LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Strengthening Healthcare through Academic and Industry Partnership Research.

    Sathian, Brijesh / van Teijlingen, Edwin / Simkhada, Padam / Banerjee, Indrajit / Manikyam, Hemanth Kumar / Kabir, Russell

    Nepal journal of epidemiology

    2023  Volume 13, Issue 2, Page(s) 1264–1267

    Language English
    Publishing date 2023-08-31
    Publishing country Nepal
    Document type Editorial
    ZDB-ID 2589539-4
    ISSN 2091-0800
    ISSN 2091-0800
    DOI 10.3126/nje.v13i2.58243
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV).

    Manikyam, Hemanth Kumar / Joshi, Sunil K

    Journal of pharmaceutics and drug research

    2020  Volume 3, Issue 2, Page(s) 341–361

    Abstract: A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Province of China at the end of 2019. This been recently declared as Global ... ...

    Abstract A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Province of China at the end of 2019. This been recently declared as Global Pandemic by WHO. There is a global emergency to identify potential drugs to treat the SARS-CoV-2. Currently, there is no specific treatment against the new virus. There is a urgency to identifying potential antiviral agents to combat the disease is urgently needed. An effective and quick approach is to test existing antiviral drugs against. Whole genome analysis and alignment carried out using BLASTn, SMART BLAST and WebDSV 2.0 had shown more than 238 ORF's coding for proteins mostly origin from Bat SARS coronavirus and root genomic origin from Archaea. Molecular docking results against protein targets Furin, papain like proteases, RdRp and Spike glycoprotein had shown paritaprevir, ritonavir, entecavir and chloroquine derivatives are the best drugs to inhibit multi targets of coronavirus infection including natural compounds corosolic acid, baicalin and glycyrrhizic acid with minimal inhibitory concentrations. Thus we propose use of paritaprevir, entecavir, ritonavir and chloroquine derivatives as best drug combination along with niacinamide, folic acid and zinc supplements to treat novel coronavirus infection. We also propose use of plant protease inhibitors (PI's) and Anti-IL8, IL-6, IL-2 as future drug models against coronavirus.
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 2640-6152
    ISSN (online) 2640-6152
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV)

    Manikyam, Hemanth Kumar / Joshi, Sunil K.

    Journal of pharmaceutics and drug research

    Abstract: A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Province of China at the end of 2019 This been recently declared as Global ... ...

    Abstract A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Province of China at the end of 2019 This been recently declared as Global Pandemic by WHO There is a global emergency to identify potential drugs to treat the SARS-CoV-2 Currently, there is no specific treatment against the new virus There is a urgency to identifying potential antiviral agents to combat the disease is urgently needed An effective and quick approach is to test existing antiviral drugs against Whole genome analysis and alignment carried out using BLASTn, SMART BLAST and WebDSV 2 0 had shown more than 238 ORF's coding for proteins mostly origin from Bat SARS coronavirus and root genomic origin from Archaea Molecular docking results against protein targets Furin, papain like proteases, RdRp and Spike glycoprotein had shown paritaprevir, ritonavir, entecavir and chloroquine derivatives are the best drugs to inhibit multi targets of coronavirus infection including natural compounds corosolic acid, baicalin and glycyrrhizic acid with minimal inhibitory concentrations Thus we propose use of paritaprevir, entecavir, ritonavir and chloroquine derivatives as best drug combination along with niacinamide, folic acid and zinc supplements to treat novel coronavirus infection We also propose use of plant protease inhibitors (PI's) and Anti-IL8, IL-6, IL-2 as future drug models against coronavirus
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #632670
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Ayurveda and Siddha systems polyherbal formulations to treat COVID-19 caused by SARS-CoV-2 and brief insight on application of Molecular Docking and SWISS Target prediction tools to study efficacy of active molecules

    Manikyam, Hemanth Kumar / Joshi, Sunil K / M, Malinidevi / Noor, Afeefa

    International Journal of Phytomedicine; Vol 12, No; 35-41 ; 0975-0185

    2020  Volume 2, Issue : International Journal of Phytomedicine

    Abstract: Ayurveda and Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan ... ...

    Abstract Ayurveda and Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan from the Ayurvedic system are the two major formulations along with many other individual herbs mentioned in the texts to treat Influenza like infections. Kabasura churan and Maha Sudarshan churan both have antipyretic, analgesic and anti-inflammatory effects. Both formulations were prepared according to Siddha and Ayurvedic texts. Herbs mentioned in both formulations like Turmeric, Tulsi (Basil), Kalmegh (Andrographis), Black Pepper, Liquorice (Mulethi), and Dronapushpi (Leucas) etc., had direct antiviral effect. Herbs like Aswagandha, Ginger, Guduchi (Tinospora), Kulanjan (Galangal) etc., had immunomodulatory and anti-inflammatory effect. Active compounds from different herbs were selected to study their antiviral activity through molecular docking algorithm. Application of modern of tools like Bioinformatics and Highthroughput screening methods can predict the efficacy of the ancient documented formulations and can be compared as per their literature. Compounds like curcumin, Glycyrrhizin, Ursolic acid, Quercetin, Andrographolide, Coumarins etc. were showed polyspecific activity like inhibition of Spike protein, Furin, Main Protease (Mpro) and Papain like Proteases (PLpro). Thus we propose use of Kabasura churan and Maha Sudharshan churan as alternative complementary medicine as a palliative treatment against COVID-19 caused by SARS-CoV-2 by conducting proper Randomized Clinical Trials
    Keywords COVID-19 ; SARS-CoV-2 ; Kabasura churan ; Maha Sudarshan churan ; Siddha system ; Ayurvedic system of medicine ; covid19
    Subject code 540
    Language English
    Publishing date 2020-06-24
    Publisher AR Journals
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Clastogenic effect of Picrorhiza kurroa rhizome extract on cultured human peripheral blood lymphocytes

    Acharya Balkrishna / Hemanth Kumar Manikyam / Vinay K Sharma / Niti Sharma

    Journal of HerbMed Pharmacology, Vol 5, Iss 4, Pp 131-

    2016  Volume 136

    Abstract: Introduction: The Picrorhiza kurroa rhizome has a long history of use in Indian Ayurvedic and Chinese system of medicine for the treatment of a wide spectrum of diseases. Today it is viewed as an important therapeutic target in both Western and Eastern ... ...

    Abstract Introduction: The Picrorhiza kurroa rhizome has a long history of use in Indian Ayurvedic and Chinese system of medicine for the treatment of a wide spectrum of diseases. Today it is viewed as an important therapeutic target in both Western and Eastern medicinal systems. This work was aimed to study the clastogenic effect of Picrorhiza kurroa rhizome extract on cultured human peripheral blood lymphocytes. Methods: Hydroalcoholic extract of rhizome was prepared and mammalian chromosomal aberration test was conducted using cultured human peripheral blood lymphocytes. The study was performed in two independent phases where the human peripheral blood lymphocytes were exposed to various of the extract in absence and presence of metabolic activation system for a continuous and short duration. Results: Picrorhiza kurroa rhizome extract did not induce chromosome aberration up to 2500 μg/mL in final culture concentration in the presence (1% v/v) and absence of metabolic activation. Conclusion: Picrorhiza kurroa rhizome extract is completely safe to be used as a medicine since it manifest its healing effects without causing genotoxicity.
    Keywords Picrorhiza kurroa ; Rhizome ; Chromosome aberration ; Human peripheral blood lymphocytes ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2016-10-01T00:00:00Z
    Publisher Shahrekord University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Cytotoxicity Study in Non Malignant Fibroblast L929 Cell Line with Mucuna pruriens Seed Extract

    Acharya Bal Krishna / Hemanth Kumar Manikyam / Vinay K. Sharma / Niti Sharma

    International Journal of Phytomedicine, Vol 7, Iss 4, Pp 366-

    2016  Volume 369

    Abstract: Mucuna pruriens (L.) DC. ( Leguminosae ), commonly called velvet bean has been long used by tribes as an antidote for various snakebite, for treating depression and various nervous disorders, Parkinson's disease, arthritis and also has potent anti- ... ...

    Abstract Mucuna pruriens (L.) DC. ( Leguminosae ), commonly called velvet bean has been long used by tribes as an antidote for various snakebite, for treating depression and various nervous disorders, Parkinson's disease, arthritis and also has potent anti-urolithiatic, anti- diabetic, anti-cancer, anti-oxidant activities. To evaluate the potential cytotoxicity of the hydroalcoholic extract of Mucuna pruriens seeds in non-malignant fibroblast L929 cell line. To access the toxic nature of the seeds, a hydroalcoholic extract was prepared and tested for its cytotoxic effects on non-malignant fibroblast L929 cell line at various concentrations (1.25 mg/ml, 2.5 mg/ml and 5 mg/ml). Viability (%), cell death (%), cytotoxicity grading, proliferation rate and growth inhibition values were calculated. No substantial difference in viability (%), cell death (%), growth inhibition (%) and proliferation rate were observed either at 24 h or 48 h following treatment with various concentrations of the extract as compared to the negative control. No toxicity was observed at any concentration of the extract, implying that the L-DOPA enriched extract of Mucuna pruriens is not toxic to the non malignant cells. These results confirmed that Mucuna pruriens seeds are safe and can be used as medicine for the treatment of various diseases.
    Keywords Mucuna pruriens seeds ; L-DOPA enriched extract ; L929 cell line ; Toxicity ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Advanced Research Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Acute Oral Toxicity Study of Paris polyphylla extract in Rats

    Acharya BalKrishna / Hemanth Kumar Manikyam / Vinay K Sharma / Niti Sharma

    International Journal of Phytomedicine, Vol 7, Iss 3, Pp 359-

    2015  Volume 365

    Abstract: Paris polyphylla Smith is regarded as “Wonder Herb” due to its vast therapeutic applications ranging from diarrhea to cancer. The cytotoxic effect of the rhizome extract on the healthy rats was monitored over a period of time. The extract proved non ... ...

    Abstract Paris polyphylla Smith is regarded as “Wonder Herb” due to its vast therapeutic applications ranging from diarrhea to cancer. The cytotoxic effect of the rhizome extract on the healthy rats was monitored over a period of time. The extract proved non cytotoxic as animals gained weight and no signs of mortality, ill health or overt toxicity were observed. A brief period of dullness indicates a possible role of the extract in neuro-suppression. The cutoff median lethal dose (LD 50 ) of extract after single oral administration to female rats, observed over a period of 14 days is found to be greater than 5000 mg/Kg body weight. Thus it can be used in the treatment of neurological disorders associated with hyper active neurons. Moreover as the extract is cytotoxic to cancerous cells only it would prove good target for future studies on anti cancer drugs. The results of this study collectively specify that oral administration of Paris polyphylla is not connected with any toxicologically significant effects and the data could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.
    Keywords Paris polyphylla ; Rhizome ; Hydroalcoholic Extract ; Cytotoxic ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher Advanced Research Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top