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  1. Article ; Online: Pulmonary embolism in an adolescent with COVID-19 pneumonia.

    Nuñez-Paucar, Héctor / Coll-Vela, Liz E De / Peña-Coello, Claudia / Guillen-Buleje, Deli / Atamari-Anahui, Noé / Gomez-Martinez, Luis / Huby-Muñoz, Cynthia L / Zamudio-Aquise, Mariela K / Bernal-Mancilla, Raúl R

    Boletin medico del Hospital Infantil de Mexico

    2023  Volume 80, Issue Supl 1, Page(s) 33–39

    Abstract: ... distress, and marked elevation of D-dimer. Pulmonary CT angiography found an extensive thrombus ...

    Title translation Tromboembolismo pulmonar en un adolescente con neumonía COVID-19.
    Abstract Background: Pulmonary embolism (PE) is a complication reported in the adult population with coronavirus disease 2019 (COVID-19); however, its documentation in the pediatric population is limiteda.
    Case report: We report the case of a 15-year-old male with obesity and Down syndrome who was admitted for severe COVID-19 pneumonia. On day 7 of admission, he presented with chest pain, hemoptysis, respiratory distress, and marked elevation of D-dimer. Pulmonary CT angiography found an extensive thrombus in the right lower lobar artery. He received treatment with enoxaparin and rivaroxaban and had a favorable clinical outcome. In the tomographic control 1 month after treatment, thrombus was not evidenced and was successfully resolved.
    Conclusions: There are few reports of PE in children with COVID-19. Prompt diagnosis and early anticoagulant treatment are important to avoid life-threatening complications.
    MeSH term(s) Child ; Male ; Adult ; Humans ; Adolescent ; COVID-19/complications ; SARS-CoV-2 ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; Lung/diagnostic imaging ; Pulmonary Artery ; Thrombosis
    Language English
    Publishing date 2023-07-25
    Publishing country Mexico
    Document type Case Reports ; Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.22000076
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  2. Article ; Online: A 3-

    Vidaurre, Maria Del Pilar Huby / Osborn, Baron K / Lowak, Kaylie D / McDonald, Michelle M / Wang, Yao-Wei W / Pa, Veda / Richter, Jillian R / Xu, Yongmei / Arnold, Katelyn / Liu, Jian / Cardenas, Jessica C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1158457

    Abstract: Introduction: Dysregulated inflammation and coagulation are underlying mechanisms driving organ injury after trauma and hemorrhagic shock. Heparan sulfates, cell surface glycosaminoglycans abundantly expressed on the endothelial surface, regulate a ... ...

    Abstract Introduction: Dysregulated inflammation and coagulation are underlying mechanisms driving organ injury after trauma and hemorrhagic shock. Heparan sulfates, cell surface glycosaminoglycans abundantly expressed on the endothelial surface, regulate a variety of cellular processes. Endothelial heparan sulfate containing a rare 3-
    Methods: Male Sprague-Dawley rats were pre-treated subcutaneously with vehicle (saline) or dekaparin (2 mg/kg) and subjected to a trauma/hemorrhagic shock model through laparotomy, gut distention, and fixed-pressure hemorrhage. Vehicle and dekaparin-treated rats were resuscitated with Lactated Ringer's solution (LR) and compared to vehicle-treated fresh-frozen-plasma-(FFP)-resuscitated rats. Serial blood samples were collected at baseline, after induction of shock, and 3 hours after fluid resuscitation to measure hemodynamic and metabolic shock indicators, inflammatory mediators, and thrombin-antithrombin complex formation. Lungs and kidneys were processed for organ injury scoring and immunohistochemical analysis to quantify presence of neutrophils.
    Results: Induction of trauma and hemorrhagic shock resulted in significant increases in thrombin-antithrombin complex, inflammatory markers, and lung and kidney injury scores. Compared to vehicle, dekaparin treatment did not affect induction, severity, or recovery of shock as indicated by hemodynamics, metabolic indicators of shock (lactate and base excess), or metrics of bleeding, including overall blood loss, resuscitation volume, or hematocrit. While LR-vehicle-resuscitated rodents exhibited increased lung and kidney injury, administration of dekaparin significantly reduced organ injury scores and was similar to organ protection conferred by FFP resuscitation. This was associated with a significant reduction in neutrophil infiltration in lungs and kidneys and reduced lung fibrin deposition among dekaparin-treated rats compared to vehicle. No differences in organ injury, neutrophil infiltrates, or fibrin staining between dekaparin and FFP groups were observed. Finally, dekaparin treatment attenuated induction of thrombin-antithrombin complex and inflammatory mediators in plasma following trauma and hemorrhagic shock.
    Conclusion: Anti-thromboinflammatory properties of a synthetic 3-
    MeSH term(s) Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Shock, Hemorrhagic/complications ; Shock, Hemorrhagic/drug therapy ; Thromboinflammation ; Inflammation/drug therapy ; Inflammation/complications ; Sulfates/therapeutic use ; Thrombosis/complications ; Heparitin Sulfate ; Fibrin
    Chemical Substances Sulfates ; Heparitin Sulfate (9050-30-0) ; Fibrin (9001-31-4)
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1158457
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  3. Article ; Online: The incidence of sexually dimorphic gene expression varies greatly between tissues in the rat.

    Huby, Russell D J / Glaves, Philip / Jackson, Richard

    PloS one

    2014  Volume 9, Issue 12, Page(s) e115792

    Abstract: The sexually dimorphic expression of genes across 26 somatic rat tissues was using Affymetrix RAE-230 genechips. We considered probesets to be sexually dimorphically expressed (SDE) if they were measurably expressed above background in at least one sex, ... ...

    Abstract The sexually dimorphic expression of genes across 26 somatic rat tissues was using Affymetrix RAE-230 genechips. We considered probesets to be sexually dimorphically expressed (SDE) if they were measurably expressed above background in at least one sex, there was at least a two-fold difference in expression (dimorphism) between the sexes, and the differences were statistically significant after correcting for false discovery. 14.5% of expressed probesets were SDE in at least one tissue, with higher expression nearly twice as prevalent in males compared to females. Most were SDE in a single tissue. Surprisingly, nearly half of the probesets that were (SDE) in multiple tissues were oppositely sex biased in different tissues, and most SDE probesets were also expressed without sex bias in other tissues. Two genes were widely SDE: Xist (female-only) and Eif2s3y (male-only). The frequency of SDE probesets varied widely between tissues, and was highest in the duodenum (6.2%), whilst less than 0.05% in over half of the surveyed tissues. The occurrence of SDE probesets was not strongly correlated between tissues. Within individual tissues, however, relational networks of SDE genes were identified. In the liver, networks relating to differential metabolism between the sexes were seen. The estrogen receptor was implicated in differential gene expression in the duodenum. To conclude, sexually dimorphic gene expression is common, but highly tissue-dependent. Sexually dimorphic gene expression may provide insights into mechanisms underlying phenotypic sex differences. Online data are provided as a resource for further analyses (GEO reference GSE63362).
    MeSH term(s) Animals ; Duodenum/metabolism ; Epididymis/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Liver/metabolism ; Male ; Ovary/metabolism ; Rats ; Rats, Wistar ; Sex Characteristics ; Testis/metabolism ; Uterus/metabolism
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0115792
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  4. Article ; Online: Características clínicas, de laboratorio y radiológicas de pacientes pediátricos hospitalizados con COVID-19: serie de casos.

    Nuñez-Paucar, Héctor / Candela-Herrera, Jorge L / Aranda-Paniora, Franklin / Huby-Muñoz, Cynthia L / Coll-Vela, Liz E De / Bernal-Mancilla, Raúl R / Zamudio-Aquise, Mariela K / Schult-Montoya, Sandra C

    Revista peruana de medicina experimental y salud publica

    2021  Volume 37, Issue 4, Page(s) 767–772

    Abstract: ... lactate dehydrogenase, D-dimer, and ferritin. The most frequent radiological pattern was perihilar peribronchial ...

    Title translation Clinical, laboratory and radiological characteristics of pediatric patients hospitalized with COVID-19: case series.
    Abstract Children represent 1 to 5% of the entire SARS-CoV-2 infected population, and it is challenging to identify them based on clinical characteristics. We present 5 cases of pediatric patients diagnosed with COVID-19; the age range was from 1 to 14 years. They had different clinical characteristics, three of them presented fever, cough and respiratory distress, another one fever and dermatosis, and the other patient had diarrhea and vomiting associated with Guillain-Barre syndrome. Laboratory tests revealed elevated lactate dehydrogenase, D-dimer, and ferritin. The most frequent radiological pattern was perihilar peribronchial thickening. All cases had favorable clinical and radiological evolution. Diverse clinical characteristics should be considered for early diagnosis of COVID-19 in children.
    MeSH term(s) Adolescent ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19 Testing ; Child, Preschool ; Cough ; Female ; Fever/etiology ; Hospitalization ; Humans ; Infant ; Male
    Language Spanish
    Publishing date 2021-02-03
    Publishing country Peru
    Document type Case Reports
    ZDB-ID 2120092-0
    ISSN 1726-4642 ; 1726-4634
    ISSN (online) 1726-4642
    ISSN 1726-4634
    DOI 10.17843/rpmesp.2020.374.5926
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  5. Article: Gene expression profiling for pharmaceutical safety assessment.

    Huby, Russell / Tugwood, Jonathan D

    Expert opinion on drug metabolism & toxicology

    2006  Volume 1, Issue 2, Page(s) 247–260

    Abstract: Toxicogenomics is the application of gene expression profiling technology to toxicology. This results in the generation of very large and complex gene expression data sets associated with the development of toxicities. It is widely assumed that this data ...

    Abstract Toxicogenomics is the application of gene expression profiling technology to toxicology. This results in the generation of very large and complex gene expression data sets associated with the development of toxicities. It is widely assumed that this data can be deconvoluted to reveal novel insights into toxicological processes that are of value to the task of risk assessment. More specifically, it is hoped that toxicogenomics will aid in the prediction of the toxic potential and mechanisms of toxicity of novel chemical entities. On the basis of such promise, the pharmaceutical industry has invested heavily in this area, as the perceived rewards in terms of improved pipeline efficiency and safer drugs are immense. Consequently, a great deal of groundwork has been done over the past several years to establish working methods in toxicogenomics, both within industry and academia, demonstrating utility in proof-of-concept studies, generating the databases on which some approaches depend, and developing new data analysis tools. Despite such activity, there is little reported evidence to suggest that toxicogenomics is making a significant impact on the discovery and development of drugs. This may partly reflect the understandable reluctance of pharmaceutical industries to share information in a competitive environment. It may also partly reflect difficulties in bridging the gap between theory and practice, as is required to deliver real value to the industry. This review will assess the successes and shortcomings of toxicogenomics, and consider how it can be usefully applied to a drug discovery pipeline.
    MeSH term(s) Animals ; Drug Design ; Drug Evaluation, Preclinical/methods ; Gene Expression Profiling/methods ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Technology, Pharmaceutical/economics ; Technology, Pharmaceutical/methods ; Technology, Pharmaceutical/standards
    Language English
    Publishing date 2006-07-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1742-5255
    ISSN 1742-5255
    DOI 10.1517/17425255.1.2.247
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  6. Article ; Online: Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study.

    Girerd, Nicolas / Levy, Daniel / Duarte, Kevin / Ferreira, Joao Pedro / Ballantyne, Christie / Collier, Timothy / Pizard, Anne / Björkman, Jens / Butler, Javed / Clark, Andrew / Cleland, John G / Delles, Christian / Diez, Javier / González, Arantxa / Hazebroek, Mark / Ho, Jennifer / Huby, Anne-Cécile / Hwang, Shih-Jen / Latini, Roberto /
    Mariottoni, Beatrice / Mebazaa, Alexandre / Pellicori, Pierpaolo / Sattar, Naveed / Sever, Peter / Staessen, Jan A / Verdonschot, Job / Heymans, Stephane / Rossignol, Patrick / Zannad, Faiez

    Circulation. Heart failure

    2023  Volume 16, Issue 5, Page(s) e009694

    Abstract: Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and assess if and ... ...

    Abstract Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and assess if and to what extent they improve HF risk prediction compared to clinical risk factors alone.
    Methods: A nested case-control design was used with cases (incident HF) and controls (without HF) matched on age and sex within each cohort. Plasma concentrations of 276 proteins were measured at baseline in ARIC (250 cases/250 controls), FHS (191/191), and HOMAGE cohort (562/871).
    Results: In single protein analysis, after adjusting for matching variables and clinical risk factors (and correcting for multiple testing), 62 proteins were associated with incident HF in ARIC, 16 in FHS, and 116 in HOMAGE cohort. Proteins associated with incident HF in all cohorts were BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-B-type natriuretic peptide), eukaryotic translation initiation factor 4E-BP1 (4E-binding protein 1), hepatocyte growth factor (HGF), Gal-9 (galectin-9), TGF-alpha (transforming growth factor alpha), THBS2 (thrombospondin-2), and U-PAR (urokinase plasminogen activator surface receptor). The increment in
    Conclusions: A multiprotein biomarker approach improves prediction of incident HF when added to natriuretic peptides and clinical risk factors.
    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Biomarkers ; Longitudinal Studies ; Risk Factors ; Aging ; Atherosclerosis/diagnosis ; Atherosclerosis/epidemiology ; Natriuretic Peptide, Brain ; Peptide Fragments
    Chemical Substances Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.122.009694
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  7. Article ; Online: The incidence of sexually dimorphic gene expression varies greatly between tissues in the rat.

    Russell D J Huby / Philip Glaves / Richard Jackson

    PLoS ONE, Vol 9, Iss 12, p e

    2014  Volume 115792

    Abstract: The sexually dimorphic expression of genes across 26 somatic rat tissues was using Affymetrix RAE-230 genechips. We considered probesets to be sexually dimorphically expressed (SDE) if they were measurably expressed above background in at least one sex, ... ...

    Abstract The sexually dimorphic expression of genes across 26 somatic rat tissues was using Affymetrix RAE-230 genechips. We considered probesets to be sexually dimorphically expressed (SDE) if they were measurably expressed above background in at least one sex, there was at least a two-fold difference in expression (dimorphism) between the sexes, and the differences were statistically significant after correcting for false discovery. 14.5% of expressed probesets were SDE in at least one tissue, with higher expression nearly twice as prevalent in males compared to females. Most were SDE in a single tissue. Surprisingly, nearly half of the probesets that were (SDE) in multiple tissues were oppositely sex biased in different tissues, and most SDE probesets were also expressed without sex bias in other tissues. Two genes were widely SDE: Xist (female-only) and Eif2s3y (male-only). The frequency of SDE probesets varied widely between tissues, and was highest in the duodenum (6.2%), whilst less than 0.05% in over half of the surveyed tissues. The occurrence of SDE probesets was not strongly correlated between tissues. Within individual tissues, however, relational networks of SDE genes were identified. In the liver, networks relating to differential metabolism between the sexes were seen. The estrogen receptor was implicated in differential gene expression in the duodenum. To conclude, sexually dimorphic gene expression is common, but highly tissue-dependent. Sexually dimorphic gene expression may provide insights into mechanisms underlying phenotypic sex differences. Online data are provided as a resource for further analyses (GEO reference GSE63362).
    Keywords Medicine ; R ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  8. Article ; Online: Parenting support for families with young children - a public health, user-focused study undertaken in a semi-rural area of Scotland.

    Hogg, Rhona / Ritchie, Deborah / de Kok, Bregje / Wood, Cathy / Huby, Guro

    Journal of clinical nursing

    2013  Volume 22, Issue 7-8, Page(s) 1140–1150

    Abstract: Aims and objectives: To work with parents and public health nurses (health visitors), to identify and design a range of public health interventions to provide support to parents of young children.: Background: In the UK, only vulnerable families are ... ...

    Abstract Aims and objectives: To work with parents and public health nurses (health visitors), to identify and design a range of public health interventions to provide support to parents of young children.
    Background: In the UK, only vulnerable families are now eligible for pro-active health visiting interventions on an individual family basis beyond the early days. Public health approaches are recommended for the majority of families who are not eligible for one-to-one professional support.
    Design: Focus groups were carried out with parents of young children, health visitors and other professionals working with them.
    Methods: The study was carried out in a semi-rural area of Scotland, consisting of a small town, and the surrounding rural area, including one area of deprivation. The area is served by a team consisting of six health visitors and one health assistant, based in two health centres in the area. Nineteen parents, five members of the health visiting team and 11 other professionals from health, education and social work took part via an invitation to contact the research team.
    Results: The needs of parents identified by both parents and professionals could best be met by social support, with skilled facilitation and suitable resources. The resolution of tensions between caseload-based and population-based health visiting, as well as the management of the tensions inherent in these changes, seems to be vital in order to implement these approaches. Many parents would like information made available online.
    Conclusions: Services to support families with young children need to be designed from the perspectives of parents and their needs.
    Relevance to clinical practice: Services need to be set up in partnership with parents to provide them with information and access to peer and professional support, using public health approaches. Multiagency working, including among senior managers, may be the most effective way of providing this support.
    MeSH term(s) Child ; Child, Preschool ; Female ; Focus Groups ; House Calls ; Humans ; Male ; Parenting ; Public Health Practice ; Rural Population ; Scotland
    Language English
    Publishing date 2013-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1159483-4
    ISSN 1365-2702 ; 0962-1067 ; 1752-9816
    ISSN (online) 1365-2702
    ISSN 0962-1067 ; 1752-9816
    DOI 10.1111/jocn.12185
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  9. Article ; Online: Author Correction: Imaging low-mass planets within the habitable zone of α Centauri.

    Wagner, K / Boehle, A / Pathak, P / Kasper, M / Arsenault, R / Jakob, G / Käufl, U / Leveratto, S / Maire, A-L / Pantin, E / Siebenmorgen, R / Zins, G / Absil, O / Ageorges, N / Apai, D / Carlotti, A / Choquet, É / Delacroix, C / Dohlen, K /
    Duhoux, P / Forsberg, P / Fuenteseca, E / Gutruf, S / Guyon, O / Huby, E / Kampf, D / Karlsson, M / Kervella, P / Kirchbauer, J-P / Klupar, P / Kolb, J / Mawet, D / N'Diaye, M / de Xivry, G Orban / Quanz, S P / Reutlinger, A / Ruane, G / Riquelme, M / Soenke, C / Sterzik, M / Vigan, A / de Zeeuw, T

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2651

    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23145-5
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  10. Article ; Online: Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.

    Jacobsen, Mette J / Mentzel, Caroline M Junker / Olesen, Ann Sofie / Huby, Thierry / Jørgensen, Claus B / Barrès, Romain / Fredholm, Merete / Simar, David

    Journal of diabetes research

    2015  Volume 2016, Page(s) 8539057

    Abstract: Obesity is associated with immunological perturbations that contribute to insulin resistance. Epigenetic mechanisms can control immune functions and have been linked to metabolic complications, although their contribution to insulin resistance still ... ...

    Abstract Obesity is associated with immunological perturbations that contribute to insulin resistance. Epigenetic mechanisms can control immune functions and have been linked to metabolic complications, although their contribution to insulin resistance still remains unclear. In this study, we investigated the link between metabolic dysfunction and immune alterations with the epigenetic signature in leukocytes in a porcine model of obesity. Global DNA methylation of circulating leukocytes, adipose tissue leukocyte trafficking, and macrophage polarisation were established by flow cytometry. Adipose tissue inflammation and metabolic function were further characterised by quantification of metabolites and expression levels of genes associated with obesity and inflammation. Here we show that obese pigs showed bigger visceral fat pads, higher levels of circulating LDL cholesterol, and impaired glucose tolerance. These changes coincided with impaired metabolism, sustained macrophages infiltration, and increased inflammation in the adipose tissue. Those immune alterations were linked to global DNA hypermethylation in both B-cells and T-cells. Our results provide novel insight into the possible contribution of immune cell epigenetics into the immunological disturbances observed in obesity. The dramatic changes in the transcriptomic and epigenetic signature of circulating lymphocytes reinforce the concept that epigenetic processes participate in the increased immune cell activation and impaired metabolic functions in obesity.
    MeSH term(s) Adiposity ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Chemotaxis, Leukocyte ; DNA Methylation ; Disease Models, Animal ; Epigenesis, Genetic ; Female ; Flow Cytometry ; Gene Expression Profiling ; Gene Expression Regulation ; Inflammation Mediators/blood ; Intra-Abdominal Fat/immunology ; Intra-Abdominal Fat/metabolism ; Lipids/blood ; Male ; Obesity/blood ; Obesity/genetics ; Obesity/immunology ; Panniculitis/blood ; Panniculitis/genetics ; Panniculitis/immunology ; Swine ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Time Factors
    Chemical Substances Inflammation Mediators ; Lipids
    Language English
    Publishing date 2015-12-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6745
    ISSN (online) 2314-6753
    ISSN 2314-6745
    DOI 10.1155/2016/8539057
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