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  1. Article ; Online: Infection Control and Prevention During the COVID-19 Pandemic.

    Jain, Vivek

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  

    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phenobarbital Toxicity in a Neonate Presenting with Intramyelinic Edema.

    Garg, Meenal / Jain, Vivek

    Indian journal of pediatrics

    2023  Volume 90, Issue 4, Page(s) 418

    MeSH term(s) Infant, Newborn ; Humans ; Edema/chemically induced ; Phenobarbital/adverse effects
    Chemical Substances Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2023-02-13
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-023-04506-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Maternal Colonization versus Nosocomial Transmission as the Source of Drug-Resistant Bloodstream Infection in an Indian Neonatal Intensive Care Unit: A Prospective Cohort Study - Correspondence.

    Kumar, Vivek / Jhurani, Divashree / Jain, Kajal

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Squamous Cell Carcinoma Arising in a Zenker's Diverticulum.

    Agarwal, Praveen / Jain, Nitish / Jindal, Sourabh / Goel, Vivek / Jain, Pradeep

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53583

    Abstract: Squamous cell carcinoma (SCC) developing in a Zenker's diverticulum (ZD) is an uncommon condition. The preferred treatment for SCC in the pharyngeal pouch is complete diverticulum resection. Only histopathological evaluation of the pouch can rule out SCC. ...

    Abstract Squamous cell carcinoma (SCC) developing in a Zenker's diverticulum (ZD) is an uncommon condition. The preferred treatment for SCC in the pharyngeal pouch is complete diverticulum resection. Only histopathological evaluation of the pouch can rule out SCC. Here, we present a case of a 62-year-old male patient, who was evaluated for repeated episodes of aspiration and dysphagia, and diagnosed to have a large ZD, the patient underwent Zenker's diverticulectomy with cricopharyngeal myotomy with wide margins due to clinically suspicious specimen. Histopathological examination revealed well-differentiated SCC arising within ZD, involving the whole thickness of the wall and almost touching the serosa (1 mm). The patient developed metastatic lung nodule on PET-CT, so metastatic lung nodule was excised with video-assisted thoracoscopic surgery (VATS), and chemotherapy and immunotherapy were given. On follow-up imaging patient is tumor-free to date, two years after the surgery. The occurrence of synchronous or metachronous lung cancer makes it one of the rarest cases.
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Harnessing the potential of fatty Acid-Surfactant-Based micellar gel for enhanced topical delivery of Apremilast in psoriasis treatment.

    Sontakke, Arun / Dighe, Sayali / Sharma, Reena / Yadav, Vivek / Jain, Sanyog

    International journal of pharmaceutics

    2024  Volume 655, Page(s) 124026

    Abstract: Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier ...

    Abstract Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier system presents a novel option to increase the efficacy of the topical treatment of APR. The current investigation deals with the development of fatty acid-surfactant conjugate-based hybrid mixed micellar gel (HMMG) for the topical delivery of APR. The developed micelles exhibited an average size of 83.59 ± 4.46 nm, PDI of 0.239 ± 0.047, % entrapment efficiency of ∼ 94.78 ± 3.98 %, with % practical drug loading of ∼11.37 ± 3.14 %. TEM analysis revealed the spherical shape of micelles. The hybrid micelles were further loaded in a carbopol®934P gel base for ease of application. Ex vivo permeation study revealed enhanced permeation and ∼ 38-fold higher retention in deeper layers of skin from a hybrid micellar gel. In vivo, assessment demonstrated augmented efficacy of APR-HMMG as compared to 0.1 % betamethasone valerate. Also, APR-HMMG showed no sign of irritation, suggesting superior safety as a topical application. Thus, the proposed formulation strategy represents a viable avenue for enhancing the therapeutic efficacy of various anti-psoriatic moieties.
    MeSH term(s) Humans ; Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; Skin ; Gels ; Pulmonary Surfactants ; Psoriasis/drug therapy ; Particle Size ; Thalidomide/analogs & derivatives
    Chemical Substances Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; apremilast (UP7QBP99PN) ; Gels ; Pulmonary Surfactants ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-03-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.124026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multicentric reticulohistiocytosis.

    Jain, Harsh / Vasdev, Vivek / S, Kartik / Kumar, Abhishek / Mishra, P S / J, Sankar / Chandwani, Ashish

    QJM : monthly journal of the Association of Physicians

    2024  

    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcae037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frosted branch angiitis in behcet disease.

    Jain, Harsh / Kumar, Pradeep / S, Kartik / Vasdev, Vivek / K, Abhishek / J, Sankar / Chandwani, Ashish / Goel, Nidhi

    QJM : monthly journal of the Association of Physicians

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcae044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Fatal Hashimoto encephalopathy presenting with acute fulminant cerebral edema in a child.

    Garg, Meenal / Sharma, Ravi / Jain, Vivek

    Journal of neurosciences in rural practice

    2022  Volume 14, Issue 1, Page(s) 194–195

    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP-2022-5-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma.

    Jain, Ankit P / Ghose, Vivek / Munshi, Srijon / Bhat, Firdous A / Dey, Gourav / Nanjappa, Vishalakshi

    Molecular & cellular oncology

    2024  Volume 11, Issue 1, Page(s) 2328873

    Abstract: Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence. Here, we aim to understand the mechanisms of action of cisplatin and emergence of ... ...

    Abstract Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence. Here, we aim to understand the mechanisms of action of cisplatin and emergence of resistance to cisplatin using mass spectrometry-based proteomic approach. A panel of head and neck squamous cell carcinoma (HNSCC) cell lines were treated with cisplatin at respective IC
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2024.2328873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antibody-conjugated pH-sensitive liposomes for HER-2 positive breast cancer: development, characterization,

    Raikwar, Sarjana / Yadav, Vivek / Jain, Sanyog / Jain, Sanjay K

    Journal of liposome research

    2023  , Page(s) 1–25

    Abstract: The object of the current study was to develop and evaluate trastuzumab-conjugated Paclitaxel (PTX) and Elacridar (ELA)-loaded PEGylated pH-sensitive liposomes (TPPLs) for site-specific delivery of an anticancer drug. In this study, paclitaxel is used as ...

    Abstract The object of the current study was to develop and evaluate trastuzumab-conjugated Paclitaxel (PTX) and Elacridar (ELA)-loaded PEGylated pH-sensitive liposomes (TPPLs) for site-specific delivery of an anticancer drug. In this study, paclitaxel is used as an anticancer drug which promotes microtubules polymerization and arrest cell cycle progression at mitosis and subsequently leading to cell death. The single use of PTX causes multiple drug resistance (MDR) and results failure of the therapy. Hence, the combination of PTX and P-glycoprotein inhibitor (ELA) are used to achieve maximum therapeutic effects of PTX. Moreover, monoclonal antibody (trastuzumab) is used as ligand for the targeting the drug bearing carriers to BC. Thus, trastuzumab anchored pH-sensitive liposomes bearing PTX and ELA were developed using thin film hydration method and Box-Behnken Design (BBD) for optimizing various formulation variables. The optimized liposomes undergo characterization such as vesicle size, PDI, and zeta potential, which were observed to be 122 ± 2.14 nm, 0.224, and -15.5 mV for PEGylated pH-sensitive liposomes (PEG-Ls) and 134 ± 1.88 nm, 0.238, and -13.98 mV for TPPLs, respectively. The results of the
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 645173-1
    ISSN 1532-2394 ; 0898-2104
    ISSN (online) 1532-2394
    ISSN 0898-2104
    DOI 10.1080/08982104.2023.2248505
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