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  1. Article ; Online: Evolution of CRISPR-enabled biosensors for amplification-free nucleic acid detection.

    Talebian, Sepehr / Dehghani, Fariba / Weiss, Paul S / Conde, João

    Trends in biotechnology

    2023  Volume 42, Issue 1, Page(s) 10–13

    Abstract: CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an ... ...

    Abstract CRISPR biosensors enable rapid and accurate detection of nucleic acids without resorting to target amplification. Specifically, these systems facilitate the simultaneous detection of multiple nucleic acid targets with single-base specificity. This is an invaluable asset that can ultimately facilitate accurate diagnoses of biologically complex diseases.
    MeSH term(s) Clustered Regularly Interspaced Short Palindromic Repeats ; Nucleic Acids/genetics ; CRISPR-Cas Systems ; Nucleic Acid Amplification Techniques ; Biosensing Techniques
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2750: Show issues Location:
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  2. Article ; Online: Protein adsorption on blood-contacting surfaces: A thermodynamic perspective to guide the design of antithrombogenic polymer coatings.

    Crago, Matthew / Lee, Aeryne / Hoang, Thanh Phuong / Talebian, Sepehr / Naficy, Sina

    Acta biomaterialia

    2024  

    Abstract: Blood-contacting medical devices often succumb to thrombosis, limiting their durability and safety in clinical applications. Thrombosis is fundamentally initiated by the nonspecific adsorption of proteins to the material surface, which is strongly ... ...

    Abstract Blood-contacting medical devices often succumb to thrombosis, limiting their durability and safety in clinical applications. Thrombosis is fundamentally initiated by the nonspecific adsorption of proteins to the material surface, which is strongly governed by thermodynamic factors established by the nature of the interaction between the material surface, surrounding water molecules, and the protein itself. Along these lines, different surface materials (such as polymeric, metallic, ceramic, or composite) induce different entropic and enthalpic changes at the surface-protein interface, with material wettability significantly impacting this behavior. Consequently, protein adsorption on medical devices can be modulated by altering their wettability and surface energy. A plethora of polymeric coating modifications have been utilized for this purpose; hydrophobic modifications may promote or inhibit protein adsorption determined by van der Waals forces, while hydrophilic materials achieve this by mainly relying on hydrogen bonding, or unbalanced/balanced electrostatic interactions. This review offers a cohesive understanding of the thermodynamics governing these phenomena, to specifically aid in the design and selection of hemocompatible polymeric coatings for biomedical applications. STATEMENT OF SIGNIFICANCE: Blood-contacting medical devices often succumb to thrombosis, limiting their durability and safety in clinical applications. A plethora of polymeric coating modifications have been utilized for addressing this issue. This review offers a cohesive understanding of the thermodynamics governing these phenomena, to specifically aid in the design and selection of hemocompatible polymeric coatings for biomedical applications.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.04.018
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  3. Article ; Online: Why Go NANO on COVID-19 Pandemic?

    Talebian, Sepehr / Conde, João

    Matter

    2020  Volume 3, Issue 3, Page(s) 598–601

    Abstract: Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here we highlight the ... ...

    Abstract Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here we highlight the importance of going NANO on the COVID-19 pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type News
    ISSN 2590-2385
    ISSN (online) 2590-2385
    DOI 10.1016/j.matt.2020.08.005
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  4. Article ; Online: Why Go NANO on COVID-19 Pandemic?

    Talebian, Sepehr / Conde, João

    Matter

    2020  Volume 3, Issue 3, Page(s) 598–601

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2590-2385
    DOI 10.1016/j.matt.2020.08.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction: Revisiting gene delivery to the brain: silencing and editing.

    Conniot, João / Talebian, Sepehr / Simões, Susana / Ferreira, Lino / Conde, João

    Biomaterials science

    2021  Volume 9, Issue 4, Page(s) 1464–1465

    Abstract: Correction for 'Revisiting gene delivery to the brain: silencing and editing' by João Conniot et al., Biomater. Sci., 2021, DOI: . ...

    Abstract Correction for 'Revisiting gene delivery to the brain: silencing and editing' by João Conniot et al., Biomater. Sci., 2021, DOI: .
    Language English
    Publishing date 2021-01-06
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm90117b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Why Go NANO on COVID-19 Pandemic?

    Talebian, Sepehr / Conde, João

    Matter

    Abstract: Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here we highlight the ... ...

    Abstract Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here we highlight the importance of going NANO on the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #741400
    Database COVID19

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  7. Article ; Online: Why Go NANO on COVID-19 Pandemic?

    Talebian, Sepehr / Conde, João

    Faculty of Science, Medicine and Health - Papers: Part B

    2020  

    Abstract: 2020 Elsevier Inc. Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here ... ...

    Abstract © 2020 Elsevier Inc. Although treating COVID-19 is shown to be challenging, NANOtechnology is around the corner to overcome potential drawbacks. The use of NANOtechnologies will definitely shape the worldwide approaches and tools to treat COVID-19. Here we highlight the importance of going NANO on the COVID-19 pandemic.
    Keywords covid19
    Publishing date 2020-01-01T08:00:00Z
    Publisher Research Online
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Hydrogels for RNA delivery.

    Zhong, Ruibo / Talebian, Sepehr / Mendes, Bárbara B / Wallace, Gordon / Langer, Robert / Conde, João / Shi, Jinjun

    Nature materials

    2023  Volume 22, Issue 7, Page(s) 818–831

    Abstract: RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success of RNA therapy is largely ... ...

    Abstract RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success of RNA therapy is largely dependent on the use of chemical modification, ligand conjugation or non-viral nanoparticles to improve RNA stability and facilitate intracellular delivery. Unlike molecular-level or nanoscale approaches, macroscopic hydrogels are soft, water-swollen three-dimensional structures that possess remarkable features such as biodegradability, tunable physiochemical properties and injectability, and recently they have attracted enormous attention for use in RNA therapy. Specifically, hydrogels can be engineered to exert precise spatiotemporal control over the release of RNA therapeutics, potentially minimizing systemic toxicity and enhancing in vivo efficacy. This Review provides a comprehensive overview of hydrogel loading of RNAs and hydrogel design for controlled release, highlights their biomedical applications and offers our perspectives on the opportunities and challenges in this exciting field of RNA delivery.
    MeSH term(s) Humans ; Hydrogels/chemistry ; RNA ; COVID-19/therapy ; Drug Delivery Systems
    Chemical Substances Hydrogels ; RNA (63231-63-0)
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01472-w
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  9. Article ; Online: Revisiting gene delivery to the brain: silencing and editing.

    Conniot, João / Talebian, Sepehr / Simões, Susana / Ferreira, Lino / Conde, João

    Biomaterials science

    2020  Volume 9, Issue 4, Page(s) 1065–1087

    Abstract: Neurodegenerative disorders, ischemic brain diseases, and brain tumors are debilitating diseases that severely impact a person's life and could possibly lead to their demise if left untreated. Many of these diseases do not respond to small molecule ... ...

    Abstract Neurodegenerative disorders, ischemic brain diseases, and brain tumors are debilitating diseases that severely impact a person's life and could possibly lead to their demise if left untreated. Many of these diseases do not respond to small molecule therapeutics and have no effective long-term therapy. Gene therapy offers the promise of treatment or even a cure for both genetic and acquired brain diseases, mediated by either silencing or editing disease-specific genes. Indeed, in the last 5 years, significant progress has been made in the delivery of non-coding RNAs as well as gene-editing formulations to the brain. Unfortunately, the delivery is a major limiting factor for the success of gene therapies. Both viral and non-viral vectors have been used to deliver genetic information into a target cell, but they have limitations. Viral vectors provide excellent transduction efficiency but are associated with toxic effects and have limited packaging capacity; however, non-viral vectors are less toxic and show a high packaging capacity at the price of low transfection efficiency. Herein, we review the progress made in the field of brain gene therapy, particularly in the design of non-toxic and trackable non-viral vectors, capable of controlled release of genes in response to internal/external triggers, and in the delivery of formulations for gene editing. The application of these systems in the context of various brain diseases in pre-clinical and clinical tests will be discussed. Such promising approaches could potentially pave the way for clinical realization of brain gene therapies.
    MeSH term(s) Brain ; Gene Editing ; Gene Transfer Techniques ; Genetic Therapy ; Genetic Vectors
    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01278e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon.

    Talebian, Sepehr / Schofield, Timothy / Valtchev, Peter / Schindeler, Aaron / Kavanagh, John M / Adil, Qayyum / Dehghani, Fariba

    Advanced healthcare materials

    2022  Volume 11, Issue 11, Page(s) e2102487

    Abstract: The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of ... ...

    Abstract The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of probiotics to critical conditions. Owing to the unique properties of biopolymers, they have been prevalently used for microencapsulation of probiotics. However, majority of microencapsulated products only contain a single layer of protection around probiotics, which is likely to be inferior to more sophisticated approaches. This review discusses emerging methods for the multilayer encapsulation of probiotic using biopolymers. Correlations are drawn between fabrication techniques and the resultant microparticle properties. Subsequently, multilayer microparticles are categorized based on their layer designs. Recent reports of specific biopolymeric formulations are examined regarding their physical and biological properties. In particular, animal models of gastrointestinal transit and disease are highlighted, with respect to trials of multilayer microencapsulated probiotics. To conclude, novel materials and approaches for fabrication of multilayer structures are highlighted.
    MeSH term(s) Animals ; Biopolymers ; Colon ; Drug Compounding/methods ; Microbial Viability ; Probiotics
    Chemical Substances Biopolymers
    Language English
    Publishing date 2022-03-03
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202102487
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    Zs.A 6966: Show issues Location:
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