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Article ; Online: Inquilinus limosus, an atypical Gram-negative rod from lung transplant recipients and cystic fibrosis patients.

Farfour, Eric / Corvec, Stéphane / Guillard, Thomas / Revillet, Hélène

2024 Volume 82, Issue 2, Page(s) 1–2

Language	English
Publishing date	2024-04-01
Publishing country	France
Document type	Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2024.1876
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Ud II Zs.203: Show issues

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Article ; Online: Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)

Corvec, Stéphane

Clinical microbiology reviews

2018 Volume 31, Issue 3

Abstract: The recent description of the ... ...

Abstract	The recent description of the genus
MeSH term(s)	Actinomycetales Infections/diagnosis ; Actinomycetales Infections/drug therapy ; Actinomycetales Infections/microbiology ; Actinomycetales Infections/pathology ; Anti-Bacterial Agents/therapeutic use ; Humans ; Phylogeny ; Propionibacterium/classification ; Propionibacterium/physiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-05-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645015-5
ISSN	1098-6618 ; 0893-8512
ISSN (online)	1098-6618
ISSN	0893-8512
DOI	10.1128/CMR.00064-17
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Zs.A 2409: Show issues

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Article ; Online: Staphylococcus succinus Infective Endocarditis, France.

Ruffier d'Epenoux, Louise / Fayoux, Erwan / Laurent, Frédéric / Bémer, Pascale / Lecomte, Raphaël / Le Tourneau, Thierry / Guillouzouic, Aurélie / Corvec, Stéphane

Emerging infectious diseases

2024 Volume 30, Issue 3, Page(s) 601–603

Abstract: Infective endocarditis is a rare condition in humans and is associated with high illness and death rates. We describe a case of infective endocarditis caused by Staphylococcus succinus bacteria in France. We used several techniques for susceptibility ... ...

Abstract	Infective endocarditis is a rare condition in humans and is associated with high illness and death rates. We describe a case of infective endocarditis caused by Staphylococcus succinus bacteria in France. We used several techniques for susceptibility testing for this case to determine the oxacillin profile.
MeSH term(s)	Humans ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis ; Staphylococcus ; France/epidemiology
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3003.230986
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Zs.A 4778: Show issues

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Article: Synovial calprotectin: A potentially useful biomarker for the diagnosis of

Leroy, Anne-Gallë / Bémer, Pascale / Decante, Cyrille / Ruffier d'Epenoux, Louise / Tessier, Eve / Crenn, Vincent / Guillouzouic, Aurélie / Corvec, Stéphane

Clinical case reports

2023 Volume 11, Issue 3, Page(s) e7106

Abstract: ... Kingella ... ...

Abstract	Kingella kingae
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7106
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Article ; Online: Retrospective analysis of a large single cohort of Enterobacteriaceae producing extended-spectrum B-lactamase (E-ESBL) patients: incidence, microbiology, and mortality.

Bouchand, Camille / Andréo, Anaïs / Le Gallou, Florence / Corvec, Stéphane / Bourigault, Céline / Lepelletier, Didier

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2022 Volume 41, Issue 10, Page(s) 1237–1243

Abstract: We conducted a retrospective study from 2005 to 2019 to describe the epidemiology and mortality of enterobacterial producing extended-spectrum β-lactamase (E-ESBL) infections in our university hospital over a 17-year period of time. Clinical and ... ...

Abstract	We conducted a retrospective study from 2005 to 2019 to describe the epidemiology and mortality of enterobacterial producing extended-spectrum β-lactamase (E-ESBL) infections in our university hospital over a 17-year period of time. Clinical and microbiological data were extracted from different software used for continuous surveillance. Stool samples from systematic screening for E-ESBL colonization were excluded from the study. The incidence rate of infected patient was calculated by E-ESBL species and by year. A comparison of mortality rate in patients with bloodstream infections versus other types of infections was conducted using a Kaplan-Meier method survival curves. A log rank test (with a risk of 5%) was carried out. A total of 3324 patients with E-ESBL infection were included with an increased incidence density per 1000 days of hospitalization from 0.03 in 2005 to 0.47 in 2019. Escherichia coli was the most frequently isolated pathogen (64%). Global mortality rate was significantly higher with E. coli than with Klebsiella spp. and Enterobacter spp. (p < 0.001). Mortality was higher in patients with E-ESBL bloodstream infection than in patients with other type of E-ESBL infection (p < 0.001). Our study showed a significant increase of the E-ESBL incidence density over a 17-year period survey with a higher mortality in patients with E-ESBL bacteremia. This highlights the need to continue efforts to control the spread of these multi-resistant bacteria in our institution.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteremia/microbiology ; Enterobacteriaceae Infections/drug therapy ; Enterobacteriaceae Infections/epidemiology ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/microbiology ; Humans ; Incidence ; Klebsiella ; Retrospective Studies ; Risk Factors ; beta-Lactamases
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2022-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-022-04489-2
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Zs.A 1732: Show issues

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Article ; Online: Functional outcomes and complications of patients contaminated with Cutibacterium acnes during primary reverse shoulder arthroplasty: study at two- and five-years of follow-up.

Torrens, Carlos / Marí, Raquel / Puig-Verdier, Lluís / Santana, Fernando / Alier, Albert / García-Jarabo, Eva / Gómez-Sánchez, Alba / Corvec, Stèphane

International orthopaedics

2023 Volume 47, Issue 11, Page(s) 2827–2833

Abstract: Purpose: The objective of the study was to compare the functional outcomes and the complication rate of the patients with C. acnes contamination at the end of the primary reverse shoulder arthroplasty (RSA) surgery to those patients without C. acnes ... ...

Abstract	Purpose: The objective of the study was to compare the functional outcomes and the complication rate of the patients with C. acnes contamination at the end of the primary reverse shoulder arthroplasty (RSA) surgery to those patients without C. acnes contamination. Method: A total of 162 patients were included. In all cases, skin and deep tissue cultures were obtained. A molecular typing characterization of the C. acnes strains was performed. Functional outcomes were assessed with the Constant score at the two and five year follow-up and all complications were also recorded. Results: A total of 1380 cultures were obtained from the 162 primary RSA surgeries. Of those, 96 turned out to be positive for C. acnes. There were 25 patients with positive cultures for C. acnes. The overall postoperative Constant score was not significantly different between those patients having C. acnes-positive cultures and those with negative cultures at the two and five year follow-up (59.2 vs. 59.6 at two years, p 0.870, and 59.5 vs. 62.4 at five years, p 0.360). Patients with positive cultures presented a higher complication rate (p 0.001) with two infections, one revision surgery, and one dislocation. Conclusion: Patients ending up with C. acnes-positive cultures after primary shoulder arthroplasty surgery do not have worse clinical outcomes when compared to patients having negative cultures, but a greater number of complications were found in those patients with C. acnes-positive cultures.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Shoulder/adverse effects ; Shoulder Joint/surgery ; Shoulder Joint/microbiology ; Follow-Up Studies ; Skin/microbiology ; Propionibacterium acnes ; Shoulder/surgery
Language	English
Publishing date	2023-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-023-05971-y
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Zs.A 1324: Show issues

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Article ; Online: Acne microbiome: From phyla to phylotypes.

Dreno, Brigitte / Dekio, Itaru / Baldwin, Hilary / Demessant, Anne Laure / Dagnelie, Marie-Ange / Khammari, Amir / Corvec, Stephane

Journal of the European Academy of Dermatology and Venereology : JEADV

2023 Volume 38, Issue 4, Page(s) 657–664

Abstract: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: (1) altered sebum production, (2) inflammation, (3) excess keratinization and (4) ... ...

Abstract	Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: (1) altered sebum production, (2) inflammation, (3) excess keratinization and (4) colonization with the commensal Cutibacterium acnes. However, the role of C. acnes has been unclear, since virtually all adults have C. acnes on their skin yet not all develop acne. In recent years, understanding of the role of C. acnes has expanded. It is still acknowledged to have an important place in acne pathogenesis, but evidence suggests that an imbalance of individual C. acnes phylotypes and an alteration of the skin microbiome trigger acne. In addition, it is now believed that Staphylococcus epidermidis is also an actor in acne development. Together, C. acnes and S. epidermidis maintain and regulate homeostasis of the skin microbiota. Antibiotics, which have long been a staple of acne therapy, induce cutaneous dysbiosis. This finding, together with the long-standing public health edict to spare antibiotic use when possible, highlights the need for a change in acne management strategies. One fertile direction of study for new approaches involves dermocosmetic products that can support epidermal barrier function and have a positive effect on the skin microbiome.
MeSH term(s)	Humans ; Acne Vulgaris/therapy ; Skin/microbiology ; Microbiota ; Dermatitis ; Dysbiosis ; Anti-Bacterial Agents ; Propionibacterium acnes/physiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19540
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical evaluation of the BioFire Respiratory Pathogen Panel for the guidance of empirical antimicrobial therapy in critically ill patients with hospital-acquired pneumonia: A multicenter, quality improvement project.

Poulain, Cécile / Launey, Yoann / Bouras, Marwan / Lakhal, Karim / Dargelos, Laura / Crémet, Lise / Gibaud, Sophie-Anne / Corvec, Stéphane / Seguin, Philippe / Rozec, Bertrand / Asehnoune, Karim / Feuillet, Fanny / Roquilly, Antoine

Anaesthesia, critical care & pain medicine

2024 Volume 43, Issue 2, Page(s) 101353

Abstract: Background: We aimed to determine whether implementing antimicrobial stewardship based on multiplex bacterial PCR examination of respiratory fluid can enhance outcomes of critically ill patients with hospital-acquired pneumonia (HAP).: Methods: We ... ...

Abstract	Background: We aimed to determine whether implementing antimicrobial stewardship based on multiplex bacterial PCR examination of respiratory fluid can enhance outcomes of critically ill patients with hospital-acquired pneumonia (HAP). Methods: We conducted a quality improvement study in two hospitals in France. Adult patients requiring invasive mechanical ventilation with a diagnosis of HAP were included. In the pre-intervention period (August 2019 to April 2020), antimicrobial therapy followed European guidelines. In the «intervention» phase (June 2020 to October 2021), treatment followed a multiplex PCR-guided protocol. The primary endpoint was a composite endpoint made of mortality on day 28, clinical cure between days 7 and 10, and duration of invasive mechanical ventilation on day 28. The primary outcome was analyzed with a DOOR strategy. Results: A total of 443 patients were included in 3 ICUs from 2 hospitals (220 pre-intervention; 223 intervention). No difference in the ranking of the primary composite outcome was found (DOOR: 50.3%; 95%CI, 49.9%-50.8%). The number of invasive mechanical ventilation-free days at day 28 was 10.0 [0.0; 19.0] in the baseline period and 9.0 [0.0; 20.0] days during the intervention period (p = 0.95). The time-to-efficient antimicrobial treatment was 0.43 ± 1.29 days before versus 0.55 ± 1.13 days after the intervention (p = 0.56). Conclusion: Implementation of Rapid Multiplex PCR to guide empirical antimicrobial therapy for critically ill patients with HAP was not associated with better outcomes. However, adherence to stewardship was low, and the study may have had limited power to detect a clinically important difference.
MeSH term(s)	Adult ; Humans ; Critical Illness ; Quality Improvement ; Anti-Infective Agents/therapeutic use ; Healthcare-Associated Pneumonia/drug therapy ; Hospitals ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-12
Publishing country	France
Document type	Multicenter Study ; Journal Article
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2024.101353
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Article ; Online: Comparative effectiveness of empirical antibiotic treatments in methicillin-susceptible Staphylococcus aureus infective endocarditis: A post hoc analysis of a prospective French cohort study.

Lecomte, Raphaël / Deschanvres, Colin / Bourreau, Alexis / Ruffier d'Epenoux, Louise / Le Turnier, Paul / Gaborit, Benjamin / Chauveau, Marie / Michel, Magali / Le Tourneau, Thierry / Bémer, Pascale / Corvec, Stéphane / Boutoille, David

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2024 Volume 142, Page(s) 106989

Abstract: Objectives: The empirical treatment of infective endocarditis is still debated. The aim of this study was to compare the impact of empirical treatment with antistaphylococcal penicillin (ASP) or cefazolin vs. other treatments in methicillin-susceptible ... ...

Abstract	Objectives: The empirical treatment of infective endocarditis is still debated. The aim of this study was to compare the impact of empirical treatment with antistaphylococcal penicillin (ASP) or cefazolin vs. other treatments in methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis. Methods: A post hoc analysis of a prospective cohort study of patients hospitalized in a French reference centre with MSSA endocarditis was conducted between 2013 and 2022. The primary outcome was the duration of bacteraemia under treatment. Results: Of the 208 patients included, 101 patients (48.6%) were classified in the reference group (ASP or cefazolin) and 107 (52.4%) in the non-reference group. Empirical treatment with ASP/cefazolin was associated with a shorter duration of bacteraemia compared to other treatments (3.6 d vs. 4.6 d, P = 0.01). This difference was not corrected by the addition of an aminoglycoside (3.6 d vs. 4.7 d, P < 0.01). In multivariate analysis, empirical treatment with ASP/cefazolin was associated with a duration of bacteraemia ≤72 h (P = 0.02), whereas endocarditis on native valves (P = 0.01), and intracardiac abscess were associated with longer duration of bacteraemia (P = 0.01). Conclusions: Empirical treatment of endocarditis with ASP or Cefazolin is more effective than other treatments in MSSA endocarditis, even when the other treatments are combined with aminoglycosides.
MeSH term(s)	Humans ; Cefazolin/therapeutic use ; Methicillin/pharmacology ; Methicillin/therapeutic use ; Prospective Studies ; Staphylococcus aureus ; Cohort Studies ; Staphylococcal Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Endocarditis, Bacterial/drug therapy ; Endocarditis/drug therapy ; Bacteremia/drug therapy
Chemical Substances	Cefazolin (IHS69L0Y4T) ; Methicillin (Q91FH1328A) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2024.106989
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Zs.A 4516: Show issues

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Article: Immediate vs. culture-initiated antibiotic therapy in suspected non-severe ventilator-associated pneumonia: a before-after study (DELAVAP).

Martin, Maëlle / Forveille, Solène / Lascarrou, Jean-Baptiste / Seguin, Amélie / Canet, Emmanuel / Lemarié, Jérémie / Agbakou, Maïté / Desmedt, Luc / Blonz, Gauthier / Zambon, Olivier / Corvec, Stéphane / Le Thuaut, Aurélie / Reignier, Jean

Annals of intensive care

2024 Volume 14, Issue 1, Page(s) 33

Abstract: Background: Ventilator-associated pneumonia (VAP) is the leading nosocomial infection in critical care and is associated with adverse outcomes. When VAP is suspected, starting antibiotic therapy (AT) immediately after pulmonary sampling may expose ... ...

Abstract	Background: Ventilator-associated pneumonia (VAP) is the leading nosocomial infection in critical care and is associated with adverse outcomes. When VAP is suspected, starting antibiotic therapy (AT) immediately after pulmonary sampling may expose uninfected patients to unnecessary treatment, whereas waiting for bacteriological confirmation may delay AT in infected patients. As no robust data exist to choose between these strategies, the decision must balance the pre-test diagnostic probability, clinical severity, and risk of antimicrobial resistance. The objective of this study in patients with suspected non-severe VAP was to compare immediate AT started after sampling to conservative AT upon receipt of positive microbiological results. The outcomes were antibiotic sparing, AT suitability, and patient outcomes. Methods: This single-center, before-after study included consecutive patients who underwent distal respiratory sampling for a first suspected non-severe VAP episode (no shock requiring vasopressor therapy or severe acute respiratory distress syndrome). AT was started immediately after sampling in 2019 and upon culture positivity in 2022 (conservative strategy). The primary outcome was the number of days alive without AT by day 28. The secondary outcomes were mechanical ventilation duration, day-28 mortality, and AT suitability (active necessary AT or spared AT). Results: The immediate and conservative strategies were applied in 44 and 43 patients, respectively. Conservative and immediate AT were associated with similar days alive without AT (median [interquartile range], 18.0 [0-21.0] vs. 16.0 [0-20.0], p = 0.50) and without broad-spectrum AT (p = 0.53) by day 28. AT was more often suitable in the conservative group (88.4% vs. 63.6%, p = 0.01), in which 27.9% of patients received no AT at all. No significant differences were found for mechanical ventilation duration (median [95%CI], 9.0 [6-19] vs. 9.0 [6-24] days, p = 0.65) or day-28 mortality (hazard ratio [95%CI], 0.85 [0.4-2.0], p = 0.71). Conclusion: In patients with suspected non-severe VAP, waiting for microbiological confirmation was not associated with antibiotic sparing, compared to immediate AT. This result may be ascribable to low statistical power. AT suitability was better with the conservative strategy. None of the safety outcomes differed between groups. These findings would seem to allow a large, randomized trial comparing immediate and conservative AT strategies.
Language	English
Publishing date	2024-02-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-024-01243-z
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