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Article ; Online: Instrumented L5-S1 interbody graft with IFUSE implant using the reverse Bohlman technique.

Chevillotte, Thomas / Darnis, Alice / Grobost, Pierre / Palmano, Marine / Guedj, Jérémie / Silvestre, Clément

2024 , Page(s) 101560

Abstract: Background: In case of high sacral slope, anterior lumbosacral fusions can be performed by retroperitoneal or transperitoneal approach using a reversed Bohlman technique with an autologous corticocancellous fibular graft. The use of a trans-lumbosacral ... ...

Abstract	Background: In case of high sacral slope, anterior lumbosacral fusions can be performed by retroperitoneal or transperitoneal approach using a reversed Bohlman technique with an autologous corticocancellous fibular graft. The use of a trans-lumbosacral implant can avoid the iatrogenic effects but currently, there is no implant specifically designed for this fusion technique. Could the IFUSE implant from SI BONE replace a fibular graft to avoiding the iatrogenic effect induced by sampling during a Reverse Bohlman technique? Patients and methods: We present the case of a 38-year-old woman with L5S1 interbody pseudarthrosis after posterior fixation for grade 2 L5-S1 spondylolisthesis with isthmic lysis of L5, and that of a 69-year-old woman who underwent a posterior T4 fusion to the pelvis for degenerative scoliosis. Both required a trans-lumbosacral instrumented fusion via an anterior approach using the reverse Bohlman technique. Surgical technique was described. Results: There were no perioperative or postoperative complications. At 6 months, the patients reported a decrease in lumbar and radicular symptomatology. There were no infectious, neurological or vascular complications. CT-scans confirmed the good position and stability of the IFUSE implant. Discussion: We present an innovative interbody grafting technique adapted to spines with high pelvic incidence. The surgical technique is safe, minimally invasive, and reduces surgical iatrogeny. The short and medium-term results are positive but require longer-term follow-up and a larger cohort.
Language	English
Publishing date	2024-04-13
Publishing country	France
Document type	Journal Article
ZDB-ID	207146-0
ISSN	1773-0619 ; 0028-3770 ; 0150-9586
ISSN (online)	1773-0619
ISSN	0028-3770 ; 0150-9586
DOI	10.1016/j.neuchi.2024.101560
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Article ; Online: A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals' models with mild cognitive impairment or dementia.

Ayari, Sawsen / Abellard, Alexandre / Carayol, Marion / Guedj, Éric / Gavarry, Olivier

Experimental gerontology

2023 Volume 175, Page(s) 112141

Abstract: Purpose: To investigate which type, frequency, duration, intensity, and volume of chronic exercise might more strongly reduce pro-inflammatory cytokines and enhance anti-inflammatory cytokines in human and animal models with Mild Cognitive Impairment ( ... ...

Abstract	Purpose: To investigate which type, frequency, duration, intensity, and volume of chronic exercise might more strongly reduce pro-inflammatory cytokines and enhance anti-inflammatory cytokines in human and animal models with Mild Cognitive Impairment (MCI) or dementia. Design: A systematic review. Data source: English-language search of 13 electronic databases: Web of Science, PubMed/Medline, Sport Discus, Scopus, Cochrane, Psych Net, Springer, ScienceDirect, Pascal & Francis, Sage journals, Pedro, Google Scholar, and Sage. Inclusion criteria: (i) human and animal studies that included exercise, physical activity, or fitness training as an experimental intervention, (ii) studies that addressed MCI, dementia, or AD, (iii) studies that focused on measuring cytokines and/or other inflammatory and/or neuroinflammatory immune markers, (iii) studies that examined inflammatory indicators in blood, CSF (Cerebrospinal Fluid), and brain tissue. Results: Of the 1290 human and animal studies found, 38 were included for qualitative analysis, 11 human articles, 25 animal articles, and two articles addressing both human and animal protocols. In the animal model, physical exercise decreased pro-inflammatory markers in 70.8 % of the articles and anti-inflammatory cytokines: IL -4, IL -10, IL-4β, IL -10β, and TGF-β in 26 % of articles. Treadmill running, resistance exercise, and swimming exercise reduce pro-inflammatory cytokines and increase anti-inflammatory cytokines. In the human model, 53.9 % of items reduced pro-inflammatory proteins and 23 % increased anti-inflammatory proteins. Cycling exercise, multimodal, and resistance training effectively decreased pro-inflammatory cytokines. Conclusion: In rodent animal models with AD phenotype, treadmill, swimming, and resistance training remain good interventions that can delay various mechanisms of dementia progression. In the human model, aerobic, multimodal, and resistance training are beneficial in both MCI and AD. Multimodal training of moderate to high intensity multimodal exercise is effective for MCI. Voluntary cycling training, moderate- or high-intensity aerobic exercise is effective in mild AD patients.
MeSH term(s)	Humans ; Animals ; Cytokines ; Cognitive Dysfunction/therapy ; Exercise ; Dementia/therapy ; Models, Animal
Chemical Substances	Cytokines
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2023.112141
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Article: The pons as reference region for intensity normalization in semi-quantitative analysis of brain

Verger, A / Doyen, M / Campion, J Y / Guedj, Eric

EJNMMI research

2021 Volume 11, Issue 1, Page(s) 31

Abstract: Background: The objective of the study is to define the most appropriate region for intensity normalization in brain : Results: The cerebellum and pons were the two sole regions showing median coefficients of correlation with age less than - 0.5. ... ...

Abstract	Background: The objective of the study is to define the most appropriate region for intensity normalization in brain Results: The cerebellum and pons were the two sole regions showing median coefficients of correlation with age less than - 0.5. With SPM, the intensity normalization by the pons provided at least 1.7- and 2.5-fold more significant cluster volumes than other normalizations for conventional and digital PET, respectively. Conclusions: The pons is the most appropriate area for brain
Language	English
Publishing date	2021-03-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-021-00771-0
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Article: Assessment of insulin adherence in diabetic outpatients: An observational study.

Despras, J / Guedj, A-M / Soula-Dion, S / Choukroun, C / Leguelinel-Blache, G

Annales pharmaceutiques francaises

2022 Volume 80, Issue 6, Page(s) 827–836

Abstract: Objectives: In the management of diabetic patients on insulin therapy, adherence to medication is a key element for avoiding chronic complications. The purpose of this study was to evaluate diabetic patients' ability to translate glycemic results into ... ...

Abstract	Objectives: In the management of diabetic patients on insulin therapy, adherence to medication is a key element for avoiding chronic complications. The purpose of this study was to evaluate diabetic patients' ability to translate glycemic results into an appropriate insulin dose and thus, adherence to insulins. Methods: This was an observational, retrospective, monocentric pilot study. Diabetic patients on insulin therapy being followed at the metabolic and endocrine diseases department were divided into two groups depending on their mode of glycemic control at home: capillary glycemia (Notebook group) or interstitial glycemia using the FreeStyle Libre® flash system (FSL group). Adherence was assessed based on the rate of compliance in adapting insulin doses to the prescribed protocols (depending on type of insulin, glycemic targets, and patients' characteristics) by a pharmacy resident and a senior diabetologist. Good adherence was defined as a minimum rate of 80% of conforming insulin injections for each patient. Results: A total of 50 patients were included, 35 in the Notebook group and 15 in the FSL group. Two-thirds of patients were non-adherent to insulin. Dose adjustment errors mainly concerned rapid-acting insulin with 51.1% of non- conformities, 10.0% of which were due to underdosing in the Notebook group and 21.7% to overdosing in the FSL group. Hyperglycemia was predominant in both populations with a median time in range of 19.0% in the FSL group and well below recommendations (>70%). Conclusions: Despite the use of increasingly efficient, easy-to-use devices in diabetes monitoring, insulin non-adherence and glycemic imbalance are unresolved major issues. Diabetic patients require reinforced medical follow-up for optimal insulin management.
MeSH term(s)	Humans ; Insulin/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Retrospective Studies ; Outpatients ; Pilot Projects ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/chemically induced ; Blood Glucose ; Insulins ; Insulin, Short-Acting
Chemical Substances	Insulin ; Hypoglycemic Agents ; Blood Glucose ; Insulins ; Insulin, Short-Acting
Language	English
Publishing date	2022-05-11
Publishing country	France
Document type	Observational Study ; Journal Article
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2022.05.001
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Article ; Online: Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two-stage approaches.

Marchand, Mathilde / Gonçalves, Antonio / Mercier, François / Chanu, Pascal / Jin, Jin Y / Guedj, Jérémie / Bruno, René

CPT: pharmacometrics & systems pharmacology

2024

Abstract: Model-based tumor growth inhibition (TGI) metrics are increasingly used to predict overall survival (OS) data in Phase III immunotherapy clinical trials. However, there is still a lack of understanding regarding the differences between two-stage or joint ...

Abstract	Model-based tumor growth inhibition (TGI) metrics are increasingly used to predict overall survival (OS) data in Phase III immunotherapy clinical trials. However, there is still a lack of understanding regarding the differences between two-stage or joint modeling methods to leverage Phase I/II trial data and help early decision-making. A recent study showed that TGI metrics such as the tumor growth rate constant K
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.13137
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Article ; Online: Comparison of two-stage and joint TGI-OS modeling using data from six atezolizumab clinical studies in patients with metastatic non-small cell lung cancer.

Gonçalves, Antonio / Marchand, Mathilde / Chan, Phyllis / Jin, Jin Y / Guedj, Jérémie / Bruno, René

CPT: pharmacometrics & systems pharmacology

2023 Volume 13, Issue 1, Page(s) 68–78

Abstract: Two-stage and joint modeling approaches are the two main approaches to investigate the link between longitudinal tumor size data and overall survival (OS) and anticipate clinical trial outcome. We here used a large database composed of one phase II and ... ...

Abstract	Two-stage and joint modeling approaches are the two main approaches to investigate the link between longitudinal tumor size data and overall survival (OS) and anticipate clinical trial outcome. We here used a large database composed of one phase II and five phase III clinical trials evaluating atezolizumab (an immunotherapy) in monotherapy or in combination with chemotherapies in 3699 patients with non-small cell lung cancer to evaluate the differences between both approaches in terms of parameter estimates, magnitude of covariate effects, and ability to predict OS. Although the two-stage approach may underestimate the magnitude of the impact of tumor growth rate (K
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms/pathology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Proportional Hazards Models ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Chemical Substances	atezolizumab (52CMI0WC3Y) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.13057
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Article ; Online: When should screening be performed for gestational diabetes?

Guedj, A-M

Diabetes & metabolism

2010 Volume 36, Issue 6 Pt 2, Page(s) 652–657

Abstract: Aim: To consider the arguments for screening outside the standard screening period of 24 to 28 weeks of gestation.: Materials and methods: A search of the literature between 1990 and 2010 was performed using the PubMed® and Cochrane® databases. ... ...

Abstract	Aim: To consider the arguments for screening outside the standard screening period of 24 to 28 weeks of gestation. Materials and methods: A search of the literature between 1990 and 2010 was performed using the PubMed® and Cochrane® databases. Recommendations from learned societies in diabetology and obstetrics & gynaecology were consulted. Results: Gestational diabetes mellitus screening is classically recommended between weeks 24 and 28 of pregnancy, the period during which glucose tolerance deteriorates. However, the increasing prevalence of type 2 diabetes in women of childbearing age with risk factors requires earlier screening. Fasting blood glucose should be measured at the fi rst visit during early pregnancy for these patients. The diagnostic threshold is the same as for patients who are not pregnant, i.e. blood glucose > 1.26 g/l. However, the benefit of screening for gestational diabetes during early pregnancy for women with risk factors has not been supported by prospective studies. Therefore oral glucose tolerance testing during early pregnancy is not currently recommended for the detection of gestational diabetes. Screening for gestational diabetes, regardless of the recommended screening policy, must be performed between weeks 24 and 28 of pregnancy. There are no reasons to consider subsequent screening for gestational diabetes at a later stage.
MeSH term(s)	Diabetes, Gestational/diagnosis ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second ; Prenatal Diagnosis/methods ; Risk Factors
Language	English
Publishing date	2010-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2010.11.015
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Article ; Online: Quand dépister le diabète gestationnel?

Guedj, A-M

Journal de gynecologie, obstetrique et biologie de la reproduction

2010 Volume 39, Issue 8 Suppl 2, Page(s) S214–9

Abstract: Aim: Consider the arguments for screening outside the classical period of 24-28 SA.: Materials and methods: A literature search between 1990 and 2010 was performed using the Pubmed and Cochrane database. Foreign societies guidelines were also ... ...

Title translation	When should we screen for gestational diabetes?.
Abstract	Aim: Consider the arguments for screening outside the classical period of 24-28 SA. Materials and methods: A literature search between 1990 and 2010 was performed using the Pubmed and Cochrane database. Foreign societies guidelines were also consulted. Results: Screening for gestational diabetes is recommended between 24 and 28 weeks of pregnancy, when glucose tolerance deteriorates. However, for patients with certain risk factors, the increasing prevalence of type 2 diabetes in women of childbearing age requires earlier screening. Fasting blood glucose should be measured at the first visit during pregnancy for these patients. The diagnostics threshold is the same as for patients who are not pregnant, i.e. blood glucose > 1.26 g/L. On the other hand, the interest of screening for gestational diabetes at the beginning of pregnancy in the case of certain risk factors is not supported by prospective studies. It is therefore not recommended to perform an OGTT in early pregnancy in order to diagnose gestational diabetes. The search for a gestational diabetes, regardless of screening policy recommended, has to be performed between 24 and 28 weeks gestational age. There are no reasons to consider a new search for gestational diabetes at later stages.
MeSH term(s)	Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/etiology ; Female ; Humans ; Mass Screening ; Pregnancy ; Pregnancy Trimesters
Language	French
Publishing date	2010-12
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	121670-3
ISSN	1773-0430 ; 0368-2315 ; 0150-9918
ISSN (online)	1773-0430
ISSN	0368-2315 ; 0150-9918
DOI	10.1016/S0368-2315(10)70048-X
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Article: [No title information]

Guedj, Myriam / Rosier, Marion / Calvas, Patrick / Julia, Sophie / Garnier, Christelle / Cambon-Thomsen, Anne / Munoz Sastre, Maria Teresa

Journal international de bioethique et d'ethique des sciences

2023 Volume 34, Issue 2, Page(s) 121–130

Abstract: Objective: New genome sequencing techniques allow new approaches in medical genetics, in particular by facilitating the diagnosis of genetic diseases. However, their use also leads to unsolicited genetic findings being uncovered. This type of discovery ... ...

Title translation	Chapitre 8. Annoncer ou pas la découverte d’anomalies non sollicitées lors d’un test génétique à séquençage haut débit ?
Abstract	Objective: New genome sequencing techniques allow new approaches in medical genetics, in particular by facilitating the diagnosis of genetic diseases. However, their use also leads to unsolicited genetic findings being uncovered. This type of discovery raises ethical, legal and psychological considerations. The objective of this psychological research was to study the different positions of patients, health professionals and general public regarding the acceptability of the announcement of unsolicited findings revealed during a high-throughput sequencing genetic test. Method: the first exploratory study aimed, through non-directive research interviews conducted with 13 patients of a medical genetics service, to understand the psychological repercussions linked to the announcement of a result of a targeted genetic test and to know the patients’ desires regarding the announcement of unsolicited findings if the test had been a high-throughput genetic test. The second study, using a quantitative methodology, aimed to identify the judgment policies of 144 patients, 94 healthcare professionals and 211 people from the general public concerning the acceptability of this type of disclosure. Results: The cluster analyses highlighted six judgment policies as to whether or not to disclose the discovery of unsolicited anomalies: “Tell everything”, “Tell even in part”, “Tell everything unless desperate”, “Undecided”, “Do not tell” and “Do not tell if no prevention”. The participants positioned themselves differently, in particular according to the patient’s consent. Conclusion: This research shows the variability of positioning and the importance of consent in the acceptability of the disclosure of unsolicited findings. However, one of the limitations of the study lies in the fact that in medical clinic, acceptability and acceptance may vary over time. A longitudinal study would undoubtedly afford a better understanding of the psychological progress of patients in this type of care pathway..
MeSH term(s)	Humans ; Longitudinal Studies ; Genetic Testing ; High-Throughput Nucleotide Sequencing
Language	French
Publishing date	2023-05-26
Publishing country	France
Document type	English Abstract ; Journal Article
ISSN	2608-1008
ISSN	2608-1008
DOI	10.3917/jibes.342.0121
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Article ; Online: EANM position on positron emission tomography in suspected functional pituitary neuroendocrine tumours.

Van Weehaeghe, Donatienne / Lapauw, Bruno / Fraioli, Francesco / Cecchin, Diego / Verger, Antoine / Guedj, Eric / Albert, Nathalie L / Brendel, Matthias / Yakushev, Igor / Barthel, Henryk / Traub-Weidinger, Tatjana / Tolboom, Nelleke / Giessen, Elsmarieke Van De

European journal of nuclear medicine and molecular imaging

2024

Language	English
Publishing date	2024-04-30
Publishing country	Germany
Document type	Editorial
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-024-06728-4
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