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Article ; Online: Development of an easy-to-set-up multiple heart-cutting achiral-chiral LC-LC method for the analysis of branched-chain amino acids in commercial tablets.

Varfaj, Ina / Abualzulof, Ghaid W A / Moretti, Simone / Migni, Anna / Uda, Irene / Goracci, Laura / Ianni, Federica / Carotti, Andrea / Sardella, Roccaldo

Electrophoresis

2024

Abstract: In this paper, the development and application of a multiple heart-cutting achiral-chiral LC-LC method (mLC-LC) for the analysis of dansylated (Dns) branched-chain amino acids in commercial tablets are described. In the first dimension, a Waters Xbridge ... ...

Abstract	In this paper, the development and application of a multiple heart-cutting achiral-chiral LC-LC method (mLC-LC) for the analysis of dansylated (Dns) branched-chain amino acids in commercial tablets are described. In the first dimension, a Waters Xbridge RP C18 achiral column was used under gradient conditions with buffered aqueous solution and acetonitrile. The elution order Dns-valine (Dns-Val) < Dns-isoleucine (Dns-Ile) < Dns-leucine (Dns-Leu) turned out with full resolution between adjacent peaks: 7.25 and 1.50 for the Val/Ile and the Ile/Leu pairs, respectively. A "research" validation study was performed, revealing high accuracy (Recovery%) and precision (RSD%) using two external set solutions, respectively, in the range 93.7%-104.1% and 0.4%-3.2%. The C18 column was connected via a two-position six-port switching valve to the quinidine-based Chiralpak quinidine-anion-exchange chiral column. A water/acetonitrile, 30/70 (v/v) with 50 mM ammonium acetate (apparent pH of 5.5) eluent allowed getting the three enantiomers' pairs resolved: R
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202300278
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Article ; Online: Oral Kaposi's sarcoma in a HIV-negative young patient.

Lombardi, Niccolò / Varoni, Elena / Sardella, Andrea / Lodi, Giovanni

Oral oncology

2020 Volume 103, Page(s) 104567

MeSH term(s)	Humans ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Sarcoma, Kaposi/diagnosis ; Sarcoma, Kaposi/pathology
Language	English
Publishing date	2020-01-17
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2020.104567
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article: HIV-Related Oral Mucosa Lesions: A Cross-Sectional Study on a Cohort of Italian Patients.

Tarozzi, Marco / Baruzzi, Elisa / Decani, Sem / Tincati, Camilla / Santoro, Andrea / Moneghini, Laura / Lodi, Giovanni / Sardella, Andrea / Carrassi, Antonio / Varoni, Elena Maria

Biomedicines

2024 Volume 12, Issue 2

Abstract: Background: Human immunodeficiency virus (HIV) infection can be associated with oral mucosal diseases, including oral candidiasis and HPV infection, which are putative indicators of the immune status.: Aim and methods: This retrospective cross- ... ...

Abstract	Background: Human immunodeficiency virus (HIV) infection can be associated with oral mucosal diseases, including oral candidiasis and HPV infection, which are putative indicators of the immune status. Aim and methods: This retrospective cross-sectional study was aimed at assessing the prevalence of HIV-related oral mucosal lesions in a cohort of Italian HIV+ patients regularly attending the Clinics of Infectious Diseases. Results: One hundred seventy-seven (n = 177) patients were enrolled and 30 (16.9%) of them showed HIV-related diseases of the oral mucosa. They were mainly found in male patients over 35 years old, undergoing Combination Antiretroviral Therapy (cART), and with CD4+ count < 500/µL. Oral candidiasis was the most common HIV-related oral lesion. No significant correlations could be detected between the prevalence of HPV infection and other clinical parameters (lymphocyte count, cART treatment and viral load). Conclusions: HIV-related oral mucosal diseases can correlate with immunosuppression. Early diagnosis and management of oral lesions in HIV+ patients should be part of the regular follow-up, from a multidisciplinary perspective of collaboration between oral medicine and infectious disease specialists, in an attempt to reduce morbidity due to oral lesions and modulate antiretroviral therapy according to the patient's immune status.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020436
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Article ; Online: COVID-19 and Dental Education: the Experience of the Dental School from the University of Milan.

Varoni, Elena Maria / Sardella, Andrea / Lodi, Giovanni / Iriti, Marcello / Carrassi, Antonio

Medical science educator

2022 Volume 32, Issue 2, Page(s) 539–544

Abstract: In late February 2020, Lombardy became one of the outbreak areas of the novel coronavirus pandemic, leading to the revolution of traditional teaching. Here, we describe our teaching experience at the Dental School of the University of Milan, with a focus ...

Abstract	In late February 2020, Lombardy became one of the outbreak areas of the novel coronavirus pandemic, leading to the revolution of traditional teaching. Here, we describe our teaching experience at the Dental School of the University of Milan, with a focus on the management of distance learning and clinical training. Distance education was enhanced with streaming lectures and videos of clinical procedures. Students' opinions on this "digital revolution" were very positive, despite few technical and organizational problems. For assuring the clinical training, we completely renovated the structural architecture from open spaces to closed spaces. The pandemic changed dental education with future repercussions.
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Editorial
ISSN	2156-8650
ISSN (online)	2156-8650
DOI	10.1007/s40670-022-01531-y
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Article ; Online: Estimating the hydrophobicity extent of molecular fragments using reversed-phase liquid chromatography.

Carotti, Andrea / Varfaj, Ina / Pruscini, Ilaria / Abualzulof, Ghaid W A / Mercolini, Laura / Bianconi, Elisa / Macchiarulo, Antonio / Camaioni, Emidio / Sardella, Roccaldo

Journal of separation science

2023 Volume 46, Issue 18, Page(s) e2300346

Abstract: A fast HPLC method was developed to study the hydrophobicity extent of pharmaceutically relevant molecular fragments. By this strategy, the reduced amount of sample available for physico-chemical evaluations in early-phase drug discovery programs does ... ...

Abstract	A fast HPLC method was developed to study the hydrophobicity extent of pharmaceutically relevant molecular fragments. By this strategy, the reduced amount of sample available for physico-chemical evaluations in early-phase drug discovery programs does not represent a limiting factor. The sixteen acid fragments investigated were previously synthesized also determining potentiometrically their experimental log D values. For four fragments it was not possible to determine such property since their values were outside of the instrumental working range (2 < pK
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202300346
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Article ; Online: Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances.

Protti, Michele / Varfaj, Ina / Carotti, Andrea / Tedesco, Daniele / Bartolini, Manuela / Favilli, Alessandro / Gerli, Sandro / Mercolini, Laura / Sardella, Roccaldo

Talanta

2023 Volume 257, Page(s) 124332

Abstract: In this paper, the development of efficient enantioselective HPLC methods for the analysis of five benzofuran-substituted phenethylamines, two substituted tryptamines, and three substituted cathinones is described. For the first time, reversed-phase ( ... ...

Abstract	In this paper, the development of efficient enantioselective HPLC methods for the analysis of five benzofuran-substituted phenethylamines, two substituted tryptamines, and three substituted cathinones is described. For the first time, reversed-phase (eluents made up with acidic water-methanol solutions) and polar-ionic (eluent made up with an acetonitrile-methanol solution incorporating both an acidic and a basic additive) conditions fully compatible with mass spectrometry (MS) detectors were applied with a chiral stationary phase (CSP) incorporating the (+)-(18-crown-6)-tetracarboxylic acid chiral selector. Enantioresolution was achieved for nine compounds with α and R
MeSH term(s)	Stereoisomerism ; Methanol ; Tandem Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Methanol (Y4S76JWI15)
Language	English
Publishing date	2023-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.124332
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Article ; Online: Oral infections in oral cancer survivors: A mini-review.

Pispero, Alberto / Lombardi, Niccolò / Manfredi, Maddalena / Varoni, Elena Maria / Sardella, Andrea / Lodi, Giovanni

Frontiers in oral health

2022 Volume 3, Page(s) 970074

Abstract: The oral cancer survivors are a group of special individuals whose disease affect anatomical structures with a key role in identity and communication and a fundamental role in basic human functions such as speaking, eating, swallowing and breathing. Thus, ...

Abstract	The oral cancer survivors are a group of special individuals whose disease affect anatomical structures with a key role in identity and communication and a fundamental role in basic human functions such as speaking, eating, swallowing and breathing. Thus, quality of life of these individuals can be impaired by the consequences of disease and treatments, in particular surgery and radiotherapy. Among others, infectious conditions of any nature, bacterial, viral, fungal, are a frequent finding among oral cancer survivors. In fact, the peculiar systemic and local conditions of these subjects are known to significantly modify the microbiota, which, besides facilitating opportunistic infections, can affect the cancer microenvironment, as well as alter the effects of the anti-cancer therapies. Similarly, mouth infections can also affect the prognosis of oral cancer survivors. Among the opportunistic infections, fungal are the most common infections affecting these subjects, since neutropenia resulting from cancer, as well as chemotherapy and/or radiotherapy treatments, promote the shift from the carrier state of Candida species, to pathogen state. Treatment of oral candidiasis can be difficult in oral cancer survivors, and good evidence supports clotrimazole as the most effective for prevention, and fluconazole as the one with the best risk-benefit profile. Probiotics, although promising, need better evidence to be considered an effective treatment or preventive measure.
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-4842
ISSN (online)	2673-4842
DOI	10.3389/froh.2022.970074
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Article ; Online: Elucidation of retention mechanism of dipeptides on a ristocetin A-based chiral stationary phase using a combination of chromatographic and molecular simulation techniques.

Varfaj, Ina / Pershina, Margarita V / Stepanova, Mariya V / Sardella, Roccaldo / Asnin, Leonid D / Carotti, Andrea

Journal of chromatography. A

2022 Volume 1675, Page(s) 463158

Abstract: Two chiral stationary phases virtually reproducing the Nautilus-R column were modeled in silico to study the enantiorecognition mechanism of some selected dipeptides, taking into consideration the two different anchoring alternatives to the silica layer ... ...

Abstract	Two chiral stationary phases virtually reproducing the Nautilus-R column were modeled in silico to study the enantiorecognition mechanism of some selected dipeptides, taking into consideration the two different anchoring alternatives to the silica layer involving the two ristocetin A amino groups. A mobile phase composed of water-methanol (40:60, v/v) was included in the system. The analyses of the trajectories supported the experimental L(LL)<D(DD) enantiomeric elution order of Ala-Ala, Gly-Leu, Leu-Gly-and Leu-Leu. In strict accordance with the enthalpy contributions observed in the thermodynamic evaluations of the retention profiles of Ala-Ala-and Leu-Leu, the molecular dynamics indicated that the selector-selectand association process is mainly controlled by electrostatic interactions. A distance analysis indicated that the carboxy-terminal of the d-Leu-d-Leu-enantiomer tends to approach closer the positive charges present on the selector with respect to its antipode. Similarly, the experimental enantiomeric elution order (L)<(D) of Leu-Gly-was explained by a higher hydrogen bond frequency for the d-Leu-Gly-in system B with respect to the l-Leu-Gly. A different interaction profile was observed for the Gly-Leu-dipeptide enantiorecognition mechanism that resulted to be mainly driven by van der Waals interactions. The Gly-Leu-and Leu-Gly-results highlighted the importance of the Leu-position in the dipeptide sequence that indeed governs the binding modes of the dipeptide with the chiral selector. The accordance observed among the thermodynamic and the molecular dynamics analyses indicate the adherence of this in silico methodology to the experimental results and its utility in the investigation of the enantiorecognition mechanisms in chiral chromatography.<br />
MeSH term(s)	Chromatography ; Dipeptides/chemistry ; Ristocetin/chemistry ; Stereoisomerism
Chemical Substances	Dipeptides ; Ristocetin (1404-55-3) ; ristocetin A (32P08CBB99)
Language	English
Publishing date	2022-05-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2022.463158
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Article ; Online: Patient attitude and habits regarding removable denture home hygiene and correlation with prosthesis cleanliness: A cross-sectional study of elderly Italians.

Cinquanta, Lucrezia / Varoni, Elena Maria / Barbieri, Christian / Sardella, Andrea

The Journal of prosthetic dentistry

2021 Volume 125, Issue 5, Page(s) 772.e1–772.e7

Abstract: Statement of problem: With the aging population, an increasing number of patients will require removable dental prostheses. Despite the recent public efforts to improve oral healthcare, knowledge of hygiene procedures for removable dental prostheses is ... ...

Abstract	Statement of problem: With the aging population, an increasing number of patients will require removable dental prostheses. Despite the recent public efforts to improve oral healthcare, knowledge of hygiene procedures for removable dental prostheses is sparse. Purpose: The purpose of this cross-sectional study was to determine, through questionnaires, the level of awareness and education of home hygiene procedures among elderly Italian individuals wearing removable dental prostheses and to correlate self-reported hygiene habits and prosthesis cleanliness, as determined by a clinical examination. Material and methods: A cross-sectional study was performed by questionnaires administered by a dental hygienist to patients attending the dental clinics (prosthodontic and periodontology clinical units) at San Paolo Hospital of Milan from January 2014 to October 2015 and who volunteered to participate. The questionnaire included demographic data and oral hygiene habits. Each participant received an intraoral and prosthesis examination performed by the same dental hygienist. The cleanliness of the removable dental prosthesis was classified according to a 3-point scoring system. Categorical variables were expressed as a percentage of study participants and compared by using the χ Results: Questionnaires were collected from 161 study participants: 92 women (mean ±standard deviation age: 76 ±7.59 years; range: 65-93 years) and 69 men (mean ±standard deviation age: 74 ±6.31 years; range: 65-86 years). A total of 239 prostheses were considered. A significant correlation was found between older participants, older removable dental prostheses, and reduced prosthesis cleanliness, correlating age ranges of participants as well as of removable dental prostheses with the degrees of prosthesis cleanliness (P=.001 and P=.004, respectively). Half the study participants (n=81; 50.3%) reported prosthesis removal during the night, while the others reported sleeping with the prosthesis in place. Some study participants (n=32; 19.9%) reported that they had never received instructions about how to clean the prosthesis. Mechanical brushing with toothbrush and toothpaste was the most common cleaning method (n=47; 29.2%), while the recommended combined cleaning method based on both mechanical brushing and immersion in dental cleanser was applied by 34 (21.1%) study participants. A similar number (n=25; 15.5%) reported at least 1 episode of denture-related stomatitis. Conclusions: In the analyzed cohort, patient attitude and habits toward home procedures for denture hygiene resulted in poor prosthesis cleanliness. Most individuals used a toothbrush and toothpaste to clean their device, although combining mechanical and chemical cleaning is typically reported to be the optimal method.
MeSH term(s)	Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Dental Implants ; Female ; Habits ; Humans ; Italy ; Male ; Oral Hygiene
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2021.01.024
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Article ; Online: Chiral high-performance liquid chromatography analysis of mono-, di-, and triacylglycerols with amylose- and cellulose-phenylcarbamate-based stationary phases.

Ianni, Federica / Carotti, Andrea / Protti, Michele / Favilli, Alessandro / Gerli, Sandro / Furlanetto, Sandra / Mercolini, Laura / Sardella, Roccaldo

Journal of pharmaceutical and biomedical analysis

2023 Volume 236, Page(s) 115720

Abstract: The ever-increasing technological advancement in the (ultra)high-performance liquid chromatography tandem (high-resolution) mass spectrometry platforms have largely contributed to steeply intensify the interest towards lipidomics research. However, mass ... ...

Abstract	The ever-increasing technological advancement in the (ultra)high-performance liquid chromatography tandem (high-resolution) mass spectrometry platforms have largely contributed to steeply intensify the interest towards lipidomics research. However, mass spectrometers alone are unable to distinguish between enantiomers. This obstacle is especially evident in the case of glycerolipids analysis due the prochiral nature of glycerol. Until a couple of decades ago, the stereoselective analysis of triacylglycerols (TAGs) was performed on the end products generated either from their enzymatic or chemical hydrolysis, namely on mono- or diacyl-sn-glycerols (MAGs and DAGs, respectively). These were then mostly analyzed with Pirkle-type chiral stationary phases (CSPs) after dedicated multi-step derivatization procedures. One of the most significant drawbacks of these traditional methods for enantioselective TAGs analysis (actually of the produced MAGs and DAGs, often investigated as target species per se) was the difficulty to totally abolish the migration of fatty acyls between glycerol positions. This made difficult to control and keep unaltered the stereochemistry of the original molecules. Over the last two decades, it has been widely demonstrated that the enantioselective analysis of intact TAGs as well as of non-derivatized MAGs and DAGs can be efficiently obtained using polysaccharide-based CSPs incorporating either amylose- or cellulose-phenylcarbamate derivatives chiral selectors. In this paper, the enantioselective methods developed with these CSPs for the enantioselective direct LC analysis of MAGs, DAGs and TAGs embedding different types of fatty acid residues are comprehensively reviewed.
Language	English
Publishing date	2023-09-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115720
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