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Article ; Online: In Memoriam: Marc R. de Leval (1941-2022).

Elliott, Martin J / Deanfield, John E

World journal for pediatric & congenital heart surgery

2022 Volume 13, Issue 5, Page(s) 551–552

Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Editorial
ZDB-ID	2550261-X
ISSN	2150-136X ; 2150-1351
ISSN (online)	2150-136X
ISSN	2150-1351
DOI	10.1177/21501351221116020
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Article ; Online: coil: an R package for cytochrome

Nugent, Cameron M / Elliott, Tyler A / Ratnasingham, Sujeevan / Adamowicz, Sarah J

Genome

2020 Volume 63, Issue 6, Page(s) 291–305

Abstract: Biological conclusions based on DNA barcoding and metabarcoding analyses can be strongly influenced by the methods utilized for data generation and curation, leading to varying levels of success in the separation of biological variation from experimental ...

Abstract	Biological conclusions based on DNA barcoding and metabarcoding analyses can be strongly influenced by the methods utilized for data generation and curation, leading to varying levels of success in the separation of biological variation from experimental error. The 5' region of cytochrome
MeSH term(s)	Animals ; DNA Barcoding, Taxonomic/methods ; DNA, Mitochondrial/genetics ; Electron Transport Complex IV/genetics ; Frameshift Mutation/genetics ; Humans ; Phylogeny ; Pseudogenes/genetics
Chemical Substances	DNA, Mitochondrial ; Electron Transport Complex IV (EC 1.9.3.1) ; cytochrome c oxidase subunit I, human (EC 1.9.3.1)
Language	English
Publishing date	2020-05-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	639031-6
ISSN	1480-3321 ; 0831-2796
ISSN (online)	1480-3321
ISSN	0831-2796
DOI	10.1139/gen-2019-0206
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Article ; Online: In Memoriam: Professor Marc R. de Leval (April 16, 1941-June 26, 2022) - a tribute.

Elliott, Martin J / Deanfield, John E

Cardiology in the young

2022 , Page(s) 1–2

Abstract: ... Professor Martin J. Elliott and Professor John E. Deanfield. As stated by the authors: "Marc's career ...

Abstract	This manuscript is a personal tribute to Professor Marc de Leval from two of his colleagues: Professor Martin J. Elliott and Professor John E. Deanfield. As stated by the authors: "Marc's career history is presented in the accompanying eulogy from the current Heart & Lung Team at Great Ormond Street Hospital (GOSH), allowing us to highlight Marc's personal qualities that made him such an inspirational colleague. … Marc was, as we have said, the cardiologist's surgeon. He was also the surgeon's cardiologist, bridging the two disciplines and fusing the team. He was delighted by the advent of interventional cardiology and did not see it as a threat or competition, but instead, as appropriate for the well-being of his patients. He recognised how traumatic surgery could be for patients and their families and sought to avoid it whenever possible by alternative treatments. Marc will be remembered with love and admiration by his many patients and their families, whose lives he changed. His technical skill, energy, devotion, humour, intellect and influence will be sorely missed. May he rest in peace."
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951122002359
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Article: Profiling the Longitudinal Development of Babbling in Infants with Cerebral Palsy: Validation of the Infant Monitor of Vocal Production (IMP) Using the Stark Assessment of Early Vocal Development-Revised (SAEVD-R).

Ward, Roslyn / Hennessey, Neville / Barty, Elizabeth / Cantle Moore, Robyn / Elliott, Catherine / Valentine, Jane

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 23

Abstract: ... with typically developing (TD) infants aged 6 to 15 months using the SAEVD-R, investigating potential pre ... the SAEVD-R and IMP, which uses parent report, in identifying departure from typical vocal development ... 15 at risk for CP and 18 TD) were assessed at 6, 9, 12, and 15 months using the SAEVD-R. Generalised ...

Abstract	Aim: We compared early vocal development in children "at risk" for cerebral palsy (CP) with typically developing (TD) infants aged 6 to 15 months using the SAEVD-R, investigating potential pre-linguistic markers of communication impairment. Additionally, we sought to examine the agreement between the SAEVD-R and IMP, which uses parent report, in identifying departure from typical vocal development in at-risk infants. Method: Utilising a longitudinal cohort study, >10,000 vocalisations of 33 infants (15 at risk for CP and 18 TD) were assessed at 6, 9, 12, and 15 months using the SAEVD-R. Generalised linear mixed models (GLMMs) compared groups, and Spearman correlations explored IMP ceiling scores and SAEVD-R measures. Results: At 6 months, both TD and CP groups reached SAEVD-R vocalisation level 3 (expansion). By 9 months, 51% of TD infants progressed to advanced babbling (levels 4 and 5), while 80% of at-risk infants remained at level 3. At 12 and 15 months, over 90% of TD children advanced, compared to 67% at 12 months and 53% at 15 months for at-risk infants, who stayed at the pre-canonical stage. Strong correlations were found between IMP scores and vocalisation levels at 9 and 12 months. Remaining at the pre-canonical stage at 12 months correlated with delayed vocal development as per IMP scores. Interpretation: TD infants achieved higher SAEVD-R levels than at-risk infants. At 12 months, IMP scores effectively identified infants with speech-like vocalisation difficulties, demonstrating its clinical utility in identifying atypical vocal development in infants at risk for CP.
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13233517
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Article ; Online: "And DPSIR begat DAPSI(W)R(M)!" - A unifying framework for marine environmental management.

Elliott, M / Burdon, D / Atkins, J P / Borja, A / Cormier, R / de Jonge, V N / Turner, R K

Marine pollution bulletin

2017 Volume 118, Issue 1-2, Page(s) 27–40

Abstract: ... advocates that DPSIR should be extended to DAPSI(W)R(M) (pronounced dap-see-worm) in which Drivers of basic ... the need for a linked-DAPSI(W)R(M) framework, and then the connectivity between marine ecosystems and ... ecosystems in the catchment and further at sea, requires an interlinked, nested-DAPSI(W)R(M) framework ...

Abstract	The marine environment is a complex system formed by interactions between ecological structure and functioning, physico-chemical processes and socio-economic systems. An increase in competing marine uses and users requires a holistic approach to marine management which considers the environmental, economic and societal impacts of all activities. If managed sustainably, the marine environment will deliver a range of ecosystem services which lead to benefits for society. In order to understand the complexity of the system, the DPSIR (Driver-Pressure-State-Impact-Response) approach has long been a valuable problem-structuring framework used to assess the causes, consequences and responses to change in a holistic way. Despite DPSIR being used for a long time, there is still confusion over the definition of its terms and so to be appropriate for current marine management, we contend that this confusion needs to be addressed. Our viewpoint advocates that DPSIR should be extended to DAPSI(W)R(M) (pronounced dap-see-worm) in which Drivers of basic human needs require Activities which lead to Pressures. The Pressures are the mechanisms of State change on the natural system which then leads to Impacts (on human Welfare). Those then require Responses (as Measures). Furthermore, because of the complexity of any managed sea area in terms of multiple Activities, there is the need for a linked-DAPSI(W)R(M) framework, and then the connectivity between marine ecosystems and ecosystems in the catchment and further at sea, requires an interlinked, nested-DAPSI(W)R(M) framework to reflect the continuum between adjacent ecosystems. Finally, the unifying framework for integrated marine management is completed by encompassing ecosystem structure and functioning, ecosystem services and societal benefits. Hence, DAPSI(W)R(M) links the socio-ecological system of the effects of changes to the natural system on the human uses and benefits of the marine system. However, to deliver these sustainably in the light of human activities requires a Risk Assessment and Risk Management framework; the ISO-compliant Bow-Tie method is used here as an example. Finally, to secure ecosystem health and economic benefits such as Blue Growth, successful, adaptive and sustainable marine management Responses (as Measures) are delivered using the 10-tenets, a set of facets covering all management disciplines and approaches.
MeSH term(s)	Conservation of Natural Resources/methods ; Ecology ; Ecosystem ; Human Activities ; Humans ; Oceans and Seas ; Risk Assessment ; Risk Management
Language	English
Publishing date	2017-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2017.03.049
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Article ; Online: Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug.

Oncotarget

2017 Volume 8, Issue 5, Page(s) 8035–8042

Abstract: ... A1-R (S. typhimurium A1-R, p<0.001 compared to untreated control). The osteosarcoma was only ... typhimurium A1-R was significantly more effective than sorafenib (P <0.001). S. typhimurium grew ... in the treated tumors and caused extensive necrosis of the tumor tissue. These data show that S. typhimurium A1-R ...

Abstract	Osteosarcoma occurs mostly in children and young adults, who are treated with multiple agents in combination with limb-salvage surgery. However, the overall 5-year survival rate for patients with recurrent or metastatic osteosarcoma is 20-30% which has not improved significantly over 30 years. Refractory patients would benefit from precise individualized therapy. We report here that a patient-derived osteosarcoma growing in a subcutaneous nude-mouse model was regressed by tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R, p<0.001 compared to untreated control). The osteosarcoma was only partially sensitive to the molecular-targeting drug sorafenib, which did not arrest its growth. S. typhimurium A1-R was significantly more effective than sorafenib (P <0.001). S. typhimurium grew in the treated tumors and caused extensive necrosis of the tumor tissue. These data show that S. typhimurium A1-R is powerful therapy for an osteosarcoma patient-derived xenograft model.
MeSH term(s)	Adolescent ; Animals ; Antineoplastic Agents/pharmacology ; Biological Therapy/methods ; Bone Neoplasms/microbiology ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Drug Resistance, Neoplasm ; Humans ; Male ; Mice, Nude ; Molecular Targeted Therapy ; Necrosis ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Osteosarcoma/microbiology ; Osteosarcoma/pathology ; Osteosarcoma/therapy ; Phenylurea Compounds/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Salmonella typhimurium/pathogenicity ; Sorafenib ; Time Factors ; Tumor Burden ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Phenylurea Compounds ; Protein Kinase Inhibitors ; Niacinamide (25X51I8RD4) ; Sorafenib (9ZOQ3TZI87)
Language	English
Publishing date	2017-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.14040
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Article: rFSA: An R Package for Finding Best Subsets and Interactions.

Lambert, Joshua / Gong, Liyu / Elliott, Corrine F / Thompson, Katherine / Stromberg, Arnold

The R journal

2018 Volume 10, Issue 2, Page(s) 295–308

Abstract: Herein we present the R package rFSA, which implements an algorithm for improved variable selection ...

Abstract	Herein we present the R package rFSA, which implements an algorithm for improved variable selection. The algorithm searches a data space for models of a user-specified form that are statistically optimal under a measure of model quality. Many iterations afford a set of
Language	English
Publishing date	2018-12-08
Publishing country	United States
Document type	Journal Article
ISSN	2073-4859
ISSN	2073-4859
DOI	10.32614/rj-2018-059
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Article ; Online ; Research data: (with research data) Polypatex: an R package for paternity exclusion in autopolyploids.

Zwart, Alexander B / Elliott, Carole / Hopley, Tara / Lovell, David / Young, Andrew

Molecular ecology resources

2016 Volume 16, Issue 3, Page(s) 694–700

Abstract: ... software. We introduce polypatex, an r package for paternity exclusion analysis using microsatellite data ...

Abstract	Microsatellite markers have demonstrated their value for performing paternity exclusion and hence exploring mating patterns in plants and animals. Methodology is well established for diploid species, and several software packages exist for elucidating paternity in diploids; however, these issues are not so readily addressed in polyploids due to the increased complexity of the exclusion problem and a lack of available software. We introduce polypatex, an r package for paternity exclusion analysis using microsatellite data in autopolyploid, monoecious or dioecious/bisexual species with a ploidy of 4n, 6n or 8n. Given marker data for a set of offspring, their mothers and a set of candidate fathers, polypatex uses allele matching to exclude candidates whose marker alleles are incompatible with the alleles in each offspring-mother pair. polypatex can analyse marker data sets in which allele copy numbers are known (genotype data) or unknown (allelic phenotype data) - for data sets in which allele copy numbers are unknown, comparisons are made taking into account all possible genotypes that could arise from the compared allele sets. polypatex is a software tool that provides population geneticists with the ability to investigate the mating patterns of autopolyploids using paternity exclusion analysis on data from codominant markers having multiple alleles per locus.
MeSH term(s)	Animals ; Biostatistics/methods ; Genotyping Techniques/methods ; Microsatellite Repeats ; Paternity ; Plants ; Polyploidy ; Software
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2406833-0
ISSN	1755-0998 ; 1755-098X ; 1755-098X
ISSN (online)	1755-0998
ISSN	1755-098X
DOI	10.1111/1755-0998.12496
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Article ; Online: Reply from Jonathan E. Elliott, Joseph W. Duke, Jerold A. Hawn, John R. Halliwill and Andrew T. Lovering.

Elliott, Jonathan E / Duke, Joseph W / Hawn, Jerold A / Halliwill, John R / Lovering, Andrew T

The Journal of physiology

2015 Volume 593, Issue 2, Page(s) 483–484

MeSH term(s)	Arteriovenous Anastomosis/physiology ; Blood Pressure ; Cardiac Output ; Female ; Humans ; Male ; Oxygen/metabolism ; Pulmonary Artery/physiology
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2015-01-15
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/jphysiol.2014.286807
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Article: “And DPSIR begat DAPSI(W)R(M)!” - A unifying framework for marine environmental management

Elliott, M / A. Borja / D. Burdon / J.P. Atkins / R. Cormier / R.K. Turner / V.N. de Jonge

Marine pollution bulletin. 2017 May 15, v. 118, no. 1-2

2017

Abstract	The marine environment is a complex system formed by interactions between ecological structure and functioning, physico-chemical processes and socio-economic systems. An increase in competing marine uses and users requires a holistic approach to marine management which considers the environmental, economic and societal impacts of all activities. If managed sustainably, the marine environment will deliver a range of ecosystem services which lead to benefits for society. In order to understand the complexity of the system, the DPSIR (Driver-Pressure-State-Impact-Response) approach has long been a valuable problem-structuring framework used to assess the causes, consequences and responses to change in a holistic way. Despite DPSIR being used for a long time, there is still confusion over the definition of its terms and so to be appropriate for current marine management, we contend that this confusion needs to be addressed. Our viewpoint advocates that DPSIR should be extended to DAPSI(W)R(M) (pronounced dap-see-worm) in which Drivers of basic human needs require Activities which lead to Pressures. The Pressures are the mechanisms of State change on the natural system which then leads to Impacts (on human Welfare). Those then require Responses (as Measures). Furthermore, because of the complexity of any managed sea area in terms of multiple Activities, there is the need for a linked-DAPSI(W)R(M) framework, and then the connectivity between marine ecosystems and ecosystems in the catchment and further at sea, requires an interlinked, nested-DAPSI(W)R(M) framework to reflect the continuum between adjacent ecosystems. Finally, the unifying framework for integrated marine management is completed by encompassing ecosystem structure and functioning, ecosystem services and societal benefits. Hence, DAPSI(W)R(M) links the socio-ecological system of the effects of changes to the natural system on the human uses and benefits of the marine system. However, to deliver these sustainably in the light of human activities requires a Risk Assessment and Risk Management framework; the ISO-compliant Bow-Tie method is used here as an example. Finally, to secure ecosystem health and economic benefits such as Blue Growth, successful, adaptive and sustainable marine management Responses (as Measures) are delivered using the 10-tenets, a set of facets covering all management disciplines and approaches.
Keywords	ecosystem services ; environmental health ; environmental management ; financial economics ; humans ; marine ecosystems ; marine environment ; risk assessment ; risk management process ; social welfare ; society ; socioeconomics ; watersheds
Language	English
Dates of publication	2017-0515
Size	p. 27-40.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2017.03.049
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