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  1. Book: Xin yi gai xia gong li yi yuan cai wu guan li yao dian, jie xi, li ju

    Li, Lebo

    Points, analysis and examples on financial management of public hospital under the new medical reform

    2014  

    Title variant Points, analysis and examples on financial management of public hospital under the new medical reform
    Author's details Li Lebo zhu
    MeSH term(s) Financial Management, Hospital/organization & administration ; Hospitals, Public/economics ; Health Care Reform/economics
    Keywords China
    Language Chinese
    Size 3, 2, 282 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787517801627 ; 7517801627
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Da bai cai si ji you zhi gao xiao zai pei

    Liang, Zuzhen / Li, Yuhong / Li, Wenlan

    (Shu cai gao Chan zai pei ji shu cong shu)

    2001  

    Author's details Liang Zuzhen, Li Yuhong, Li Wenlan bian zhu
    Series title Shu cai gao Chan zai pei ji shu cong shu
    Keywords Chinese cabbage.
    Language Chinese
    Size 2, 90 p. ;, 19 cm.
    Edition Di 1 ban.
    Publisher Guangxi ke xue ji shu chu ban she ; Guangxi xin hua shu dian fa xing
    Publishing place Naning shi
    Document type Book
    ISBN 7806660143 ; 9787806660140
    Database NAL-Catalogue (AGRICOLA)

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  3. Book: Qin cai you zhi gao xiao zai pei

    Tang, Xuejun / Li, Yeyong / Liu, Chunchang

    (San nong gong cheng shu ku ; Shu cai gao chan zai pei ji shu cong shu)

    2000  

    Author's details Tang Xuejun, Li Yeyong, Liu Chunchang bian zhu
    Series title San nong gong cheng shu ku
    Shu cai gao chan zai pei ji shu cong shu
    Keywords Celery.
    Language Chinese
    Size 69 p. :, ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Giangxi ke xue ji xhu chu ban she ; Guangxi xin hua shu dian fa xing
    Publishing place Nanning shi
    Document type Book
    ISBN 7806199934 ; 9787806199930
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: A CD6 homolog of Nile tilapia (Oreochromis niloticus) conserved binding bacteria involved in the regulation of Streptococcus agalactiae induced inflammation.

    Wang, Zhiwen / Xie, Caixia / Li, Yuan / Cai, Jia / Jian, Jichang / Xia, Liqun / Lu, Yishan

    Fish & shellfish immunology

    2024  Volume 146, Page(s) 109360

    Abstract: As a lymphocyte-specific surface receptor belonging to the cysteine-rich superfamily of scavenger receptors, CD6 acts as a pattern recognition receptor for microbial components and is involved in the regulation of inflammatory responses. However, the ... ...

    Abstract As a lymphocyte-specific surface receptor belonging to the cysteine-rich superfamily of scavenger receptors, CD6 acts as a pattern recognition receptor for microbial components and is involved in the regulation of inflammatory responses. However, the characteristics and functions of CD6 molecules in lower vertebrates represented by teleost fish are unknown. In this study, a CD6 homolog (designated OnCD6) was characterized from Nile tilapia (Oreochromis niloticus), and establishing its role as a PRRs that participates in immune recognition. OnCD6 contains an open reading frame of 1872 bp that encodes a peptide of 623 amino acids, and contains two conserved SR domain. Multiple sequence alignment revealed that OnCD6 shares a relatively high level of identity with those of other species. Transcriptional expression analysis revealed that OnCD6 was constitutively expressed in immunes tissues such as head kidney and thymus. The expression level of OnCD6 in mainly immune tissues were found significantly upregulated after the injection of Streptococcus agalactiae (S. agalactiae). Moreover, OnCD6 protein was located in the head kidney and brain, mainly over the plasma membrane of lymphocytes in these immune tissues. In vitro experiments showed that CD6 extracellular protein bound to and aggregated several Gram-positive and -negative bacterial strains through the recognition of bacterial surface conserved components LPS and LTA etc. In vivo experiments demonstrated that overexpression OnCD6 before S. agalactiae challenge significantly improved tilapia survival, and this was concomitant with reduced bacterial load and pro-inflammatory cytokines (IL-1β and TNF-α). Taken together, our results illustrated the function of CD6 molecular pattern recognition receptors (PRRs) is conserved and plays an important role in antibacterial infection.
    MeSH term(s) Animals ; Streptococcus agalactiae/physiology ; Cichlids ; Amino Acid Sequence ; Cytokines/metabolism ; Inflammation ; Fish Diseases ; Fish Proteins/chemistry ; Streptococcal Infections/veterinary ; Gene Expression Regulation
    Chemical Substances Cytokines ; Fish Proteins
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2024.109360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Paternal genetic structure analysis of the modern Han populations based on Y-SNP and Y-STR.

    Xin, Zhu / Xin, Jin / Jun, Liu / Lan, Yang / Li-Xin, Zou / Cai-Xia, Li / Jiang, Huang / Li, Jiang

    Yi chuan = Hereditas

    2024  Volume 46, Issue 2, Page(s) 149–167

    Abstract: ... with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup ...

    Abstract The Han populations represent the largest ethnic group in China. Previous studies have primarily focused on investigating their genetic origins, migration and integration, as well as paternal genetic relationships within specific regional Han populations. However, a comprehensive analysis of the global paternal genetic structure of Han populations is lacking. In this study, we performed Y-chromosome sequencing on 362 unrelated male samples from Chinese Han individuals collected from Qinghai, Sichuan and Liaoning provinces. We then integrated relevant data from reported studies. Our final dataset comprised 1830 samples from 16 Han populations across 15 provinces in China, encompassing information on 89 Y-SNPs and 16 Y-STRs. Statistical analyses were conducted to assess Y-STR haplotype diversity (HD) and Y-SNP haplogroup frequencies. Additionally, we employed principal component analysis (PCA), phylogenetic tree and haplotype network to explore genetic differentiation within Han populations and the genetic relationships between Han populations and ethnic minorities surrounding them. Our results demonstrated that the O-M175 haplogroup represents the predominant paternal lineage in Han populations, with frequencies ranging from 60.53% (Qinghai Han) to 92.7% (Guangdong Han). Moreover, the subclades downstream of O-M175 showed distinct regional variations in their distribution patterns. The O2-M122 haplogroup was prevalent in all Han populations and demonstrated a gradual decline in frequency from north to south. Conversely, the distribution frequency of the O1b-M268 haplogroup decreased from south to north, particularly showed significant presence among Han populations in the Lingnan region. Haplogroup O1a-M119 distributed more frequently in the central Han populations. Our findings revealed that Chinese Han populations can be categorized into three subgroups: northern, central, and southern. Notably, there were significant differences among Han in Qinghai and other regions. Regarding the genetic relationships between Han populations and surrounding ethnic minorities, we observed a closer genetic affinity between different Han populations, but northern Han demonstrated a stronger relationship with the Hui ethnic group, while southern Han exhibited a closer connection with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup distribution, genetic substructure of Han populations and genetic relationships between Han populations and surrounding ethnic minorities based on 89 Y-SNPs and 16 Y-STRs systematically. Our research supplemented valuable insights into population genetics and forensic genetics, and provided data support for the forensic application of Y chromosome. The integration of Y-SNP haplogroups with Y-STR haplotypes offers enhanced understanding of the genetic substructure within Han populations, which holds significance for both population genetics research and forensic science applications.
    MeSH term(s) Humans ; Polymorphism, Single Nucleotide ; Phylogeny ; Microsatellite Repeats ; Genetics, Population ; Ethnicity/genetics ; Haplotypes ; Chromosomes, Human, Y/genetics ; China
    Language English
    Publishing date 2024-02-10
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.23-260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Scutellaria Baicalensis Georgi Stem and Leaf Flavonoids Ameliorate the Learning and Memory Impairment in Rats Induced by Okadaic Acid.

    Ma, Shuai / Xu, Cong-Cong / Dong, Yong-Cai / Li, Cai-Xia / Shang, Ya-Zhen

    Combinatorial chemistry & high throughput screening

    2024  

    Abstract: Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.: ... ...

    Abstract Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.
    Methods: An experimental model of Alzheimer's disease (AD) was induced in rats by intracerebroventricular injection of OA, resulting in memory impairment. The Morris water maze test was employed to confirm the successful establishment of the memory impairment model. The rats that exhibited significant memory impairment were randomly divided into different groups, including a model group, three SSFs dose groups (25, 50, and 100 mg/kg), and a positive control group treated with Ginkgo biloba tablets (GLT) at a dose of 200 mg/kg. To evaluate the learning and memory abilities of the rats, the Morris water maze test was conducted. Hematoxylin-eosin (HE) staining was used to observe any morphological changes in neurons. Immunohistochemistry (IHC) was performed to measure the expression of choline acetyltransferase (ChAT) protein. Western blotting (WB) was utilized to assess the phosphorylation levels of tau protein at Ser262 and Ser396. The activities of inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS) were quantified using ultraviolet spectrophotometry. The levels of inflammatory factors, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), were measured using ELISA.
    Results: In rats, the administration of OA via intracerebroventricular injection resulted in cognitive impairment, neuropathological changes, and alterations in protein expression and activity levels. Specifically, the protein expression of ChAT was significantly reduced (P<0.01), while the phosphorylation levels of tau protein at Ser262 and Ser396 were significantly increased (P<0.01). Moreover, iNOS activity in the hippocampus and cerebral cortex exhibited a significant increase (P<0.01), whereas cNOS activity showed a decrease (P<0.05). Furthermore, the levels of IL-1β and TNF-α in the cerebral cortex were elevated (P<0.01), while the level of IL-6 was decreased (P<0.05). The administration of three doses of SSFs and GLT to rats exhibited varying degrees of improvement in the aforementioned pathological alterations induced by OA.
    Conclusion: SSFs demonstrated the ability to enhance cognitive function and mitigate memory deficits in rats following intracerebroventricular injection of OA. This beneficial effect may be attributed to the modulation of ChAT protein expression, tau hyperphosphorylation, NOS activity, and inflammatory cytokine levels by SSFs.
    Language English
    Publishing date 2024-01-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/0113862073265060231127054325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association between dietary intake of saturated fatty acid subgroups and breast cancer risk.

    Jiang, Ying / Li, Lan-Ting / Hou, Si-Han / Chen, Le-Ning / Zhang, Cai-Xia

    Food & function

    2024  Volume 15, Issue 4, Page(s) 2282–2294

    Abstract: The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending on their carbon chain lengths, attributable to the discrepancy in their dietary sources and biological activities. The associations between SFA subgroups ... ...

    Abstract The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending on their carbon chain lengths, attributable to the discrepancy in their dietary sources and biological activities. The associations between SFA subgroups classified by chain length and breast cancer risk remain controversial. In this case-control study, we aimed to investigate the association between the dietary intake of SFA subgroups, classified by chain lengths, and odds of breast cancer in China. This study included 1661 cases of breast cancer (confirmed as primary and histologically) and 1674 frequency-matched controls. Face-to-face interviews were used to collect basic information, while dietary intake information was obtained by a food frequency questionnaire. The unconditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). All SFA subgroups were inversely associated with odds of breast cancer. The adjusted ORs (95% CIs) were 0.78 (0.61-0.99) for medium-chain SFAs, 0.50 (0.31-0.83) for long even-chain SFAs, 0.69 (0.54-0.88) for long odd-chain, and 0.67 (0.48-0.95) for very long-chain SFAs, respectively. In the restricted cubic spline (RCS) models, a non-linear M-shaped association was observed between long odd-chain SFAs and odds of breast cancer (
    MeSH term(s) Humans ; Female ; Fatty Acids ; Prospective Studies ; Risk Factors ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Case-Control Studies ; Eating ; Dietary Fats
    Chemical Substances Fatty Acids ; Dietary Fats
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04279k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: FluPMT: Prediction of Predominant Strains of Influenza A Viruses Via Multi-task Learning.

    Cai, Changfeng / Li, Jianghui / Xia, Yuanling / Li, Weihua

    IEEE/ACM transactions on computational biology and bioinformatics

    2024  Volume PP

    Abstract: Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vaccine ... ...

    Abstract Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vaccine strain is generally based on the assessment of the current predominant strains. Nevertheless, the process of vaccine production and distribution is very time-consuming, leaving a window for the emergence of new variants that could decrease vaccine effectiveness, so predictions of influenza A virus evolution can inform vaccine evaluation and selection. Hence, we present FluPMT, a novel sequence prediction model that applies an encoder-decoder architecture to predict the hemagglutinin (HA) protein sequence of the upcoming season's predominant strain by capturing the patterns of evolution of influenza A viruses. Specifically, we employ time series to model the evolution of influenza A viruses, and utilize attention mechanisms to explore dependencies among residues of sequences. Additionally, antigenic distance prediction based on graph network representation learning is incorporated into the sequence prediction as an auxiliary task through a multi-task learning framework. Experimental results on two influenza datasets highlight the exceptional predictive performance of FluPMT, offering valuable insights into virus evolutionary dynamics, as well as vaccine evaluation and production.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2024.3378468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Alteromonas Aquimaris sp. nov., Isolated from Surface Seawater.

    Wang, Qin / Hu, Xin-Yuan / Sun, Li-Ping / Niu, Hui-Jing / Pei, Cai-Xia / Li, Yi / Xia, Cheng-Qiang

    Current microbiology

    2023  Volume 80, Issue 11, Page(s) 343

    Abstract: A Gram-negative, aerobic, motile by flagellum, and rod-shaped bacterium, designated ASW11- ... ...

    Abstract A Gram-negative, aerobic, motile by flagellum, and rod-shaped bacterium, designated ASW11-7
    MeSH term(s) Alteromonas/genetics ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; China ; DNA
    Chemical Substances RNA, Ribosomal, 16S ; DNA (9007-49-2)
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03472-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical characteristics of acute acquired concomitant esotropia before and after the COVID-19 pandemic: a retrospective analysis.

    Cai, Jie / Li, Xia / Li, Qin / Cai, Ying / Chen, Jinmao

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  

    Abstract: Purpose: This study aimed to observe the clinical characteristics of acute acquired concomitant esotropia (AACE) patients in recent five years and to examine the changes in the proportion of AACE cases before and after the COVID-19 pandemic.: Methods!# ...

    Abstract Purpose: This study aimed to observe the clinical characteristics of acute acquired concomitant esotropia (AACE) patients in recent five years and to examine the changes in the proportion of AACE cases before and after the COVID-19 pandemic.
    Methods: A retrospective study included 148 patients who underwent strabismus correction surgery for AACE between January 1, 2017, and December 31, 2021. The study analyzed the changing proportion of AACE cases before and after the COVID-19 pandemic and analyzed its clinical characteristics.
    Results: Abnormalities in the worth 4 dot examination (both distance and near) were present in 134 cases (90.54%) before surgery, while 140 cases (94.59%) showed normal results after surgery. Near stereoacuity was present in 135 cases (91.22%). The near and distance deviations were (55.01 ± 18.77) PD and (57.30 ± 17.64) PD, respectively, and there was no significant difference between the two (p = 0.279). There were significant differences in the ratio of refractive status among different age groups (p < 0.001), while no statistically significant difference was observed in the ratio of refractive status for near deviation (p = 0.085) or distance deviation (p = 0.116). The proportion of AACE cases after the COVID-19 pandemic was significantly higher than that before the COVID-19 pandemic (p = 0.042). There was no statistically significant difference in the clinical characteristics between the two groups (p > 0.05).
    Conclusions: Myopia is the most common refractive status in AACE. More than half of patients had occupations that involved long hours of close work. The proportion of AACE cases increased significantly after the COVID-19 pandemic.
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-024-06416-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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