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Article ; Online: Removal of Intraocular Foreign Bodies Using a Modified Flute Needle.

Chan, Yvonne Y Y / Liu, Shasha / Tang, Geoffrey C H / Cheung, Janice C C / Liu, Candice C H / Li, Kenneth K W

2023 Volume 43, Issue 7, Page(s) 1209–1212

Abstract: Purpose: To describe the construction of a novel intraocular snare and evaluate its effectiveness in intraocular foreign body (IOFB) removal.: Method: This is a retrospective consecutive case series. Five patients underwent pars plana vitrectomy and ... ...

Abstract	Purpose: To describe the construction of a novel intraocular snare and evaluate its effectiveness in intraocular foreign body (IOFB) removal. Method: This is a retrospective consecutive case series. Five patients underwent pars plana vitrectomy and IOFB removal using the intraocular snare constructed from modified flute needle. Results: All IOFBs were successfully engaged and removed with the snare on the first attempt. Three of the 5 cases (60%) enjoyed good visual outcome (0.4-1.0) postoperatively. No complication related to the use of the snare was encountered in this case series. Conclusion: Intraocular foreign body snare is simple, safe, and effective in IOFB removal.
MeSH term(s)	Humans ; Retrospective Studies ; Eye Injuries, Penetrating/diagnosis ; Eye Injuries, Penetrating/surgery ; Eye Injuries, Penetrating/complications ; Eye Foreign Bodies/diagnosis ; Eye Foreign Bodies/surgery ; Vitrectomy ; Microsurgery
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000002964
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Article ; Online: Why ophthalmologists should mask: a perspective from Hong Kong.

Tang, Geoffrey C H / Steel, David H W / Li, Kenneth K W

Eye (London, England)

2020 Volume 34, Issue 7, Page(s) 1168–1169

MeSH term(s)	COVID-19 ; Hong Kong ; Humans ; Influenza A Virus, H1N1 Subtype ; Masks ; Ophthalmologists ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-0916-y
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Zs.MO 603: Show issues

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Article ; Online: Intraocular pressure measurement during COVID pandemic.

Ng, Vikki W K / Tang, Geoffrey C H / Lai, Tracy H T / Tang, Emily W H / Li, Kenneth K W

Indian journal of ophthalmology

2020 Volume 68, Issue 5, Page(s) 950–951

MeSH term(s)	COVID-19 ; Humans ; Intraocular Pressure ; Pandemics ; SARS-CoV-2 ; Tonometry, Ocular
Keywords	covid19
Language	English
Publishing date	2020-04-21
Publishing country	India
Document type	Letter
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_723_20
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Zs.B 329: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 598: Show issues

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Article ; Online: Deep Parasternal Intercostal Plane Block for Intraoperative Pain Control in Cardiac Surgical Patients for Sternotomy: A Prospective Randomized Controlled Trial.

Wong, Henry M K / Chen, P Y / Tang, Geoffrey C C / Chiu, Sandra L C / Mok, Louis Y H / Au, Sylvia S W / Wong, Randolph H L

Journal of cardiothoracic and vascular anesthesia

2023 Volume 38, Issue 3, Page(s) 683–690

Abstract: Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of ... ...

Abstract	Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of bilateral DPIP blocks on intraoperative pain control in cardiac surgery. Design: This is a double-blinded, prospective randomized controlled trial (Oct 2020-Dec 2022). Settings: This study was conducted in a single institution, which is an academic university hospital. Participants: Eighty-six elective cardiac surgical patients with median sternotomy were recruited. Interventions: Patients were randomly divided into DPIP or control group. Either 20ml 0.25% levobupivacaine or 0.9% normal saline was injected for the DPIP under ultrasound guidance after induction of general anaesthesia. Measurements and main results: The primary outcome was intraoperative opioids consumption and hemodynamic changes at sternotomy. Secondary outcomes included postoperative morphine consumption, postoperative pain and time to tracheal extubation. Intraoperative opioids requirement was reduced from a median (IQR) intravenous morphine equivalence of 21.4mg (13.8-24.3mg) in control group to 9.5mg (7.3-11.2mg) in the DPIP group (P<0.001). Hemodynamic parameters were more stable in DPIP group at sternotomy, as evidenced by lower percentage increase in systolic, diastolic and mean arterial blood pressure from baseline. No difference was observed in time to tracheal extubation, postoperative morphine consumption, postoperative pain score and spirometry. Conclusions: Bilateral DPIP block provides effective intraoperative analgesia and opioid-sparing. It may be included as part of the multimodal analgesia for enhanced recovery in cardiac surgery.
MeSH term(s)	Humans ; Sternotomy/adverse effects ; Prospective Studies ; Nerve Block/methods ; Cardiac Surgical Procedures/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Analgesics, Opioid ; Morphine ; Iopanoic Acid/analogs & derivatives
Chemical Substances	1,3-dihydroxypropan-2-one 1,3-diiopanoate ; Analgesics, Opioid ; Morphine (76I7G6D29C) ; Iopanoic Acid (FE9794P71J)
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2023.11.038
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 31: Show issues

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Article: Intraocular pressure measurement during COVID pandemic

Ng, Vikki W K / Tang, Geoffrey C H / Lai, Tracy H T / Tang, Emily W H / Li, Kenneth K W

Indian J Ophthalmol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #102066
Database	COVID19

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Article ; Online: Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget's disease of bone.

Phillips, Jonathan / Subedi, Deepak / Lewis, Steff C / Keerie, Catriona / Cronin, Owen / Porteous, Mary / Moore, David / Cetnarskyj, Roseanne / Ranganath, Lakshminarayan / Selby, Peter L / Turgut, Tolga / Hampson, Geeta / Chandra, Rama / Ho, Shu / Tobias, Jon / Young-Min, Steven / McKenna, Malachi J / Crowley, Rachel K / Fraser, William D /

Annals of the rheumatic diseases

2024 Volume 83, Issue 4, Page(s) 529–536

Abstract: Introduction: Paget's disease of bone (PDB) frequently presents at an advanced stage with irreversible skeletal damage. Clinical outcomes might be improved by earlier diagnosis and prophylactic treatment.: Methods: We randomised 222 individuals at ... ...

Abstract	Introduction: Paget's disease of bone (PDB) frequently presents at an advanced stage with irreversible skeletal damage. Clinical outcomes might be improved by earlier diagnosis and prophylactic treatment. Methods: We randomised 222 individuals at increased risk of PDB because of pathogenic Results: The median duration of follow-up was 84 months (range 0-127) and 180 participants (81%) completed the study. At baseline, 9 (8.1%) of the ZA group had PDB lesions vs 12 (10.8%) of the placebo group. Two of the placebo group developed new lesions versus none in the ZA group (OR 0.41, 95% CI 0.00 to 3.43, p=0.25). Eight of the placebo group had a poor outcome (lesions which were new, unchanged or progressing) compared with none of the ZA group (OR 0.08, 95% CI 0.00 to 0.42, p=0.003). At the study end, 1 participant in the ZA group had lesions compared with 11 in the placebo group. Biochemical markers of bone turnover were significantly reduced in the ZA group. One participant allocated to placebo required rescue therapy with ZA because of symptomatic disease. The number and severity of adverse events did not differ between groups. Conclusions: Genetic testing for pathogenic Trial registration number: ISRCTN11616770.
MeSH term(s)	Humans ; Diphosphonates/adverse effects ; Osteitis Deformans/complications ; Osteitis Deformans/drug therapy ; Osteitis Deformans/genetics ; Sequestosome-1 Protein/genetics ; Zoledronic Acid/therapeutic use ; Genetic Testing ; Biomarkers
Chemical Substances	Diphosphonates ; Sequestosome-1 Protein ; Zoledronic Acid (6XC1PAD3KF) ; Biomarkers
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-224990
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Zs.MO 167: Show issues

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Article ; Online: Association between Time Spent on Smart Devices and Change in Refractive Error: A 1-Year Prospective Observational Study among Hong Kong Children and Adolescents.

Do, Chi-Wai / Chan, Lily Y L / Tse, Andy C Y / Cheung, Teris / So, Billy C L / Tang, Wing Chun / Yu, W Y / Chu, Geoffrey C H / Szeto, Grace P Y / Lee, Regina L T / Lee, Paul H

International journal of environmental research and public health

2020 Volume 17, Issue 23

Abstract: ... group (<2 h per day on both smartphone and tablet usages), those who spent ≥2 h per day using ... a smartphone and <2 h per day using a tablet had a significantly negative shift in refractive error (1-year ...

Abstract	This study examined the association between smart device usage and the 1-year change in refractive error among a representative sample of Hong Kong children and adolescents aged 8-14 years. A total of 1597 participants (49.9% male, mean age 10.9, SD 2.0) who completed both baseline (2017-2018) and 1-year follow-up (2018-2019) eye examinations were included in the present study. The non-cycloplegic auto-refractive error was measured and the average spherical equivalent refraction (SER) was analyzed. The participants also self-reported their smart device usage at baseline. Multivariate regression adjusted for age, sex, baseline SER, parents' short-sightedness, BMI, time spent on moderate-to-vigorous physical activity (MVPA), and caregiver-reported socio-economic status showed that, compared with the reference group (<2 h per day on both smartphone and tablet usages), those who spent ≥2 h per day using a smartphone and <2 h per day using a tablet had a significantly negative shift in refractive error (1-year change in SER -0.25 vs. -0.09 D,
MeSH term(s)	Adolescent ; Child ; Eye ; Female ; Hong Kong ; Humans ; Male ; Myopia ; Prospective Studies ; Refractive Errors/epidemiology
Language	English
Publishing date	2020-11-30
Publishing country	Switzerland
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17238923
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Article ; Online: The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma.

Sihag, Smita / Nussenzweig, Samuel C / Walch, Henry S / Hsu, Meier / Tan, Kay See / De La Torre, Sergio / Janjigian, Yelena Y / Maron, Steven B / Ku, Geoffrey Y / Tang, Laura H / Shah, Pari M / Wu, Abraham / Jones, David R / Solit, David B / Schultz, Nikolaus / Ganesh, Karuna / Berger, Michael F / Molena, Daniela

Clinical cancer research : an official journal of the American Association for Cancer Research

2022 Volume 28, Issue 12, Page(s) 2669–2678

Abstract: Purpose: In patients with locally advanced esophageal adenocarcinoma, response to neoadjuvant therapy strongly predicts survival, but robust molecular predictors of response have been lacking. We therefore sought to discover meaningful predictors of ... ...

Abstract	Purpose: In patients with locally advanced esophageal adenocarcinoma, response to neoadjuvant therapy strongly predicts survival, but robust molecular predictors of response have been lacking. We therefore sought to discover meaningful predictors of response in these patients. Experimental design: We retrospectively identified all patients with adenocarcinoma of the lower esophagus or gastroesophageal junction who (i) were treated with multimodality therapy with curative intent at our institution from 2014 through 2020 and (ii) underwent prospective sequencing by Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets. Clinicopathologic and genomic data were analyzed to identify potential genomic features, somatic alterations, and oncogenic pathways associated with treatment response. Results: In total, 237 patients were included. MDM2 amplification was independently associated with poor response to neoadjuvant therapy [OR, 0.10 (95% confidence interval, 0.01-0.55); P = 0.032], when accounting for significant clinicopathologic variables, including clinical stage, tumor grade, and chemotherapy regimen. Moreover, TP53 pathway alterations, grouped according to inferred severity of TP53 dysfunction, were significantly associated with response to neoadjuvant therapy (P = 0.004, q = 0.07). Patients with MDM2 amplifications or truncating biallelic TP53 mutations had similar outcomes in terms of poor responses to neoadjuvant therapy and, consequently, shorter progression-free survival, compared with patients with TP53 pathway wild-type tumors. Thus, worsening TP53 dysfunction was directly correlated with worse outcomes. Conclusions: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Given the dearth of actionable targets in esophageal adenocarcinoma, MDM2 inhibition, in combination with cytotoxic chemotherapy, may represent an important therapeutic strategy to overcome treatment resistance and improve outcomes in these patients.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/genetics ; Humans ; Neoadjuvant Therapy ; Prospective Studies ; Retrospective Studies ; Tumor Suppressor Protein p53/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2022-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-21-4016
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Article ; Online: Association between Time Spent on Smart Devices and Change in Refractive Error

Chi-wai Do / Lily Y. L. Chan / Andy C. Y. Tse / Teris Cheung / Billy C. L. So / Wing Chun Tang / W. Y. Yu / Geoffrey C. H. Chu / Grace P. Y. Szeto / Regina L. T. Lee / Paul H. Lee

International Journal of Environmental Research and Public Health, Vol 17, Iss 8923, p

A 1-Year Prospective Observational Study Among Hong Kong Children and Adolescents

2020 Volume 8923

Abstract: This study examined the association between smart device usage and the 1-year change in refractive error among a representative sample of Hong Kong children and adolescents aged 8–14 years. A total of 1597 participants (49.9% male, mean age 10.9, SD 2.0) ...

Abstract	This study examined the association between smart device usage and the 1-year change in refractive error among a representative sample of Hong Kong children and adolescents aged 8–14 years. A total of 1597 participants (49.9% male, mean age 10.9, SD 2.0) who completed both baseline (2017–2018) and 1-year follow-up (2018–2019) eye examinations were included in the present study. The non-cycloplegic auto-refractive error was measured and the average spherical equivalent refraction (SER) was analyzed. The participants also self-reported their smart device usage at baseline. Multivariate regression adjusted for age, sex, baseline SER, parents’ short-sightedness, BMI, time spent on moderate-to-vigorous physical activity (MVPA), and caregiver-reported socio-economic status showed that, compared with the reference group (<2 hours per day on both smartphone and tablet usages), those who spent ≥2 hours per day using a smartphone and <2 hours per day using a tablet had a significantly negative shift in refractive error (1-year change in SER −0.25 vs. −0.09 D, p = 0.01) for the right eye, while the level of significance was marginal (1-year change −0.28 vs. −0.15 D, p = 0.055) for the left eye. To conclude, our data suggested spending at most 2 hours per day on both smartphones and tablets.
Keywords	handheld device ; myopia ; prospective ; smartphone ; tablet ; teenage ; Medicine ; R
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.

de Matos Simoes, Ricardo / Shirasaki, Ryosuke / Downey-Kopyscinski, Sondra L / Matthews, Geoffrey M / Barwick, Benjamin G / Gupta, Vikas A / Dupéré-Richer, Daphné / Yamano, Shizuka / Hu, Yiguo / Sheffer, Michal / Dhimolea, Eugen / Dashevsky, Olga / Gandolfi, Sara / Ishiguro, Kazuya / Meyers, Robin M / Bryan, Jordan G / Dharia, Neekesh V / Hengeveld, Paul J / Brüggenthies, Johanna B /

Nature cancer

2023 Volume 4, Issue 5, Page(s) 754–773

Abstract: Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target ... ...

Abstract	Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target pathways critical for PC biology yet largely dispensable for malignant or normal cells of most other lineages. Here we systematically characterized the lineage-preferential molecular dependencies of MM through genome-scale clustered regularly interspaced short palindromic repeats (CRISPR) studies in 19 MM versus hundreds of non-MM lines and identified 116 genes whose disruption more significantly affects MM cell fitness compared with other malignancies. These genes, some known, others not previously linked to MM, encode transcription factors, chromatin modifiers, endoplasmic reticulum components, metabolic regulators or signaling molecules. Most of these genes are not among the top amplified, overexpressed or mutated in MM. Functional genomics approaches thus define new therapeutic targets in MM not readily identifiable by standard genomic, transcriptional or epigenetic profiling analyses.
MeSH term(s)	Humans ; Multiple Myeloma/genetics ; Genomics ; Genome ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00550-x
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