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Article ; Online: Why mother rats protect their children.

Meyza, Ksenia Z / Knapska, Ewelina

2017 Volume 6

Abstract: The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in danger in order to protect her offspring. ...

Abstract	The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in danger in order to protect her offspring.
MeSH term(s)	Animals ; Central Amygdaloid Nucleus ; Child ; Female ; Freezing ; Humans ; Maternal Behavior ; Mothers ; Oxytocin ; Rats
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2017-06-13
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.28514
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Why mother rats protect their children

Ksenia Z Meyza / Ewelina Knapska

eLife, Vol

2017 Volume 6

Abstract: The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in danger in order to protect her offspring. ...

Abstract	The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in danger in order to protect her offspring.
Keywords	maternal behavior ; freezing ; social interactions ; learning ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism.

Corley, Michael J / Meyza, Ksenia Z / Blanchard, D Caroline / Blanchard, Robert J

Physiology & behavior

2012 Volume 107, Issue 5, Page(s) 663–665

Abstract: Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, ... ...

Abstract	Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.
MeSH term(s)	Animals ; Autistic Disorder/blood ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL/blood ; Mice, Inbred Strains/blood ; Sulfates/blood
Chemical Substances	Sulfates
Language	English
Publishing date	2012-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2012.04.010
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Zs.A 747: Show issues

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Article ; Online: Age increases anxiety and reactivity of the fear/anxiety circuit in Lewis rats.

Meyza, Ksenia Z / Boguszewski, Pawel M / Nikolaev, Evgeni / Zagrodzka, Jolanta

Behavioural brain research

2011 Volume 225, Issue 1, Page(s) 192–200

Abstract: A growing body of data indicates that changes in emotional behavior occur with age. Young Lewis rats are known to display hypofunction of the HPA axis. With age the reactivity of this axis is thought to increase with a concomitant rise in anxiety. In the ...

Abstract	A growing body of data indicates that changes in emotional behavior occur with age. Young Lewis rats are known to display hypofunction of the HPA axis. With age the reactivity of this axis is thought to increase with a concomitant rise in anxiety. In the current study, we investigate how and if the pattern of neuronal activation (measured as c-Fos protein expression) in Lewis rat brains changes with age and in response to novel environments differing in aversiveness. We found that distinct parts of the fear/anxiety circuit (i.e., the amygdalar complex, hippocampus and hypothalamus) undergo diverse age-related changes in response to behavioral challenges. While in the hypothalamus an increase in responsivity to mild stressors was observed with age, no such effect was present in the hippocampus. The amygdalar complex (especially the medial and cortical nuclei) on the other hand exhibited an age-dependent decrease in neuronal activation to mild stressors. This was accompanied by a marked increase in anxiety not correlated with a decline in locomotor activity.
MeSH term(s)	Aging ; Analysis of Variance ; Animals ; Anxiety/pathology ; Anxiety/physiopathology ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Exploratory Behavior ; Fear/psychology ; Gene Expression Regulation/physiology ; Immobility Response, Tonic/physiology ; Male ; Maze Learning/physiology ; Neural Pathways/pathology ; Principal Component Analysis ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Inbred Lew
Chemical Substances	Proto-Oncogene Proteins c-fos
Language	English
Publishing date	2011-11-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2011.07.011
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Article: Photoperiod affects distribution of dynorphin A in the brain of Siberian hamster.

Meyza, Ksenia Z / Sotowska-Brochocka, Jolanta

Acta neurobiologiae experimentalis

2006 Volume 66, Issue 3, Page(s) 207–213

Abstract: Dynorphin A1-77 (DYN A1-17) acting in the CNS is known to affect thermoregulation, water and energy balance in the short time scale. In this study a long-term alteration of these functions induced by changes of day length in the highly photoperiodic ... ...

Abstract	Dynorphin A1-77 (DYN A1-17) acting in the CNS is known to affect thermoregulation, water and energy balance in the short time scale. In this study a long-term alteration of these functions induced by changes of day length in the highly photoperiodic species, the Siberian hamster (Phodopus sungorus) was studied using immunohistochemistry for DYN A1-17. We found that in the long day (LD, L:D 16 h:8 h) more brain areas express DYN A1-17 peptide than in the short day (SD, L:D 8 h:16 h) conditions. Structures of the hypothalamo-pituitary axis as well as cells of the ependyma, subcomissural organ and choroid plexus of the lateral and third brain ventricles are immunoreactive to anti-dynorphin IgG only in the LD. This might indicate a seasonal regulatory role of DYN A1-17 in physiological adaptations to severe climate changes.
MeSH term(s)	Animals ; Brain/metabolism ; Cricetinae ; Dynorphins/metabolism ; Female ; Immunohistochemistry/methods ; Male ; Phodopus/metabolism ; Photoperiod ; Time Factors
Chemical Substances	Dynorphins (74913-18-1)
Language	English
Publishing date	2006-11-28
Publishing country	Poland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
DOI	10.55782/ane-2006-1608
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Article ; Online: Diverse sensitivity of RHA/Verh and RLA/Verh rats to emotional and spatial aspects of a novel environment as a result of a distinct pattern of neuronal activation in the fear/anxiety circuit.

Meyza, Ksenia Z / Boguszewski, Pawel M / Nikolaev, Evgeni / Zagrodzka, Jolanta

Behavior genetics

2009 Volume 39, Issue 1, Page(s) 48–61

Abstract: Psychogenetically selected Roman high (RHA/Verh) and Roman low (RLA/Verh) avoidance rats constitute a well-recognized model of diverse emotional reactivity. The two Swiss lines display marked behavioral and endocrine differences in reaction to a novel ... ...

Abstract	Psychogenetically selected Roman high (RHA/Verh) and Roman low (RLA/Verh) avoidance rats constitute a well-recognized model of diverse emotional reactivity. The two Swiss lines display marked behavioral and endocrine differences in reaction to a novel environment. In our study we found that these differences are accompanied by a distinct, line-specific pattern of neuronal activation within the fear/anxiety circuit. We have compared the c-Fos protein expression in the medial prefrontal cortex (mPFC), basolateral (BLA), central (CeA), medial (MeA), and cortical (CoA) nuclei of amygdala, paraventricular nucleus of the hypothalamus (PVN), and CA1, CA2, and CA3 fields of the hippocampus upon exposure to a novel situation of different stressorgeneity (open field with illuminated center, elevated plus maze, hole board test and acute restraint). Profound between-line differences in the sensitivity to emotional and spatial aspects of the behavioral challenge were observed for tests measuring spontaneous behavior. This effect seems to reflect different motivational factors driving the rat behavior, which clearly suggests that the diverse emotional reactivity of RHA/Verh and RLA/Verh rats is a result of different activation of the fear/anxiety circuit.
MeSH term(s)	Animals ; Anxiety/genetics ; Anxiety/physiopathology ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Brain/physiology ; Brain/physiopathology ; Emotions/physiology ; Environment ; Fear/physiology ; Habituation, Psychophysiologic ; Hippocampus/physiology ; Hippocampus/physiopathology ; Housing, Animal ; Lighting ; Male ; Maze Learning ; Multivariate Analysis ; Neurons/physiology ; Proto-Oncogene Proteins c-fos/genetics ; Rats ; Restraint, Physical
Chemical Substances	Proto-Oncogene Proteins c-fos
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280238-7
ISSN	1573-3297 ; 0005-7851 ; 0001-8244
ISSN (online)	1573-3297
ISSN	0005-7851 ; 0001-8244
DOI	10.1007/s10519-008-9234-z
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Article ; Online: Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism.

Meyza, Ksenia Z / Blanchard, D Caroline / Pearson, Brandon L / Pobbe, Roger L H / Blanchard, Robert J

Behavioural brain research

2011 Volume 228, Issue 2, Page(s) 247–253

Abstract: BTBR T+tf/J (BTBR) mice show abnormal social, communicatory, and repetitive/stereotyped behaviors paralleling many of the symptoms of autism spectrum disorders. BTBR also show agenesis of the corpus callosum (CC) suggesting major perturbations of growth ... ...

Abstract	BTBR T+tf/J (BTBR) mice show abnormal social, communicatory, and repetitive/stereotyped behaviors paralleling many of the symptoms of autism spectrum disorders. BTBR also show agenesis of the corpus callosum (CC) suggesting major perturbations of growth or guidance factors in the dorsal forebrain [1]. Heparan sulfate (HS) is a polysaccaride found in the brain and other animal tissues. It binds to a wide variety of ligands and through these ligands modulates a number of biological processes, including cell proliferation and differentiation, migration and guidance. It is aggregated on fractal-like structures (fractones) in the subventricular zone (SVZ), that may be visualized by laminin immunoreactivity (LAM-ir), as well as by HS immunoreactivity (HS-ir). We report that the lateral ventricles of BTBR mice were drastically reduced in area compared to C57BL/6J (B6) mice while the BTBR SVZ was significantly shorter than that of B6. In addition to much smaller fractones for BTBR, both HS and LAM-ir associated with fractones were significantly reduced in BTBR, and their anterior-posterior distributions were also altered. Finally, the ratio of HS to LAM in individual fractones was significantly higher in BTBR than in B6 mice. These data, in agreement with other findings linking HS to callosal development, suggest that variations in the quantity and distribution of HS in the SVZ of the lateral ventricles may be important modulators of the brain structural abnormalities of BTBR mice, and, potentially, contribute to the behavioral pathologies of these animals.
MeSH term(s)	Analysis of Variance ; Animals ; Autistic Disorder/genetics ; Autistic Disorder/metabolism ; Autistic Disorder/pathology ; Autistic Disorder/physiopathology ; Brain/pathology ; Corpus Callosum/metabolism ; Corpus Callosum/pathology ; Disease Models, Animal ; Heparitin Sulfate/metabolism ; Lamins/metabolism ; Lateral Ventricles/metabolism ; Lateral Ventricles/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Neurologic Mutants ; Phenotype
Chemical Substances	Lamins ; Heparitin Sulfate (9050-30-0)
Language	English
Publishing date	2011-11-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2011.11.004
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Zs.A 1599: Show issues

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Article ; Online: Addendum to 'BTBR T+tf/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate' [Neurosci. Biobehav. Rev. 36(1) (2012) 285-296].

Blanchard, D Caroline / Defensor, Erwin B / Meyza, Ksenia Z / Pobbe, Roger L H / Pearson, Brandon L / Bolivar, Valerie J / Blanchard, Robert J

Neuroscience and biobehavioral reviews

2012 Volume 36, Issue 10, Page(s) 2370

MeSH term(s)	Animals ; Autistic Disorder/genetics ; Autistic Disorder/metabolism ; Autistic Disorder/physiopathology ; Disease Models, Animal ; Heparitin Sulfate/metabolism ; Mice ; Mice, Inbred Strains
Chemical Substances	Heparitin Sulfate (9050-30-0)
Language	English
Publishing date	2012-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2012.09.005
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Article: The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats.

Meyza, Ksenia Z / Boguszewski, Pawel M / Nikolaev, Evgeni / Zagrodzka, Jolanta

Behavioural brain research

2007 Volume 180, Issue 2, Page(s) 183–189

Abstract: Recent studies have reported an age-related increase of anxiety in rodents with a concomitant decrease in neuronal activity in some of the key structures of the fear/anxiety circuit. In the present study we present evidence that distinct parts of this ... ...

Abstract	Recent studies have reported an age-related increase of anxiety in rodents with a concomitant decrease in neuronal activity in some of the key structures of the fear/anxiety circuit. In the present study we present evidence that distinct parts of this circuit are differentially affected by age in Lewis rats. The effect of ageing is observed both at the actual level of neuronal activation and its time-course. While the structures belonging to the HPA axis react with a bigger neuronal activation and almost no change in the shape of dynamics curve in response to restraint, the structures involved in higher processing of emotional cues (amygdala and hippocampus) become deficiently activated with age despite their generally higher basal level of activation.
MeSH term(s)	Aging ; Animals ; Behavior, Animal ; Brain/anatomy & histology ; Brain/metabolism ; Enzyme Activation/physiology ; Gene Expression Regulation/physiology ; Male ; Multivariate Analysis ; Nonlinear Dynamics ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Inbred Lew ; Restraint, Physical/methods ; Time Factors
Chemical Substances	Proto-Oncogene Proteins c-fos
Language	English
Publishing date	2007-06-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2007.03.007
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Zs.A 1599: Show issues

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Article: Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism

Corley, Michael J / Meyza, Ksenia Z / Blanchard, D. Caroline / Blanchard, Robert J

Physiology & behavior. 2012 Dec. 5, v. 107, no. 5

2012

Abstract	Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.
Keywords	animal models ; autism ; chemistry ; children ; clinical trials ; mice
Language	English
Dates of publication	2012-1205
Size	p. 663-665.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2012.04.010
Database	NAL-Catalogue (AGRICOLA)

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