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  1. Article: Evasion of toll-like receptor recognition by

    Tan, Aaron / Alsenani, Qusai / Lanz, Marcello / Birchall, Christopher / Drage, Lauren K L / Picton, David / Mowbray, Catherine / Ali, Ased / Harding, Christopher / Pickard, Robert S / Hall, Judith / Aldridge, Phillip D

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1093922

    Abstract: ... ...

    Abstract Uropathogenic
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1093922
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  2. Article ; Online: Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.

    Wang, Xiaoyi / Koirala, Santosh / Aldridge, Phillip D / Rao, Christopher V

    Journal of bacteriology

    2020  Volume 202, Issue 13

    Abstract: Flagellar gene expression is bimodal ... ...

    Abstract Flagellar gene expression is bimodal in
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Flagella/genetics ; Flagella/metabolism ; Gene Expression Regulation, Bacterial ; Promoter Regions, Genetic ; Salmonella enterica/genetics ; Salmonella enterica/growth & development ; Salmonella enterica/metabolism
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00787-19
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.50: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Exploring the in situ evolution of nitrofurantoin resistance in clinically derived uropathogenic Escherichia coli isolates.

    Vallée, Maxime / Harding, Chris / Hall, Judith / Aldridge, Phillip D / Tan, Aaron

    The Journal of antimicrobial chemotherapy

    2022  Volume 78, Issue 2, Page(s) 373–379

    Abstract: Background: Nitrofurantoin has been re-introduced as a first-choice antibiotic to treat uncomplicated acute urinary tract infections in England and Wales. Highly effective against common uropathogens such as Escherichia coli, its use is accompanied by a ...

    Abstract Background: Nitrofurantoin has been re-introduced as a first-choice antibiotic to treat uncomplicated acute urinary tract infections in England and Wales. Highly effective against common uropathogens such as Escherichia coli, its use is accompanied by a low incidence (<10%) of antimicrobial resistance. Resistance to nitrofurantoin is predominantly via the acquisition of loss-of-function, step-wise mutations in the nitroreductase genes nfsA and nfsB.
    Objective: To explore the in situ evolution of NitR in E. coli isolates from 17 patients participating in AnTIC, a 12-month open label randomized controlled trial assessing the efficacy of antibiotic prophylaxis in reducing urinary tract infections (UTIs) incidence in clean intermittent self-catheterizing patients.
    Methods: The investigation of NitR evolution in E. coli used general microbiology techniques and genetics to model known NitR mutations in NitSE. coli strains.
    Results: Growth rate analysis identified a 2%-10% slower doubling time for nitrofurantoin resistant strains: NitS: 20.8 ± 0.7 min compared to NitR: 23 ± 0.8 min. Statistically, these data indicated no fitness advantage of evolved strains compared to the sensitive predecessor (P-value = 0.13). Genetic manipulation of E. coli to mimic NitR evolution, supported no fitness advantage (P-value = 0.22). In contrast, data argued that a first-step mutant gained a selective advantage, at sub-MIC (4-8 mg/L) nitrofurantoin concentrations.
    Conclusion: Correlation of these findings to nitrofurantoin pharmacokinetic data suggests that the low incidence of E. coli NitR, within the community, is driven by urine-based nitrofurantoin concentrations that selectively inhibit the growth of E. coli strains carrying the key first-step loss-of-function mutation.
    MeSH term(s) Humans ; Nitrofurantoin/pharmacology ; Nitrofurantoin/therapeutic use ; Uropathogenic Escherichia coli/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Urinary Tract Infections/microbiology ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Microbial Sensitivity Tests
    Chemical Substances Nitrofurantoin (927AH8112L) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac398
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  4. Article ; Online: Multidrug-resistant Uro-associated

    Mowbray, Catherine / Tan, Aaron / Vallée, Maxime / Fisher, Holly / Chadwick, Thomas / Brennand, Catherine / Walton, Katherine E / Pickard, Robert S / Harding, Christopher / Aldridge, Phillip D / Hall, Judith

    European urology open science

    2022  Volume 37, Page(s) 90–98

    Abstract: Background: The AnTIC trial linked continuous low-dose antibiotic prophylaxis treatments to a lower incidence of symptomatic urinary tract infections (UTIs) among individuals performing clean intermittent self-catheterisation (CISC).: Objective: To ... ...

    Abstract Background: The AnTIC trial linked continuous low-dose antibiotic prophylaxis treatments to a lower incidence of symptomatic urinary tract infections (UTIs) among individuals performing clean intermittent self-catheterisation (CISC).
    Objective: To explore potential mechanisms underlying the protective effects of low-dose antibiotic prophylaxis treatments, blood and urine samples and uro-associated
    Design setting and participants: Blood samples (
    Outcome measurements and statistical analysis: TLR
    Results and limitations: Urine samples from CISC users, irrespective of antibiotic treatment regimens, were associated with robust urothelial innate responses. No links were identified between
    Conclusions: Antibiotic treatments did not impact urogenital responses to infection in CISC users. Host genetics in terms of
    Patient summary: Our findings show that the natural urogenital defences of clean intermittent self-catheterisation (CISC) users were not impacted by antibiotic treatments. For some CISC users, prophylaxis with low-dose antibiotics selected for a stable, predominantly,
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2021.12.015
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  5. Article ; Online: Driving the expression of the Salmonella enterica sv Typhimurium flagellum using flhDC from Escherichia coli results in key regulatory and cellular differences.

    Albanna, Ayman / Sim, Martin / Hoskisson, Paul A / Gillespie, Colin / Rao, Christopher V / Aldridge, Phillip D

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 16705

    Abstract: The flagellar systems of Escherichia coli and Salmonella enterica exhibit a significant level of genetic and functional synteny. Both systems are controlled by the flagellar specific master regulator ... ...

    Abstract The flagellar systems of Escherichia coli and Salmonella enterica exhibit a significant level of genetic and functional synteny. Both systems are controlled by the flagellar specific master regulator FlhD
    MeSH term(s) Bacterial Proteins/metabolism ; Electrophoretic Mobility Shift Assay ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Flagella/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Promoter Regions, Genetic/genetics ; Protein Binding ; Salmonella enterica/genetics ; Salmonella enterica/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Bacterial Proteins ; Escherichia coli Proteins ; Trans-Activators ; Transcription Factors ; flhC protein, E coli ; flhD protein, E coli
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-35005-2
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  6. Article ; Online: Author Correction: Possible role of L-form switching in recurrent urinary tract infection.

    Mickiewicz, Katarzyna M / Kawai, Yoshikazu / Drage, Lauren / Gomes, Margarida C / Davison, Frances / Pickard, Robert / Hall, Judith / Mostowy, Serge / Aldridge, Phillip D / Errington, Jeff

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 5254

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-11-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-13256-5
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  7. Article ; Online: Author Correction

    Katarzyna M. Mickiewicz / Yoshikazu Kawai / Lauren Drage / Margarida C. Gomes / Frances Davison / Robert Pickard / Judith Hall / Serge Mostowy / Phillip D. Aldridge / Jeff Errington

    Nature Communications, Vol 10, Iss 1, Pp 1-

    Possible role of L-form switching in recurrent urinary tract infection

    2019  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Author Correction

    Katarzyna M. Mickiewicz / Yoshikazu Kawai / Lauren Drage / Margarida C. Gomes / Frances Davison / Robert Pickard / Judith Hall / Serge Mostowy / Phillip D. Aldridge / Jeff Errington

    Nature Communications, Vol 10, Iss 1, Pp 1-

    Possible role of L-form switching in recurrent urinary tract infection

    2019  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Bacterial Flagellar Type III Export Gate Complex Is a Dual Fuel Engine That Can Use Both H+ and Na+ for Flagellar Protein Export.

    Minamino, Tohru / Morimoto, Yusuke V / Hara, Noritaka / Aldridge, Phillip D / Namba, Keiichi

    PLoS pathogens

    2016  Volume 12, Issue 3, Page(s) e1005495

    Abstract: The bacterial flagellar type III export apparatus utilizes ATP and proton motive force (PMF) to transport flagellar proteins to the distal end of the growing flagellar structure for self-assembly. The transmembrane export gate complex is a H+-protein ... ...

    Abstract The bacterial flagellar type III export apparatus utilizes ATP and proton motive force (PMF) to transport flagellar proteins to the distal end of the growing flagellar structure for self-assembly. The transmembrane export gate complex is a H+-protein antiporter, of which activity is greatly augmented by an associated cytoplasmic ATPase complex. Here, we report that the export gate complex can use sodium motive force (SMF) in addition to PMF across the cytoplasmic membrane to drive protein export. Protein export was considerably reduced in the absence of the ATPase complex and a pH gradient across the membrane, but Na+ increased it dramatically. Phenamil, a blocker of Na+ translocation, inhibited protein export. Overexpression of FlhA increased the intracellular Na+ concentration in the presence of 100 mM NaCl but not in its absence, suggesting that FlhA acts as a Na+ channel. In wild-type cells, however, neither Na+ nor phenamil affected protein export, indicating that the Na+ channel activity of FlhA is suppressed by the ATPase complex. We propose that the export gate by itself is a dual fuel engine that uses both PMF and SMF for protein export and that the ATPase complex switches this dual fuel engine into a PMF-driven export machinery to become much more robust against environmental changes in external pH and Na+ concentration.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Flagella/genetics ; Flagella/metabolism ; Hydrogen/metabolism ; Mutation ; Promoter Regions, Genetic/genetics ; Protein Transport ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Salmonella/genetics ; Salmonella/metabolism ; Sodium/metabolism
    Chemical Substances Bacterial Proteins ; Hydrogen (7YNJ3PO35Z) ; Sodium (9NEZ333N27) ; Proton-Translocating ATPases (EC 3.6.3.14)
    Language English
    Publishing date 2016-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005495
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  10. Article ; Online: Growth rate control of flagellar assembly in Escherichia coli strain RP437.

    Sim, Martin / Koirala, Santosh / Picton, David / Strahl, Henrik / Hoskisson, Paul A / Rao, Christopher V / Gillespie, Colin S / Aldridge, Phillip D

    Scientific reports

    2017  Volume 7, Page(s) 41189

    Abstract: The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar ... ...

    Abstract The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a systematic study has not yet been described under controlled growth conditions. Here, we investigated the effect of growth rate on flagellar assembly in Escherichia coli using steady-state chemostat cultures where we could precisely control the cell growth-rate. Our results demonstrate that flagellar abundance correlates with growth rate, where faster growing cells produce more flagella. They also demonstrate that this growth-rate dependent control occurs through the expression of the flagellar master regulator, FlhD
    MeSH term(s) Bacterial Physiological Phenomena ; Endopeptidase Clp/physiology ; Escherichia coli/physiology ; Escherichia coli Proteins/physiology ; Flagella/physiology ; Movement
    Chemical Substances Escherichia coli Proteins ; ClpP protease, E coli (EC 3.4.21.92) ; Endopeptidase Clp (EC 3.4.21.92)
    Language English
    Publishing date 2017-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep41189
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