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Article ; Online: Repetitive Blast Injury and CSF Alzheimer Disease Biomarkers: Navigating a Complex Narrative.

Alosco, Michael L / Tartaglia, Maria Carmela

2024 Volume 102, Issue 7, Page(s) e209294

MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Blast Injuries ; Amyloid beta-Peptides ; tau Proteins ; Biomarkers ; Peptide Fragments
Chemical Substances	Amyloid beta-Peptides ; tau Proteins ; Biomarkers ; Peptide Fragments
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Editorial
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000209294
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Article ; Online: In search of cost-effective and non-invasive biomarkers of traumatic brain injury.

Daneshvar, Daniel H / Alosco, Michael L

EBioMedicine

2022 Volume 76, Page(s) 103823

MeSH term(s)	Biomarkers ; Brain Injuries, Traumatic/diagnosis ; Cost-Benefit Analysis ; Humans
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.103823
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Article ; Online: In search of cost-effective and non-invasive biomarkers of traumatic brain injury

Daniel H. Daneshvar / Michael L. Alosco

EBioMedicine, Vol 76, Iss , Pp 103823- (2022)

2022

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans.

Marcolini, Sofia / Rojczyk, Philine / Seitz-Holland, Johanna / Koerte, Inga K / Alosco, Michael L / Bouix, Sylvain

Journal of Alzheimer's disease : JAD

2023 Volume 95, Issue 4, Page(s) 1427–1448

Abstract: Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer's disease.: Objective: We studied the synergistic ... ...

Abstract	Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer's disease. Objective: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans. Methods: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, and Veteran controls without PTSD or TBI. We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N = 91), cingulum (N = 87), and inferior longitudinal fasciculus (N = 95). ANCOVAs were used to compare Veterans' baseline behavioral and cognitive functioning (N = 285), white matter microstructure, amyloid-β (N = 230), and tau PET (N = 120). Additional ANCOVAs examined scores' differences from baseline to follow-up. Results: Veterans with PTSD and PTSD+TBI, but not Veterans with TBI only, exhibited poorer behavioral and cognitive functioning at baseline than controls. The groups did not differ in baseline white matter, amyloid-β, or tau, nor in behavioral and cognitive functioning, and tau accumulation change. Progression of white matter abnormalities of the uncinate fasciculus in Veterans with PTSD compared to controls was observed; analyses in TBI and PTSD+TBI were not run due to insufficient sample size. Conclusions: PTSD and PTSD+TBI negatively affect behavioral and cognitive functioning, while TBI does not contribute independently. Whether progressive decline in uncinate fasciculus microstructure in Veterans with PTSD might account for cognitive decline should be further studied. Findings did not support an association between PTSD, TBI, and Alzheimer's disease pathology based on amyloid and tau PET.
MeSH term(s)	Humans ; Male ; Veterans ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Alzheimer Disease/complications ; Vietnam ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Cognition ; Neuroimaging ; Amyloid beta-Peptides
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-221304
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Article ; Online: Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.

Alosco, Michael L / Culhane, Julia / Mez, Jesse

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2021 Volume 18, Issue 2, Page(s) 772–791

Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, such as those from contact sports. The pathognomonic lesion for CTE is the perivascular accumulation of hyper-phosphorylated tau in ...

Abstract	Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, such as those from contact sports. The pathognomonic lesion for CTE is the perivascular accumulation of hyper-phosphorylated tau in neurons and other cell process at the depths of sulci. CTE cannot be diagnosed during life at this time, limiting research on risk factors, mechanisms, epidemiology, and treatment. There is an urgent need for in vivo biomarkers that can accurately detect CTE and differentiate it from other neurological disorders. Neuroimaging is an integral component of the clinical evaluation of neurodegenerative diseases and will likely aid in diagnosing CTE during life. In this qualitative review, we present the current evidence on neuroimaging biomarkers for CTE with a focus on molecular, structural, and functional modalities routinely used as part of a dementia evaluation. Supporting imaging-pathological correlation studies are also presented. We targeted neuroimaging studies of living participants at high risk for CTE (e.g., aging former elite American football players, fighters). We conclude that an optimal tau PET radiotracer with high affinity for the 3R/4R neurofibrillary tangles in CTE has not yet been identified. Amyloid PET scans have tended to be negative. Converging structural and functional imaging evidence together with neuropathological evidence show frontotemporal and medial temporal lobe neurodegeneration, and increased likelihood for a cavum septum pellucidum. The literature offers promising neuroimaging biomarker targets of CTE, but it is limited by cross-sectional studies of small samples where the presence of underlying CTE is unknown. Imaging-pathological correlation studies will be important for the development and validation of neuroimaging biomarkers of CTE.
MeSH term(s)	Academic Medical Centers/trends ; Biomarkers/metabolism ; Chronic Traumatic Encephalopathy/diagnostic imaging ; Chronic Traumatic Encephalopathy/metabolism ; Chronic Traumatic Encephalopathy/therapy ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/trends ; Memory Disorders/diagnostic imaging ; Memory Disorders/metabolism ; Memory Disorders/therapy ; Neuroimaging/methods ; Neuroimaging/trends ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; tau Proteins/metabolism
Chemical Substances	Biomarkers ; MAPT protein, human ; tau Proteins
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-021-01028-3
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Article: The long-term consequences of repetitive head impacts: Chronic traumatic encephalopathy.

Alosco, Michael L / Stern, Robert A

Handbook of clinical neurology

2019 Volume 167, Page(s) 337–355

Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI). Although described in boxers for almost a century, scientific and public interest in CTE grew tremendously following a report ...

Abstract	Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI). Although described in boxers for almost a century, scientific and public interest in CTE grew tremendously following a report of postmortem evidence of CTE in the first former professional American football player in 2005. Neuropathologic diagnostic criteria for CTE have been defined, with abnormal perivascular deposition of hyperphosphorylated tau at the sulcal depths as the pathognomonic feature. CTE can currently only be diagnosed postmortem, but clinical research criteria for the in vivo diagnosis of CTE have been proposed. The clinical phenotype of CTE is still ill-defined and there are currently no validated biomarkers to support an in-life diagnosis of "Probable CTE." Many knowledge gaps remain regarding the neuropathologic and clinical make-up of CTE. An increased understanding of CTE is critical given the millions that could potentially be impacted by this disease. This chapter describes the state of the literature on CTE. The historical origins of CTE are first presented, followed by a comprehensive description of the neuropathologic and clinical features. The chapter concludes with discussion on future research directions, emphasizing the importance of diagnosing CTE during life to facilitate development of preventative and intervention strategies.
MeSH term(s)	Chronic Traumatic Encephalopathy ; Humans
Language	English
Publishing date	2019-11-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-12-804766-8.00018-2
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Article ; Online: Youth Exposure to Repetitive Head Impacts From Tackle Football and Long-term Neurologic Outcomes: A Review of the Literature, Knowledge Gaps and Future Directions, and Societal and Clinical Implications.

Alosco, Michael L / Stern, Robert A

Seminars in pediatric neurology

2019 Volume 30, Page(s) 107–116

Abstract: Youth participation in contact and collision sports, particularly tackle football, is associated with exposure to repetitive head impacts during a time period when tremendous brain maturation is occurring. Accumulating evidence suggests that exposure to ... ...

Abstract	Youth participation in contact and collision sports, particularly tackle football, is associated with exposure to repetitive head impacts during a time period when tremendous brain maturation is occurring. Accumulating evidence suggests that exposure to repetitive head impacts from youth tackle football may increase vulnerability to long-term cognitive, neuropsychiatric, and neurologic disturbances. There are limitations to the current literature and conflicting findings exist. Nonetheless, participation in youth football has become a cause of concern to clinicians, scientists, politicians, coaches, parents, and children. The objective of this paper is to review the literature on the long-term cognitive, neuropsychiatric, and neurologic outcomes associated with participation in youth contact and collision sports, with a focus on tackle football. We provide an overview of the empirically derived framework that has served as the foundation for the investigation of youth tackle football and neurologic outcomes. The extant research studies on age of first exposure to tackle football and later-life cognitive and neuropsychiatric functioning, as well as structural brain changes are reviewed. We discuss the limitations of the current evidence, suggest future directions, and conclude with our opinions on societal and clinical implications.
MeSH term(s)	Age Factors ; Brain Concussion/epidemiology ; Brain Concussion/pathology ; Brain Concussion/psychology ; Football/injuries ; Football/psychology ; Forecasting ; Humans ; Pediatrics/methods
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1290000-x
ISSN	1558-0776 ; 1071-9091
ISSN (online)	1558-0776
ISSN	1071-9091
DOI	10.1016/j.spen.2019.03.016
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Article: Chronic traumatic encephalopathy: clinical presentation and in vivo diagnosis.

D'Ascanio, Steven / Alosco, Michael L / Stern, Robert A

Handbook of clinical neurology

2019 Volume 158, Page(s) 281–296

Abstract: Exposure to repetitive head impacts from contact sport participation (e.g., American football, boxing, soccer) is associated with the neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). The neuropathology of CTE is becoming well ... ...

Abstract	Exposure to repetitive head impacts from contact sport participation (e.g., American football, boxing, soccer) is associated with the neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). The neuropathology of CTE is becoming well defined, and diagnostic criteria have been developed and are being refined. The critical next step in this emerging field is the diagnosis of CTE during life. The objective of this chapter is to describe what is currently known about the clinical presentation and in vivo diagnosis of CTE. This chapter reviews studies in which clinical manifestation of CTE was examined through retrospective telephone interviews with informants of individuals whose brains were donated and were diagnosed with CTE through neuropathologic examination. In vivo research examining the long-term neurobehavioral consequences of repetitive head impacts is also reviewed, followed by a comparison of the existing provisional clinical diagnostic criteria for CTE, as well as preliminary research on possible fluid and neuroimaging biomarkers. An illustrative case study of CTE is presented, and the chapter concludes with a discussion of gaps in knowledge and future directions.
MeSH term(s)	Athletic Injuries/complications ; Chronic Traumatic Encephalopathy/diagnosis ; Chronic Traumatic Encephalopathy/etiology ; History, 20th Century ; History, 21st Century ; Humans ; Retrospective Studies
Language	English
Publishing date	2019-01-15
Publishing country	Netherlands
Document type	Historical Article ; Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-63954-7.00027-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reader Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players.

Mez, Jesse / Alosco, Michael L / Nowinski, Christopher J / McKee, Ann C / Tripodis, Yorghos

Neurology

2021 Volume 97, Issue 6, Page(s) 297–298

MeSH term(s)	Athletes ; Autopsy ; Chronic Traumatic Encephalopathy ; Football ; Hockey ; Humans ; Soccer
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012381
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Article ; Online: Risk Factors for Chronic Traumatic Encephalopathy: A Proposed Framework.

Phelps, Alyssa / Mez, Jesse / Stern, Robert A / Alosco, Michael L

Seminars in neurology

2020 Volume 40, Issue 4, Page(s) 439–449

Abstract: Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that has been neuropathologically diagnosed in contact and collision sport athletes, military veterans, and others with a history of exposure to repetitive head impacts ( ... ...

Abstract	Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that has been neuropathologically diagnosed in contact and collision sport athletes, military veterans, and others with a history of exposure to repetitive head impacts (RHI). Identifying methods to diagnose and prevent CTE during life is a high priority. Timely diagnosis and implementation of treatment and preventative strategies for neurodegenerative diseases, including CTE, partially hinge upon early and accurate risk characterization. Here, we propose a framework of risk factors that influence the neuropathological development of CTE. We provide an up-to-date review of the literature examining cumulative exposure to RHI as the environmental trigger for CTE. Because not all individuals exposed to RHI develop CTE, the direct and/or indirect influence of nonhead trauma exposure characteristics (e.g., age, sex, race, genetics) on the pathological development of CTE is reviewed. We conclude with recommendations for future directions, as well as opinions for preventative strategies that could mitigate risk.
MeSH term(s)	Brain Concussion/complications ; Chronic Traumatic Encephalopathy/etiology ; Humans ; Risk Factors
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0040-1713633
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