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  1. Article: Ongoing challenges of off-label prescribing.

    Day, Richard O

    Australian prescriber

    2023  Volume 46, Issue 4, Page(s) 86–89

    Abstract: Off-label prescribing refers to prescribing that is not concordant with the indications, doses, routes of administration or patient groups included in the Australian approved product information. Off-label prescribing is common, especially for vulnerable ...

    Abstract Off-label prescribing refers to prescribing that is not concordant with the indications, doses, routes of administration or patient groups included in the Australian approved product information. Off-label prescribing is common, especially for vulnerable patient groups who tend to be excluded from clinical trials, such as children and pregnant women. There may be increased risk of prescriber liability if the patient experiences an adverse event following off-label prescription, particularly when supporting evidence or guidelines are lacking. There may be additional costs to the patient if the medicine is not subsidised for the off-label indication. Prescribers should ensure patients are aware when a medicine is being prescribed off label, and informed of potential benefits and harms. Alternative pathways for approval of new indications, doses and patient groups may reduce the need for off-label prescribing.
    Language English
    Publishing date 2023-12-20
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1075442-8
    ISSN 0312-8008
    ISSN 0312-8008
    DOI 10.18773/austprescr.2023.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3233: Show issues Location:
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  2. Book: Antirheumatic therapy

    Day, Richard O.

    actions and outcomes

    (Progress in inflammation research)

    2005  

    Author's details Richard O. Day ... ed
    Series title Progress in inflammation research
    Language English
    Size XIII, 343 S. : graph. Darst.
    Publisher Birkhäuser
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT014260111
    ISBN 3-7643-6595-1 ; 978-3-7643-6595-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 257 order for loan Magazin

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  3. Article ; Online: Avoiding severe drug hypersensitivity reactions: a case for HLA genotyping for at-risk patients.

    Stojanova, Jana / Day, Richard O / Suthers, Graeme

    The Medical journal of Australia

    2023  Volume 218, Issue 10, Page(s) 441–444

    MeSH term(s) Humans ; Genotype ; Drug Hypersensitivity/genetics ; Genetic Predisposition to Disease ; HLA-B Antigens/genetics ; Pharmacogenetics
    Chemical Substances HLA-B Antigens
    Language English
    Publishing date 2023-05-14
    Publishing country Australia
    Document type Journal Article ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Crying Over Stark Differences: Resource Disparity and Therapeutic Drug Monitoring.

    Carland, Jane E / Stojanova, Jana / Lau, Cindy / Day, Richard O / Marriott, Deborah J E

    Therapeutic drug monitoring

    2024  

    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424443-6
    ISSN 1536-3694 ; 0163-4356
    ISSN (online) 1536-3694
    ISSN 0163-4356
    DOI 10.1097/FTD.0000000000001185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sodium-Glucose Cotransporter 2 Inhibitor-Associated "Ketoacidosis" Versus "Diabetic Ketoacidosis": The Importance of Accurate Terminology.

    Milder, Tamara Y / Milder, David A / Greenfield, Jerry R / Day, Richard O

    Drug safety

    2023  Volume 46, Issue 12, Page(s) 1303–1305

    MeSH term(s) Humans ; Diabetic Ketoacidosis/chemically induced ; Diabetic Ketoacidosis/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Sodium
    Chemical Substances Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-10-17
    Publishing country New Zealand
    Document type Editorial
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-023-01358-5
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  6. Article ; Online: Introduction to the Special Section: Phase I Clinical Trials.

    Day, Richard O

    Therapeutic innovation & regulatory science

    2016  Volume 51, Issue 3, Page(s) 274–275

    Language English
    Publishing date 2016-12-22
    Publishing country Switzerland
    Document type Introductory Journal Article
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1177/2168479017706513
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  7. Article ; Online: Honorary Professor Garry Graham.

    Day, Richard O / Williams, Kenneth M / Scott, Kieran F

    Inflammopharmacology

    2021  Volume 29, Issue 5, Page(s) 1255–1259

    Abstract: An appreciation of the contribution of Professor Gary Graham to anti-inflammatory and antirheumatic pharmacology and clinical pharmacology. ...

    Abstract An appreciation of the contribution of Professor Gary Graham to anti-inflammatory and antirheumatic pharmacology and clinical pharmacology.
    MeSH term(s) Anti-Inflammatory Agents/history ; Anti-Inflammatory Agents/pharmacology ; Antirheumatic Agents/history ; Antirheumatic Agents/pharmacology ; History, 20th Century ; History, 21st Century ; Humans ; Pharmacology, Clinical/history
    Chemical Substances Anti-Inflammatory Agents ; Antirheumatic Agents
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-021-00872-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 3274: Show issues Location:
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  8. Article: Prednisone for cardiac failure in patients with hypertension.

    Day, Richard O

    The Journal of rheumatology

    2015  Volume 42, Issue 5, Page(s) 739–740

    MeSH term(s) Female ; Gout Suppressants/therapeutic use ; Heart Failure/complications ; Humans ; Hyperuricemia/drug therapy ; Male ; Prednisone/therapeutic use
    Chemical Substances Gout Suppressants ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2015-05
    Publishing country Canada
    Document type Comment ; Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.150276
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    Zs.MO 135: Show issues

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  9. Article ; Online: Estimation of adherence to urate-lowering therapy in people living with gout using Australia's Pharmaceutical Benefits Scheme and patient-reported dosing.

    Schulz, Marcel / Coleshill, Matthew J / Day, Richard O / Wright, Daniel F B / Brett, Jonathan / Briggs, Nancy E / Aung, Eindra

    British journal of clinical pharmacology

    2024  Volume 90, Issue 5, Page(s) 1322–1332

    Abstract: ... namely, allopurinol (400 mg/day) or febuxostat (80 mg/day).: Methods: Proportion of days covered (PDC ... 291 (167) mg/day. Mean PDC (SD) for allopurinol was 83% (21%) calculated using self-reported dose, and ...

    Abstract Aims: The aim of this study was to estimate adherence to urate-lowering therapy (ULT), predominately allopurinol, from Australia's Pharmaceutical Benefits Scheme (PBS) claims database in association with (1) patient-reported doses and (2) World Health Organization's (WHO) defined daily doses (DDD), namely, allopurinol (400 mg/day) or febuxostat (80 mg/day).
    Methods: Proportion of days covered (PDC) was calculated in 108 Gout App (Gout APP) trial participants with at least two recorded ULT dispensings in an approximately 12-month period before provision of intervention or control apps. Adherence was defined as PDC ≥80%. We measured the correlation between the two methods of calculating PDC using a Wilcoxon signed rank test. Agreement between ULT-taking status (self-reports) and ULT-dispensed status (PBS records) was tested with Cohen's kappa (κ), and positive and negative percent agreement.
    Results: Allopurinol was prescribed in 93.5% of participants taking ULT. Their self-reported mean daily dose (SD) was 291 (167) mg/day. Mean PDC (SD) for allopurinol was 83% (21%) calculated using self-reported dose, and 63% (24%) using WHO's DDD. Sixty-three percent of allopurinol users were identified as adherent (PDC ≥80%) using self-reported dose. There was good agreement between self-reported ULT use and PBS dispensing claims (κ = 0.708, P < .001; positive percent agreement = 90%, negative percent agreement = 82%).
    Conclusions: Participant-reported allopurinol daily doses, in addition to PBS dispensing claims, may enhance confidence in estimating PDC and adherence compared to using DDD. This approach improves adherence estimations from pharmaceutical claims datasets for medications where daily doses vary between individuals or where there is a wide therapeutic dose range.
    MeSH term(s) Humans ; Gout/drug therapy ; Gout/blood ; Allopurinol/administration & dosage ; Allopurinol/therapeutic use ; Gout Suppressants/administration & dosage ; Gout Suppressants/therapeutic use ; Medication Adherence/statistics & numerical data ; Australia ; Male ; Female ; Middle Aged ; Febuxostat/administration & dosage ; Febuxostat/therapeutic use ; Self Report/statistics & numerical data ; Uric Acid/blood ; Aged ; Adult ; Databases, Factual
    Chemical Substances Allopurinol (63CZ7GJN5I) ; Gout Suppressants ; Febuxostat (101V0R1N2E) ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1118: Show issues Location:
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  10. Article ; Online: Optimizing the dosing of vancomycin in patients receiving intermittent haemodialysis with low-flux filters, and the potential impact of dosing software.

    Stefani, Maurizio / Musgrave, Kirsty / Sevastos, Jacob / Penny, Mark / Day, Richard O / Roberts, Darren M

    Nephrology (Carlton, Vic.)

    2023  Volume 28, Issue 10, Page(s) 534–539

    Abstract: Aim: Iterative approaches to vancomycin dosing (e.g., dosing when trough concentrations <15-20 mg/L) can be inadequate. Computer-guided dosing may be superior but has not been evaluated in patients with kidney failure receiving replacement therapy. We ... ...

    Abstract Aim: Iterative approaches to vancomycin dosing (e.g., dosing when trough concentrations <15-20 mg/L) can be inadequate. Computer-guided dosing may be superior but has not been evaluated in patients with kidney failure receiving replacement therapy. We evaluated vancomycin concentrations using a hospital protocol and a pharmacokinetic software. We measured vancomycin clearance by the FX8 low-flux filter because data are absent.
    Methods: We retrospectively reviewed records of adults with kidney failure requiring replacement therapy receiving vancomycin and dialysed with the FX8 low-flux filter, and calculated the proportion of pre-dialysis concentrations that were within, above or below a specified range. One and two-compartment models in the pharmacokinetic software were assessed by computing mean prediction error (MPE) and root mean square error (RMSE) of observed versus predicted concentrations. Vancomycin extracorporeal clearance was prospectively determined using the extraction method.
    Results: In 24 patients (34 courses; 139 paired observed and predicted concentrations), 62/139 (45%) pre-dialysis concentrations were 15-25 mg/L, 29/139 (21%) were above, and 48/139 (35%) were below. MPE for the one-compartment model was -0.2 mg/L, RMSE 5.3 mg/L. MPE for the two-compartment model was 2.0 mg/L, RMSE 5.6 mg/L. Excluding the first paired concentrations, the subsequent MPE (n = 105) using one-compartment model was -0.5 mg/L, RMSE 5.6 mg/L. The MPE for the two-compartment model was 2.1 mg/L, RMSE 5.8 mg/L. The median extracorporeal clearance was 70.7 mL/min (range: 10.3-130.3; n = 22).
    Conclusions: Vancomycin dosing was suboptimal and the pharmacokinetic software was not sufficiently predictive. These may improve with a loading dose. The substantial removal of vancomycin by low-flux filters is not accounted for by the models tested.
    MeSH term(s) Adult ; Humans ; Vancomycin ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Renal Dialysis/methods ; Renal Insufficiency/drug therapy
    Chemical Substances Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14198
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    Zs.A 4822: Show issues Location:
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