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  1. Article: Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).

    Müllbacher, A / Blanden, R V

    Immunogenetics

    2011  Volume 7, Issue 1, Page(s) 551–561

    Abstract: A secondary in vitro response to alphaviruses Bebaru, Sindbis, and Semliki Forest is described. Optimum response appears at day 5-6 of culture. The cells responsible for lytic activity are nonadherent, Φ-positive, Ig(-), and mainly Ly-2.1 positive. Out ... ...

    Abstract A secondary in vitro response to alphaviruses Bebaru, Sindbis, and Semliki Forest is described. Optimum response appears at day 5-6 of culture. The cells responsible for lytic activity are nonadherent, Φ-positive, Ig(-), and mainly Ly-2.1 positive. Out of five haplotypes tested (H- 2 ( d ),H- 2 ( b ),H- 2 ( s ),H- 2 ( q ), andH- 2 ( k )) onlyH- 2 ( k ) was a responder. Genetic mapping of the response located it solely in theD region of theH- 2 complex. The other four haplotypes responded with a high antiself activity after a second stimulation with viruses. This antiself response also maps in theD region of theH- 2 complex. No complementation was observed in F(1) hybrids between responder and nonresponder strains.
    Language English
    Publishing date 2011-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 186560-2
    ISSN 1432-1211 ; 0093-7711
    ISSN (online) 1432-1211
    ISSN 0093-7711
    DOI 10.1007/BF01844044
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  2. Article: Why do class I MHC molecules bind smaller peptides than class II MHC molecules?

    Blanden, R V

    Immunology and cell biology

    1995  Volume 73, Issue 1, Page(s) 95–97

    Abstract: This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding ...

    Abstract This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-self discrimination. I propose that the small size of most class I-binding peptides precludes the production of 'MHC-restricted' antibodies. Such a strategy avoids the possibility of antibodies binding to the epitopes recognized by CD8+ T cells, thus blocking effector function required for clearance of potentially lethal infections.
    MeSH term(s) Animals ; Histocompatibility Antigens Class I/metabolism ; Histocompatibility Antigens Class II/metabolism ; Peptides/chemistry ; Peptides/immunology ; Protein Binding/immunology
    Chemical Substances Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Peptides
    Language English
    Publishing date 1995-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.1995.15
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  3. Article: T-cell-mediated control of poxvirus infection in mice.

    Müllbacher, A / Blanden, R V

    Progress in molecular and subcellular biology

    2004  Volume 36, Page(s) 39–55

    MeSH term(s) Animals ; Apoptosis/immunology ; Apoptosis/physiology ; Cytokines/immunology ; Cytotoxicity, Immunologic ; Enzyme Inhibitors/metabolism ; Exocytosis/physiology ; Humans ; Mice ; Poxviridae Infections/immunology ; Poxviridae Infections/metabolism ; Serine Endopeptidases/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; fas Receptor/metabolism
    Chemical Substances Cytokines ; Enzyme Inhibitors ; fas Receptor ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2004-05-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0079-6484
    ISSN 0079-6484
    DOI 10.1007/978-3-540-74264-7_3
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  4. Article: The reverse transcriptase model of somatic hypermutation.

    Steele, E J / Blanden, R V

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2001  Volume 356, Issue 1405, Page(s) 61–66

    Abstract: The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human ... ...

    Abstract The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.
    MeSH term(s) Animals ; DNA-Binding Proteins/genetics ; Humans ; Immunoglobulin Variable Region/genetics ; Models, Genetic ; Mutation ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-6 ; RNA-Directed DNA Polymerase/physiology ; Recombination, Genetic ; Transcription Factors/genetics
    Chemical Substances DNA-Binding Proteins ; Immunoglobulin Variable Region ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-6 ; Transcription Factors ; RNA-Directed DNA Polymerase (EC 2.7.7.49)
    Language English
    Publishing date 2001-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0962-8436 ; 0080-4622 ; 0264-3839
    ISSN (online) 1471-2970
    ISSN 0962-8436 ; 0080-4622 ; 0264-3839
    DOI 10.1098/rstb.2000.0749
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    Einzelsignatur: Show issues

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  5. Article: Lamarck and antibody genes.

    Steele, E J / Blanden, R V

    Science (New York, N.Y.)

    2000  Volume 288, Issue 5475, Page(s) 2318d–9d

    Language English
    Publishing date 2000-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.288.5475.2318d
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  6. Article: Possible factors contributing to persistence of cytomegalovirus infection.

    Blanden, R V

    Advances in experimental medicine and biology

    1989  Volume 257, Page(s) 27–36

    MeSH term(s) Animals ; Chronic Disease ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/immunology ; Immunity, Cellular/physiology ; Killer Cells, Natural/immunology ; Ligands ; Mice ; T-Lymphocytes, Cytotoxic/immunology
    Chemical Substances Ligands
    Language English
    Publishing date 1989
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4684-5712-4_5
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  7. Article: Misinterpretation of DNA sequence data generated by polymerase chain reactions.

    Blanden, R V / Steele, E J

    Molecular immunology

    2000  Volume 37, Issue 6, Page(s) 329

    MeSH term(s) Animals ; Complementarity Determining Regions ; Gene Rearrangement, B-Lymphocyte ; Humans ; Mice ; Polymerase Chain Reaction ; Sequence Analysis, DNA/statistics & numerical data
    Chemical Substances Complementarity Determining Regions
    Language English
    Publishing date 2000-12-14
    Publishing country England
    Document type Letter
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/s0161-5890(00)00051-1
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  8. Article: Lamarck and antibody genes.

    Steele, E J / Blanden, R V

    Science (New York, N.Y.)

    2000  Volume 288, Issue 5475, Page(s) 2318–2319

    MeSH term(s) Animals ; Antibodies/genetics ; Biological Evolution ; Gene Expression Regulation ; Genes, Immunoglobulin ; Germ Cells ; Lymphocytes/immunology ; Mutation
    Chemical Substances Antibodies
    Language English
    Publishing date 2000-06-30
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.288.5475.2318d
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  9. Article: A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.

    Blanden, R V / Steele, E J

    Immunology and cell biology

    1998  Volume 76, Issue 3, Page(s) 288–293

    Abstract: We have reviewed available data concerning the mechanism of somatic hypermutation in rearranged variable genes of Ig in B lymphocytes of mice and the gene conversion process which generates diversity in these genes in the B lymphocytes of chickens. In ... ...

    Abstract We have reviewed available data concerning the mechanism of somatic hypermutation in rearranged variable genes of Ig in B lymphocytes of mice and the gene conversion process which generates diversity in these genes in the B lymphocytes of chickens. In our view, these data are consistent with a unifying hypothesis of diversity generating mechanisms involving reverse transcription to produce cDNA from RNA transcripts followed by homologous recombination into chromosomal DNA. Thus, seemingly different processes in the mouse and chicken may have a common molecular basis.
    MeSH term(s) Animals ; Gene Conversion/genetics ; Gene Rearrangement, B-Lymphocyte/genetics ; Immunoglobulin Variable Region/genetics ; Models, Biological ; Models, Chemical ; Mutation/genetics
    Chemical Substances Immunoglobulin Variable Region
    Language English
    Publishing date 1998-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1046/j.1440-1711.1998.00738.x
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  10. Article: Q. How can DNA patterns of somatically acquired immunity be imprinted on the germline of immunoglobulin variable (V) genes?

    Steele, E J / Hapel, A J / Blanden, R V

    IUBMB life

    2002  Volume 54, Issue 5, Page(s) 305–307

    MeSH term(s) Animals ; B-Lymphocytes/cytology ; Genomic Imprinting ; Germ Cells ; Humans ; Immunoglobulin Variable Region/genetics ; Immunoglobulins/genetics ; Immunologic Memory ; Models, Biological ; Recombination, Genetic
    Chemical Substances Immunoglobulin Variable Region ; Immunoglobulins
    Language English
    Publishing date 2002-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1080/15216540215680
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