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  1. Article: Non-optimal maturation of the oocyte, maternal MTHFR polymorphisms, periconceptional folate, and decrease of congenital heart defects.

    Jongbloet, Piet Hein

    European heart journal

    2007  Volume 28, Issue 16, Page(s) 2043

    MeSH term(s) Dietary Supplements ; Folic Acid/administration & dosage ; Folic Acid Deficiency/diet therapy ; Heart Defects, Congenital/genetics ; Heterozygote ; Homozygote ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Oocytes/physiology ; Polymorphism, Genetic ; Preconception Care
    Chemical Substances Folic Acid (935E97BOY8) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
    Language English
    Publishing date 2007-08
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehm235
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    Zs.A 1563: Show issues Location:
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  2. Article: Do sunlight and vitamin D reduce the likelihood of colon cancer? Time for a paradigm shift?

    Jongbloet, Piet Hein

    International journal of epidemiology

    2006  Volume 35, Issue 5, Page(s) 1359–1360

    MeSH term(s) Colonic Neoplasms/prevention & control ; Humans ; Risk Factors ; Seasons ; Sunlight ; Vitamin D/administration & dosage
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2006-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyl206
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  3. Article: 'Conception origin'versus'ambient outdoor temperature throughout pregnancy' in relation to offspring birthweight.

    Jongbloet, Piet Hein

    BJOG : an international journal of obstetrics and gynaecology

    2005  Volume 112, Issue 12, Page(s) 1667–8; author reply 1668

    MeSH term(s) Birth Weight ; Female ; Fertilization/physiology ; Humans ; Male ; Seasons ; Sex Ratio ; Temperature
    Language English
    Publishing date 2005-12
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 1470-0328 ; 0306-5456
    ISSN (online) 1471-0528
    ISSN 1470-0328 ; 0306-5456
    DOI 10.1111/j.1471-0528.2005.00775.x
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  4. Article: Influences of maternal weight on the secondary sex ratio of human offspring.

    Jongbloet, Piet Hein

    Human reproduction (Oxford, England)

    2004  Volume 19, Issue 10, Page(s) 2425; author reply 2425–6

    MeSH term(s) Body Weight ; Female ; Humans ; Pregnancy ; Sex Ratio
    Language English
    Publishing date 2004-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deh363
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    Zs.B 2892: Show issues Location:
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  5. Article: Offspring sex ratio at population level versus early and late onset preeclampsia.

    Jongbloet, Piet Hein

    Early human development

    2004  Volume 79, Issue 2, Page(s) 159–163

    Abstract: Male dominance being higher at preterm than term delivery was described in a population-based study by Vatten and Skjaerven [Early Hum. Dev. 76 (2004) 47]. A so-called "reversion" and "cross-over" in the sex ratio took place in preeclamptic gestations. ... ...

    Abstract Male dominance being higher at preterm than term delivery was described in a population-based study by Vatten and Skjaerven [Early Hum. Dev. 76 (2004) 47]. A so-called "reversion" and "cross-over" in the sex ratio took place in preeclamptic gestations. These phenomena occurred earlier and stronger when associated with perinatal mortality and are in line with the overripeness ovopathy concept.
    MeSH term(s) Adult ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Male ; Norway/epidemiology ; Ovulation/physiology ; Ovum/growth & development ; Ovum/pathology ; Pre-Eclampsia/complications ; Pre-Eclampsia/mortality ; Pregnancy ; Pregnancy Outcome/epidemiology ; Registries ; Sex Factors ; Sex Ratio ; Time Factors
    Language English
    Publishing date 2004-09
    Publishing country Ireland
    Document type Comment ; Journal Article ; Review
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2004.04.008
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  6. Article ; Online: "Conception origin" versus "fetal origins" hypothesis and stroke.

    Jongbloet, Piet Hein

    Stroke

    2004  Volume 35, Issue 1, Page(s) e1–2

    MeSH term(s) England/epidemiology ; Environment ; Female ; Fertility/physiology ; Fetal Growth Retardation/etiology ; Growth Disorders/epidemiology ; Growth Disorders/etiology ; Humans ; Incidence ; Infant Mortality ; Infant, Low Birth Weight/physiology ; Infant, Newborn ; Male ; Malnutrition/complications ; Malnutrition/epidemiology ; Oocytes/physiology ; Poverty Areas ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology ; Wales/epidemiology
    Language English
    Publishing date 2004-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/01.STR.0000107232.50242.1B
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    Zs.A 448: Show issues Location:
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  7. Article: Siblings and adult mortality and stroke risk.

    Jongbloet, Piet Hein

    Journal of epidemiology and community health

    2004  Volume 58, Issue 9, Page(s) 803

    MeSH term(s) Adult ; Family Characteristics ; Female ; Humans ; Mortality ; Pregnancy ; Prenatal Exposure Delayed Effects ; Risk Factors ; Stroke/embryology
    Language English
    Publishing date 2004-09
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 391868-3
    ISSN 1470-2738 ; 0143-005X ; 0142-467X ; 0141-7681
    ISSN (online) 1470-2738
    ISSN 0143-005X ; 0142-467X ; 0141-7681
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    Zs.A 186: Show issues Location:
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  8. Article: Is the Mediterranean diet relevant to myocardial infarction? Olive oil consumption versus geographical latitude.

    Jongbloet, Piet Hein

    International journal of epidemiology

    2003  Volume 32, Issue 5, Page(s) 878–879

    MeSH term(s) Dietary Fats, Unsaturated/administration & dosage ; Feeding Behavior ; Humans ; Mediterranean Region ; Myocardial Infarction/prevention & control ; Olive Oil ; Plant Oils/administration & dosage ; Seasons
    Chemical Substances Dietary Fats, Unsaturated ; Olive Oil ; Plant Oils
    Language English
    Publishing date 2003-07-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyg242
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  9. Article: Maternal lead exposure, secondary sex ratio and dose-exposure fallacy.

    Jongbloet, Piet Hein / Roeleveld, Nel

    Human reproduction (Oxford, England)

    2007  Volume 22, Issue 10, Page(s) 2792; author reply 2792–3

    MeSH term(s) Female ; Humans ; Infant, Newborn ; Lead/blood ; Lead Poisoning/physiopathology ; Male ; Pregnancy ; Sex Ratio
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dem193
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    Zs.B 2892: Show issues Location:
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  10. Article ; Online: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy.

    Jongbloet, Piet Hein / Verbeek, André Lm / den Heijer, Martin / Roeleveld, Nel

    Journal of experimental & clinical assisted reproduction

    2008  Volume 5, Page(s) 5

    Abstract: Several conditions apparent at birth, e.g., neural tube defects (NTDs) and cardiac anomalies, are associated with polymorphisms in folate-related genes, such as the 677C --> T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Similar ... ...

    Abstract Several conditions apparent at birth, e.g., neural tube defects (NTDs) and cardiac anomalies, are associated with polymorphisms in folate-related genes, such as the 677C --> T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Similar associations have been established for several constitutional chronic diseases in adulthood, such as schizophrenia, cardiovascular diseases, dementia, and even neoplasias in different organ systems. This spectrum of developmental anomalies and constitutional diseases may be linked to high-risk conceptions related to preovulatory overripeness ovopathy (PrOO). Some developmental anomalies, such as NTDs, are to a large extent prevented by supplementation of folic acid before conception, but supplementation does not seem to prevent cardiovascular disease or cognitive decline. These diverging results can be elucidated by introduction of the PrOO concept, as MTHFR polymorphisms and inherent low folate levels induce both non-optimal maturation of the oocyte and unsuccessful DNA methylation and demethylation, i.e. epigenetic mutations. The PrOO concept is testable and predicts in a random population the following: (1) female carriers of specific genetic MTHFR variants exhibit more ovulatory disturbances and inherent subfecundity traits, (2) descendents from a carrier mother, when compared with those from a wild-type mother, are more frequently conceived in PrOO high-risk conditions and, thus, (3) disadvantaged in life expectancy. If so, some MTHFR polymorphisms represent a novel, genetically determined, PrOO high-risk conception category comparable to those which are environmentally and behaviorly influenced. These high-risk conditions may cause developmental anomalies and defective epigenetic reprogramming in progeny. The interaction between genetic and environmental factors is a plausible mechanism of multifactorial inheritance.
    Language English
    Publishing date 2008-07-10
    Publishing country Ireland
    Document type Journal Article
    ISSN 1743-1050
    ISSN (online) 1743-1050
    DOI 10.1186/1743-1050-5-5
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