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Article ; Online: Poly(d,l-lactide-

Lima, Alexandre Ferreira / Amado, Isabel R / Pires, Liliana R

2020 Volume 12, Issue 12

Abstract: The administration of specific antigens is being explored as a mean to re-establish immunological tolerance, namely in the context of multiple sclerosis (MS). PLP139-151 is a peptide of the myelin's most abundant protein, proteolipid protein (PLP), which ...

Abstract	The administration of specific antigens is being explored as a mean to re-establish immunological tolerance, namely in the context of multiple sclerosis (MS). PLP139-151 is a peptide of the myelin's most abundant protein, proteolipid protein (PLP), which has been identified as a potent tolerogenic molecule in MS. This work explored the encapsulation of the peptide into poly(lactide-
Language	English
Publishing date	2020-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym12123063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue.

Yonekawa, Murilo K A / Penteado, Bruna de B / Dal'Ongaro Rodrigues, Amanda / Lourenço, Estela M G / Barbosa, Euzébio G / das Neves, Silvia C / de Oliveira, Rodrigo J / Marques, Maria R / Silva, Denise B / de Lima, Dênis P / Beatriz, Adilson / Oses, Jean P / Dos S Jaques, Jeandre A / Santos, Edson Dos A Dos

Bioorganic & medicinal chemistry letters

2021 Volume 47, Page(s) 128206

Abstract: ... on the central nervous system (CNS). The goal of this research was to synthesize l-HYP and d-HYP and test ... human cells (HaCaT) was observed in the case of l-HYP and d-HYP although an increase ... in cell proliferation. Molecular modeling studies revealed that d-HYP and l-HYP have significant differences ...

Abstract	Acetylcholinesterase (AChEis) inhibitors are used to treat neurodegenerative diseases like Alzheimer's disease (AD). l-Hypaphorine (l-HYP) is a natural indole alkaloid that has been shown to have effects on the central nervous system (CNS). The goal of this research was to synthesize l-HYP and d-HYP and test their anticholinesterasic properties in rat brain regions. l-HYP suppressed acetylcholinesterase (AChE) activity only in the cerebellum, whereas d-HYP inhibited AChE activity in all CNS regions studied. No cytotoxic effect on normal human cells (HaCaT) was observed in the case of l-HYP and d-HYP although an increase in cell proliferation. Molecular modeling studies revealed that d-HYP and l-HYP have significant differences in their binding mode positions and interact stereospecifically with AChE's amino acid residues.
MeSH term(s)	Acetylcholinesterase/metabolism ; Animals ; Brain/enzymology ; Brain/pathology ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Indoles/chemistry ; Indoles/pharmacology ; Molecular Structure ; Rats ; Structure-Activity Relationship
Chemical Substances	Cholinesterase Inhibitors ; Indoles ; Acetylcholinesterase (EC 3.1.1.7) ; lenticin (GJ3358U63L)
Language	English
Publishing date	2021-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2021.128206
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Article ; Online: Malicia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) improves depressive-like behaviour, somatic, biochemical and inflammatory parameters of obese rats.

Luiza Rolim Bezerra, Maria / Gouveia-Nhanca, Mirela / D' Angelo da Silva Andrade, Artur / Oliveira Pinheiro, Rafael / Francisco Alves, Adriano / Carolina de Paiva Sousa, Maria / Dos Santos Lima, Marcos / Magnani, Marciane / de Souza Aquino, Jailane

Food research international (Ottawa, Ont.)

2022 Volume 164, Page(s) 112391

Abstract: Malícia honey produced by the jandaíra bee has hypoglycaemic and hypolipidemic effects and antioxidant activity in vitro and in vivo, which makes it potential adjuvant treatment for obesity. This study aimed to evaluate the effects of malícia honey on ... ...

Abstract	Malícia honey produced by the jandaíra bee has hypoglycaemic and hypolipidemic effects and antioxidant activity in vitro and in vivo, which makes it potential adjuvant treatment for obesity. This study aimed to evaluate the effects of malícia honey on somatic and biochemical parameters, depressive-like behaviour and anti-inflammatory activity in obese rats. A total of 40 adult male Wistar rats were initially randomized into a healthy group (HG, n = 20) that consumed a control diet, and an obese group (OG, n = 20) which consumed a cafeteria diet for eight weeks. Then, they were subdivided into four groups: healthy (HG, n = 10); healthy treated with malícia honey (HGH, n = 10); obese (OG, n = 10); and obese treated with malícia honey (OGH, n = 10), maintaining their diets for another eight weeks. The HGH and OGH groups received malícia honey (1000 mg/kg body weight) via gavage. Food intake was monitored daily and body weight was monitored weekly. Biochemical tests related to obesity and glucose and insulin tolerance test, somatic parameters, histological parameters and quantification of NF-κB in the brain were performed. Treatment with malícia honey improved depressive-like behaviour, reduced weight (14 %), body mass index (6 %), and improved lipid profile, leptin, insulin, HOMA-β, and glucose and insulin tolerance in obese rats. It also decreased NF-κB (58.08 %) in the brain. Malícia honey demonstrated anti-obesity and anti-inflammatory effects, and reversed changes in obesity-induced depressive-like behaviour.
MeSH term(s)	Bees ; Rats ; Male ; Animals ; Honey ; Mimosa ; Rats, Wistar ; NF-kappa B ; Obesity ; Glucose ; Insulin ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	NF-kappa B ; Glucose (IY9XDZ35W2) ; Insulin ; Anti-Inflammatory Agents
Language	English
Publishing date	2022-12-31
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.112391
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Article: Improvement in physicochemical characteristics, bioactive compounds and antioxidant activity of acerola (Malpighia emarginata D.C.) guava (Psidium guajava L.) fruit by-products fermented with potentially probiotic lactobacilli

de Oliveira, S. D. / Araújo, C. M. / d. S. C. Borges, G. / d. S. Lima, M. / Viera, V. B. / Garcia, E. F. / de Souza, E. L. / de Oliveira, M. E. G.

LWT - food science and technology

2020 Volume 134, Issue -, Page(s) 110200

Language	English
Document type	Article
ZDB-ID	2169058-3
ISSN	0023-6438
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Malicia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) improves depressive-like behaviour, somatic, biochemical and inflammatory parameters of obese rats

Luiza Rolim Bezerra, Maria / Gouveia-Nhanca, Mirela / D' Angelo da Silva Andrade, Artur / Oliveira Pinheiro, Rafael / Francisco Alves, Adriano / Carolina de Paiva Sousa, Maria / dos Santos Lima, Marcos / Magnani, Marciane / de Souza Aquino, Jailane

Food Research International. 2023 Feb., v. 164 p.112391-

2023

Abstract	Malícia honey produced by the jandaíra bee has hypoglycaemic and hypolipidemic effects and antioxidant activity in vitro and in vivo, which makes it potential adjuvant treatment for obesity. This study aimed to evaluate the effects of malícia honey on somatic and biochemical parameters, depressive-like behaviour and anti-inflammatory activity in obese rats. A total of 40 adult male Wistar rats were initially randomized into a healthy group (HG, n = 20) that consumed a control diet, and an obese group (OG, n = 20) which consumed a cafeteria diet for eight weeks. Then, they were subdivided into four groups: healthy (HG, n = 10); healthy treated with malícia honey (HGH, n = 10); obese (OG, n = 10); and obese treated with malícia honey (OGH, n = 10), maintaining their diets for another eight weeks. The HGH and OGH groups received malícia honey (1000 mg/kg body weight) via gavage. Food intake was monitored daily and body weight was monitored weekly. Biochemical tests related to obesity and glucose and insulin tolerance test, somatic parameters, histological parameters and quantification of NF-κB in the brain were performed. Treatment with malícia honey improved depressive-like behaviour, reduced weight (14 %), body mass index (6 %), and improved lipid profile, leptin, insulin, HOMA-β, and glucose and insulin tolerance in obese rats. It also decreased NF-κB (58.08 %) in the brain. Malícia honey demonstrated anti-obesity and anti-inflammatory effects, and reversed changes in obesity-induced depressive-like behaviour.
Keywords	Melipona ; Mimosa ; adjuvants ; adults ; anti-inflammatory activity ; antioxidant activity ; bees ; body mass index ; brain ; cafeteria foods ; food intake ; food research ; glucose ; histology ; honey ; insulin ; insulin resistance ; insulin tolerance test ; leptin ; lipid composition ; males ; obesity ; Anti-obesity ; Anti-depressant ; Cafeteria diet ; NF-kB ; Stingless bees
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.112391
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of honey from Mimosa quadrivalvis L. (malícia) produced by the Melipona subnitida D. (jandaíra) stingless bee on dyslipidaemic rats.

Bezerra, Maria Luiza Rolim / de Souza, Evandro Leite / de Sousa, Janaína Maria Batista / Lima, Marcos Dos Santos / Alves, Adriano Francisco / Almeida, Maria das Graças / Coutinho Alves, Raquel / Veríssimo de Araújo, Emmanuel / Soares, Naís Lira / da Silva, Gabriel Araújo / Magnani, Marciane / Aquino, Jailane de Souza

Food & function

2018 Volume 9, Issue 8, Page(s) 4480–4492

Abstract: This study assessed the effects of supplementation with honey from Mimosa quadrivalvis L. (malícia ... MH) produced by jandaíra stingless bees (Melipona subnitida D.) on the lipid metabolism, antioxidant ...

Abstract	This study assessed the effects of supplementation with honey from Mimosa quadrivalvis L. (malícia) (MH) produced by jandaíra stingless bees (Melipona subnitida D.) on the lipid metabolism, antioxidant status and some intestinal health parameters of rats with diet-induced dyslipidaemia. Rats were randomly divided into four groups: healthy control (HC), dyslipidaemic control (DC), healthy experimental (EHH) and dyslipidaemic experimental (EDH). Malícia honey (MH) was administered (1000 mL kg-1) via orogastric feeding for 35 days. Dyslipidaemic rats supplemented with MH showed lower food consumption, increased glucose tolerance and superoxide dismutase (SOD) activity, and decreased total cholesterol, LDL and AST blood levels. Counts of Bifidobacterium spp. and Lactobacillus spp. and excretion of organic acids in faeces increased in dyslipidaemic rats supplemented with MH. MH supplementation protected the colon and liver from tissue damage induced by the dyslipidaemic diet. These results show the beneficial effects of MH on the lipid metabolism, antioxidant status and intestinal health of rats with diet-induced dyslipidaemia.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Bees ; Bifidobacterium/genetics ; Bifidobacterium/growth & development ; Bifidobacterium/isolation & purification ; Cholesterol/metabolism ; Dietary Supplements/analysis ; Dyslipidemias/diet therapy ; Dyslipidemias/metabolism ; Dyslipidemias/microbiology ; Feces/microbiology ; Gastrointestinal Microbiome ; Glucose/metabolism ; Honey/analysis ; Humans ; Lactobacillus/genetics ; Lactobacillus/growth & development ; Lactobacillus/isolation & purification ; Male ; Mimosa/chemistry ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Cholesterol (97C5T2UQ7J) ; Superoxide Dismutase (EC 1.15.1.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c8fo01044g
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Article ; Online: Poly( d,l -lactide- co -glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)—Exploring a New Administration Route

Alexandre Ferreira Lima / Isabel R. Amado / Liliana R. Pires

Polymers, Vol 12, Iss 3063, p

2020 Volume 3063

Abstract: ... of the nanoparticles and the peptide into the skin, a highly immune-active organ. Different poly( d,l -lactide- co ...

Abstract	The administration of specific antigens is being explored as a mean to re-establish immunological tolerance, namely in the context of multiple sclerosis (MS). PLP139-151 is a peptide of the myelin’s most abundant protein, proteolipid protein (PLP), which has been identified as a potent tolerogenic molecule in MS. This work explored the encapsulation of the peptide into poly(lactide- co -glycolide) nanoparticles and its subsequent incorporation into polymeric microneedle patches to achieve efficient delivery of the nanoparticles and the peptide into the skin, a highly immune-active organ. Different poly( d,l -lactide- co -glycolide) (PLGA) formulations were tested and found to be stable and to sustain a freeze-drying process. The presence of trehalose in the nanoparticle suspension limited the increase in nanoparticle size after freeze-drying. It was shown that rhodamine can be loaded in PLGA nanoparticles and these into poly(vinyl alcohol)–poly(vinyl pyrrolidone) microneedles, yielding fluorescently labelled structures. The incorporation of PLP into the PLGA nanoparticles resulted in nanoparticles in a size range of 200 µm and an encapsulation efficiency above 20%. The release of PLP from the nanoparticles occurred in the first hours after incubation in physiological media. When loading the nanoparticles into microneedle patches, structures were obtained with 550 µm height and 180 µm diameter. The release of PLP was detected in PLP–PLGA.H20 nanoparticles when in physiological media. Overall, the results show that this strategy can be explored to integrate a new antigen-specific therapy in the context of multiple sclerosis, providing minimally invasive administration of PLP-loaded nanoparticles into the skin.
Keywords	dissolving microneedles ; multiple sclerosis ; PLP ; transdermal delivery ; PLGA ; Organic chemistry ; QD241-441
Subject code	000
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Variations in Essential Oil Chemical Composition and Biological Activities of Cryptomeria japonica (Thunb. ex L.f.) D. Don from Different Geographical Origins—A Critical Review

Ana Lima / Filipe Arruda / Jorge Medeiros / José Baptista / João Madruga / Elisabete Lima

Applied Sciences, Vol 11, Iss 11097, p

2021 Volume 11097

Abstract: The scientific community is paying increasing attention to plant waste valorization, and also to “greener” practices in the agriculture, food and cosmetic sectors. In this context, unused forest biomass (e.g., leaves, seed cones, branches/twigs, bark and ...

Abstract	The scientific community is paying increasing attention to plant waste valorization, and also to “greener” practices in the agriculture, food and cosmetic sectors. In this context, unused forest biomass (e.g., leaves, seed cones, branches/twigs, bark and sapwood) of Cryptomeria japonica , a commercially important tree throughout Asia and the Azores Archipelago (Portugal), is currently waste/by-products of wood processing that can be converted into eco-friendly and high added-value products, such as essential oils (EOs), with social, environmental and economic impacts. Plant-derived EOs are complex mixtures of metabolites, mostly terpenes and terpenoids, with valuable bioactivities (e.g., antioxidant, anti-inflammatory, anticancer, neuroprotective, antidepressant, antimicrobial, antiviral and pesticide), which can find applications in several industries, such as pharmaceutical, medical, aromatherapy, food, cosmetic, perfumery, household and agrochemical (e.g., biopesticides), with manifold approaches. The EOs components are also of value for taxonomic investigations. It is known that the variation in EOs chemical composition and, consequently, in their biological activities and commercial use, is due to different exogenous and endogenous factors that can lead to ecotypes or chemotypes in the same plant species. The present paper aims to provide an overview of the chemical composition, biological properties and proposals of valorization of C. japonica EO from several countries, and also to indicate gaps in the current knowledge.
Keywords	sustainability ; circular economy ; Cryptomeria japonica ; waste/by-products valorization ; plant secondary metabolites ; essential oil ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coatings with chitosan and phenolic-rich extract from acerola (Malpighia emarginata D.C.) or jabuticaba (Plinia jaboticaba (Vell.) Berg) processing by-product to control rot caused by Lasiodiplodia spp. in papaya (Carica papaya L.) fruit.

Gomes, Ana Cristina Alves / da Costa Lima, Maiara / de Oliveira, Kataryne Árabe Rimá / Dos Santos Lima, Marcos / Magnani, Marciane / Câmara, Marcos Paz Saraiva / de Souza, Evandro Leite

International journal of food microbiology

2020 Volume 331, Page(s) 108694

Abstract: ... Malpighia emarginata D.C., PEA) or jabuticaba (Plinia jaboticaba (Vell.) Berg, PEJ) processing by-products ... are effective to control the development of rot caused by Lasiodiplodia pseudotheobromae, L. viticola ... L. euphorbicola, L. theobromae and L. hormozganensis in papaya (Carica papaya L.) fruit. Effects ...

Abstract	This study evaluated if coatings with chitosan (Chi) and phenolic-rich extract from acerola (Malpighia emarginata D.C., PEA) or jabuticaba (Plinia jaboticaba (Vell.) Berg, PEJ) processing by-products are effective to control the development of rot caused by Lasiodiplodia pseudotheobromae, L. viticola, L. euphorbicola, L. theobromae and L. hormozganensis in papaya (Carica papaya L.) fruit. Effects of formulated coatings on some physicochemical parameters indicative of postharvest quality of papaya were investigated. Twenty-six different phenolics were found in PEA and PEJ, including flavonoids, stilbenes, tannins and phenolic acids. Chi (1-5 mg/mL), PEA and PEJ (25-100 mg/mL) separately caused mycelial growth inhibition on all isolates. Combinations of Chi (3 and 4 mg/mL) and PEA (50 and 75 mg/mL) or PEJ (75 and 100 mg/mL) had additive interactions. Coatings with Chi (4 mg/mL) and PEA (50 or 75 mg/mL) or PEA (75 or 100 mg/mL) inhibited rot development in papaya fruit infected with Lasiodiplodia isolates during 8 days of room temperature storage. Coatings with 4 mg/mL Chi and 75 mg/mL PEA or 100 mg/mL PEJ were the most effective to control rot development. These coatings did not affect negatively physicochemical parameters indicative of postharvest quality of papaya fruit during storage. Coatings with combined Chi and PEA or PEJ could be novel strategies to control postharvest rot caused by Lasiodiplodia in papaya fruit.
MeSH term(s)	Ascomycota/drug effects ; Carica/microbiology ; Chitosan/pharmacology ; Food Handling/methods ; Food Microbiology ; Fruit/microbiology ; Malpighiaceae/chemistry ; Myrtaceae/chemistry ; Phenols/pharmacology ; Plant Extracts/pharmacology
Chemical Substances	Phenols ; Plant Extracts ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2020.108694
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Article ; Online: Anticiper l’activité par les configurations d’usage

Francisco Duarte / Francisco Lima

Activités, Vol 9, Iss

proposition méthodologique pour conduite de projet

2012 Volume 2

Abstract: The intervention of ergonomists in the early stages of the design process depends on the ability to predict the future activity characteristics of transformational work situations. The paradox of ergonomic design has been addressed using several ... ...

Abstract	The intervention of ergonomists in the early stages of the design process depends on the ability to predict the future activity characteristics of transformational work situations. The paradox of ergonomic design has been addressed using several different approaches. Typical situations of action, practical schemes and transformational models based on certain courses of action provide designers with information on the use of technical systems. These concepts deal with the transition between analysis of work in actual situations and the need to guide the design process. To this same end, in this paper we introduce the concept of settings of usage. We present examples of this concept to guide the design of future oil platforms beginning with the initial baseline studies. Settings of usage are intended to capture experiences gained in the operation of platforms and to transfer the accumulated knowledge to future projects, creating appropriate working conditions for the activity. The goal is to create, as a complement to the expertise of the operators, ergonomists and designers, a knowledge base organized around the settings of usage. This will enable the transfer of experiential knowledge before the project teams have even been constituted.
Keywords	experience transfer ; activity centered design ; ergonomics guidelines ; setting of usage ; Psychology ; BF1-990 ; Social Sciences ; H
Subject code	380
Language	English
Publishing date	2012-10-01T00:00:00Z
Publisher	Association Recherche et Pratique sur les Activités
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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