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  1. Article ; Online: Exaggerated responses to a virus long gone.

    Brodin, Petter

    Science (New York, N.Y.)

    2023  Volume 379, Issue 6632, Page(s) 538–539

    Abstract: Multisystem inflammatory syndrome in children is caused by abnormal cell activation. ...

    Abstract Multisystem inflammatory syndrome in children is caused by abnormal cell activation.
    MeSH term(s) Child ; Humans
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg2776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immune responses to SARS-CoV-2 infection and vaccination in children.

    Brodin, Petter

    Seminars in immunology

    2023  Volume 69, Page(s) 101794

    Abstract: During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time ...

    Abstract During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become clear that this is not universally true, as some children develop severe COVID-19 hypoxic pneumonia and even succumb to the infection, while another group of children develop a rare but serious multisystem inflammatory syndrome (MIS-C) and some other children experience prolonged illness following acute infection, post-COVID. Here I will discuss some of the findings made to explain these diverse disease manifestations in children and young people infected by SARS-CoV-2. I will also discuss the vaccines developed at record speed and their efficacy in protecting children from disease.
    MeSH term(s) Child ; Humans ; Adolescent ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Immunity
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 infections in children: Understanding diverse outcomes.

    Brodin, Petter

    Immunity

    2022  Volume 55, Issue 2, Page(s) 201–209

    Abstract: SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to ...

    Abstract SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.
    MeSH term(s) Adaptive Immunity ; Age Factors ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/virology ; Disease Susceptibility ; Energy Metabolism ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Patient Outcome Assessment ; SARS-CoV-2/physiology ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/etiology ; Trauma Severity Indices ; Virus Replication
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immune-microbe interactions early in life: A determinant of health and disease long term.

    Brodin, Petter

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6596, Page(s) 945–950

    Abstract: Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal tolerance, and the transfer of maternal antibodies. Less is known about postnatal adaptation to environmental exposures. The microbiome and its importance for health ...

    Abstract Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal tolerance, and the transfer of maternal antibodies. Less is known about postnatal adaptation to environmental exposures. The microbiome and its importance for health have been extensively studied, but it remains unclear how mutually beneficial relationships between commensal microbes and human cells first arise and are maintained throughout life. Such immune-microbe mutualism, and perturbations thereof, is most likely a root cause of increasing incidences of immune-mediated disorders such as allergies and autoimmunity across many industrialized nations during the past century. In this Review, I discuss our current understanding of immune development and propose that mismatches among ancestral, early-life, and adult environments can explain perturbations to immune-microbe interactions, immune dysregulation, and increased risks of immune-mediated diseases.
    MeSH term(s) Environmental Exposure ; Gastrointestinal Microbiome/immunology ; Health ; Host Microbial Interactions/immunology ; Humans ; Immune System Diseases/immunology ; Immune System Diseases/microbiology ; Infant, Newborn ; Symbiosis
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abk2189
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  5. Article ; Online: [No title information]

    Brodin, Petter

    Lakartidningen

    2021  Volume 118

    Title translation Viktigt att uppmärksamma MIS-A inom vuxensjukvården.
    MeSH term(s) Adult ; Delivery of Health Care ; Humans ; Quality of Health Care
    Language Swedish
    Publishing date 2021-05-17
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  6. Article ; Online: Immune system perturbations in patients with long COVID.

    Rodriguez, Lucie / Brodin, Petter

    Trends in molecular medicine

    2024  Volume 30, Issue 3, Page(s) 200–201

    Abstract: Klein et al. report multimodal analyses of immune cells, proteins, and physiological parameters in patients with long COVID (LC). At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to ...

    Abstract Klein et al. report multimodal analyses of immune cells, proteins, and physiological parameters in patients with long COVID (LC). At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to a general suppression of viral control mechanisms in LC.
    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; COVID-19 ; Immune System
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.12.008
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  7. Article ; Online: Immune determinants of COVID-19 disease presentation and severity.

    Brodin, Petter

    Nature medicine

    2021  Volume 27, Issue 1, Page(s) 28–33

    Abstract: COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most important determinant of disease severity ... ...

    Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most important determinant of disease severity is age, with individuals over 65 years having the greatest risk of requiring intensive care, and men are more susceptible than women. In contrast to other respiratory viral infections, young children seem to be less severely affected. It is now clear that mild to severe acute infection is not the only outcome of COVID-19, and long-lasting symptoms are also possible. In contrast to severe acute COVID-19, such 'long COVID' is seemingly more likely in women than in men. Also, postinfectious hyperinflammatory disease has been described as an additional outcome after SARS-CoV-2 infection. Here I discuss our current understanding of the immunological determinants of COVID-19 disease presentation and severity and relate this to known immune-system differences between young and old people and between men and women, and other factors associated with different disease presentations and severity.
    MeSH term(s) Adaptive Immunity ; Adult ; Age Factors ; Aged ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/immunology ; COVID-19/physiopathology ; Child ; Female ; Humans ; Immunity, Innate ; Immunologic Deficiency Syndromes/chemically induced ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/virology ; Male ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Severity of Illness Index ; Sex Factors ; Systemic Inflammatory Response Syndrome/etiology ; Virus Internalization
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-01202-8
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  8. Article ; Online: Why is COVID-19 so mild in children?

    Brodin, Petter

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 6, Page(s) 1082–1083

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Infant ; Pandemics ; Pediatricians ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country Norway
    Document type Editorial
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15271
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  9. Article ; Online: Technologies for assessing vaccine responses in the very young.

    Brodin, Petter

    Current opinion in immunology

    2020  Volume 65, Page(s) 28–31

    Abstract: Many vaccines are administered to young children in order to prevent infectious diseases early in life. At the same time, most of these vaccines are not developed specifically with the immune system of young children in mind and our understanding of how ... ...

    Abstract Many vaccines are administered to young children in order to prevent infectious diseases early in life. At the same time, most of these vaccines are not developed specifically with the immune system of young children in mind and our understanding of how newborn immune systems differ from adult counterparts is incomplete. The main reason for this lack of understanding stems from the ethical and logistical difficulties in obtaining samples from young children as well as the challenges associated with the small volume samples available. Here I review some recent developments made in this field and discuss their implications for studying vaccine responses in young children and developing better vaccines, tailored to this important population of susceptible individuals in the future.
    MeSH term(s) Child ; Humans ; Immune System/immunology ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.03.011
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  10. Article ; Online: New approaches to the study of immune responses in humans.

    Brodin, Petter

    Human genetics

    2020  Volume 139, Issue 6-7, Page(s) 795–799

    Abstract: The human immune system consists of multiple, layered mechanisms of sensing and responding to cellular stress, infection and tissue damage to ensure defense from pathogens, maintenance of tissue homeostasis, and the integrity of the holobiont. Every ... ...

    Abstract The human immune system consists of multiple, layered mechanisms of sensing and responding to cellular stress, infection and tissue damage to ensure defense from pathogens, maintenance of tissue homeostasis, and the integrity of the holobiont. Every single cell in the body has a role to play, but a few dozen, specialized white blood cells are particularly important in this respect. Understanding the overall state of this multifaceted system in a single individual is challenging, and we are only beginning to do this across populations of individuals, to understand the vast range of inter-individual variation, and the influences of genes and environmental factors that collectively shape the immune system in a given individual. We are also only beginning to understand the changes occurring within this system over time, and how this relates to health and disease susceptibility. Several technological breakthroughs in recent years have enabled these developments and the emergence of a new, complementary approach to studying human immune systems, namely systems immunology. In this paradigm, the focus is shifted from the understanding of individual immune system components and their mechanisms of action, towards analyses of cell-cell interactions, and mechanisms of coordination and regulation within the human immune system.
    MeSH term(s) Animals ; Cell Communication ; Homeostasis ; Humans ; Immune System/immunology ; Infections/etiology ; Signal Transduction
    Language English
    Publishing date 2020-02-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 223009-4
    ISSN 1432-1203 ; 0340-6717
    ISSN (online) 1432-1203
    ISSN 0340-6717
    DOI 10.1007/s00439-020-02129-3
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