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  1. Article ; Online: In vitro

    Garza, Samuel / Sottas, Chantal / Gukasyan, Hovhannes J / Papadopoulos, Vassilios

    Frontiers in toxicology

    2024  Volume 6, Page(s) 1357857

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2024.1357857
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  2. Article ; Online: Cops5 in Peritubular Myoid Cells Influences Reproductive Development and Hormone Production.

    Garza, Samuel / Papadopoulos, Vassilios

    Endocrinology

    2023  Volume 164, Issue 7

    MeSH term(s) Mice ; Animals ; Male ; Testis/cytology ; Seminiferous Tubules ; Hormones ; Myocytes, Smooth Muscle ; Homeostasis
    Chemical Substances Hormones
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lifelong cell-cell interactions in the testis: A driver for male fertility. Summary of the XXVth North American Testis Workshop.

    Papadopoulos, Vassilios

    Andrology

    2020  Volume 8, Issue 4, Page(s) 818–819

    MeSH term(s) Animals ; Cell Communication ; Fertility ; Humans ; Infertility, Male/metabolism ; Infertility, Male/physiopathology ; Male ; Testis
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Congress ; Editorial ; Introductory Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.12833
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    Zs.A 6983: Show issues Location:
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  4. Article ; Online: ATAD3A: A Key Regulator of Mitochondria-Associated Diseases.

    Chen, Liting / Li, Yuchang / Zambidis, Alexander / Papadopoulos, Vassilios

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number ... ...

    Abstract Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number of
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512511
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  5. Article ; Online: Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells.

    Galano, Melanie / Papadopoulos, Vassilios

    Endocrinology

    2022  Volume 163, Issue 8

    Abstract: The steroidogenic acute regulatory protein (STAR; STARD1) is critical for the transport of cholesterol into the mitochondria for hormone-induced steroidogenesis. Steroidogenic cells express STAR under control conditions (constitutive STAR). On hormonal ... ...

    Abstract The steroidogenic acute regulatory protein (STAR; STARD1) is critical for the transport of cholesterol into the mitochondria for hormone-induced steroidogenesis. Steroidogenic cells express STAR under control conditions (constitutive STAR). On hormonal stimulation, STAR localizes to the outer mitochondrial membrane (OMM) where it facilitates cholesterol transport and where it is processed to its mature form. Here, we show that knockout of Star in MA-10 mouse tumor Leydig cells (STARKO1) causes defects in mitochondrial structure and function under basal conditions. We also show that overexpression of Star in STARKO1 cells exacerbates, rather than recovers, mitochondrial structure and function, which further disrupts the processing of STAR at the OMM. Our findings suggest that constitutive STAR is necessary for proper mitochondrial structure and function and that mitochondrial dysfunction leads to defective STAR processing at the OMM.
    MeSH term(s) Animals ; Biological Transport ; Cholesterol/metabolism ; Leydig Cells/metabolism ; Male ; Mice ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Phosphoproteins/metabolism
    Chemical Substances Phosphoproteins ; steroidogenic acute regulatory protein ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac091
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  6. Article ; Online: Testosterone recovery therapy targeting dysfunctional Leydig cells.

    Garza, Samuel / Papadopoulos, Vassilios

    Andrology

    2022  Volume 11, Issue 5, Page(s) 816–825

    Abstract: Reduced serum testosterone affects millions of men across the world and has been linked to several comorbidities, metabolic dysfunctions, and quality of life changes. The standard treatment for testosterone deficiency remains testosterone replacement ... ...

    Abstract Reduced serum testosterone affects millions of men across the world and has been linked to several comorbidities, metabolic dysfunctions, and quality of life changes. The standard treatment for testosterone deficiency remains testosterone replacement therapy. However, limitations on its use and the risk of significant adverse effects make alternative therapeutics desirable. Studies on the mechanisms regulating and synthesizing testosterone formation in testicular Leydig cells demonstrate numerous endogenous targets that could increase testosterone biosynthesis, which could alleviate reduced testosterone effects. Testosterone biosynthesis is facilitated by a conglomerate of cytosolic and mitochondrial proteins that facilitate cholesterol translocation into the mitochondria, the rate-limiting step in steroidogenesis. An effective therapeutic approach would be required to increase endogenous testosterone formation by enhancing steroidogenesis in Leydig cells. Numerous ligands for steroidogenic proteins have been developed, which increase steroid hormone formation. However, off-target effects on neurosteroid and adrenal steroid formation may limit their clinical use. First-in-class biologics, such as voltage-dependent anion channel peptides and transplantation of induced human Leydig-like cells offer advances in the development of specific strategies that could be used to enhance endogenous steroid formation in hormone deficient patients.
    MeSH term(s) Male ; Humans ; Leydig Cells/metabolism ; Testosterone ; Quality of Life ; Testis/metabolism ; Cholesterol/metabolism
    Chemical Substances Testosterone (3XMK78S47O) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13304
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  7. Article: Translocator protein in the rise and fall of central nervous system neurons.

    Cheung, Garett / Lin, Yiqi Christina / Papadopoulos, Vassilios

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1210205

    Abstract: Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane, has historically been associated with the transport of cholesterol in highly steroidogenic tissues though it is found in all cells throughout the mammalian body. ... ...

    Abstract Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane, has historically been associated with the transport of cholesterol in highly steroidogenic tissues though it is found in all cells throughout the mammalian body. TSPO has also been associated with molecular transport, oxidative stress, apoptosis, and energy metabolism. TSPO levels are typically low in the central nervous system (CNS), but a significant upregulation is observed in activated microglia during neuroinflammation. However, there are also a few specific regions that have been reported to have higher TSPO levels than the rest of the brain under normal conditions. These include the dentate gyrus of the hippocampus, the olfactory bulb, the subventricular zone, the choroid plexus, and the cerebellum. These areas are also all associated with adult neurogenesis, yet there is no explanation of TSPO's function in these cells. Current studies have investigated the role of TSPO in microglia during neuron degeneration, but TSPO's role in the rest of the neuron lifecycle remains to be elucidated. This review aims to discuss the known functions of TSPO and its potential role in the lifecycle of neurons within the CNS.
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1210205
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  8. Article ; Online: The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases.

    Li, Yuchang / Chen, Liting / Papadopoulos, Vassilios

    Biochimie

    2023  

    Abstract: Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various ... ...

    Abstract Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various fundamental physiological functions and cellular processes. Its expression is altered in pathological conditions, thus rendering TSPO a potential tool for diagnostic imaging and an appealing therapeutic target. The investigation of synthetic TSPO ligands as both agonists and antagonists has provided valuable insights into the regulatory mechanisms and functional properties of TSPO. Recently, accumulating evidence has highlighted the significance of TSPO in liver diseases. However, a comprehensive summary of TSPO function in the normal liver and diverse liver diseases is lacking. This review aims to provide an overview of recent advances in understanding TSPO function in both normal liver cells and various liver diseases, with a particular emphasis on its involvement in liver fibrosis and inflammation and addresses the existing knowledge gaps in the field that require further investigation.
    Language English
    Publishing date 2023-12-06
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.11.013
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  9. Article: Editorial: Endocrine and paracrine regulation of spermatogenesis.

    Goldberg, Erwin / Lishko, Polina V / Papadopoulos, Vassilios / Zirkin, Barry

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 984409

    MeSH term(s) Humans ; Male ; Spermatogenesis/physiology ; Testis/physiology
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.984409
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  10. Article ; Online: Neurosteroidogenic enzymes: CYP11A1 in the central nervous system.

    Lin, Yiqi Christina / Papadopoulos, Vassilios

    Frontiers in neuroendocrinology

    2021  Volume 62, Page(s) 100925

    Abstract: Neurosteroids, steroid hormones synthesized locally in the nervous system, have important neuromodulatory and neuroprotective effects in the central nervous system. Progress in neurosteroid research has led to the successful translation of ... ...

    Abstract Neurosteroids, steroid hormones synthesized locally in the nervous system, have important neuromodulatory and neuroprotective effects in the central nervous system. Progress in neurosteroid research has led to the successful translation of allopregnanolone into an approved therapy for postpartum depression. However, there is insufficient evidence to support the assumption that steroidogenesis is exactly the same between the nervous system and the periphery. This review focuses on CYP11A1, the only enzyme currently known to catalyze the first reaction in steroidogenesis to produce pregnenolone, the precursor to all other steroids. Although CYP11A1 mRNA has been found in brain of many mammals, the presence of CYP11A1 protein has been difficult to detect, particularly in humans. Here, we highlight the discrepancies in the current evidence for CYP11A1 in the central nervous system and propose new directions for understanding neurosteroidogenesis, which will be crucial for developing neurosteroid-based therapies for the future.
    MeSH term(s) Animals ; Brain ; Central Nervous System ; Cholesterol Side-Chain Cleavage Enzyme ; Female ; Humans ; Pregnanolone ; Pregnenolone
    Chemical Substances Pregnenolone (73R90F7MQ8) ; Pregnanolone (BXO86P3XXW) ; Cholesterol Side-Chain Cleavage Enzyme (EC 1.14.15.6)
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 390985-2
    ISSN 1095-6808 ; 0532-7466 ; 0091-3022
    ISSN (online) 1095-6808
    ISSN 0532-7466 ; 0091-3022
    DOI 10.1016/j.yfrne.2021.100925
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