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  1. Article ; Online: Homocysteine lowering and severe kidney disease.

    van Guldener, Coen

    JAMA

    2008  Volume 299, Issue 3, Page(s) 287–8; author reply 288

    MeSH term(s) Dietary Supplements ; Homocysteine/blood ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/therapy ; Vitamins/metabolism
    Chemical Substances Vitamins ; Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2008-01-23
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.299.3.287-b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Why is homocysteine elevated in renal failure and what can be expected from homocysteine-lowering?

    van Guldener, Coen

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2006  Volume 21, Issue 5, Page(s) 1161–1166

    MeSH term(s) Female ; Folic Acid/therapeutic use ; Homocysteine/blood ; Homocysteine/metabolism ; Humans ; Hyperhomocysteinemia/diagnosis ; Hyperhomocysteinemia/drug therapy ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy ; Kidney Function Tests ; Male ; Prognosis ; Renal Dialysis/methods ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Vitamin B 6/therapeutic use
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Vitamin B 6 (8059-24-3) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2006-05
    Publishing country England
    Document type Comparative Study ; Editorial
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfl044
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2198: Show issues Location:
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  3. Article ; Online: Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial.

    Burggraaf-van Delft, J Louise I / van Rein, Nienke / Bemelmans, Remy H H / van den Berg, Jan-Willem K / Bruggeman, Coty Y / Cloos-van Balen, Marissa / Coppens, Michiel / Eefting, Matthijs / Ende-Verhaar, Yvonne / van Es, Nick / van Guldener, Coen / de Jong, Wouter K / Kleijwegt, Fleur / Koster, Ted / Kroon, Cees / Kuipers, Saskia / Leentjens, Jenneke / Luijten, Dieuwke / Mairuhu, Albert T A /
    Meijer, Karina / van de Ree, Marcel A / Roos, Rick / Schrover, Ilse / Swart-Heikens, Janneke / van der Velden, Annette W G / van den Akker-van Marle, Elske M / le Cessie, Saskia / Geersing, Geert-Jan / Middeldorp, Saskia / Huisman, Menno V / Klok, Frederikus A / Cannegieter, Suzanne C

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e078676

    Abstract: Introduction: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain ... ...

    Abstract Introduction: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with an intermediate recurrence risk or with a high recurrence and high bleeding risk will benefit from extended anticoagulant treatment, and whether a strategy where anticoagulant duration is tailored on the predicted risks of rVTE and bleeding can improve outcomes. The aim of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study is to evaluate the outcomes of tailored duration of long-term anticoagulant treatment based on individualised assessment of rVTE and major bleeding risks.
    Methods and analysis: The L-TRRiP study is a multicentre, open-label, cohort-based, randomised controlled trial, including patients with a first VTE. We classify the risk of rVTE and major bleeding using the L-TRRiP and VTE-BLEED scores, respectively. After 3 months of anticoagulant therapy, patients with a low rVTE risk will discontinue anticoagulant treatment, patients with a high rVTE and low bleeding risk will continue anticoagulant treatment, whereas all other patients will be randomised to continue or discontinue anticoagulant treatment. All patients will be followed up for at least 2 years. Inclusion will continue until the randomised group consists of 608 patients; we estimate to include 1600 patients in total. The primary outcome is the combined incidence of rVTE and major bleeding in the randomised group after 2 years of follow-up. Secondary outcomes include the incidence of rVTE and major bleeding, functional outcomes, quality of life and cost-effectiveness in all patients.
    Ethics and dissemination: The protocol was approved by the Medical Research Ethics Committee Leiden-Den Haag-Delft. Results are expected in 2028 and will be disseminated through peer-reviewed journals and during (inter)national conferences.
    Trial registration number: NCT06087952.
    MeSH term(s) Humans ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/complications ; Multicenter Studies as Topic ; Quality of Life ; Randomized Controlled Trials as Topic ; Recurrence ; Thrombosis ; Venous Thromboembolism/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-078676
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  4. Article: Homocysteine and the kidney.

    van Guldener, Coen

    Current drug metabolism

    2005  Volume 6, Issue 1, Page(s) 23–26

    Abstract: Plasma homocysteine concentration exhibits a strong relationship with (indices of) renal function. Hyperhomocysteinemia has been implicated in the high vascular event rate in patients with chronic renal failure. The precise pathophysiological explanation ...

    Abstract Plasma homocysteine concentration exhibits a strong relationship with (indices of) renal function. Hyperhomocysteinemia has been implicated in the high vascular event rate in patients with chronic renal failure. The precise pathophysiological explanation for the occurrence of hyperhomocysteinemia in renal failure is not yet elucidated. A defective intrinsic renal metabolism of homocysteine seems unlikely. There are several indications that whole body homocysteine metabolism is altered in renal insufficiency. Stable isotope studies in dialysis patients have shown a decreased homocysteine clearance by transsulfuration and decreased homocysteine remethylation and methionine transmethylation. Several, but not all, prospective studies have linked hyperhomocysteinemia to adverse cardiovascular outcomes in renal failure patients. Treatment of hyperhomocysteinemia in renal insufficiency is based on folic acid-containing regimens, but so far, none of the regimens has been shown to successfully normalize plasma homocysteine concentration. Intervention studies have not yet demonstrated beneficial vascular effects of homocysteine-lowering treatment in dialysis patients.
    MeSH term(s) Animals ; Homocysteine/blood ; Homocysteine/metabolism ; Humans ; Hyperhomocysteinemia/complications ; Hyperhomocysteinemia/therapy ; Renal Insufficiency/blood ; Renal Insufficiency/etiology
    Chemical Substances Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2005-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200052997410
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    Zs.A 5584: Show issues Location:
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  5. Article ; Online: Takotsubo cardiomyopathy precipitated by thyrotoxicosis.

    Alidjan, Fazil / Ezzhati, Mustafa / Bruggeling, Wim / van Guldener, Coen

    Thyroid : official journal of the American Thyroid Association

    2010  Volume 20, Issue 12, Page(s) 1427–1428

    MeSH term(s) Aged ; Catecholamines/blood ; Female ; Humans ; Takotsubo Cardiomyopathy/etiology ; Thyrotoxicosis/complications
    Chemical Substances Catecholamines
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2009.0444
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    Zs.A 3307: Show issues Location:
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    Zs.MO 106: Show issues

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  6. Article ; Online: Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients.

    Stals, Milou A M / Grootenboers, Marco J J H / van Guldener, Coen / Kaptein, Fleur H J / Braken, Sander J E / Chen, Qingui / Chu, Gordon / van Driel, Erik M / Iglesias Del Sol, Antonio / de Jonge, Evert / Kant, K Merijn / Pals, Fleur / Toorop, Myrthe M A / Cannegieter, Suzanne C / Klok, Frederikus A / Huisman, Menno V

    Research and practice in thrombosis and haemostasis

    2021  Volume 5, Issue 3, Page(s) 412–420

    Abstract: Background: Whereas accumulating studies on patients with coronavirus disease 2019 (COVID-19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are ... ...

    Abstract Background: Whereas accumulating studies on patients with coronavirus disease 2019 (COVID-19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are lacking. How this high risk in COVID-19 patients compares to those observed in hospitalized patients with other viral pneumonias such as influenza is unknown.
    Objectives: To assess the incidence of venous and arterial thrombotic complications in hospitalized patients with influenza as opposed to that observed in hospitalized patients with COVID-19.
    Methods: This was a retrospective cohort study; we used data from Statistics Netherlands (study period: 2018) on thrombotic complications in hospitalized patients with influenza. In parallel, we assessed the cumulative incidence of thrombotic complications-adjusted for competing risk of death-in patients with COVID-19 in three Dutch hospitals (February 24 to April 26, 2020).
    Results: Of the 13 217 hospitalized patients with influenza, 437 (3.3%) were diagnosed with thrombotic complications, versus 66 (11%) of the 579 hospitalized patients with COVID-19. The 30-day cumulative incidence of any thrombotic complication in influenza was 11% (95% confidence interval [CI], 9.4-12) versus 25% (95% CI, 18-32) in COVID-19. For venous thrombotic (VTC) complications and arterial thrombotic complications alone, these numbers were, respectively, 3.6% (95% CI, 2.7-4.6) and 7.5% (95% CI, 6.3-8.8) in influenza versus 23% (95% CI, 16-29) and 4.4% (95% CI, 1.9-8.8) in COVID-19.
    Conclusions: The incidence of thrombotic complications in hospitalized patients with influenza was lower than in hospitalized patients with COVID-19. This difference was mainly driven by a high risk of VTC complications in the patients with COVID-19 admitted to the Intensive Care Unit. Remarkably, patients with influenza were more often diagnosed with arterial thrombotic complications.
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12496
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  7. Article ; Online: Transient cefuroxime/metronidazole treatment induced factor V antibodies.

    Van den Berg, Sjoerd Adrianus Antonius / Verwer, Patricia E / Idema, René N / Van Guldener, Coen

    BMJ case reports

    2014  Volume 2014

    Abstract: A 29-year-old patient presented with an appendicular infiltrate, initially treated with intravenous antibiotics, but later requiring percutaneous drainage. Both prothrombin time (PT) and activated partial thromboplastin time (aPTT) were prolonged on 3 ... ...

    Abstract A 29-year-old patient presented with an appendicular infiltrate, initially treated with intravenous antibiotics, but later requiring percutaneous drainage. Both prothrombin time (PT) and activated partial thromboplastin time (aPTT) were prolonged on 3 days of antibiotic treatment and unresponsive to vitamin K or prothrombin complex concentrate. Laboratory investigation ultimately showed reduced factor V activity and factor V antibodies. In contrast to previously described cases of factor V antibodies, PT and aPTT were only mildly prolonged and residual factor V activity was still >20%. Draining of the abscess did not induce significant bleeding. Afterwards, no haemostatic medication was required. The patient was discharged from the hospital without complications. One week after cessation of the antibiotic treatment, PT and aPTT were within normal range again, with a factor V activity level of 36%. In conclusion, we present a patient with transient factor V antibodies, induced by antibiotics, without clinical bleeding tendency.
    MeSH term(s) Abdominal Abscess/drug therapy ; Abdominal Abscess/therapy ; Adult ; Anti-Bacterial Agents/adverse effects ; Antibodies/blood ; Blood Coagulation Disorders/etiology ; Cefuroxime/adverse effects ; Drainage ; Factor V/immunology ; Humans ; Male ; Metronidazole/adverse effects ; Partial Thromboplastin Time ; Prothrombin Time
    Chemical Substances Anti-Bacterial Agents ; Antibodies ; factor V clotting antigen ; Metronidazole (140QMO216E) ; Factor V (9001-24-5) ; Cefuroxime (O1R9FJ93ED)
    Language English
    Publishing date 2014-08-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2014-205523
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  8. Article: Symptomatic hypocalcemia after sodium phosphate preparation in an adult with asymptomatic hypoparathyroidism.

    Niemeijer, Nicolasine D / Rijk, Marno C / van Guldener, Coen

    European journal of gastroenterology & hepatology

    2008  Volume 20, Issue 4, Page(s) 356–358

    Abstract: Sodium phosphate is widely used as a bowel cleansing preparation. Its use is, however, not without risk. It can induce serious adverse effects like hypocalcemia, hyperphosphatemia and renal failure. In this case, a 75-year-old woman without known ... ...

    Abstract Sodium phosphate is widely used as a bowel cleansing preparation. Its use is, however, not without risk. It can induce serious adverse effects like hypocalcemia, hyperphosphatemia and renal failure. In this case, a 75-year-old woman without known contraindications developed hypocalcemic tetany, hyperphosphatemia and renal failure after oral sodium phosphate. Asymptomatic hypoparathyroidism owing to previous thyroid surgery was identified as a new contributing risk factor for this complication.
    MeSH term(s) Age Factors ; Aged ; Cathartics/adverse effects ; Colonoscopy ; Female ; Humans ; Hypocalcemia/chemically induced ; Hypocalcemia/therapy ; Hypoparathyroidism/complications ; Hypoparathyroidism/surgery ; Phosphates/adverse effects ; Preoperative Care ; Thyroidectomy/adverse effects ; Treatment Outcome
    Chemical Substances Cathartics ; Phosphates ; sodium phosphate (SE337SVY37)
    Language English
    Publishing date 2008-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0b013e3282efa590
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    Zs.A 2932: Show issues Location:
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  9. Article ; Online: Symptomatische hypocalciëmie geïnduceerd door denosumab.

    Baptista Lopes, Vania / Robbrecht, Debbie / van Thiel, Sjoerd / van Guldener, Coen

    Nederlands tijdschrift voor geneeskunde

    2013  Volume 157, Issue 29, Page(s) A6159

    Abstract: Background: Bone resorption inhibitors such as denosumab may induce symptomatic hypocalcaemia if a vitamin D deficiency is present. Amongst other causes, this type of deficiency may arise following bariatric surgery.: Case description: We describe a ... ...

    Title translation Symptomatic hypocalcaemia on denosumab use.
    Abstract Background: Bone resorption inhibitors such as denosumab may induce symptomatic hypocalcaemia if a vitamin D deficiency is present. Amongst other causes, this type of deficiency may arise following bariatric surgery.
    Case description: We describe a 51-year-old woman who, a few years after undergoing bariatric surgery, developed symptomatic hypocalcaemia after she started taking denosumab.
    Conclusion: An adequate calcium and vitamin D status is a general condition before prescribing medication to treat osteoporosis. Therefore we recommend that before starting treatment with a bone resorption inhibitor that not only the calcium but also the vitamin D status should be determined, and if necessary, optimised.
    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Bariatric Surgery/adverse effects ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Calcium, Dietary/administration & dosage ; Calcium, Dietary/therapeutic use ; Denosumab ; Female ; Health Status ; Humans ; Hypocalcemia/drug therapy ; Hypocalcemia/etiology ; Middle Aged ; Osteoporosis/drug therapy ; Osteoporosis/etiology ; Vitamin D/administration & dosage ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Bone Density Conservation Agents ; Calcium, Dietary ; Vitamin D (1406-16-2) ; Denosumab (4EQZ6YO2HI)
    Language Dutch
    Publishing date 2013
    Publishing country Netherlands
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  10. Article: A delirious patient with opioid intoxication after chewing a fentanyl patch.

    van Rijswijk, Rein / van Guldener, Coen

    Journal of the American Geriatrics Society

    2006  Volume 54, Issue 8, Page(s) 1298–1299

    MeSH term(s) Aged, 80 and over ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/poisoning ; Delirium/chemically induced ; Fentanyl/administration & dosage ; Fentanyl/poisoning ; Humans ; Male ; Mastication ; Risk Factors
    Chemical Substances Analgesics, Opioid ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.2006.00832.x
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