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  1. Article: Long-Term Health-Related Quality of Life following Acute Type A Aortic Dissection with a Focus on Male-Female Differences: A Cross Sectional Study.

    Meccanici, Frederike / Thijssen, Carlijn G E / Gökalp, Arjen L / Bom, Annemijn W / Geuzebroek, Guillaume S C / Ter Woorst, Joost F / van Kimmenade, Roland R J / Post, Marco C / Takkenberg, Johanna J M / Roos-Hesselink, Jolien W

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082265
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  2. Article ; Online: What Is the Effect of Obesity on the Natriuretic Peptide Pathway?

    Herrmann, Job J / van Kimmenade, Roland R J / Gommans, D H Frank

    JACC. Heart failure

    2021  Volume 9, Issue 9, Page(s) 697

    MeSH term(s) Heart Failure ; Humans ; Natriuretic Peptides ; Obesity/complications
    Chemical Substances Natriuretic Peptides
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2021.05.022
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  3. Article ; Online: Type A Aortic Dissection in a 24-Year-Old Patient With Kabuki Syndrome.

    Hasami, Nesar A / Ko, Kinsing / Kempers, Marlies J E / van Kimmenade, Roland R J / Geuzebroek, Guillaume S C

    JACC. Case reports

    2023  Volume 29, Issue 1, Page(s) 102149

    Abstract: Our case report documents the first type A aortic dissection in a patient with Kabuki syndrome (KS) and emphasize the need for intensive cardiovascular risk monitoring in patients with KS. It stresses the importance of further research to establish a ... ...

    Abstract Our case report documents the first type A aortic dissection in a patient with Kabuki syndrome (KS) and emphasize the need for intensive cardiovascular risk monitoring in patients with KS. It stresses the importance of further research to establish a correlation and awareness for patients with KS.
    Language English
    Publishing date 2023-11-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.102149
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  4. Article ; Online: Reply to letter to the editor: "Novel biomarkers associated with thoracic aortic disease".

    Thijssen, Carlijn G E / Dekker, Silvy / Bons, Lidia R / Geenen, Laurie W / Gökalp, Arjen L / Takkenberg, Johanna J M / Mokhles, Mostafa M / Bekkers, Jos A / Boersma, Eric / Bouwens, Elke / van Kimmenade, Roland R J / Roos-Hesselink, Jolien W

    International journal of cardiology

    2023  Volume 388, Page(s) 131104

    MeSH term(s) Humans ; Aorta ; Aortic Diseases ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.05.054
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  5. Article ; Online: Associations of Lifelong Exercise Characteristics With Valvular Function and Aortic Diameters in Patients With a Bicuspid Aortic Valve.

    Schreurs, Bibi A / Hopman, Maria T E / Bakker, Chantal M / Duijnhouwer, Anthonie L / van Royen, Niels / Thompson, Paul D / van Kimmenade, Roland R J / Eijsvogels, Thijs M H

    Journal of the American Heart Association

    2024  Volume 13, Issue 3, Page(s) e031850

    Abstract: Background: The potential impact of exercise on valvular function and aortic diameters in patients with a bicuspid aortic valve remains unclear. Therefore, we assessed the association between lifelong exercise characteristics, valvular dysfunction, and ... ...

    Abstract Background: The potential impact of exercise on valvular function and aortic diameters in patients with a bicuspid aortic valve remains unclear. Therefore, we assessed the association between lifelong exercise characteristics, valvular dysfunction, and aortic dilatation in patients with a bicuspid aortic valve.
    Methods and results: In this cross-sectional study, exercise volume (metabolic equivalent of task minutes per week), exercise intensity, and sport type were determined from the age of 12 years to participation using a validated questionnaire. Echocardiography was used to assess aortic stenosis or aortic regurgitation and to measure diameters at the sinuses of Valsalva and ascending aorta. Aortic dilatation was defined as a
    Conclusions: We found no deleterious associations between lifelong exercise characteristics, valvular dysfunction, and aortic dilatation in patients with a bicuspid aortic valve. Vigorous intensity and exercise in mixed sports were associated with a lower prevalence of moderate-to-severe aortic stenosis. These observations suggest that lifelong exercise does not appear to induce adverse cardiovascular effects in patients with a bicuspid aortic valve.
    MeSH term(s) Male ; Humans ; Child ; Female ; Bicuspid Aortic Valve Disease ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/epidemiology ; Aortic Valve Insufficiency/complications ; Aortic Valve/diagnostic imaging ; Cross-Sectional Studies ; Retrospective Studies ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/complications ; Dilatation, Pathologic
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031850
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  6. Article ; Online: Reply: Neprilysin and Corin in HF: Does Combining 2 Biomarkers Double Our Insights?

    Gommans, D H Frank / Revuelta-Lopez, Elena / Bayés-Genis, Antoni / van Kimmenade, Roland R J

    JACC. Heart failure

    2021  Volume 9, Issue 5, Page(s) 407–408

    MeSH term(s) Biomarkers ; Heart Failure ; Humans ; Natriuretic Peptide, Brain ; Neprilysin ; Serine Endopeptidases
    Chemical Substances Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; CORIN protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2021.02.007
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  7. Article ; Online: Necessity of life-long follow-up after surgery for coarctation of the aorta: a case series of very late false aneurysm formation.

    Somers, Tim / Nies, Hedwig M J M / van Kimmenade, Roland R J / Bosboom, Dennis G H / Geuzebroek, Guillaume S C / Morshuis, Wim J

    European heart journal. Case reports

    2022  Volume 6, Issue 2, Page(s) ytac073

    Abstract: Background: Coarctation of the aorta accounts for 5-7% of congenital defects of the heart and great vessels. It requires treatment in the form of open surgical or percutaneous repair. Common long-term complications include re-stenosis and aneurysm ... ...

    Abstract Background: Coarctation of the aorta accounts for 5-7% of congenital defects of the heart and great vessels. It requires treatment in the form of open surgical or percutaneous repair. Common long-term complications include re-stenosis and aneurysm formation. The formation of a false aneurysm is a complication with a significant morbidity and mortality.
    Case summary: We reviewed six cases of late false aneurysm after repair of a coarctation of the aorta. Our six cases developed a false aneurysm after an open surgical repair of a coarctation more than 30 years after initial surgical repair. All aneurysms were located at the aortic repair site.
    Discussion: The symptoms or risk factors in the described cases are not uniform and are difficult to include in a general follow-up protocol. Guidelines recommend frequent evaluation, but do not specify duration or intervals of imaging follow-up. Our cases support the necessity of life-long follow-up in patients with open aortic repairs irrespective of symptomatology.
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac073
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  8. Article ; Online: Improved Maximal Workload and Systolic Blood Pressure After Cardiac Rehabilitation Following Thoracic Aortic Repair: A SYSTEMATIC REVIEW AND META-ANALYSIS.

    Koenders, Niek / van Zetten, Henrita / Smulders, Michelle / Verra, Martin L / van Kimmenade, Roland R J / van Brakel, Thomas / Eijsvogels, Thijs M H / Smith, Tim

    Journal of cardiopulmonary rehabilitation and prevention

    2023  Volume 43, Issue 6, Page(s) 419–426

    Abstract: Purpose: It is of clinical importance to gain more knowledge about the risks and benefits of exercise in patients recovering from thoracic aortic repair. Therefore, the aim of this review was to perform a meta-analysis on changes in cardiorespiratory ... ...

    Abstract Purpose: It is of clinical importance to gain more knowledge about the risks and benefits of exercise in patients recovering from thoracic aortic repair. Therefore, the aim of this review was to perform a meta-analysis on changes in cardiorespiratory fitness, blood pressure, and the incidence of adverse events during cardiac rehabilitation (CR) in patients recovering from thoracic aortic repair.
    Review methods: We performed a systematic review and random-effects meta-analysis of outcomes before versus after outpatient CR in patients recovering from thoracic aortic repair. The study protocol was registered (PROSPERO CRD42022301204) and published. MEDLINE, EMBASE, and CINAHL were systematically searched for eligible studies. Overall certainty of evidence was scored with Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
    Summary: We included five studies with data from in total 241 patients. Data from one study could not be used in our meta-analysis because they were provided in a different unit of measure. Four studies with data of 146 patients were included in the meta-analysis. The mean maximal workload increased with 28.7 W (95% CI: 21.8-35.6 W, n = 146, low certainty of evidence). The mean systolic blood pressure during exercise testing increased with 25.4 mm Hg (95% CI: 16.6-34.3, n = 133, low certainty of evidence). No exercise-induced adverse events were reported. These outcomes indicate that CR seems beneficial and safe to improve exercise tolerance in patients recovering from thoracic aortic repair, although outcomes were based on data from a small, heterogeneous group of patients.
    MeSH term(s) Humans ; Cardiac Rehabilitation/methods ; Blood Pressure ; Workload ; Exercise ; Cardiorespiratory Fitness
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2272063-7
    ISSN 1932-751X ; 1932-7501
    ISSN (online) 1932-751X
    ISSN 1932-7501
    DOI 10.1097/HCR.0000000000000798
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    Zs.A 1998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Health-related quality of life in patients with aortic dissection: An unmet need.

    Carbone, Andreina / Palladino, Raffaele / Franzese, Monica / Castaldo, Rossana / Ranieri, Brigida / Crisci, Giulia / Izzo, Raffaele / Esposito, Giovanni / Cittadini, Antonio / Schreurs, Bibi / van Kimmenade, Roland R J / Bossone, Eduardo

    Current problems in cardiology

    2023  Volume 49, Issue 1 Pt C, Page(s) 102138

    Abstract: Knowledge about the Health-related Quality of Life (HR-QoL) after Type A (TA-AAD) and Type B acute aortic dissection (TB-AAD) is still insufficient. Through this systematic review, including 22 studies (16 for TA-AAD and 6 TB-AAD -1998-2023), the entire ... ...

    Abstract Knowledge about the Health-related Quality of Life (HR-QoL) after Type A (TA-AAD) and Type B acute aortic dissection (TB-AAD) is still insufficient. Through this systematic review, including 22 studies (16 for TA-AAD and 6 TB-AAD -1998-2023), the entire literature on HR-QoL after surgical and/or endovascular and/or medical interventions has been investigated. In TA-AAD patients, despite overall SF-36 score was similar to the standard population, with > 80 years patients displaying a better emotional domain, the SF-12 was significant lower to controls in physical and mental well-being domains. Exercise-based cardiac rehabilitation improved HR-QoL. In TB-AAD, vitality and mental health SF-36 scores improved after thoracic endovascular aortic repair (TEVAR); long-term QoL was similar in the open surgery group compared to TEVAR. Overall, HR-QoL after AAD seems adequate irrespective of age or sex, except for some specific domains. Physical exercise and cardiac rehabilitation may improve HR-QoL in these patients. PROSPERO registry ID: CRD42023421130.
    MeSH term(s) Humans ; Quality of Life ; Aortic Aneurysm, Thoracic/surgery ; Retrospective Studies ; Endovascular Procedures ; Aortic Dissection/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.102138
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    Se 505: Show issues Location:
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  10. Article ; Online: Novel biomarkers associated with thoracic aortic disease.

    Thijssen, Carlijn G E / Dekker, Silvy / Bons, Lidia R / Geenen, Laurie W / Gökalp, Arjen L / Takkenberg, Johanna J M / Mokhles, Mostafa M / Bekkers, Jos A / Boersma, Eric / Bouwens, Elke / van Kimmenade, Roland R J / Roos-Hesselink, Jolien W

    International journal of cardiology

    2023  Volume 378, Page(s) 115–122

    Abstract: Background: Biomarkers might help to improve diagnosis, surveillance and risk stratification of thoracic aortic disease (TAD). We explored the association between a broad spectrum of cardiovascular biomarkers with clinical characteristics and thoracic ... ...

    Abstract Background: Biomarkers might help to improve diagnosis, surveillance and risk stratification of thoracic aortic disease (TAD). We explored the association between a broad spectrum of cardiovascular biomarkers with clinical characteristics and thoracic aortic diameter in TAD patients.
    Methods: Venous blood-samples were obtained in 158 clinically stable TAD patients visiting our outpatient clinic (2017-2020). TAD was defined as a thoracic aortic diameter ≥ 40 mm, or genetic confirmation (hereditary TAD). The cardiovascular panel III of the Olink multiplex platform was used for batch analysis of 92 proteins. A comparison was made between biomarker levels in patients with and without previous aortic dissection and/or surgery, and with and without hereditary TAD. Linear regression analyses were applied to identify (relative, normalized) biomarker concentrations associated with the absolute thoracic aortic diameter (AD
    Results: Median age of study patients was 61.0 (IQR 50.3-68.8) years, 37.3% females. Mean AD
    Conclusions: Among a broad range of biomarkers, MMP-3 and IGFBP-2 were associated with disease severity in TAD patients. The pathophysiological pathways uncovered by these biomarkers, and their potential clinical use warrants further research.
    MeSH term(s) Female ; Humans ; Middle Aged ; Aged ; Male ; Matrix Metalloproteinase 3/metabolism ; Insulin-Like Growth Factor Binding Protein 2 ; Aortic Aneurysm, Thoracic/diagnosis ; Aortic Aneurysm, Thoracic/genetics ; Aortic Diseases ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/metabolism ; Aortic Dissection/diagnosis ; Biomarkers/metabolism
    Chemical Substances Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Insulin-Like Growth Factor Binding Protein 2 ; Biomarkers
    Language English
    Publishing date 2023-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.02.006
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