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Article: Search for the production of single sleptons through R-parity violation in pp; collisions at square root (s) =1.8 TeV.

Abazov, V M / Abbott, B / Abdesselam, A / Abolins, M / Abramov, V / Acharya, B S / Adams, D L / Adams, M / Ahmed, S N / Alexeev, G D / Alton, A / Alves, G A / Anderson, E W / Arnoud, Y / Avila, C / Babintsev, V V / Babukhadia, L / Bacon, T C / Baden, A /

Baldin, B / Balm, P W / Banerjee, S / Barberis, E / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bauer, D / Bean, A / Beaudette, F / Begel, M / Belyaev, A / Beri, S B / Bernardi, G / Bertram, I / Besson, A / Beuselinck, R / Bezzubov, V A / Bhat, P C / Bhatnagar, V / Bhattacharjee, M / Blazey, G / Blekman, F / Blessing, S / Boehnlein, A / Bojko, N I / Bolton, T A / Borcherding, F / Bos, K / Bose, T / Brandt, A / Breedon, R / Briskin, G / Brock, R / Brooijmans, G / Bross, A / Buchholz, D / Buehler, M / Buescher, V / Burtovoi, V S / Butler, J M / Canelli, F / Carvalho, W / Casey, D / Casilum, Z / Castilla-Valdez, H / Chakraborty, D / Chan, K M / Chekulaev, S V / Cho, D K / Choi, S / Chopra, S / Christenson, J H / Claes, D / Clark, A R / Coney, L / Connolly, B / Cooper, W E / Coppage, D / Crépé-Renaudin, S / Cummings, M A C / Cutts, D / Davis, G A / De, K / De Jong, S J / Demarteau, M / Demina, R / Demine, P / Denisov, D / Denisov, S P / Desai, S / Diehl, H T / Diesburg, M / Doulas, S / Ducros, Y / Dudko, L V / Duensing, S / Duflot, L / Dugad, S R / Duperrin, A / Dyshkant, A / Edmunds, D / Ellison, J / Eltzroth, J T / Elvira, V D / Engelmann, R / Eno, S / Eppley, G / Ermolov, P / Eroshin, O V / Estrada, J / Evans, H / Evdokimov, V N / Fein, D / Ferbel, T / Filthaut, F / Fisk, H E / Fisyak, Y / Flattum, E / Fleuret, F / Fortner, M / Fox, H / Fu, S / Fuess, S / Gallas, E / Galyaev, A N / Gao, M / Gavrilov, V / Genik, R J / Genser, K / Gerber, C E / Gershtein, Y / Gilmartin, R / Ginther, G / Gómez, B / Goncharov, P I / Gordon, H / Goss, L T / Gounder, K / Goussiou, A / Graf, N / Grannis, P D / Green, J A / Greenlee, H / Greenwood, Z D / Grinstein, S / Groer, L / Grünendahl, S / Gupta, A / Gurzhiev, S N / Gutierrez, G / Gutierrez, P / Hadley, N J / Haggerty, H / Hagopian, S / Hagopian, V / Hall, R E / Hansen, S / Hauptman, J M / Hays, C / Hebert, C / Hedin, D / Heinmiller, J M / Heinson, A P / Heintz, U / Hildreth, M D / Hirosky, R / Hobbs, J D / Hoeneisen, B / Huang, Y / Iashvili, I / Illingworth, R / Ito, A S / Jaffré, M / Jain, S / Jesik, R / Johns, K / Johnson, M / Jonckheere, A / Jöstlein, H / Juste, A / Kahl, W / Kahn, S / Kajfasz, E / Kalinin, A M / Karmanov, D / Karmgard, D / Kehoe, R / Khanov, A / Kharchilava, A / Kim, S K / Klima, B / Knuteson, B / Ko, W / Kohli, J M / Kostritskiy, A V / Kotcher, J / Kothari, B / Kozelov, A V / Kozlovsky, E A / Krane, J / Krishnaswamy, M R / Krivkova, P / Krzywdzinski, S / Kubantsev, M / Kuleshov, S / Kulik, Y / Kunori, S / Kupco, A / Kuznetsov, V E / Landsberg, G / Lee, W M / Leflat, A / Leggett, C / Lehner, F / Leonidopoulos, C / Li, J / Li, Q Z / Lima, J G R / Lincoln, D / Linn, S L / Linnemann, J / Lipton, R / Lucotte, A / Lueking, L / Lundstedt, C / Luo, C / Maciel, A K A / Madaras, R J / Malyshev, V L / Manankov, V / Mao, H S / Marshall, T / Martin, M I / Mayorov, A A / McCarthy, R / McMahon, T / Melanson, H L / Merkin, M / Merritt, K W / Miao, C / Miettinen, H / Mihalcea, D / Mishra, C S / Mokhov, N / Mondal, N K / Montgomery, H E / Moore, R W / Mostafa, M / Da Motta, H / Mutaf, Y D / Nagy, E / Nang, F / Narain, M / Narasimham, V S / Naumann, N A / Neal, H A / Negret, J P / Nomerotski, A / Nunnemann, T / O'Neil, D / Oguri, V / Olivier, B / Oshima, N / Padley, P / Papageorgiou, K / Parashar, N / Partridge, R / Parua, N / Patwa, A / Peters, O / Pétroff, P / Piegaia, R / Pope, B G / Popkov, E / Prosper, H B / Protopopescu, S / Przybycien, M B / Qian, J / Raja, R / Rajagopalan, S / Rapidis, P A / Reay, N W / Reucroft, S / Ridel, M / Rijssenbeek, M / Rizatdinova, F / Rockwell, T / Roco, M / Royon, C / Rubinov, P / Ruchti, R / Rutherfoord, J / Sabirov, B M / Sajot, G / Santoro, A / Sawyer, L / Schamberger, R D / Schellman, H / Schwartzman, A / Shabalina, E / Shivpuri, R K / Shpakov, D / Shupe, M / Sidwell, R A / Simak, V / Singh, H / Sirotenko, V / Slattery, P / Smith, R P / Snihur, R / Snow, G R / Snow, J / Snyder, S / Solomon, J / Song, Y / Sorín, V / Sosebee, M / Sotnikova, N / Soustruznik, K / Souza, M / Stanton, N R / Steinbrück, G / Stephens, R W / Stoker, D / Stolin, V / Stone, A / Stoyanova, D A / Strang, M A / Strauss, M / Strovink, M / Stutte, L / Sznajder, A / Talby, M / Taylor, W / Tentindo-Repond, S / Tripathi, S M / Trippe, T G / Turcot, A S / Tuts, P M / Vaniev, V / Kooten, R Van / Varelas, N / Vertogradov, L S / Villeneuve-Seguier, F / Volkov, A A / Vorobiev, A P / Wahl, H D / Wang, H / Wang, Z-M / Warchol, J / Watts, G / Wayne, M / Weerts, H / White, A / White, J T / Whiteson, D / Wijngaarden, D A / Willis, S / Wimpenny, S J / Womersley, J / Wood, D R / Xu, Q / Yamada, R / Yamin, P / Yasuda, T / Yatsunenko, Y A / Yip, K / Youssef, S / Yu, J / Zanabria, M / Zhang, X / Zheng, H / Zhou, B / Zhou, Z / Zielinski, M / Zieminska, D / Zieminski, A / Zutshi, V / Zverev, E G / Zylberstejn, A

Physical review letters

2002 Volume 89, Issue 26, Page(s) 261801

Abstract: We report the first search for supersymmetric particles via s-channel production and decay ... collected by the D0 experiment and correspond to an integrated luminosity of 94+/-5 pb(-1). Assuming that R ...

Abstract	We report the first search for supersymmetric particles via s-channel production and decay of smuons or muon sneutrinos at hadronic colliders. The data for the two-muon and two-jets final states were collected by the D0 experiment and correspond to an integrated luminosity of 94+/-5 pb(-1). Assuming that R parity is violated via the single coupling lambda'211, the number of candidate events is in agreement with expectation from the standard model. Exclusion contours are given in the (m(0),m(1/2)) and (m(x),m(v)) planes for lambda(')(211)=0.09, 0.08, and 0.07.
Language	English
Publishing date	2002-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.89.261801
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Article: A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen, Stine B / Greenwood, Jeremy R / Varming, Annemarie R / Brehm, Lotte / Pickering, Darryl S / Nielsen, Birgitte / Liljefors, Tommy / Clausen, Rasmus P / Johansen, Tommy N / Krogsgaard-Larsen, Povl

Organic & biomolecular chemistry

2004 Volume 2, Issue 2, Page(s) 206–213

Abstract: ... of (S)- from (S)-AMPA, the pharmacologically active form of AMPA. The pharmacological effects at native ... and cloned (GluR1-4) AMPA receptors were shown to reside exclusively with (R)-(+)-, in striking ...

Abstract	(RS)-3-Hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid (5-HPCA)(), which is a conformationally constrained cyclised analogue of AMPA has previously been described as causing glutamate receptor mediated excitations of spontaneously firing cat spinal interneurons in a similar fashion to AMPA. We have now prepared the enantiomers of through chiral chromatographic resolution of (RS)-3-(carboxymethoxy)-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid () followed by a stereoconservative hydrolysis resulting in the enantiomers of with high enantiomeric excess (% ee [greater-than-or-equal] 99). The absolute configurations indicated by an X-ray analysis of (-)- monohydrate were confirmed by comparing observed and ab initio calculated electronic circular dichroism spectra and by stereoconservative synthesis of (S)- from (S)-AMPA, the pharmacologically active form of AMPA. The pharmacological effects at native and cloned (GluR1-4) AMPA receptors were shown to reside exclusively with (R)-(+)-, in striking contrast to the usual stereoselectivity trend among AMPA receptor agonists. The reasons for this anomalous behaviour became clear upon docking both enantiomers of to the agonist binding site of GluR2.
MeSH term(s)	2-Amino-5-phosphonovalerate/analogs & derivatives ; 2-Amino-5-phosphonovalerate/chemistry ; 2-Amino-5-phosphonovalerate/metabolism ; Animals ; Chromatography, High Pressure Liquid/methods ; Circular Dichroism/methods ; Crystallography, X-Ray ; Cyclization ; Isoxazoles/chemical synthesis ; Isoxazoles/chemistry ; Isoxazoles/metabolism ; Models, Molecular ; Molecular Conformation ; Radioligand Assay ; Rats ; Receptors, AMPA/chemistry ; Receptors, AMPA/metabolism ; Receptors, Kainic Acid/chemistry ; Receptors, Kainic Acid/metabolism ; Stereoisomerism ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/analogs & derivatives ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/chemical synthesis ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
Chemical Substances	Isoxazoles ; Receptors, AMPA ; Receptors, Kainic Acid ; CGP 39653 (132472-31-2) ; 2-Amino-5-phosphonovalerate (76726-92-6) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0)
Language	English
Publishing date	2004-01-21
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/b310450h
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Article: Simultaneous measurement of the ratio R=B(t --> Wb)/B(t --> Wq) and the top-quark pair production cross section with the D0 detector at sqrt(s) = 1.96 TeV.

Abazov, V M / Abbott, B / Abolins, M / Acharya, B S / Adams, M / Adams, T / Aguilo, E / Ahn, S H / Ahsan, M / Alexeev, G D / Alkhazov, G / Alton, A / Alverson, G / Alves, G A / Anastasoaie, M / Ancu, L S / Andeen, T / Anderson, S / Andrieu, B /

Anzelc, M S / Arnoud, Y / Arov, M / Arthaud, M / Askew, A / Asman, B / Assis Jesus, A C S / Atramentov, O / Autermann, C / Avila, C / Ay, C / Badaud, F / Baden, A / Bagby, L / Baldin, B / Bandurin, D V / Banerjee, S / Banerjee, P / Barberis, E / Barfuss, A-F / Bargassa, P / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bauer, D / Beale, S / Bean, A / Begalli, M / Begel, M / Belanger-Champagne, C / Bellantoni, L / Bellavance, A / Benitez, J A / Beri, S B / Bernardi, G / Bernhard, R / Bertram, I / Besançon, M / Beuselinck, R / Bezzubov, V A / Bhat, P C / Bhatnagar, V / Biscarat, C / Blazey, G / Blekman, F / Blessing, S / Bloch, D / Bloom, K / Boehnlein, A / Boline, D / Bolton, T A / Borissov, G / Bose, T / Brandt, A / Brock, R / Brooijmans, G / Bross, A / Brown, D / Buchanan, N J / Buchholz, D / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Burke, S / Burnett, T H / Buszello, C P / Butler, J M / Calfayan, P / Calvet, S / Cammin, J / Carvalho, W / Casey, B C K / Cason, N M / Castilla-Valdez, H / Chakrabarti, S / Chakraborty, D / Chan, K M / Chan, K / Chandra, A / Charles, F / Cheu, E / Chevallier, F / Cho, D K / Choi, S / Choudhary, B / Christofek, L / Christoudias, T / Cihangir, S / Claes, D / Coadou, Y / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Crépé-Renaudin, S / Cutts, D / Cwiok, M / da Motta, H / Das, A / Davies, G / De, K / de Jong, S J / De La Cruz-Burelo, E / De Oliveira Martins, C / Degenhardt, J D / Déliot, F / Demarteau, M / Demina, R / Denisov, D / Denisov, S P / Desai, S / Diehl, H T / Diesburg, M / Dominguez, A / Dong, H / Dudko, L V / Duflot, L / Dugad, S R / Duggan, D / Duperrin, A / Dyer, J / Dyshkant, A / Eads, M / Edmunds, D / Ellison, J / Elvira, V D / Enari, Y / Eno, S / Ermolov, P / Evans, H / Evdokimov, A / Evdokimov, V N / Ferapontov, A V / Ferbel, T / Fiedler, F / Filthaut, F / Fisher, W / Fisk, H E / Ford, M / Fortner, M / Fox, H / Fu, S / Fuess, S / Gadfort, T / Galea, C F / Gallas, E / Galyaev, E / Garcia, C / Garcia-Bellido, A / Gavrilov, V / Gay, P / Geist, W / Gelé, D / Gerber, C E / Gershtein, Y / Gillberg, D / Ginther, G / Gollub, N / Gómez, B / Goussiou, A / Grannis, P D / Greenlee, H / Greenwood, Z D / Gregores, E M / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Guo, J / Guo, F / Gutierrez, P / Gutierrez, G / Haas, A / Hadley, N J / Haefner, P / Hagopian, S / Haley, J / Hall, I / Hall, R E / Han, L / Hansson, P / Harder, K / Harel, A / Harrington, R / Hauptman, J M / Hauser, R / Hays, J / Hebbeker, T / Hedin, D / Hegeman, J G / Heinmiller, J M / Heinson, A P / Heintz, U / Hensel, C / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hobbs, J D / Hoeneisen, B / Hoeth, H / Hohlfeld, M / Hong, S J / Hossain, S / Houben, P / Hu, Y / Hubacek, Z / Hynek, V / Iashvili, I / Illingworth, R / Ito, A S / Jabeen, S / Jaffré, M / Jain, S / Jakobs, K / Jarvis, C / Jesik, R / Johns, K / Johnson, C / Johnson, M / Jonckheere, A / Jonsson, P / Juste, A / Kajfasz, E / Kalinin, A M / Kalk, J R / Kalk, J M / Kappler, S / Karmanov, D / Kasper, P A / Katsanos, I / Kau, D / Kaur, R / Kaushik, V / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y M / Khatidze, D / Kim, T J / Kirby, M H / Kirsch, M / Klima, B / Kohli, J M / Konrath, J-P / Korablev, V M / Kozelov, A V / Krop, D / Kuhl, T / Kumar, A / Kunori, S / Kupco, A / Kurca, T / Kvita, J / Lacroix, F / Lam, D / Lammers, S / Landsberg, G / Lebrun, P / Lee, W M / Leflat, A / Lehner, F / Lellouch, J / Leveque, J / Li, J / Li, Q Z / Li, L / Lietti, S M / Lima, J G R / Lincoln, D / Linnemann, J / Lipaev, V V / Lipton, R / Liu, Y / Liu, Z / Lobodenko, A / Lokajicek, M / Love, P / Lubatti, H J / Luna, R / Lyon, A L / Maciel, A K A / Mackin, D / Madaras, R J / Mättig, P / Magass, C / Magerkurth, A / Mal, P K / Malbouisson, H B / Malik, S / Malyshev, V L / Mao, H S / Maravin, Y / Martin, B / McCarthy, R / Melnitchouk, A / Mendoza, L / Mercadante, P G / Merkin, M / Merritt, K W / Meyer, J / Meyer, A / Millet, T / Mitrevski, J / Molina, J / Mommsen, R K / Mondal, N K / Moore, R W / Moulik, T / Muanza, G S / Mulders, M / Mulhearn, M / Mundal, O / Mundim, L / Nagy, E / Naimuddin, M / Narain, M / Naumann, N A / Neal, H A / Negret, J P / Neustroev, P / Nilsen, H / Nogima, H / Novaes, S F / Nunnemann, T / O'Dell, V / O'Neil, D C / Obrant, G / Ochando, C / Onoprienko, D / Oshima, N / Osta, J / Otec, R / Otero Y Garzón, G J / Owen, M / Padley, P / Pangilinan, M / Parashar, N / Park, S-J / Park, S K / Parsons, J / Partridge, R / Parua, N / Patwa, A / Pawloski, G / Penning, B / Perfilov, M / Peters, K / Peters, Y / Pétroff, P / Petteni, M / Piegaia, R / Piper, J / Pleier, M-A / Podesta-Lerma, P L M / Podstavkov, V M / Pogorelov, Y / Pol, M-E / Polozov, P / Pope, B G / Popov, A V / Potter, C / Prado da Silva, W L / Prosper, H B / Protopopescu, S / Qian, J / Quadt, A / Quinn, B / Rakitine, A / Rangel, M S / Ranjan, K / Ratoff, P N / Renkel, P / Reucroft, S / Rich, P / Rieger, J / Rijssenbeek, M / Ripp-Baudot, I / Rizatdinova, F / Robinson, S / Rodrigues, R F / Rominsky, M / Royon, C / Rubinov, P / Ruchti, R / Safronov, G / Sajot, G / Sánchez-Hernández, A / Sanders, M P / Santoro, A / Savage, G / Sawyer, L / Scanlon, T / Schaile, D / Schamberger, R D / Scheglov, Y / Schellman, H / Schliephake, T / Schwanenberger, C / Schwartzman, A / Schwienhorst, R / Sekaric, J / Severini, H / Shabalina, E / Shamim, M / Shary, V / Shchukin, A A / Shivpuri, R K / Siccardi, V / Simak, V / Sirotenko, V / Skubic, P / Slattery, P / Smirnov, D / Snow, J / Snow, G R / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Sopczak, A / Sosebee, M / Soustruznik, K / Spurlock, B / Stark, J / Steele, J / Stolin, V / Stoyanova, D A / Strandberg, J / Strandberg, S / Strang, M A / Strauss, M / Strauss, E / Ströhmer, R / Strom, D / Stutte, L / Sumowidagdo, S / Svoisky, P / Sznajder, A / Talby, M / Tamburello, P / Tanasijczuk, A / Taylor, W / Temple, J / Tiller, B / Tissandier, F / Titov, M / Tokmenin, V V / Toole, T / Torchiani, I / Trefzger, T / Tsybychev, D / Tuchming, B / Tully, C / Tuts, P M / Unalan, R / Uvarov, S / Uvarov, L / Uzunyan, S / Vachon, B / van den Berg, P J / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Vaupel, M / Verdier, P / Vertogradov, L S / Verzocchi, M / Villeneuve-Seguier, F / Vint, P / Vokac, P / Von Toerne, E / Voutilainen, M / Wagner, R / Wahl, H D / Wang, L / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weber, M / Weber, G / Welty-Rieger, L / Wenger, A / Wermes, N / Wetstein, M / White, A / Wicke, D / Wilson, G W / Wimpenny, S J / Wobisch, M / Wood, D R / Wyatt, T R / Xie, Y / Yacoob, S / Yamada, R / Yan, M / Yasuda, T / Yatsunenko, Y A / Yip, K / Yoo, H D / Youn, S W / Yu, J / Zatserklyaniy, A / Zeitnitz, C / Zhao, T / Zhou, B / Zhu, J / Zielinski, M / Zieminska, D / Zieminski, A / Zivkovic, L / Zutshi, V / Zverev, E G

Physical review letters

2008 Volume 100, Issue 19, Page(s) 192003

Abstract: We present the first simultaneous measurement of the ratio of branching fractions, R=B(t --> Wb)/B ... t --> Wq), with q being a d, s, or b quark, and the top-quark pair production cross section sigma(tt ... over]) in the lepton plus jets channel using 0.9 fb(-1) of pp[over] collision data at sqrt(s)=1.96 TeV ...

Abstract	We present the first simultaneous measurement of the ratio of branching fractions, R=B(t --> Wb)/B(t --> Wq), with q being a d, s, or b quark, and the top-quark pair production cross section sigma(tt[over]) in the lepton plus jets channel using 0.9 fb(-1) of pp[over] collision data at sqrt(s)=1.96 TeV collected with the D0 detector. We extract R and sigma(tt[over]) by analyzing samples of events with 0, 1, and > or =2 identified b jets. We measure R=0.97(+0.09)/(-0.08)(stat+syst) and sigma(tt[over])=8.18(+0.09)(-0.84)(stat+syst) +/- 0.50(lumi) pb, in agreement with the standard model prediction.
Language	English
Publishing date	2008-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.100.192003
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Article: Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

Beich-Frandsen, Mads / Pickering, Darryl S / Mirza, Osman / Johansen, Tommy N / Greenwood, Jeremy / Vestergaard, Bente / Schousboe, Arne / Gajhede, Michael / Liljefors, Tommy / Kastrup, Jette S

Journal of medicinal chemistry

2008 Volume 51, Issue 5, Page(s) 1459–1463

Abstract: ... structures of ( R)-TDPA and ( S)-TDPA in complex with the ligand-binding core of iGluR2 and investigated ...

Abstract	AMPA-type ionotropic glutamate receptors generally display high stereoselectivity in agonist binding. However, the stereoisomers of 2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid (TDPA) have similar enantiopharmacology. To understand this observation, we have determined the X-ray structures of ( R)-TDPA and ( S)-TDPA in complex with the ligand-binding core of iGluR2 and investigated the binding pharmacology at AMPA and kainate receptors. Both enantiomers induce full domain closure in iGluR2 but adopt different conformations when binding to the receptor, which may explain the similar enantiopharmacology.
MeSH term(s)	Alanine/analogs & derivatives ; Alanine/chemistry ; Binding Sites ; Crystallography, X-Ray ; Ligands ; Models, Molecular ; Radioligand Assay ; Receptors, AMPA/agonists ; Receptors, AMPA/chemistry ; Receptors, AMPA/genetics ; Recombinant Proteins/agonists ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Stereoisomerism ; Structure-Activity Relationship ; Thiadiazoles/chemistry
Chemical Substances	2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid ; Ligands ; Receptors, AMPA ; Recombinant Proteins ; Thiadiazoles ; glutamate receptor ionotropic, AMPA 2 ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2008-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm701126w
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Book ; Online: Pollen abundances, and temperature and precipitation reconstruction for the Eocene to Oligocene transition in northern high latitudes, supplementary data to: Eldrett, James S; Greenwood, David R; Harding, Ian C; Huber, Matthew (2009): Increased seasonality through the Eocene to Oligocene transition in northern high latitudes. Nature, 459(7249), 969-973

Eldrett, James S / Greenwood, David R / Harding, Ian C / Huber, Matthew

2007

Abstract: A profound global climate shift took place at the Eocene-Oligocene transition (~33.5?million years ago) when Cretaceous/early Palaeogene greenhouse conditions gave way to icehouse conditions (Zachos et al., 2001, doi:10.1126/science.1059412; Coxall et al. ...

Abstract	A profound global climate shift took place at the Eocene-Oligocene transition (~33.5?million years ago) when Cretaceous/early Palaeogene greenhouse conditions gave way to icehouse conditions (Zachos et al., 2001, doi:10.1126/science.1059412; Coxall et al., 2005, doi:10.1038/nature03135; Lear et al., 2008, doi:10.1130/G24584A.1). During this interval, changes in the Earth's orbit and a long-term drop in atmospheric carbon dioxide concentrations (Pagani et al., 2005, doi:10.1126/science.1110063; Pearson and Palmer, 2000, doi:10.1038/35021000; DeConto and Pollard, 2003, doi:10.1038/nature01290) resulted in both the growth of Antarctic ice sheets to approximately their modern size (Coxall et al., 2005, doi:10.1038/nature03135; Lear et al., 2008, doi:10.1130/G24584A.1) and the appearance of Northern Hemisphere glacial ice (Eldrett et al., 2007, doi:10.1038/nature05591; Moran et al., 2006, doi:10.1038/nature04800). However, palaeoclimatic studies of this interval are contradictory: although some analyses indicate no major climatic changes (Kohn et al., 2004, doi:10.1130/G20442.1; Grimes et al., 2005, doi:10.1130/G21019.1), others imply cooler temperatures (Zanazzi et al., 2007, doi:10.1038/nature05551), increased seasonality (Ivany et al., 2000, doi:10.1038/35038044; Terry, 2001, doi:10.1016/S0031-0182(00)00248-0) and/or aridity (Ivany et al., 2000, doi:10.1038/35038044; Terry, 2001, doi:10.1016/S0031-0182(00)00248-0; Sheldon et al., 2002, doi:10.1086/342865; Dupont-Nivet et al., 2007, doi:10.1038/nature05516). Climatic conditions in high northern latitudes over this interval are particularly poorly known. Here we present northern high-latitude terrestrial climate estimates for the Eocene to Oligocene interval, based on bioclimatic analysis of terrestrially derived spore and pollen assemblages preserved in marine sediments from the Norwegian-Greenland Sea. Our data indicate a cooling of ~5 ?C in cold-month (winter) mean temperatures to 0-2 ?C, and a concomitant increased seasonality before the Oi-1 glaciation event. These data indicate that a cooling component is indeed incorporated in the d18O isotope shift across the Eocene-Oligocene transition. However, the relatively warm summer temperatures at that time mean that continental ice on East Greenland was probably restricted to alpine outlet glaciers.
Language	English
Dates of publication	2007-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/nature08069
DOI	10.1594/PANGAEA.770704
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Clausen, Rasmus P / Bräuner-Osborne, Hans / Greenwood, Jeremy R / Hermit, Mette B / Stensbøl, Tine B / Nielsen, Birgitte / Krogsgaard-Larsen, Povl

Journal of medicinal chemistry

2002 Volume 45, Issue 19, Page(s) 4240–4245

Abstract: ... stereospecifically activates group I mGluRs. We have now synthesized the (S)- and (R)-forms of 2-amino-4-(4-hydroxy[1 ... with AMPA receptors, (S)- and (R)-7 appear to be selective and equipotent agonists at group II mGluRs ... as represented by the mGluR2 subtype. The activities of (S)- and (R)-7 are rationalized by conformational ...

Abstract	Homologation of analogues of the central excitatory neurotransmitter glutamic acid (Glu), in which the distal carboxy group has been bioisosterically replaced by acidic heterocyclic units, has previously provided subtype selective ligands for metabotropic Glu receptors (mGluRs). The (S)-form of the 1,2,5-thiadiazol-3-ol Glu analogue, 2-amino-3-(4-hydroxy[1,2,5]thiadiazol-3-yl)propionic acid (TDPA, 6), is an 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor agonist, which in addition stereospecifically activates group I mGluRs. We have now synthesized the (S)- and (R)-forms of 2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid (homo-TDPA, 7) and shown that whereas neither enantiomer interacts with AMPA receptors, (S)- and (R)-7 appear to be selective and equipotent agonists at group II mGluRs as represented by the mGluR2 subtype. The activities of (S)- and (R)-7 are rationalized by conformational analysis, comparison with the potent and specific group II mGluR agonist (-)-LY379268 [(-)-12], and docking to a homology model of mGluR2.
MeSH term(s)	Amino Acids/chemical synthesis ; Amino Acids/chemistry ; Amino Acids/pharmacology ; Animals ; Binding Sites ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Models, Molecular ; Radioligand Assay ; Rats ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/metabolism ; Stereoisomerism ; Structure-Activity Relationship ; Thiadiazoles/chemical synthesis ; Thiadiazoles/chemistry ; Thiadiazoles/pharmacology
Chemical Substances	2-amino-4-(4-hydroxy(1,2,5)thiadiazol-3-yl)butyric acid ; Amino Acids ; Bridged Bicyclo Compounds, Heterocyclic ; LY 379268 ; Receptors, Metabotropic Glutamate ; Thiadiazoles ; metabotropic glutamate receptor 2
Language	English
Publishing date	2002-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm020122x
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Book ; Online: Pollen and spores, calculated temperature and precipitation of IODP Hole 318-U1356A, supplementary data to: Pross, Jörg; Contreras, Lineth; Bijl, Peter K; Greenwood, David R; Bohaty, Steven M; Schouten, Stefan; Bendle, James A; Röhl, Ursula; Tauxe, Lisa; Raine, J Ian; Huck, Claire E; van de Flierdt, Tina; Jamieson, Stewart S R; Stickley, Catherine E; van de Schootbrugge, Bas; Escutia, Carlota; Brinkhuis, Henk; IODP Expedition 318 Scientists (2012): Persistent near-tropical warmth on the Antarctic continent during the early Eocene epoch. Nature, 488 (7409), 73-77

Pross, Jörg / Bendle, James A / Bijl, Peter K / Bohaty, Steven M / Contreras, Lineth / Greenwood, David R / Röhl, Ursula / Schouten, Stefan / Tauxe, Lisa / al., et

2012

Abstract: The warmest global climates of the past 65 million years occurred during the early Eocene epoch (about 55 to 48 million years ago), when the Equator-to-pole temperature gradients were much smaller than today (doi:10.1130/0091-7613(1995)023 ... 2 ... ...

Abstract	The warmest global climates of the past 65 million years occurred during the early Eocene epoch (about 55 to 48 million years ago), when the Equator-to-pole temperature gradients were much smaller than today (doi:10.1130/0091-7613(1995)023<1044:ECCALT>2.3.CO;2, doi:10.1038/nature08399) and atmospheric carbon dioxide levels were in excess of one thousand parts per million by volume (doi:10.1016/j.gca.2003.09.002, doi:10.1038/ngeo1186). Recently the early Eocene has received considerable interest because it may provide insight into the response of Earth's climate and biosphere to the high atmospheric carbon dioxide levels that are expected in the near future (doi:10.1007/s10584-011-0156-z) as a consequence of unabated anthropogenic carbon emissions (doi:10.1038/ngeo1186, doi:10.1038/nature06588). Climatic conditions of the early Eocene 'greenhouse world', however, are poorly constrained in critical regions, particularly Antarctica. Here we present a well-dated record of early Eocene climate on Antarctica from an ocean sediment core recovered off the Wilkes Land coast of East Antarctica. The information from biotic climate proxies (pollen and spores) and independent organic geochemical climate proxies (indices based on branched tetraether lipids) yields quantitative, seasonal temperature reconstructions for the early Eocene greenhouse world on Antarctica. We show that the climate in lowland settings along the Wilkes Land coast (at a palaeolatitude of about 70° south) supported the growth of highly diverse, near-tropical forests characterized by mesothermal to megathermal floral elements including palms and Bombacoideae. Notably, winters were extremely mild (warmer than 10 °C) and essentially frost-free despite polar darkness, which provides a critical new constraint for the validation of climate models and for understanding the response of high-latitude terrestrial ecosystems to increased carbon dioxide forcing.
Language	English
Dates of publication	2012-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/nature11300
DOI	10.1594/PANGAEA.786960
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Adaptation and conservation insights from the koala genome

Johnson, Rebecca / Ho, Simon / Grueber, Catherine / Greenwood, Alex / Hobbs, Matthew

Nature genetics, 50:1102–1111

2018

Abstract: ... and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability ... of translocation programs to aid the koala’s survival in the wild. ...

Institution	Leibniz-Institut für Zoo- und Wildtierforschung (Berlin)
Abstract	The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild.
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Requisite role of dorsal raphé in contextual cocaine-memory reconsolidation.

Ritchie, J L / Qi, S / Christian, R J / Greenwood, M J / Grenz, H I / Swatzell, S E / Krych, P J / Fuchs, R A

Neuropharmacology

2024 Volume 246, Page(s) 109832

Abstract: Memory reconsolidation is a process by which labile drug memories are restabilized in long-term memory stores, permitting their enduring control over drug-seeking behaviors. In the present study, we investigated the involvement of the dorsal raphé nuclei ...

Abstract	Memory reconsolidation is a process by which labile drug memories are restabilized in long-term memory stores, permitting their enduring control over drug-seeking behaviors. In the present study, we investigated the involvement of the dorsal raphé nuclei (DRN) in cocaine-memory reconsolidation. Sprague-Dawley rats (male, female) were trained to self-administer cocaine in a distinct environmental context to establish contextual drug memories. They then received extinction training in a different context. Next, the rats were re-exposed to the cocaine-predictive context for 15 min to reactivate their cocaine memories or remained in their home cages (no-reactivation control). Memory reactivation was sufficient to increase c-Fos expression, an index of neuronal activation, in the DRN, but not in the median raphé nuclei, during reconsolidation, compared to no reactivation. To determine whether DRN neuronal activity was necessary for cocaine-memory reconsolidation, rats received intra-DRN baclofen plus muscimol (BM; GABA
MeSH term(s)	Female ; Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Dorsal Raphe Nucleus ; Memory ; Extinction, Psychological ; Cocaine/pharmacology
Chemical Substances	Cocaine (I5Y540LHVR)
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2023.109832
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Article ; Online: Comparative transcriptomic analysis of Staphylococcus epidermidis associated with periprosthetic joint infection under in vivo and in vitro conditions.

Fisher, Cody R / Masters, Thao L / Johnson, Stephen / Greenwood-Quaintance, Kerryl E / Chia, Nicholas / Abdel, Matthew P / Patel, Robin

International journal of medical microbiology : IJMM

2024 Volume 315, Page(s) 151620

Abstract: ... joint infection (PJI). Transcriptomic profiling may provide insights into mechanisms by which S ... was used to profile and compare the transcriptomes of 19 paired PJI-associated S. epidermidis samples ... significant genomic differences between known commensal and PJI-associated S. epidermidis isolates, suggesting ...

Abstract	Staphylococcus epidermidis is part of the commensal microbiota of the skin and mucous membranes, though it can also act as a pathogen in certain scenarios, causing a range of infections, including periprosthetic joint infection (PJI). Transcriptomic profiling may provide insights into mechanisms by which S. epidermidis adapts while in a pathogenic compared to a commensal state. Here, a total RNA-sequencing approach was used to profile and compare the transcriptomes of 19 paired PJI-associated S. epidermidis samples from an in vivo clinical source and grown in in vitro laboratory culture. Genomic comparison of PJI-associated and publicly available commensal-state isolates were also compared. Of the 1919 total transcripts found, 145 were from differentially expressed genes (DEGs) when comparing in vivo or in vitro samples. Forty-two transcripts were upregulated and 103 downregulated in in vivo samples. Of note, metal sequestration-associated genes, specifically those related to staphylopine activity (cntA, cntK, cntL, and cntM), were upregulated in a subset of clinical in vivo compared to laboratory grown in vitro samples. About 70% of the total transcripts and almost 50% of the DEGs identified have not yet been annotated. There were no significant genomic differences between known commensal and PJI-associated S. epidermidis isolates, suggesting that differential genomics may not play a role in S. epidermidis pathogenicity. In conclusion, this study provides insights into phenotypic alterations employed by S epidermidis to adapt to infective and non-infected microenvironments, potentially informing future therapeutic targets for related infections.
Language	English
Publishing date	2024-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2024.151620
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