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  1. Article ; Online: Bile duct tissue acquisition by cholangioscopy-guided cryobiopsy technique: first-in-human application.

    Peveling-Oberhag, Jan / Zimmermann, Corinna / Linzenbold, Walter / Ott, German / Enderle, Markus / Albert, Jörg G

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 8, Issue 4, Page(s) 158–161

    Abstract: Video 1Case description and video in cholangioscopic view demonstrating bile duct tissue acquisition by cholangioscopy-guided cryobiopsy technique. ...

    Abstract Video 1Case description and video in cholangioscopic view demonstrating bile duct tissue acquisition by cholangioscopy-guided cryobiopsy technique.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy.

    Wirsing, Lukas / Linzenbold, Walter / Jaeger, Simon U / Stahl, Phillip / Ott, German / Leibold, Tobias / Enderle, Markus / Albert, Jörg / Peveling-Oberhag, Jan

    Endoscopy international open

    2022  Volume 10, Issue 6, Page(s) E809–E814

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2022-06-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1797-8966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: Behandlungssteuerung bei Patienten mit post-pankreatitischen Flüssigkeitsansammlungen: die Endosonographie als diagnostisches und therapeutisches Schlüsselinstrument

    Widmann, Annina / Meisner, Christoph / Grün, Kira / Rothfuss, Katja / Peveling-Oberhag, Jan / Lubomierski, Nikolaus / Albert, Jörg

    Ultraschall in der Medizin - European Journal of Ultrasound

    2022  Volume 43, Issue S 01

    Event/congress Interdisziplinärer Kongress | Ultraschall 2022, Zürich, 2022-06-29
    Language German
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/s-0042-1749487
    Database Thieme publisher's database

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    Zs.A 1572: Show issues Location:
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  4. Article: A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy

    Wirsing, Lukas / Linzenbold, Walter / Jaeger, Simon U. / Stahl, Phillip / Ott, German / Leibold, Tobias / Enderle, Markus / Albert, Jörg / Peveling-Oberhag, Jan

    Endoscopy International Open

    2022  Volume 10, Issue 06, Page(s) E809–E814

    Abstract: Background and study aims : Indeterminate biliary strictures represent a major challenge in clinical diagnostics. Diagnostic yield of radiological, endoscopic imaging and histopathological diagnosis is insufficient. The cryobiopsy technique is a new ... ...

    Abstract Background and study aims : Indeterminate biliary strictures represent a major challenge in clinical diagnostics. Diagnostic yield of radiological, endoscopic imaging and histopathological diagnosis is insufficient. The cryobiopsy technique is a new method for tissue extraction already used in different clinical settings. The aim of this ex vivo clinical study was to investigate feasibility and tissue quality of cryobiopsy in the bile duct.
    Patients and methods : We included 14 patients who underwent pancreaticoduodenectomy. Bile duct samples were taken with either a new prototype cryoprobe or one of two forceps types. Results were analyzed for general feasibility, specimen size, histological assessability as well as representativity of retrieved tissue.
    Results : Feasibility of cholangioscopic forceps was poor compared to gastric biopsy forceps or cryobiopsy. Significantly larger tissue samples were obtained with cryobiopsy (5.6 ± 4.5 mm 2 ) compared to gastric biopsy forceps (3.3 ± 5.1 mm 2 P  = 0.006). Furthermore, cryobiopsy was superior in histological assessment quality ( P  = 0.02) and concerning representativity ( P  = 0.03).
    Conclusions : Cryobiopsy in the bile duct is feasible and the quality of the obtained tissue is high. Further investigation of bile duct cryobiopsy in vivo is warranted.
    Language English
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722 ; 2196-9736
    ISSN (online) 2196-9736
    ISSN 2364-3722 ; 2196-9736
    DOI 10.1055/a-1797-8966
    Database Thieme publisher's database

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  5. Article ; Online: Evaluation of the Integrated Pulmonary Index® during non-anesthesiologist sedation for percutaneous endoscopic gastrostomy.

    Michael, Florian Alexander / Peveling-Oberhag, Jan / Herrmann, Eva / Zeuzem, Stefan / Bojunga, Jörg / Friedrich-Rust, Mireen

    Journal of clinical monitoring and computing

    2020  Volume 35, Issue 5, Page(s) 1085–1092

    Abstract: Standard monitoring of heart rate, blood pressure and arterial oxygen saturation during endoscopy is recommended by current guidelines on procedural sedation. A number of studies indicated a reduction of hypoxic (art. oxygenation ... 15 s) and ... ...

    Abstract Standard monitoring of heart rate, blood pressure and arterial oxygen saturation during endoscopy is recommended by current guidelines on procedural sedation. A number of studies indicated a reduction of hypoxic (art. oxygenation < 90% for > 15 s) and severe hypoxic events (art. oxygenation < 85%) by additional use of capnography. Therefore, U.S. and the European guidelines comment that additional capnography monitoring can be considered in long or deep sedation. Integrated Pulmonary Index® (IPI) is an algorithm-based monitoring parameter that combines oxygenation measured by pulse oximetry (art. oxygenation, heart rate) and ventilation measured by capnography (respiratory rate, apnea > 10 s, partial pressure of end-tidal carbon dioxide [PetCO
    MeSH term(s) Capnography ; Conscious Sedation ; Gastrostomy ; Humans ; Monitoring, Physiologic ; Propofol ; Prospective Studies ; Respiration
    Chemical Substances Propofol (YI7VU623SF)
    Language English
    Publishing date 2020-07-30
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-020-00563-2
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    Zs.A 2054: Show issues Location:
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  6. Article ; Online: To treat or not to treat - Successful hepatitis C virus eradication in a patient with advanced hepatocellular carcinoma and complete response to sorafenib.

    Waidmann, Oliver / Peveling-Oberhag, Jan / Eichler, Katrin / Schulze, Falko / Vermehren, Johannes

    Zeitschrift fur Gastroenterologie

    2017  Volume 55, Issue 6, Page(s) 564–568

    Abstract: Background and ... ...

    Abstract Background and aims
    Language English
    Publishing date 2017-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/s-0042-118232
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    Zs.A 111: Show issues Location:
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  7. Article ; Online: Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital.

    Winkelmann, Ria / Schneider, Markus / Hartmann, Sylvia / Schnitzbauer, Andreas A / Zeuzem, Stefan / Peveling-Oberhag, Jan / Hansmann, Martin Leo / Walter, Dirk

    International journal of molecular sciences

    2018  Volume 19, Issue 5

    Abstract: Immune-modulating therapy is a promising therapy for patients with cholangiocarcinoma (CCA). Microsatellite instability (MSI) might be a favorable predictor for treatment response, but comprehensive data on the prevalence of MSI in CCA are missing. The ... ...

    Abstract Immune-modulating therapy is a promising therapy for patients with cholangiocarcinoma (CCA). Microsatellite instability (MSI) might be a favorable predictor for treatment response, but comprehensive data on the prevalence of MSI in CCA are missing. The aim of the current study was to determine the prevalence of MSI in a German tertiary care hospital. Formalin-fixed paraffin-embedded tissue samples, obtained in the study period from 2007 to 2015 from patients with CCA undergoing surgical resection with curative intention at Johann Wolfgang Goethe University hospital, were examined. All samples were investigated immunohistochemically for the presence of MSI (expression of MLH1, PMS2, MSH2, and MSH6) as well as by pentaplex polymerase chain reaction for five quasimonomorphic mononucleotide repeats (
    MeSH term(s) Aged ; Alleles ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/pathology ; Female ; Germany ; Hospitals ; Humans ; Kaplan-Meier Estimate ; Male ; Microsatellite Instability ; Middle Aged ; Retrospective Studies ; Tertiary Care Centers
    Language English
    Publishing date 2018-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19051421
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  8. Article ; Online: Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management.

    Peveling-Oberhag, Jan / Arcaini, Luca / Hansmann, Martin-Leo / Zeuzem, Stefan

    Journal of hepatology

    2013  Volume 59, Issue 1, Page(s) 169–177

    Abstract: There is ample epidemiologic evidence for an association of chronic hepatitis C virus (HCV) infection with B-cell non-Hodgkin lymphoma (B-NHL). B-NHL subtypes most frequently associated with HCV are marginal zone lymphoma and diffuse large B-cell ... ...

    Abstract There is ample epidemiologic evidence for an association of chronic hepatitis C virus (HCV) infection with B-cell non-Hodgkin lymphoma (B-NHL). B-NHL subtypes most frequently associated with HCV are marginal zone lymphoma and diffuse large B-cell lymphoma. The most convincing evidence for a causal relationship between HCV infection and lymphoma development is the observation of B-NHL regression after HCV eradication by antiviral therapy (AVT). In fact, for indolent HCV-associated B-NHL, first-line AVT instead of standard immune-chemotherapy might be considered. Molecular mechanisms of HCV-NHL development are still poorly understood. Three general theories have emerged to understand the HCV-induced lymphomagenesis: (1) continuous external stimulation of lymphocyte receptors by viral antigens and consecutive proliferation; (2) HCV replication in B cells with oncogenic effect mediated by intracellular viral proteins; (3) permanent B-cell damage, e.g., mutation of tumor suppressor genes, caused by a transiently intracellular virus ("hit and run" theory). This review systematically summarizes the data on epidemiology, interventional studies, and molecular mechanisms of HCV-associated B-NHL.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Hepacivirus/immunology ; Hepacivirus/pathogenicity ; Hepatitis C Antigens ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/epidemiology ; Lymphoma, B-Cell/etiology ; Models, Biological ; Risk Factors
    Chemical Substances Antineoplastic Agents ; Antiviral Agents ; Hepatitis C Antigens
    Language English
    Publishing date 2013-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2013.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  9. Book ; Online ; Thesis: Dynamik des Thrombuswachstums in vitro

    Peveling-Oberhag, Jan Franz-Josef

    Validierung digitaler Imaging-Techniken zur exakten Bestimmung der Thrombusvolumina

    2010  

    Author's details Jan Franz-Josef Peveling-Oberhag
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Düsseldorf, 2010
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book ; Online ; Thesis: Dynamik des Thrombuswachstums in vitro. Validierung digitaler Imaging-Techniken zur exakten Bestimmung der Thrombusvolumina

    Peveling-Oberhag, Jan Franz-Josef [Verfasser]

    2010  

    Author's details vorgelegt von Jan Franz-Josef Peveling-Oberhag
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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