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  1. Article ; Online: Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy.

    Chakhtoura, Marlene / Mantzoros, Christos S

    Metabolism: clinical and experimental

    2023  Volume 142, Page(s) 155531

    MeSH term(s) Humans ; Obesity/drug therapy ; Anti-Obesity Agents/therapeutic use
    Chemical Substances Anti-Obesity Agents
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2023.155531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sarcopenia: still in relative definition-penia and severe treatment-penia.

    Polyzos, Stergios A / Mantzoros, Christos S

    Metabolism: clinical and experimental

    2023  Volume 150, Page(s) 155717

    MeSH term(s) Humans ; Sarcopenia/therapy ; Muscle Strength ; Muscle, Skeletal/pathology ; Hand Strength
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2023.155717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Obesity and Diabetes

    Mantzoros, Christos S.

    2006  

    Author's details edited by Christos S. Mantzoros
    Keywords Endocrinology
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387100
    ISBN 978-1-588-29538-5 ; 978-1-592-59985-1 ; 1-588-29538-9 ; 1-592-59985-0
    DOI 10.1007/978-1-59259-985-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Nutrition and metabolism

    Mantzoros, Christos S.

    underlying mechanisms and clinical consequences

    (Nutrition and health)

    2009  

    Author's details ed. Christos S. Mantzoros
    Series title Nutrition and health
    Keywords Obesity ; Nutritional Physiological Phenomena ; Diabetes Mellitus, Type 2 ; Metabolic Syndrome X ; Metabolism/Diseases ; Nutrition
    Subject code 613.2
    Language English
    Size XX, 423, IV S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015585446
    ISBN 1-60327-452-9 ; 978-1-60327-452-4 ; 9781603274531 ; 1603274537
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  5. Book: Nutrition and metabolism

    Mantzoros, Christos S.

    underlying mechanisms and clinical consequences

    (Nutrition and health)

    2009  

    Author's details ed. Christos S. Mantzoros
    Series title Nutrition and health
    Keywords Obesity ; Nutritional Physiological Phenomena ; Diabetes Mellitus, Type 2 ; Metabolic Syndrome X ; Metabolism/Diseases ; Nutrition
    Subject code 613.2
    Language English
    Size XX, 423, IV S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015585446
    ISBN 1-60327-452-9 ; 978-1-60327-452-4 ; 9781603274531 ; 1603274537
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Metreleptin for the treatment of lipodystrophy: leading the way among novel therapeutics for this unmet clinical need.

    Polyzos, Stergios A / Mantzoros, Christos S

    Current medical research and opinion

    2022  Volume 38, Issue 6, Page(s) 885–888

    MeSH term(s) Humans ; Leptin/analogs & derivatives ; Leptin/therapeutic use ; Lipodystrophy/drug therapy
    Chemical Substances Leptin ; metreleptin (TL60C27RLH)
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Editorial
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2022.2059974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cross-talk between SARS-CoV-2 infection and the insulin/IGF signaling pathway: Implications for metabolic diseases in COVID-19 and for post-acute sequelae of SARS-CoV-2 infection.

    Kelesidis, Theodoros / Mantzoros, Christos S

    Metabolism: clinical and experimental

    2022  Volume 134, Page(s) 155267

    MeSH term(s) COVID-19/complications ; Disease Progression ; Humans ; Insulin ; Metabolic Diseases/etiology ; SARS-CoV-2 ; Signal Transduction
    Chemical Substances Insulin
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2022.155267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Obesity and diabetes

    Mantzoros, Christos S.

    (Contemporary diabetes)

    2006  

    Author's details ed. by Christos S. Mantzoros
    Series title Contemporary diabetes
    Keywords Diabetes Complications / complications ; Obesity / complications ; Obesity / physiopathology ; Diabetes Mellitus / physiopathology ; Diabetes mellitus ; Fettsucht
    Subject Adipositas ; Fettleibigkeit ; Korpulenz ; Obesität ; Obesity ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language English
    Size XVII, 555 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa
    Publishing country United States
    Document type Book
    HBZ-ID HT014354790
    ISBN 1-58829-538-9 ; 978-1-58829-538-5
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on.

    Boutari, Chrysoula / Mantzoros, Christos S

    Metabolism: clinical and experimental

    2022  Volume 133, Page(s) 155217

    Abstract: The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especially as it ... ...

    Abstract The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especially as it interacts with the COVID pandemic to create a twin pandemic, to increase morbidity and mortality. Obesity is a complex disease which has reached pandemic dimensions. The worldwide prevalence of obesity has nearly tripled since 1975, mainly due to the adoption of a progressively more sedentary lifestyle and the consumption of less healthy diets. We first report herein updated prevalence rates of overweight and obesity by sex, age, and region first in Europe, per the WHO report, and then worldwide between 1980 and 2019, as we analyze and present herein the data provided by the Global Burden of Disease Study. The prevalence of obesity is higher in women than in men of any age and the prevalence of both overweight and obesity increases with age and has reached their highest point between the ages of 50 to 65 years showing a slight downward trend afterwards. The age-standardized prevalence of obesity has increased from 4.6% in 1980 to 14.0% in 2019. The American and European region have the highest obesity prevalence and the USA and Russia are the countries with the most obese residents. Given dire implications in terms of comorbidities and mortality, these updated epidemiological findings call for coordinated actions from local and regional governments, the scientific community and individual patients alike, as well as the food industry for the obesity pandemic to be controlled and alleviated. We can hopefully learn from the COVID-19 pandemic, where collaborative efforts worldwide, focused intense work at both the local and global level and well-coordinated leadership have demonstrated that humankind is capable of amazing accomplishments by leveraging science and public health, and that we can finally make strides in terms of understanding and combating the obesity pandemic and its dire comorbidities including diabetes, NAFLD, CVD and obesity associated malignancies.
    MeSH term(s) Aged ; Body Mass Index ; COVID-19/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Overweight/epidemiology ; Pandemics ; Prevalence
    Language English
    Publishing date 2022-05-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2022.155217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Obesity and diabetes.

    Boutari, Chrysoula / DeMarsilis, Antea / Mantzoros, Christos S

    Diabetes research and clinical practice

    2023  Volume 202, Page(s) 110773

    Abstract: Obesity, which has currently reached pandemic dimensions, is usually accompanied by diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological mechanisms. Adipose tissue secretes cytokines which are involved in inflammation and ...

    Abstract Obesity, which has currently reached pandemic dimensions, is usually accompanied by diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological mechanisms. Adipose tissue secretes cytokines which are involved in inflammation and various endocrine functions. As for T2DM, it is characterized also by inflammation, mitochondrial dysfunction, and hyperinsulinemia. These conditions occur also in other diseases related to obesity and T2DM, like cardiovascular disease (CVD) and nonalcoholic fatty liver disease (NAFLD). Thus, management of obesity-related complications with lifestyle modification, anti-obesity drugs, and bariatric surgery, all contribute to improvement in any of these conditions. This review provides an overview of the literature addressing the association between obesity and T2DM, briefly discussing the pathophysiological mechanisms linking these conditions and outlining the management approach at the overlap of obesity and T2DM.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Obesity/complications ; Obesity/epidemiology ; Obesity/therapy ; Non-alcoholic Fatty Liver Disease/complications ; Cytokines ; Inflammation/complications
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-06-23
    Publishing country Ireland
    Document type Review ; Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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