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  1. Article: The L.Y.G.H.T. program

    Mitchell, Monique B. / Schuurman, Donna L. / Shapiro, Cheri J. / Sattler, Sebastian / Sorensen, Carl / Martinez, Juliette

    Child and Adolescent Social Work Journal (CASW)

    An evaluation of a peer grief support intervention for youth in foster care

    2022  , Page(s) 1–18

    Abstract: ... the efficacy of a newly developed peer grief support program, the L.Y.G.H.T. program, for youth in foster care ... recommendation of the program, and additional feedback. The findings suggest that the L.Y.G.H.T. program is ...

    Title translation Das L.Y.G.H.T.-Programm: Eine Evaluierung einer Peer-Trauerunterstützungsmaßnahme für Jugendliche in Pflegefamilien
    Abstract Youth in foster care experience high rates of social, emotional, and behavioral challenges that are complicated by trauma and grief. To address these concerns, the current intervention study examines the efficacy of a newly developed peer grief support program, the L.Y.G.H.T. program, for youth in foster care, using an embedded sequential mixed methods design. Forty-two youth residing in three separate foster care group homes ("community sites") in a southeastern state participated in this study. Youth were randomly assigned to either the treatment program or a waitlist control group. Baseline and post-intervention (after 6 weeks) assessments of the Children's Hope Scale, the Inventory of Social Support, the Rosenberg Self-Esteem Scale, and the Strengths and Difficulties Questionnaire-Self Report were administered. After each weekly group, participants completed a survey to assess trauma-informed program environment and facilitators completed a survey to assess fidelity to the intervention. Focus groups (n = 3) were conducted at each of the community sites after the post-intervention assessments were completed. To examine program impact, we evaluated whether increases in well-being (i.e., social support, hopefulness, and self-worth) and decreases in total problem behaviors would be found for participants in the treatment group. Social support, hopefulness, and self-worth increased and total problems remained the same for youth in the treatment program. Large effects were found for program helpfulness, a trauma-informed program environment, and reduction in perceived problems. Focus group feedback explained why youth were initially interested in the program, perceived program benefits, program dislikes, barriers to program participation, recommendation of the program, and additional feedback. The findings suggest that the L.Y.G.H.T. program is an efficacious intervention which addresses loss and grief and enhances the well-being of youth in foster care who are grieving.
    Keywords Evaluation psychosozialer Gesundheitsprogramme ; Foster Care ; Grief ; Intervention ; Mental Health Program Evaluation ; Peers ; Psychische Gesundheit von Jugendlichen ; Social Support ; Soziale Unterstützung ; Trauer ; Versorgung in Pflegefamilien ; Well Being ; Wohlbefinden ; Youth Mental Health
    Language English
    Document type Article
    ZDB-ID 2015019-2
    ISSN 1573-2797 ; 0738-0151
    ISSN (online) 1573-2797
    ISSN 0738-0151
    DOI 10.1007/s10560-022-00843-7
    Database PSYNDEX

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  2. Article ; Online: Reply to L. Kennedy et al.

    Shapiro, Charles L / Moriarty, James P / Borah, Bijan

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  Volume 36, Issue 10, Page(s) 1052–1053

    MeSH term(s) Breast Neoplasms ; Cost-Benefit Analysis ; Denosumab ; Female ; Humans ; Zoledronic Acid
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Zoledronic Acid (6XC1PAD3KF)
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2017.77.2749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Microscopy Techniques for Biomedical Education and Healthcare Practice

    Shapiro, Leonard

    Principles in Light, Fluorescence, Super-Resolution and Digital Microscopy, and Medical Imaging

    (Biomedical Visualization)

    2023  

    Author's details Leonard Shapiro Leonard is a visual artist affiliated with the Department of Human Biology at the University of Cape Town, South Africa. He has a keen interest in Anatomy Education and has developed a number of art-based exercises to address and improve students' three-dimensional (3D) spatial awareness and observation ability. His courses and workshops are in collaboration with lecturers who are actively engaged in improving education methodology in anatomy. These are offered to medical students and lecturers in South Africa and abroad. Leonard has developed a multi-sensory observation method that crucially employs the sense of touch (haptics) coupled with the simultaneous act of drawing. It is called the haptico-visual observation and drawing (HVOD) method. In anatomy education, the benefits of using the HVOD method include the enhanced observation of the 3D form of anatomical parts, the cognitive memorization of anatomical parts as a 3D mental picture, improved spatial orientatio
    Series title Biomedical Visualization
    Keywords AnatomyEducation ; biomedicalimaging ; BiologyTeaching ; computedtomography ; graphicmedicine ; Histology ; MedicalEducation ; medicalillustration ; MorphometricImageAnaylsis ; Ultrasound ; virtualmicroscopy ; Super-resolutionmicroscopy ; healthethics ; ParticleTracking ; Anatomy Education ; Biomedical Imaging ; Biology Teaching ; Computed Tomography ; Graphic Medicine ; Health Ethics ; Medical Education ; Medical Illustration ; Morphometric Image Anaylsis ; Particle Tracking ; Super-Resolution Microscopy ; Virtual Microscopy
    Language English
    Size 244 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_23
    Format 183 x 260 x 19
    ISBN 9783031368493 ; 3031368495
    Database PDA

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  4. Article ; Online: Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge.

    Gallagher-Jones, Marcus / Dias, Carlos Sato Baraldi / Pryor, Alan / Bouchmella, Karim / Zhao, Lingrong / Lo, Yuan Hung / Cardoso, Mateus Borba / Shapiro, David / Rodriguez, Jose / Miao, Jianwei

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 4757

    Abstract: ... of the fine features in the region at high resolution. By tuning the X-ray energy to the Fe L-edge ...

    Abstract Precise localization of nanoparticles within a cell is crucial to the understanding of cell-particle interactions and has broad applications in nanomedicine. Here, we report a proof-of-principle experiment for imaging individual functionalized nanoparticles within a mammalian cell by correlative microscopy. Using a chemically-fixed HeLa cell labeled with fluorescent core-shell nanoparticles as a model system, we implemented a graphene-oxide layer as a substrate to significantly reduce background scattering. We identified cellular features of interest by fluorescence microscopy, followed by scanning transmission X-ray tomography to localize the particles in 3D, and ptychographic coherent diffractive imaging of the fine features in the region at high resolution. By tuning the X-ray energy to the Fe L-edge, we demonstrated sensitive detection of nanoparticles composed of a 22 nm magnetic Fe
    MeSH term(s) Cells, Immobilized ; Ferrosoferric Oxide/chemistry ; Fluorescence ; Graphite/chemistry ; HeLa Cells ; Humans ; Microscopy, Fluorescence/instrumentation ; Microscopy, Fluorescence/methods ; Molecular Imaging/instrumentation ; Molecular Imaging/methods ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Oxidation-Reduction ; Oxides/chemistry ; Silicon Dioxide/chemistry ; Tomography, X-Ray Computed/instrumentation ; Tomography, X-Ray Computed/methods
    Chemical Substances Oxides ; Silicon Dioxide (7631-86-9) ; Graphite (7782-42-5) ; Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2017-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-04784-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: David L. Rimoin.

    Cohn, Daniel H / Shapiro, Larry J / Kaback, Michael M

    American journal of human genetics

    2012  Volume 91, Issue 3, Page(s) 403–407

    MeSH term(s) History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2012-11-28
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2012.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer.

    Ricciuti, Biagio / Recondo, Gonzalo / Spurr, Liam F / Li, Yvonne Y / Lamberti, Giuseppe / Venkatraman, Deepti / Umeton, Renato / Cherniack, Andrew D / Nishino, Mizuki / Sholl, Lynette M / Shapiro, Geoffrey I / Awad, Mark M / Cheng, Michael L

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 15, Page(s) 4135–4142

    Abstract: ... alterations are associated with clinical outcomes to programmed death ligand 1 [PD-(L)1] blockade ... in non-small cell lung cancer (NSCLC) is unknown.: Experimental design: Tumors from patients treated with PD-(L)1 inhibitors ... of the presence or absence of deleterious mutations across a panel of 53 DDR genes. Clinical outcomes to PD-(L)1 ...

    Abstract Purpose: DNA damage response and repair (DDR) gene alterations are associated with increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TMB) in cancer. Whether DDR alterations are associated with clinical outcomes to programmed death ligand 1 [PD-(L)1] blockade in non-small cell lung cancer (NSCLC) is unknown.
    Experimental design: Tumors from patients treated with PD-(L)1 inhibitors were analyzed using targeted next-generation sequencing (NGS). Cancers were categorized on the basis of the presence or absence of deleterious mutations across a panel of 53 DDR genes. Clinical outcomes to PD-(L)1 inhibitors were evaluated according to DDR mutation status.
    Results: Of 266 patients with successful NGS who received PD-(L)1 inhibitors, 132 (49.6%) were identified as having deleterious DDR mutations (DDR-positive). DDR-positive and DDR-negative groups were similar in terms of baseline clinicopathologic characteristics. The median TMB was significantly higher in the DDR-positive group compared with the DDR-negative group (12.1 vs. 7.6 mutations/megabase;
    Conclusions: Deleterious DDR mutations are frequent in NSCLC and are associated with improved clinical outcomes in patients with NSCLC treated with PD-(L)1 blockade.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; DNA Damage ; DNA Mutational Analysis ; DNA Repair ; Drug Resistance, Neoplasm/genetics ; Female ; Follow-Up Studies ; High-Throughput Nucleotide Sequencing ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Mutation ; Progression-Free Survival ; Retrospective Studies
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: L-Tryptophan As Treatment for Pediatric Non-Rapid Eye Movement Parasomnia.

    van Zyl, Louis T / Chung, Sharon A / Shahid, Azmeh / Shapiro, Colin M

    Journal of child and adolescent psychopharmacology

    2018  Volume 28, Issue 6, Page(s) 395–401

    Abstract: ... for parasomnias. The aim of this study was to (1) report on the outcome of using L-tryptophan to manage ... patients were either prescribed L-tryptophan (daily dose range: 500-4500 mg, mean dose of 2400 mg ... parasomnia. A significantly (p < 0.001) higher proportion (84%) of children taking L-tryptophan experienced ...

    Abstract Objective: Parasomnias are common in childhood but there is no established treatment for parasomnias. The aim of this study was to (1) report on the outcome of using L-tryptophan to manage parasomnias in children and (2) examine sleep architecture and subjective psychological/sleep symptoms in children with parasomnia.
    Method: A retrospective analysis was conducted of charts of children (3-18 years old) who underwent polysomnographic testing and were diagnosed with primary parasomnia. Study patients were either prescribed L-tryptophan (daily dose range: 500-4500 mg, mean dose of 2400 mg) to manage their parasomnias or administered no treatment whereby parents/guardians declined treatment. Questionnaires assessing sleep and psychosocial symptoms were administered at the initial clinical consultation and a follow-up parasomnia outcome questionnaire was administered over the phone to parents/guardians.
    Results: One hundred and sixty-five children (106 boys, 59 girls) received a sleep diagnosis of primary parasomnia. A significantly (p < 0.001) higher proportion (84%) of children taking L-tryptophan experienced improvements in their parasomnia symptoms compared with those (47%) who chose not to use L-tryptophan. Polysomnography revealed that children with parasomnias had an altered sleep architecture based on age-related normative values. Children with a diagnosis of parasomnia were also subjectively more fatigued and endorsed more depressive symptoms.
    Conclusions: This study finds that parasomnias in children are not benign and that treatment with L-tryptophan provides a favorable outcome. Children diagnosed with parasomnia had altered sleep architecture, were more fatigued, and endorsed depressive symptoms. This study supports the need to diagnose and treat parasomnias in children.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Male ; Parasomnias/drug therapy ; Polysomnography ; Retrospective Studies ; Sleep/physiology ; Sleep Stages/physiology ; Surveys and Questionnaires ; Tryptophan/administration & dosage
    Chemical Substances Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2018-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2017.0164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Detecting bird movements with L‐band avian radar and S‐band dual‐polarization Doppler weather radar

    Sidney A. Gauthreaux Jr / Ann‐Marie Shapiro / Dave Mayer / Barry L. Clark / Edwin E. Herricks

    Remote Sensing in Ecology and Conservation, Vol 5, Iss 3, Pp 237-

    2019  Volume 246

    Abstract: ... discrimination of echoes from birds difficult. We compare the density of bird tracks recorded by an L‐band (ca ...

    Abstract Abstract Marine surveillance radars with X‐band (3‐cm) and S‐band (10‐cm) wavelengths not only detect birds but also record return from insects, rain, ground objects and rough seas that often make discrimination of echoes from birds difficult. We compare the density of bird tracks recorded by an L‐band (ca. 23‐cm wavelength) avian radar at the Dallas/Fort Worth International Airport that does not detect insects and rain with the amount of mean bird reflectivity in resolution cells of a dual‐polarization S‐band Doppler weather surveillance radar. Radar data files of 1.5° scans gathered near midnight from January through May for the years 2014, 2015 and 2016 were processed by filtering radar resolution cells to retain only those with backscatter differential phase values characteristic of birds flying more or less perpendicular to the radar beam. In general, increases and decreases in the density of bird movements were correlated significantly between the two radars, but the low R2 values confirm that results obtained from one radar cannot be used to make quantitative estimates for the other. A decrease in the mean biomass index of migrating birds from January through May, and the difference in coverage volume and resolution between the two radars likely account for the low R2 values. Each type of radar has advantages and provides important information on bird movements at different spatial scales.
    Keywords Bird migration ; body size ; L‐band radar ; S‐ band radar ; seasonal change ; Technology ; T ; Ecology ; QH540-549.5
    Subject code 333 ; 910
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Growth phase-specific evaporative demand and nighttime temperatures determine Maize (Zea Mays L.) yield deviations as revealed from a long-term field experiment

    Singh, Arshdeep / Kukal, Meetpal S. / Shapiro, Charles A. / Snow, Daniel D. / Irmak, Suat / Iqbal, Javed

    Agricultural and forest meteorology. 2021 Oct. 15, v. 308-309

    2021  

    Abstract: ... on rainfed maize (Zea Mays L.) yield in the western Corn Belt, at seasonal and sub-seasonal scales ...

    Abstract Weather impacts on crop productivity have emerged as a significant research area, and agroecosystems globally have been evaluated for these impacts. However, only a limited body of research relies on experimental determination of field-scale impacts, relative to coarser-scale estimations. Experimental frameworks can control confounding factors that potentially undesirably affect coarser-scale assessments. Here, we employ a long-term (31-year) experimental trial to investigate weather-related signatures on rainfed maize (Zea Mays L.) yield in the western Corn Belt, at seasonal and sub-seasonal scales. Among all the weather indices evaluated [(maximum, minimum, and average air temperatures (Tₘₐₓ, Tₘᵢₙ, Tₐᵥg), precipitation (Pcp), incoming shortwave radiation (Rₛ), wind speed (u₂), relative humidity (RH), vapor pressure deficit (VPD), alfalfa-reference evapotranspiration (ETᵣ), and aridity index (AI)], ETᵣ accounted for the most (⁓50%) yield variance, followed by Tₐᵥg, Tₘₐₓ, VPD, Rₛ, Tₘᵢₙ, Pcp, u₂, RH, and AI. Weather indices most effectively accounted for yield variance during the late reproductive (R) phase, followed by early R phase, late vegetative (V) phase and lastly, early V phase. While seasonal ETᵣ was responsible for highest yield sensitivity (-0.69 s.d. s.d.⁻¹), sub-seasonal weather indices were also identified for highest yield sensitivity (u₂, Tₐᵥg, ETᵣ, Tₘₐₓ during early V, late V, early R, and late R, respectively). Among all possible combinations, a multiple linear regression model consisting of ETᵣ and Tₘᵢₙ best predicted yield deviations (R²=0.64) at the seasonal scale, while a sub seasonal model consisting of early V ETᵣ, early R ETᵣ, and late R Tₘᵢₙ performed the best (R²=0.66). Both models were validated for five independent counties to predict USDA estimates of rainfed maize yield deviations. Recent advances in mechanistic understanding of nighttime warming (increasing Tₘᵢₙ) and evaporative demand impacts on crop performance concur with our experimental inference of importance of ETᵣ and Tₘᵢₙ for rainfed maize yields.
    Keywords USDA ; Zea mays ; agroecosystems ; air ; corn ; dry environmental conditions ; evaporative demand ; evapotranspiration ; field experimentation ; forests ; meteorology ; regression analysis ; relative humidity ; shortwave radiation ; vapor pressure deficit ; variance ; wind speed ; Corn Belt region
    Language English
    Dates of publication 2021-1015
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 409905-9
    ISSN 0168-1923
    ISSN 0168-1923
    DOI 10.1016/j.agrformet.2021.108543
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Aggression in Psychodynamic Psychotherapy and Supervision: Becoming a More Effective Therapist.

    Shapiro, Elizabeth L

    Psychodynamic psychiatry

    2024  Volume 52, Issue 1, Page(s) 96–113

    Abstract: Access to one's healthy aggression is critical for both patient and therapist. On the patient's end, the ability to access and modulate aggression is fundamental to the establishment of healthy self-esteem and the capacity to sustain relationships and ... ...

    Abstract Access to one's healthy aggression is critical for both patient and therapist. On the patient's end, the ability to access and modulate aggression is fundamental to the establishment of healthy self-esteem and the capacity to sustain relationships and pursue life goals. On the therapist's end, access to aggression allows for the setting of a secure therapeutic frame and the subsequent conduct of the deep work of therapy. Conversely, lack of access to aggression creates burdensome and problematic situations that may subvert the treatment. Beginning therapists have a particular susceptibility to minimize their own aggression given certain factors in their choice of profession. Supervisors' modeling of the experience of aggression, as well as the provision of a safe atmosphere in which new clinicians become comfortably aware of their own and their patients' aggression, will help fortify beginning therapists' capacity to harness their aggression in the service of the work.
    MeSH term(s) Humans ; Psychotherapy, Psychodynamic ; Aggression ; Professional-Patient Relations ; Psychotherapy
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2633567-0
    ISSN 2162-2604 ; 2162-2590
    ISSN (online) 2162-2604
    ISSN 2162-2590
    DOI 10.1521/pdps.2024.52.1.96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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