels and couple to G(i2) proteins leading to a localised activation of calcineurin and depriming of secretory granules situated close to the L-type Ca(2+) channels.
MeSH term(s)	Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Animals ; Calcineurin/metabolism ; Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/metabolism ; Calcium Channels, N-Type/metabolism ; Colforsin/pharmacology ; Cytoplasm/metabolism ; Exocytosis/drug effects ; Exocytosis/physiology ; GTP-Binding Protein alpha Subunit, Gi2 ; GTP-Binding Protein alpha Subunits, Gi-Go/genetics ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Islets of Langerhans/metabolism ; Male ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Nifedipine/pharmacology ; Oligoribonucleotides, Antisense/pharmacology ; Patch-Clamp Techniques ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Rats ; Rats, Inbred Lew ; Secretory Vesicles/metabolism ; Somatostatin/pharmacology ; omega-Conotoxin GVIA/pharmacology
Chemical Substances	Calcium Channel Blockers ; Calcium Channels, L-Type ; Calcium Channels, N-Type ; Oligoribonucleotides, Antisense ; Proto-Oncogene Proteins ; Colforsin (1F7A44V6OU) ; 5'-adenylyl (beta,gamma-methylene)diphosphonate (3469-78-1) ; Somatostatin (51110-01-1) ; Adenosine Triphosphate (8L70Q75FXE) ; omega-Conotoxin GVIA (92078-76-7) ; Calcineurin (EC 3.1.3.16) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; GTP-Binding Protein alpha Subunit, Gi2 (EC 3.6.5.1) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1) ; Gnai2 protein, rat (EC 3.6.5.1) ; Nifedipine (I9ZF7L6G2L) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2001-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1111/j.1469-7793.2001.00519.x
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Article ; Online: Psoriasis: Recognition and Management Strategies.

Garner, Kathryn K / Hoy, Kattie D S / Carpenter, Adriana M

American family physician

2024 Volume 108, Issue 6, Page(s) 562–573

Abstract: ... environmental, physical (e.g., skin trauma), and infectious factors. Associated comorbidities include ...

Abstract	Psoriasis is an inflammatory skin and systemic disorder that affects 3.2% of the U.S. population, including 1% of children. It is an immune-mediated process triggered by an interplay of genetic, environmental, physical (e.g., skin trauma), and infectious factors. Associated comorbidities include cardiovascular disease, obesity, metabolic syndrome, diabetes mellitus, and inflammatory bowel disease. Psoriasis presents in various forms, including plaque, guttate, erythrodermic, pustular, inverse, nail, and psoriatic arthritis. The most common form is plaque psoriasis, which affects 90% of adults with psoriasis. Psoriasis is diagnosed clinically based on the presence of characteristic erythematous, scaly skin plaques in typical locations, with associated history and systemic symptoms. Treatment strategies are similar for most forms of psoriasis and based on body surface area involved. Topical corticosteroids, vitamin D analogues, and tazarotene are used to treat mild to moderate disease. Systemic treatment with nonbiologic and biologic agents and ultraviolet B phototherapy are used for moderate to severe disease, with the exception of apremilast, a systemic agent approved for mild psoriasis. Disease management is improved with maintaining ideal body weight, avoiding tobacco products, limiting alcohol, and practicing stress reduction techniques. The Psoriasis Area and Severity Index is a tool to assess severity and monitor treatment effectiveness over time. Special consideration is needed for treatment of children and patients who are pregnant, breastfeeding, or trying to conceive.
MeSH term(s)	Adult ; Pregnancy ; Female ; Child ; Humans ; Psoriasis/diagnosis ; Psoriasis/therapy ; Skin ; Phototherapy/methods ; Comorbidity ; Glucocorticoids
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	412694-4
ISSN	1532-0650 ; 0002-838X ; 0572-3612
ISSN (online)	1532-0650
ISSN	0002-838X ; 0572-3612
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