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  1. Article: Pathologie inflammatoire du tube digestif en 2023 : point de vue du clinicien.

    Uzzan, Mathieu

    Annales de pathologie

    2022  Volume 43, Issue 3, Page(s) 168–169

    Title translation Inflammatory bowel disease in 2023: The clinician's perspective.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/diagnosis
    Language French
    Publishing date 2022-12-07
    Publishing country France
    Document type Editorial
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2022.11.002
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  2. Article ; Online: Tofacitinib: A Small Molecule for Biologic-Refractory Crohn's Disease?

    Uzzan, Mathieu

    Digestive diseases and sciences

    2022  Volume 67, Issue 8, Page(s) 3479–3480

    MeSH term(s) Biological Products ; Crohn Disease/drug therapy ; Humans ; Piperidines/therapeutic use ; Pyrimidines/adverse effects
    Chemical Substances Biological Products ; Piperidines ; Pyrimidines ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07448-1
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  3. Article ; Online: Concise Commentary: Calling in Your Marker-Rectal CD30-Positive Cells Differentiate Ulcerative Colitis from Crohn's Disease.

    Uzzan, Mathieu

    Digestive diseases and sciences

    2018  Volume 63, Issue 7, Page(s) 1819–1820

    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-018-5099-z
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  4. Article ; Online: Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies.

    Calméjane, Louis / Laharie, David / Kirchgesner, Julien / Uzzan, Mathieu

    United European gastroenterology journal

    2023  Volume 11, Issue 8, Page(s) 722–732

    Abstract: Acute severe ulcerative colitis (ASUC) occurs in up to 25% of patients with ulcerative colitis (UC). Therapeutic approaches have evolved during the past years with the increasing bio exposure of admitted patients and the extension of the number of ... ...

    Abstract Acute severe ulcerative colitis (ASUC) occurs in up to 25% of patients with ulcerative colitis (UC). Therapeutic approaches have evolved during the past years with the increasing bio exposure of admitted patients and the extension of the number of approved drugs for UC. In this review, we aimed to summarize the latest evidence in short-term and long-term medical strategies for ASUC. In addition to general principles such as venous thromboembolism prophylaxis, screening for triggering and worsening factors and close monitoring, first-line therapy for ASUC remains intravenous corticosteroids. In naive patients, the optimum maintenance strategy for steroid-responding patients does not necessarily include biologics. Second-line therapy includes infliximab or calcineurin inhibitors (CNIs) with similar short- and long-term colectomy rates. Despite its pathophysiological relevance, there is insufficient evidence to promote intensified induction with infliximab. Prior treatment exposure is a cornerstone for guiding therapeutic choice of short- and long-term therapies in the context of ASUC: in anti-TNF exposed patients, CNIs may be favored as a bridge therapy to vedolizumab or ustekinumab. Third-line salvage therapy could be a therapeutic option in selected patients referred to expert centers. Additionally, evidence is accumulating regarding the use of tofacitinib in ASUC.
    MeSH term(s) Humans ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Infliximab/therapeutic use ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Treatment Outcome ; Steroids/therapeutic use
    Chemical Substances Infliximab (B72HH48FLU) ; Tumor Necrosis Factor Inhibitors ; Steroids
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12442
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  5. Article ; Online: Effectiveness and safety of tofacitinib in patients with chronic pouchitis multirefractory to biologics.

    Uzzan, Mathieu / Nachury, Maria / Amiot, Aurélien / Peyrin-Biroulet, Laurent / Kirchgesner, Julien / Bouhnik, Yoram

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 8, Page(s) 1158–1160

    MeSH term(s) Humans ; Pouchitis/drug therapy ; Biological Products ; Proctocolectomy, Restorative ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/surgery
    Chemical Substances tofacitinib (87LA6FU830) ; Biological Products
    Language English
    Publishing date 2023-05-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.04.028
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  6. Article ; Online: A rare case of arteriovenous fistula leading to mesenteric ischemia.

    Marcellier, Gabriel / Uzzan, Mathieu / Corcos, Olivier

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 53, Issue 11, Page(s) 1508

    MeSH term(s) Arteriovenous Fistula/complications ; Arteriovenous Fistula/diagnosis ; Arteriovenous Fistula/pathology ; Humans ; Male ; Mesenteric Ischemia/etiology ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-14
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.08.037
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  7. Article ; Online: Focal loss of mural stratification as a radiological predictor for small bowel adenocarcinoma in Crohn's disease.

    Uzzan, Mathieu / Assouline, Victoria / Chambenois, Edouard / Djabbari, Marjan / Arrive, Lionel / Charpy, Cécile / Luciani, Alain / Sobhani, Iradj / Becq, Aymeric / Beaugerie, Laurent / Svrcek, Magali / Kirchgesner, Julien

    Clinics and research in hepatology and gastroenterology

    2023  Volume 47, Issue 10, Page(s) 102246

    Abstract: Aim: Patients with Crohn's disease (CD) are at higher risk of small bowel adenocarcinoma (SBA). We aimed to identify radiological predictors of SBA in CD.: Methods: We conducted a retrospective case-control study at two tertiary inflammatory bowel ... ...

    Abstract Aim: Patients with Crohn's disease (CD) are at higher risk of small bowel adenocarcinoma (SBA). We aimed to identify radiological predictors of SBA in CD.
    Methods: We conducted a retrospective case-control study at two tertiary inflammatory bowel disease centers and identified CD patients diagnosed with SBA between 2003 and 2019. Patients were matched with up to four controls. Pre-operative imaging (magnetic resonance imaging (MRI) or computed tomography (CT)) were reviewed by three gastrointestinal radiologists.
    Results: Nineteen patients with CD-associated SBA with a mean age of 54.9 and 32 matched controls were included. Mean length of small bowel involvement was 216 (± 188) mm in the SBA group versus 156 (± 167) mm in the control group (p = 0.76). Only 11.8 % of cases had a diagnosis of SBA made preoperatively. In univariate analysis, focal loss of mural stratification (odds ratio [OR], 11; 95%CI, 2.43-49.5, p = 0.002), and wall thickening (OR, 1.32; 95%CI, 1.05-1.66, p = 0.02) were significantly associated with SBA. After adjustment, focal loss of mural stratification was the only independent risk factor (OR, 11; 95 % CI, 2.43-49.5, p = 0.002).
    Conclusions: Focal loss of mural stratification was identified as a predictor of CD-associated SBA, which should be described in imaging reports and further validated.
    MeSH term(s) Humans ; Crohn Disease/complications ; Crohn Disease/diagnostic imaging ; Retrospective Studies ; Case-Control Studies ; Intestine, Small/diagnostic imaging ; Intestine, Small/pathology ; Ileal Neoplasms/diagnostic imaging ; Ileal Neoplasms/etiology ; Ileal Neoplasms/pathology ; Duodenal Neoplasms/pathology ; Magnetic Resonance Imaging ; Adenocarcinoma/pathology
    Language English
    Publishing date 2023-11-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102246
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  8. Article ; Online: Patients with COVID-19 present with low plasma citrulline concentrations that associate with systemic inflammation and gastrointestinal symptoms.

    Uzzan, Mathieu / Soudan, Damien / Peoc'h, Katell / Weiss, Emmanuel / Corcos, Olivier / Treton, Xavier

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 52, Issue 10, Page(s) 1104–1105

    MeSH term(s) Abdominal Pain/blood ; Abdominal Pain/etiology ; Abdominal Pain/physiopathology ; Aged ; Ageusia/blood ; Ageusia/etiology ; Ageusia/physiopathology ; Anorexia/blood ; Anorexia/etiology ; Anorexia/physiopathology ; Betacoronavirus ; C-Reactive Protein/metabolism ; COVID-19 ; Citrulline/blood ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/physiopathology ; Diarrhea/blood ; Diarrhea/etiology ; Diarrhea/physiopathology ; Female ; Ferritins/blood ; Humans ; Inflammation/blood ; Male ; Middle Aged ; Nausea/blood ; Nausea/etiology ; Nausea/physiopathology ; Olfaction Disorders/blood ; Olfaction Disorders/etiology ; Olfaction Disorders/physiopathology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology ; Prospective Studies ; SARS-CoV-2 ; Serum Albumin/metabolism ; Severity of Illness Index ; Vomiting/blood ; Vomiting/etiology ; Vomiting/physiopathology
    Chemical Substances Serum Albumin ; Citrulline (29VT07BGDA) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.06.042
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  9. Article ; Online: Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - Lung axis hypothesis.

    Uzzan, Mathieu / Corcos, Olivier / Martin, Jerome C / Treton, Xavier / Bouhnik, Yoram

    Medical hypotheses

    2020  Volume 144, Page(s) 110023

    Abstract: Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the ... ...

    Abstract Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract. Several factors may increase intestinal permeability including direct enterocyte damage by SARS-CoV2, systemic inflammatory response syndrome (SIRS) and epithelial ischemia secondary to SARS-CoV2- associated endothelial dysfunction. This increase permeability further leads to translocation of microbial components such as MAMPs (microbial-associated molecular pattern), triggering an inflammatory immune response by TLR-expressing cells of the mesentery fat (mostly macrophages and adipocytes). The pro-inflammatory cytokines produced by the mesentery fat mediates systemic inflammation and aggravate acute respiratory distress syndrome (ARDS) through the mesenteric lymph drainage.
    MeSH term(s) COVID-19/complications ; COVID-19/physiopathology ; Critical Care ; Cytokines/metabolism ; Gastrointestinal Microbiome ; Humans ; Immune System ; Inflammation ; Intensive Care Units ; Intra-Abdominal Fat/pathology ; Ischemia/pathology ; Lung/physiopathology ; Lymphatic System/physiopathology ; Male ; Metabolic Syndrome/immunology ; Models, Theoretical ; Obesity/complications ; Obesity/physiopathology ; Overweight/complications ; Permeability ; Risk Factors ; Systemic Inflammatory Response Syndrome/immunology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110023
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  10. Article ; Online: A Unique Case of Diffuse Intestinal and Colonic Leiomyomatosis.

    Uzzan, Mathieu / Corcos, Olivier / Cazals-Hatem, Dominique

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2016  Volume 14, Issue 9, Page(s) A21–2

    MeSH term(s) Adult ; Colon/pathology ; Female ; Humans ; Ileum/pathology ; Intestinal Obstruction/etiology ; Intestines ; Leiomyomatosis/complications ; Leiomyomatosis/pathology ; Postoperative Complications/etiology ; Pregnancy ; Pregnancy Complications/etiology ; Recurrence
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2016.05.021
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