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Article ; Online: Impact of COVID-19 mitigations on anxiety and depression amongst university students: A systematic review and meta-analysis.

2023 Volume 13, Page(s) 6035

Abstract: Background: While much research has addressed mental health concerns related to the coronavirus disease 2019 (COVID-19) pandemic, there remains a scarcity of studies specifically exploring the changes in anxiety and depression among university students ... ...

Abstract	Background: While much research has addressed mental health concerns related to the coronavirus disease 2019 (COVID-19) pandemic, there remains a scarcity of studies specifically exploring the changes in anxiety and depression among university students before and after the implementation of COVID-19 mitigation measures. Methods: In this systematic review and meta-analysis, we searched databases including MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), ERIC (EBSCO), the WHO COVID-19 database, Scopus, and Science Citation Index (Web of Science) as of 15 February 2023. We included studies that used a validated tool to measure changes in anxiety or depression at two distinct time points - before (T1) and during (T2); during (T2) and after (T3); or before (T1) and after (T3) COVID-19 mitigation. The quality of studies was assessed using an adapted Joanna Briggs Institute Checklist for longitudinal studies. Utilising random-effects models, we synthesised changes in continuous outcomes as standardised mean difference (SMD) with 95% confidence interval (CI) and binary outcomes as risk difference (RD) with 95% CI. Results: In total, 15 studies were included in this review, with eight of moderate and seven of high quality. In most of the included studies (n = 13), the majority of participants were women. Eleven studies analysed mental health outcomes between T1 and T2 of COVID-19 mitigations. Continuous symptom changes were a minimal or small improvement for anxiety (SMD = -0.03, 95% CI = -0.24 to 0.19, I Conclusions: Mental health outcomes, especially depressive symptoms, were observed to worsen in university students during COVID-19 mitigations. Despite considerable heterogeneity requiring careful interpretation of results, the impact of COVID-19 mitigations on mental health in university students is evident. Registration: PROSPERO (CRD42021266889).
MeSH term(s)	Female ; Humans ; Male ; Depression/epidemiology ; Universities ; COVID-19/epidemiology ; Anxiety/epidemiology ; Databases, Factual
Language	English
Publishing date	2023-09-01
Publishing country	Scotland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.13.06035
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Care co-ordination and continuity of care for patients with complex needs

Lara Sonola / Veronika Thiel / Nick Goodwin

International Journal of Integrated Care, Vol 13, Iss

emerging lessons from five models in the UK

2013 Volume 5

Keywords	integrated care ; care co-ordination ; continuity of care ; primary care ; care coordinators ; patient experience ; Medicine (General) ; R5-920
Language	English
Publishing date	2013-10-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Care co-ordination and continuity of care for patients with complex needs

Lara Sonola / Veronika Thiel / Nick Goodwin

International Journal of Integrated Care, Vol 13, Iss

emerging lessons from five models in the UK

2013 Volume 5

Keywords	integrated care ; care co-ordination ; continuity of care ; primary care ; care coordinators ; patient experience ; Medicine (General) ; R5-920
Language	English
Publishing date	2013-10-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non-Small Cell Lung Cancer.

Woo, Xing Yi / Srivastava, Anuj / Mack, Philip C / Graber, Joel H / Sanderson, Brian J / Lloyd, Michael W / Chen, Mandy / Domanskyi, Sergii / Gandour-Edwards, Regina / Tsai, Rebekah A / Keck, James / Cheng, Mingshan / Bundy, Margaret / Jocoy, Emily L / Riess, Jonathan W / Holland, William / Grubb, Stephen C / Peterson, James G / Stafford, Grace A /

Paisie, Carolyn / Neuhauser, Steven B / Karuturi, R Krishna Murthy / George, Joshy / Simons, Allen K / Chavaree, Margaret / Tepper, Clifford G / Goodwin, Neal / Airhart, Susan D / Lara, Primo N / Openshaw, Thomas H / Liu, Edison T / Gandara, David R / Bult, Carol J

Cancer research

2022 Volume 82, Issue 22, Page(s) 4126–4138

Abstract: Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung ... ...

Abstract	Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine carcinomas, two adenosquamous carcinomas, and one pleomorphic carcinoma. Models with both de novo and acquired resistance to targeted therapies with tyrosine kinase inhibitors are available in the collection. The genomic profiles of the LUAD and LUSC PDX models are consistent with those observed in patient tumors from The Cancer Genome Atlas and previously characterized gene expression-based molecular subtypes. Clinically relevant mutations identified in the original patient tumors were confirmed in engrafted PDX tumors. Treatment studies performed in a subset of the models recapitulated the responses expected on the basis of the observed genomic profiles. These models therefore serve as a valuable preclinical platform for translational cancer research. Significance: Patient-derived xenografts of lung cancer retain key features observed in the originating patient tumors and show expected responses to treatment with standard-of-care agents, providing experimentally tractable and reproducible models for preclinical investigations.
MeSH term(s)	Humans ; Animals ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Heterografts ; Xenograft Model Antitumor Assays ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Disease Models, Animal
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-0948
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Article ; Online: Which factors influence the extent of indoor transmission of SARS-CoV-2? A rapid evidence review.

Goodwin, Lara / Hayward, Toneka / Krishan, Prerna / Nolan, Gemma / Nundy, Madhurima / Ostrishko, Kayla / Attili, Antonio / Cárceles, Salva Barranco / Epelle, Emmanuel I / Gabl, Roman / Pappa, Evanthia J / Stajuda, Mateusz / Zen, Simone / Dozier, Marshall / Anderson, Niall / Viola, Ignazio M / McQuillan, Ruth

Journal of global health

2021 Volume 11, Page(s) 10002

Abstract: Background: This rapid evidence review identifies and integrates evidence from epidemiology, microbiology and fluid dynamics on the transmission of SARS-CoV-2 in indoor environments.: Methods: Searches were conducted in May 2020 in PubMed, medRxiv, ... ...

Abstract	Background: This rapid evidence review identifies and integrates evidence from epidemiology, microbiology and fluid dynamics on the transmission of SARS-CoV-2 in indoor environments. Methods: Searches were conducted in May 2020 in PubMed, medRxiv, arXiv, Scopus, WHO COVID-19 database, Compendex & Inspec. We included studies reporting data on any indoor setting except schools, any indoor activities and any potential means of transmission. Articles were screened by a single reviewer, with rejections assessed by a second reviewer. We used Joanna Briggs Institute and Critical Appraisal Skills Programme tools for evaluating epidemiological studies and developed bespoke tools for the evaluation of study types not covered by these instruments. Data extraction and quality assessment were conducted by a single reviewer. We conducted a meta-analysis of secondary attack rates in household transmission. Otherwise, data were synthesised narratively. Results: We identified 1573 unique articles. After screening and quality assessment, fifty-eight articles were retained for analysis. Experimental evidence from fluid mechanics and microbiological studies demonstrates that aerosolised transmission is theoretically possible; however, we found no conclusive epidemiological evidence of this occurring. The evidence suggests that ventilation systems have the potential to decrease virus transmission near the source through dilution but to increase transmission further away from the source through dispersal. We found no evidence for faecal-oral transmission. Laboratory studies suggest that the virus survives for longer on smooth surfaces and at lower temperatures. Environmental sampling studies have recovered small amounts of viral RNA from a wide range of frequently touched objects and surfaces; however, epidemiological studies are inconclusive on the extent of fomite transmission. We found many examples of transmission in settings characterised by close and prolonged indoor contact. We estimate a pooled secondary attack rate within households of 11% (95% confidence interval (CI) = 9, 13). There were insufficient data to evaluate the transmission risks associated with specific activities. Workplace challenges related to poverty warrant further investigation as potential risk factors for workplace transmission. Fluid mechanics evidence on the physical properties of droplets generated by coughing, speaking and breathing reinforce the importance of maintaining 2 m social distance to reduce droplet transmission. Conclusions: This review provides a snap-shot of evidence on the transmission of SARS-CoV-2 in indoor environments from the early months of the pandemic. The overall quality of the evidence was low. As the quality and quantity of available evidence grows, it will be possible to reach firmer conclusions on the risk factors for and mechanisms of indoor transmission.
MeSH term(s)	Air Pollution, Indoor/analysis ; Air Pollution, Indoor/prevention & control ; COVID-19/prevention & control ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Disease Transmission, Infectious/statistics & numerical data ; Environment, Controlled ; Environmental Microbiology ; Environmental Monitoring/statistics & numerical data ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-04-03
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.11.10002
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Book: Co-ordinated care for people with complex chronic conditions

Goodwin, Nick / Sonola, Lara / Thiel, Veronika / Kodner, Dennis L

key lessons and markers for success

2013

Institution	King's Fund (London, England) Aetna Life & Casualty. Aetna Foundation
Author's details	authors, Nick Goodwin, Lara Sonola, Veronika Thiel, Dennis L. Kodner
MeSH term(s)	Chronic Disease ; Health Services Administration
Keywords	Great Britain
Language	English
Size	36 pages ;, 30 cm
Publisher	King's Fund
Publishing place	London
Document type	Book
ISBN	9781909029194 ; 190902919X
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Outcomes and efficacy of thoracic surgery biopsy for tumor molecular profiling in patients with advanced lung cancer.

Cooke, David T / Gandara, David R / Goodwin, Neal C / Calhoun, Royce F / Lara, Primo N / Mack, Philip C / David, Elizabeth A

The Journal of thoracic and cardiovascular surgery

2014 Volume 148, Issue 1, Page(s) 36–40

Abstract: Background: Molecular testing of patients with advanced non-small cell lung cancer for personalized therapy often is limited by insufficient specimen from nonsurgical biopsies. We measured the feasibility, patient safety, and clinical impact of thoracic ...

Abstract	Background: Molecular testing of patients with advanced non-small cell lung cancer for personalized therapy often is limited by insufficient specimen from nonsurgical biopsies. We measured the feasibility, patient safety, and clinical impact of thoracic surgical tumor biopsy in patients with stage IV non-small cell lung cancer. Methods: This is a single institution retrospective analysis. Patients with stage IV non-small cell lung cancer undergoing elective surgical tissue biopsy for molecular analysis were evaluated from March 2011 to November 2012. Perioperative specific variables were measured. Results: Twenty-five patients with known or suspected stage IV non-small cell lung cancer undergoing surgical biopsy were identified. All cases were discussed at a multidisciplinary thoracic oncology conference or a multidisciplinary thoracic oncology clinic. Preoperative histologies included adenocarcinoma in 20 patients (80.0%) and squamous cell carcinoma in 2 patients (8.0%). Surgical procedures consisted of video-assisted thoracic surgery wedge biopsy (16, 64%), video-assisted thoracic surgery pleural biopsy (4, 16.0%), mediastinoscopy (2, 8.0%), supraclavicular/cervical lymph node excisional biopsy (3, 12.0%), and rib/chest wall resection (2, 8.0%). There were no deaths and 5 postoperative complications (20.0%). Surgery identified potentially targetable molecular information in 19 of the total patients undergoing operation (76.0%) and changed the treatment strategy in 14 patients (56.0%); 10 of the total cohort (40.0%) were enrolled into therapeutic targeted clinical trials. Conclusions: These data suggest that thoracic surgical biopsy can be safely performed in appropriately selected patients with stage IV non-small cell lung cancer and direct personalized therapy and enrollment into relevant clinical trials. Patients with advanced-stage non-small cell lung cancer should be discussed in a multidisciplinary setting to determine the need and strategy for thoracic surgical biopsy for molecular analysis.
MeSH term(s)	Adult ; Aged ; Biopsy/adverse effects ; Biopsy/mortality ; California ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Chemotherapy, Adjuvant ; Feasibility Studies ; Female ; Gene Expression Profiling/methods ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lymph Node Excision/adverse effects ; Lymph Node Excision/mortality ; Male ; Mediastinoscopy/adverse effects ; Mediastinoscopy/mortality ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Staging ; Precision Medicine ; Predictive Value of Tests ; Retrospective Studies ; Thoracic Surgery, Video-Assisted/adverse effects ; Thoracic Surgery, Video-Assisted/mortality ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2014.03.014
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Article ; Online: Algorithm for codevelopment of new drug-predictive biomarker combinations: accounting for inter- and intrapatient tumor heterogeneity.

Gandara, David R / Li, Tianhong / Lara, Primo N / Mack, Philip C / Kelly, Karen / Miyamoto, Suzanne / Goodwin, Neal / Beckett, Laurel / Redman, Mary W

Clinical lung cancer

2012 Volume 13, Issue 5, Page(s) 321–325

MeSH term(s)	Algorithms ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Precision Medicine
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2012-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2012.05.004
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Article: Evaluation of a SUMO E2 Conjugating Enzyme Involved in Resistance to Clavibacter michiganensis Subsp. michiganensis in Solanum peruvianum, Through a Tomato Mottle Virus VIGS Assay.

Esparza-Araiza, Mayra J / Bañuelos-Hernández, Bernardo / Argüello-Astorga, Gerardo R / Lara-Ávila, José P / Goodwin, Paul H / Isordia-Jasso, María I / Castillo-Collazo, Rosalba / Rougon-Cardoso, Alejandra / Alpuche-Solís, Ángel G

Frontiers in plant science

2015 Volume 6, Page(s) 1019

Abstract: Clavibacter michiganensis subsp. michiganensis (Cmm) causes bacterial wilt and canker of tomato. Currently, no Solanum lycopersicum resistant varieties are commercially available, but some degree of Cmm resistance has been identified in Solanum ... ...

Abstract	Clavibacter michiganensis subsp. michiganensis (Cmm) causes bacterial wilt and canker of tomato. Currently, no Solanum lycopersicum resistant varieties are commercially available, but some degree of Cmm resistance has been identified in Solanum peruvianum. Previous research showed up-regulation of a SUMO E2 conjugating enzyme (SCEI) transcript in S. peruvianum compared to S. lycopersicum following infection with Cmm. In order to test the role of SCEI in resistance to Cmm, a fragment of SCEI from S. peruvianum was cloned into a novel virus-induced gene-silencing (VIGS) vector based on the geminivirus, Tomato Mottle Virus (ToMoV). Using biolistic inoculation, the ToMoV-based VIGS vector was shown to be effective in S. peruvianum by silencing the magnesium chelatase gene, resulting in leaf bleaching. VIGS with the ToMoV_SCEI construct resulted in ~61% silencing of SCEI in leaves of S. peruvianum as determined by quantitative RT-PCR. The SCEI-silenced plants showed unilateral wilting (15 dpi) and subsequent death (20 dpi) of the entire plant after Cmm inoculation, whereas the empty vector-treated plants only showed wilting in the Cmm-inoculated leaf. The SCEI-silenced plants showed higher Cmm colonization and an average of 4.5 times more damaged tissue compared to the empty vector control plants. SCEI appears to play an important role in the innate immunity of S. peruvianum against Cmm, perhaps through the regulation of transcription factors, leading to expression of proteins involved in salicylic acid-dependent defense responses.
Language	English
Publishing date	2015-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2015.01019
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Article ; Online: Monitoring quality of care in hepatocellular carcinoma: A modified Delphi consensus.

Maharaj, Ashika D / Lubel, John / Lam, Eileen / Clark, Paul J / Duncan, Oliver / George, Jacob / Jeffrey, Gary P / Lipton, Lara / Liu, Howard / McCaughan, Geoffrey / Neo, Eu-Ling / Philip, Jennifer / Strasser, Simone I / Stuart, Katherine / Thompson, Alexander / Tibballs, Jonathan / Tu, Thomas / Wallace, Michael C / Wigg, Alan /

Hepatology communications

2022 Volume 6, Issue 11, Page(s) 3260–3271

Abstract: Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of ... ...

Abstract	Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of quality indicators (QIs) to underpin the management of HCC. We undertook a modified, two-round, Delphi consensus study comprising a working group and experts involved in the management of HCC as well as consumer representatives. QIs were derived from an extensive review of the literature. The role of the participants was to identify the most important and measurable QIs for inclusion in an HCC clinical quality registry. From an initial 94 QIs, 40 were proposed to the participants. Of these, 23 QIs ultimately met the inclusion criteria and were included in the final set. This included (a) nine related to the initial diagnosis and staging, including timing to diagnosis, required baseline clinical and laboratory assessments, prior surveillance for HCC, diagnostic imaging and pathology, tumor staging, and multidisciplinary care; (b) thirteen related to treatment and management, including role of antiviral therapy, timing to treatment, localized ablation and locoregional therapy, surgery, transplantation, systemic therapy, method of response assessment, and supportive care; and (c) one outcome assessment related to surgical mortality. Conclusion: We identified a core set of nationally agreed measurable QIs for the diagnosis, staging, and management of HCC. The adherence to these best practice QIs may lead to system-level improvement in quality of care and, ultimately, improvement in patient outcomes, including survival.
MeSH term(s)	Humans ; Delphi Technique ; Quality Indicators, Health Care ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Antiviral Agents
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-09-25
Publishing country	United States
Document type	Review ; Journal Article
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1002/hep4.2089
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