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Article ; Online: Reply to Wentao Liu, Xiaokun Zhao, Zhaohui Zhong's Letter to the Editor re: Marcus G. Cumberbatch, Matteo Rota, James W.F. Catto, Carlo La Vecchia. The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. Eur Urol 2016;70:458-66.

Cumberbatch, Marcus G / Rota, Matteo / Catto, James W F / La Vecchia, Carlo

2015 Volume 70, Issue 4, Page(s) e106–e107

MeSH term(s)	Carcinogenesis ; Humans ; Incidence ; Smoke ; Nicotiana ; Urinary Bladder
Chemical Substances	Smoke
Language	English
Publishing date	2015-09-09
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2015.08.033
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Increased mortality in socioeconomic disadvantaged municipalities during the first phase of the COVID-19 pandemic in Lombardy region.

Alicandro, Gianfranco / Gerli, Alberto / La Vecchia, Carlo

European journal of public health

2024

Abstract: Background: Lombardy was the first European region most severely affected by the coronavirus disease 2019 pandemic in the spring of 2020. During that period, a substantial increase in socioeconomic inequality in total mortality was observed. This study ... ...

Abstract	Background: Lombardy was the first European region most severely affected by the coronavirus disease 2019 pandemic in the spring of 2020. During that period, a substantial increase in socioeconomic inequality in total mortality was observed. This study aims to evaluate mortality data in the region up to September 2023 to verify whether the increased disparities between the poorest and the wealthiest municipalities persisted in the subsequent phases of the pandemic. Methods: This study analyzed mortality data from January 2019 to September 2023 in Lombardy's municipalities by month and pandemic phases characterized by the predominance of the different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Municipalities were grouped according to the average income or pension of their residents. Age-standardized mortality rates (ASMRs) and the ASMR ratio between the poorest and the wealthiest municipalities were compared throughout the study period. Results: In the pre-pandemic period (January 2019 - February 2020), the ASMR ratio at all ages between the poorest and the wealthiest municipalities fluctuated between 1.12 [95% confidence interval (CI): 1.07-1.16] and 1.29 (95% CI: 1.25-1.34). In March 2020, the ASMR ratio increased to 1.49 (95% CI: 1.45-1.52 95%) and returned to values registered before the pandemic thereafter. A similar pattern was observed in the analysis of mortality ≥ 65, using the average pension for group municipalities. Conclusions: During the dramatic circumstances that the region faced in March 2020, pre-existing socioeconomic inequalities substantially widened. With the reorganization of the health system and the availability of vaccines, these disparities returned to the levels recorded before the pandemic.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckae054
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Zs.A 3499: Show issues

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Article ; Online: Cancer prevention: innovative strategies in the role of the European Cancer Prevention Organization.

Corso, Giovanni / Janssens, Jaak Ph / La Vecchia, Carlo

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

2023 Volume 32, Issue 3, Page(s) 203–206

Abstract: Epidemiological studies demonstrate the key role of cancer prevention in reducing global cancer mortality. However, within Europe there are persisting important disparities in incidence and cancer-related mortality. The future strategy of cancer ... ...

Abstract	Epidemiological studies demonstrate the key role of cancer prevention in reducing global cancer mortality. However, within Europe there are persisting important disparities in incidence and cancer-related mortality. The future strategy of cancer prevention will aim at reducing these disparities through abolition of tobacco educational campaigns to a correct diet and lifestyle through primary prevention, increasing screening (secondary prevention). We also consider focusing on genetics and precision oncology to identify high-risk individuals, and on tertiary prevention to reduce second cancer risk. The application of these approaches could reduce cancer mortality by 35% and increase cancer survival to 70% in 2070. Tobacco control and abolition remain key measures across Europe.
MeSH term(s)	Humans ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/prevention & control ; Precision Medicine ; Neoplasms, Second Primary ; Diet ; Life Style ; Europe/epidemiology
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1137033-6
ISSN	1473-5709 ; 0959-8278
ISSN (online)	1473-5709
ISSN	0959-8278
DOI	10.1097/CEJ.0000000000000782
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Zs.A 3621: Show issues

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Article ; Online: Correction: Diabetes risk reduction diet and ovarian cancer risk: an Italian case-control study.

Esposito, Giovanna / Turati, Federica / Parazzini, Fabio / Augustin, Livia S A / Serraino, Diego / Negri, Eva / La Vecchia, Carlo

Cancer causes & control : CCC

2024

Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-024-01863-7
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Zs.A 3375: Show issues

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Article ; Online: Low-dose aspirin reduces the risk of HBV-associated HCC even when administered short-term: Too good to be true?

Guidotti, Luca G / La Vecchia, Carlo / Colombo, Massimo

Hepatology (Baltimore, Md.)

2022 Volume 76, Issue 2, Page(s) 300–302

MeSH term(s)	Aspirin/therapeutic use ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/prevention & control ; Hepatitis B virus ; Humans ; Liver Cirrhosis ; Liver Neoplasms/etiology ; Liver Neoplasms/prevention & control ; Risk Factors
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-03-19
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.32445
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Zs.A 1660: Show issues

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Article ; Online: Association of national smoke-free policies with per-capita cigarette consumption and acute myocardial infarction mortality in Europe.

Sassano, Michele / Mariani, Marco / Pastorino, Roberta / Ricciardi, Walter / La Vecchia, Carlo / Boccia, Stefania

Journal of epidemiology and community health

2024

Abstract: Background: Evidence on the association between smoke-free policies and per-capita cigarette consumption and mortality due to acute myocardial infarction (AMI) in Europe is limited. Hence, we aimed to assess this association and to evaluate which ... ...

Abstract	Background: Evidence on the association between smoke-free policies and per-capita cigarette consumption and mortality due to acute myocardial infarction (AMI) in Europe is limited. Hence, we aimed to assess this association and to evaluate which factors influence it. Methods: We performed an interrupted time series analysis, including 27 member states of the European Union and the UK, on per-capita cigarette consumption and AMI mortality.A multivariate meta-regression was used to assess the potential influence of other factors on the observed associations. Results: Around half of the smoke-free policies introduced were associated with a level or slope change, or both, of per-capita cigarette consumption and AMI mortality (17 of 35). As for cigarette consumption, the strongest level reduction was observed for the smoking ban issued in 2010 in Poland (rate ratio (RR): 0.47; 95% CI: 0.41, 0.53). Instead, the largest level reduction of AMI mortality was observed for the intervention introduced in 2012 in Bulgaria (RR: 0.38; 95% CI: 0.34, 0.42).Policies issued more recently or by countries with a lower human development index were found to be associated with a larger decrease in per-capita cigarette consumption. In addition, smoking bans applying to bars had a stronger inverse association with both cigarette consumption and AMI mortality. Conclusions: The results of our study suggest that smoke-free policies are effective at reducing per-capita cigarette consumption and AMI mortality. It is extremely important to monitor and register data on tobacco, its prevalence and consumption to be able to tackle its health effects with concerted efforts.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	391868-3
ISSN	1470-2738 ; 0142-467X ; 0141-7681 ; 0143-005X
ISSN (online)	1470-2738
ISSN	0142-467X ; 0141-7681 ; 0143-005X
DOI	10.1136/jech-2023-220746
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Zs.A 186: Show issues

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Article ; Online: Global trends in cutaneous malignant melanoma incidence and mortality.

De Pinto, Giuseppe / Mignozzi, Silvia / La Vecchia, Carlo / Levi, Fabio / Negri, Eva / Santucci, Claudia

Melanoma research

2024 Volume 34, Issue 3, Page(s) 265–275

Abstract: Mortality from cutaneous malignant melanoma (CMM) increased in the past, but trends have been favorable in more recent years in many high-income countries. However, incidence has been increasing in several countries. We provided an up-to-date overview of ...

Abstract	Mortality from cutaneous malignant melanoma (CMM) increased in the past, but trends have been favorable in more recent years in many high-income countries. However, incidence has been increasing in several countries. We provided an up-to-date overview of mortality trends from CMM. We analyzed death certification data from the WHO in selected countries worldwide from 1980 to the most recent available calendar years. We also reported incidence data derived from Cancer Incidence in Five Continents from 1990 to 2012. Separate analyses were performed for young adults aged 20-44 and middle-aged adults aged 45-64 years. Mortality from CMM in all age groups showed a favorable pattern in the majority of the countries considered. Mortality trends declined by 40 to 50% in Australia over the last decades, confirming the importance of prevention measures. Considering young adults aged 20-44, Australia, New Zealand and Northern Europe reported the highest death rates for both sexes (>0.90/100 000 in men and >0.60/100 000 in women) while Japan, the Philippines, and Latin America the lowest ones (<0.50/100 000 and <0.35/100 000 in men and women, respectively). Incidence trends were stable or upward in most countries, with higher rates among women. Our study highlights a global reduction of CMM mortality over the last three decades. The increasing awareness of risk factors, mainly related to UV exposure, along with early diagnosis and progress in treatment for advanced disease played pivotal roles in reducing CMM mortality, particularly in Australia.
MeSH term(s)	Humans ; Melanoma/mortality ; Melanoma/epidemiology ; Skin Neoplasms/mortality ; Skin Neoplasms/epidemiology ; Incidence ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Melanoma, Cutaneous Malignant ; Global Health
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000959
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Zs.A 3378: Show issues

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Article ; Online: Early-life alcohol intake and high-grade prostate cancer.

La Vecchia, Carlo

Nature reviews. Urology

2018 Volume 15, Issue 12, Page(s) 730–731

Language	English
Publishing date	2018-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-018-0094-x
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Zs.A 6030: Show issues

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Article ; Online: Cancer mortality in Germany-born Americans and Germans.

Mignozzi, Silvia / Santucci, Claudia / Medina, Heidy N / Negri, Eva / La Vecchia, Carlo / Pinheiro, Paulo S

Cancer epidemiology

2024 Volume 88, Page(s) 102519

Abstract: Introduction: Comparing cancer mortality and associated risk factors among immigrant populations in a host country to those in their country of origin reveals disparities in cancer risk, access to care, diagnosis, and disease management. This study ... ...

Abstract	Introduction: Comparing cancer mortality and associated risk factors among immigrant populations in a host country to those in their country of origin reveals disparities in cancer risk, access to care, diagnosis, and disease management. This study compares cancer mortality between the German resident population and Germany-born individuals who migrated to the US. Methods: Cancer mortality data from 2008-2018 were derived for Germans from the World Health Organization database and for Germany-born Americans resident in four states (California, Florida, Massachusetts, and New York) from respective Departments of Vital Statistics. We calculated age-standardized mortality rates (ASMRs) using the European standard population and standardized mortality ratios (SMR) compared to the German resident population along with 95% confidence intervals (CIs). Results: Germany-born American males had lower ASMRs (253.8 per 100,000) than German resident population (325.6 per 100,000). The difference in females was modest, with ASMRs of 200.7 and 203.7 per 100,000, respectively. For all cancers, Germany-born American males had an SMR of 0.72 (95% CI: 0.70-0.74) and females 0.98 (95% CI: 0.95-1.00). Male SMRs among Germany-born Americans were significantly below one for oral cavity, stomach, colorectal, liver, lung, prostate, and kidney cancer. Among females, SMRs were below one for oral cavity, stomach, colorectal, gallbladder, breast, cervix uteri, and kidney cancer. For both sexes, SMRs were over one for bladder cancer (1.14 for males, 1.21 for females). Mortality was higher for lung cancer (SMR: 1.68), non-Hodgkin's lymphoma (1.18) and uterine cancer (1.22) among Germany-born American females compared to the German resident population. Conclusion: Germany-born American males but not females showed lower cancer mortality than German resident population. Disparities may stem from variations in risk factors (e.g., smoking and alcohol use) as well as differences in screening practices and participation, cancer treatment, besides some residual potential "healthy immigrant effect".
MeSH term(s)	Female ; Humans ; Male ; Carcinoma, Renal Cell ; Colorectal Neoplasms ; European People ; Germany/epidemiology ; Kidney Neoplasms ; Lung Neoplasms ; Neoplasms/mortality ; United States/epidemiology
Language	English
Publishing date	2024-01-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2023.102519
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Zs.A 1427: Show issues

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Article ; Online: Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence.

Pavanello, Sofia / Moretto, Angelo / La Vecchia, Carlo / Alicandro, Gianfranco

Regulatory toxicology and pharmacology : RTP

2023 Volume 139, Page(s) 105369

Abstract: Several toxicological and epidemiological studies were published during the last five decades on non-sugar sweeteners (NSS) and cancer. Despite the large amount of research, the issue still continues to be of interest. In this review, we provided a ... ...

Abstract	Several toxicological and epidemiological studies were published during the last five decades on non-sugar sweeteners (NSS) and cancer. Despite the large amount of research, the issue still continues to be of interest. In this review, we provided a comprehensive quantitative review of the toxicological and epidemiological evidence on the possible relation between NSS and cancer. The toxicological section includes the evaluation of genotoxicity and carcinogenicity data for acesulfame K, advantame, aspartame, cyclamates, saccharin, steviol glycosides and sucralose. The epidemiological section includes the results of a systematic search of cohort and case-control studies. The majority of the 22 cohort studies and 46 case-control studies showed no associations. Some risks for bladder, pancreas and hematopoietic cancers found in a few studies were not confirmed in other studies. Based on the review of both the experimental data on genotoxicity or carcinogenicity of the specific NSS evaluated, and the epidemiological studies it can be concluded that there is no evidence of cancer risk associated to NSS consumption.
MeSH term(s)	Humans ; Sweetening Agents/toxicity ; Sugars ; Saccharin ; Aspartame/toxicity ; Neoplasms/chemically induced ; Neoplasms/epidemiology
Chemical Substances	Sweetening Agents ; Sugars ; Saccharin (FST467XS7D) ; Aspartame (Z0H242BBR1)
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2023.105369
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