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Book ; Online: L'Antiquité est une fête

Lacroix, Audrey

(B@lades ; 2)

2022

Series title	B@lades ; 2
Keywords	History of art / art & design styles ; Archaeology by period / region ; Children's, Teenage & educational ; Antiquity ; Ancient History ; Greek Antiquity ; Roman Antiquity ; Greece ; Athens ; Rome ; Roman Empire ; end of year ; festivals ; festivities ; ceremonies ; honouring the Gods ; deities ; banquets ; sociability ; entertainment ; pleasures ; birth ; gifts ; victory ; calendar ; games ; music ; wine ; preparations ; excess
Language	0\|f
Size	1 electronic resource (149 pages)
Publisher	Ausonius Éditions
Publishing place	Pessac
Document type	Book ; Online
Note	French ; English ; Open Access
HBZ-ID	HT021612275
ISBN	9782356135025 ; 2356135022
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: La montée du niveau de la mer d'ici 2100 : Scénarios et conséquences

Lacroix, Denis / Mora, Olivier / de Menthière, Nicolas / Béthinger, Audrey

2021

Keywords	Risk assessment ; sea water ; human activity ; decision support ; sustainable development ; ecology ; environment ; public policy ; natural risk
Size	1 electronic resource (128 pages)
Publisher	éditions Quae
Document type	Book ; Online
Note	French ; Open Access
HBZ-ID	HT021231637
ISBN	9782759233090 ; 275923309X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mechanical and chemical activation of GPR68 probed with a genetically encoded fluorescent reporter.

Ozkan, Alper D / Gettas, Tina / Sogata, Audrey / Phaychanpheng, Wynn / Zhou, Miou / Lacroix, Jérôme J

Journal of cell science

2021 Volume 134, Issue 16

Abstract: G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology, neuroplasticity and cancer progression. Inspired by previous GPCR- ... ...

Abstract	G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology, neuroplasticity and cancer progression. Inspired by previous GPCR-based reporters, here, we inserted a cyclic permuted fluorescent protein into the third intracellular loop of GPR68 to create a genetically encoded fluorescent reporter of GPR68 activation we call 'iGlow'. iGlow responds to known physiological GPR68 activators such as fluid shear stress and extracellular acidifications. In addition, iGlow responds to Ogerin, a synthetic GPR68-selective agonist, but not to a non-active Ogerin analog, showing the specificity of iGlow-mediated fluorescence signals. Flow-induced iGlow activation is not eliminated by pharmacological modulation of downstream G-protein signaling, disruption of actin filaments or application of GsMTx4, an inhibitor of certain mechanosensitive ion channels activated by membrane stretch. Deletion of the conserved helix 8, proposed to mediate mechanosensitivity in certain GPCRs, does not eliminate flow-induced iGlow activation. iGlow could be useful to investigate the contribution of GPR68-dependent signaling in health and disease.
MeSH term(s)	Receptors, G-Protein-Coupled/genetics ; Signal Transduction ; Stress, Mechanical
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.255455
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Zs.A 1200: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy of infliximab after loss of response of/intolerance to adalimumab in pediatric Crohn's disease: A retrospective multicenter cohort study of the "GETAID pédiatrique".

Lecoutour, Anne / Dupont, Claire / Caldari, Dominique / Dumant, Clémentine / Vanrenterghem, Audrey / Ruiz, Mathias / Duclaux-Loras, Rémi / Berthet, Stéphanie / Dimitrov, Georges / Lacroix, Delphine / Duvant, Pauline / Roman, Céline / Wagner, Anne Claire / Bourmaud, Aurélie / Viala, Jérôme / Ruemmele, Frank M / Pigneur, Bénédicte

Journal of pediatric gastroenterology and nutrition

2024

Abstract: Background: Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can ... ...

Abstract	Background: Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can occur over time. The aim was to assess the efficacy of IFX as second line therapy after LOR or intolerance to ADA in pediatric CD patients at 1 year. Methods: We conducted a retrospective and multicenter study in France among the "GETAID pédiatrique" centers between April 2019 and April 2022. CD patients under 18 years old and treated with IFX after ADA failure or intolerance were included. We collected anthropometric, clinical, and biological data at baseline (start of IFX), at 6 and 12 months. Clinical remission was defined by a Weighted Pediatric CD Activity Index (wPCDAI) score less than 12.5 points. Results: Of the 32 patients included in our study, 27 (84.4%) were still on IFX at 12 months of the switch. Among them, 13 had discontinued ADA because of a LOR, 12 for insufficient response and 2 due to primary nonresponse. At M12, 22 patients were in corticosteroid free clinical remission (68.7%). Under IFX, the wPCDAI decreased over time (47.5 ± 24.1, 16.6 ± 21.2 and 9.7 ± 19.0 at M0, M6 and M12 respectively). The only factor associated with clinical remission at 12 months was absence of perianal disease at the end of the IFX induction. Conclusions: IFX is effective in maintaining remission at 1 year in pediatric CD patients experiencing a LOR or intolerance with ADA, and IFX could be an interesting therapeutic choice instead of other biologics in this situation.
Language	English
Publishing date	2024-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1002/jpn3.12044
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Article ; Online: Inter-arm difference in systolic blood pressure: Prevalence and associated factors in an African population.

Gbaguidi, Gwladys Nadia / Kaboure, Audrey / Houehanou, Yessito Corine / Amidou, Salimanou Ariyo / Houinato, Dismand Stephan / Aboyans, Victor / Lacroix, Philippe

PloS one

2022 Volume 17, Issue 8, Page(s) e0272619

Abstract: Objectives: Inter-arm blood pressure difference (IABPD) can lead to underdiagnosis and poor management of hypertension, when not recognized and are associated with increased cardiovascular mortality and morbidity. However, the prevalence and associated ... ...

Abstract	Objectives: Inter-arm blood pressure difference (IABPD) can lead to underdiagnosis and poor management of hypertension, when not recognized and are associated with increased cardiovascular mortality and morbidity. However, the prevalence and associated risk factors of IABPD in sub-Saharan Africa are unknown. This study aims to determine the prevalence and associated risk factors of IABPD among Tanve Health Study (TAHES) participants, a cohort about cardiovascular diseases in a rural area in Benin. Methods: The cohort was conducted since 2015 among adults aged 25 years and over in Tanve village. Data were collected from February to March, 2020. Brachial blood pressure were recorded at rest on both arm with an electronic device. Systolic IABPD (sIABPD) was defined as the absolute value of the difference in systolic blood pressure between left and right arms ≥ 10 mmHg. A multivariate logistic regression models identified factors associated with sIABPD. Results: A total of 1,505 participants (women 59%) were included. The mean age was 45.08 ±15.65 years. The prevalence of sIABPD ≥ 10 mmHg was 19% (95%CI: 17-21). It was 19% (95%CI: 16-22) in men and 20% (95%CI: 17-22) in women. In final multivariable model, the probability of sIABPD ≥ 10 mmHg increased significantly with age (adjusted OR (aOR) = 1.1; 95%CI: 1.02-1.20 per 10-years), hypertension (aOR = 2.33; 95%CI: 1.77-3.07) and diabetes (aOR = 1.96; 95%CI: 1.09-3.53). Conclusion: Almost quarter of sample have a sIABPD ≥ 10 mmHg, with an increased risk with older age and hypertension and diabetes.
MeSH term(s)	Adult ; Blood Pressure/physiology ; Blood Pressure Determination ; Diabetes Mellitus/diagnosis ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Prevalence ; Risk Factors
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0272619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inter-arm difference in systolic blood pressure

Gwladys Nadia Gbaguidi / Audrey Kaboure / Yessito Corine Houehanou / Salimanou Ariyo Amidou / Dismand Stephan Houinato / Victor Aboyans / Philippe Lacroix

PLoS ONE, Vol 17, Iss 8, p e

Prevalence and associated factors in an African population.

2022 Volume 0272619

Abstract: Objectives Inter-arm blood pressure difference (IABPD) can lead to underdiagnosis and poor management of hypertension, when not recognized and are associated with increased cardiovascular mortality and morbidity. However, the prevalence and associated ... ...

Abstract	Objectives Inter-arm blood pressure difference (IABPD) can lead to underdiagnosis and poor management of hypertension, when not recognized and are associated with increased cardiovascular mortality and morbidity. However, the prevalence and associated risk factors of IABPD in sub-Saharan Africa are unknown. This study aims to determine the prevalence and associated risk factors of IABPD among Tanve Health Study (TAHES) participants, a cohort about cardiovascular diseases in a rural area in Benin. Methods The cohort was conducted since 2015 among adults aged 25 years and over in Tanve village. Data were collected from February to March, 2020. Brachial blood pressure were recorded at rest on both arm with an electronic device. Systolic IABPD (sIABPD) was defined as the absolute value of the difference in systolic blood pressure between left and right arms ≥ 10 mmHg. A multivariate logistic regression models identified factors associated with sIABPD. Results A total of 1,505 participants (women 59%) were included. The mean age was 45.08 ±15.65 years. The prevalence of sIABPD ≥ 10 mmHg was 19% (95%CI: 17-21). It was 19% (95%CI: 16-22) in men and 20% (95%CI: 17-22) in women. In final multivariable model, the probability of sIABPD ≥ 10 mmHg increased significantly with age (adjusted OR (aOR) = 1.1; 95%CI: 1.02-1.20 per 10-years), hypertension (aOR = 2.33; 95%CI: 1.77-3.07) and diabetes (aOR = 1.96; 95%CI: 1.09-3.53). Conclusion Almost quarter of sample have a sIABPD ≥ 10 mmHg, with an increased risk with older age and hypertension and diabetes.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid.

Roussel-Simonin, Cyril / Blanc-Durand, Felix / Tang, Roseline / Vasseur, Damien / Le Formal, Audrey / Chardin, Laure / Yaniz, Elisa / Gouy, Sébastien / Maulard, Amandine / Scherier, Stéphanie / Sanson, Claire / Lacroix, Ludovic / Cotteret, Sophie / Mauny, Lea / Zaccarini, François / Rouleau, Etienne / Leary, Alexandra

Molecular cancer

2023 Volume 22, Issue 1, Page(s) 178

Abstract: Background: Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management. HRD is determined by BRCA1/BRCA2 pathogenic variants or genomic instability. However, tumor DNA ... ...

Abstract	Background: Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management. HRD is determined by BRCA1/BRCA2 pathogenic variants or genomic instability. However, tumor DNA analysis is inconclusive in 15-19% of cases. Peritoneal fluid, available in > 95% of advanced EOC cases, could serve as an alternative source of cell-free tumor DNA (cftDNA) for HRD testing. Limited data show the feasibility of cancer panel gene testing on ascites cfDNA but no study, to date, has investigated HRD testing. Methods: We collected ascites/peritoneal washings from 53 EOC patients (19 from retrospective cohort and 34 from prospective cohort) and performed a Cancer Gene Panel (CGP) using NGS for TP53/HR genes and shallow Whole Genome Sequencing (sWGS) for genomic instability on cfDNA. Results: cfDNA was detectable in 49 out of 53 patients (92.5%), including those with limited peritoneal fluid. Median cfDNA was 3700 ng/ml, with a turnaround time of 21 days. TP53 pathogenic variants were detected in 86% (42/49) of patients, all with HGSOC. BRCA1 and BRCA2 pathogenic variants were found in 14% (7/49) and 10% (5/49) of cases, respectively. Peritoneal cftDNA showed high sensitivity (97%), specificity (83%), and concordance (95%) with tumor-based TP53 variant detection. NGS CGP on cftDNA identified BRCA2 pathogenic variants in one case where tumor-based testing failed. sWGS on cftDNA provided informative results even when tumor-based genomic instability testing failed. Conclusion: Profiling cftDNA from peritoneal fluid is feasible, providing a significant amount of tumor DNA. This fast and reliable approach enables HRD testing, including BRCA1/2 mutations and genomic instability assessment. HRD testing on cfDNA from peritoneal fluid should be offered to all primary laparoscopy patients.
MeSH term(s)	Female ; Humans ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation ; Ovarian Neoplasms/genetics ; Circulating Tumor DNA ; Homologous Recombination ; Ascitic Fluid/pathology ; Ascites ; Prospective Studies ; Retrospective Studies ; Carcinoma, Ovarian Epithelial ; Genomic Instability
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein ; Circulating Tumor DNA
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-023-01864-1
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Article ; Online: Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis.

Cambon, Audrey / Rebelle, Charlotte / Bachelier, Richard / Arnaud, Laurent / Robert, Stéphane / Lagarde, Marie / Muller, Romain / Tellier, Edwige / Kara, Yéter / Leroyer, Aurélie / Farnarier, Catherine / Vallier, Loris / Chareyre, Corinne / Retornaz, Karine / Jurquet, Anne-Laure / Tran, Tu-Anh / Lacroix, Romaric / Dignat-George, Françoise / Kaplanski, Gilles

Frontiers in immunology

2023 Volume 14, Page(s) 1228122

Abstract: Objective: IL-1β is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1β-mediated disease such as systemic juvenile idiopathic arthritis (sJIA). Leukocyte ... ...

Abstract	Objective: IL-1β is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1β-mediated disease such as systemic juvenile idiopathic arthritis (sJIA). Leukocyte microvesicles (MVs) may be a mechanism of IL-1β secretion. The first objective of our study was to characterize IL-1β-positive MVs obtained from macrophage cell culture supernatants and to investigate their biological functions Methods: MVs were purified by serial centrifugations from PBMCs, or THP-1 differentiated into macrophages, then stimulated with LPS ± ATP. MV content was analyzed for the presence of IL-1β, NLRP3 inflammasome, caspase-1, P2X7 receptor, and tissue factor (TF) using ELISA, Western blot, or flow cytometry. MV biological properties were studied Results: THP-1-derived macrophages stimulated with LPS and ATP released MVs, which contained NLRP3, caspase-1, and the 33-kDa precursor and 17-kDa mature forms of IL-1β and bioactive TF. IL-1β-positive MVs expressed P2X7 receptor and released soluble IL-1β in response to ATP stimulation Conclusion: MVs shed from activated macrophages contain IL-1β, NLRP3 inflammasome components, and TF, and constitute thrombo-inflammatory vectors that can be detected in the plasma from active JIA patients.
MeSH term(s)	Humans ; Animals ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Inflammasomes/metabolism ; Arthritis, Juvenile/metabolism ; Lipopolysaccharides/pharmacology ; Receptors, Purinergic P2X7/metabolism ; Macrophages/metabolism ; Caspase 1/metabolism ; Adenosine Triphosphate/metabolism
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Lipopolysaccharides ; Receptors, Purinergic P2X7 ; Caspase 1 (EC 3.4.22.36) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1228122
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Article ; Online: Dynamics of Antibodies to Ebolaviruses in an

Djomsi, Dowbiss Meta / Mba Djonzo, Flaubert Auguste / Ndong Bass, Innocent / Champagne, Maëliss / Lacroix, Audrey / Thaurignac, Guillaume / Esteban, Amandine / De Nys, Helene / Bourgarel, Mathieu / Akoachere, Jane-Francis / Delaporte, Eric / Ayouba, Ahidjo / Cappelle, Julien / Mpoudi Ngole, Eitel / Peeters, Martine

Viruses

2022 Volume 14, Issue 3

Abstract: The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats ( ...

Abstract	The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (
MeSH term(s)	Animals ; Antibodies, Viral ; Cameroon/epidemiology ; Chiroptera ; Ebolavirus/genetics ; Female ; Lactation
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14030560
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Article ; Online: Mutations in the non-coding RNU4ATAC gene affect the homeostasis and function of the Integrator complex.

Almentina Ramos Shidi, Fatimat / Cologne, Audric / Delous, Marion / Besson, Alicia / Putoux, Audrey / Leutenegger, Anne-Louise / Lacroix, Vincent / Edery, Patrick / Mazoyer, Sylvie / Bordonné, Rémy

Nucleic acids research

2022 Volume 51, Issue 2, Page(s) 712–727

Abstract: Various genetic diseases associated with microcephaly and developmental defects are due to pathogenic variants in the U4atac small nuclear RNA (snRNA), a component of the minor spliceosome essential for the removal of U12-type introns from eukaryotic ... ...

Abstract	Various genetic diseases associated with microcephaly and developmental defects are due to pathogenic variants in the U4atac small nuclear RNA (snRNA), a component of the minor spliceosome essential for the removal of U12-type introns from eukaryotic mRNAs. While it has been shown that a few RNU4ATAC mutations result in impaired binding of essential protein components, the molecular defects of the vast majority of variants are still unknown. Here, we used lymphoblastoid cells derived from RNU4ATAC compound heterozygous (g.108_126del;g.111G>A) twin patients with MOPD1 phenotypes to analyze the molecular consequences of the mutations on small nuclear ribonucleoproteins (snRNPs) formation and on splicing. We found that the U4atac108_126del mutant is unstable and that the U4atac111G>A mutant as well as the minor di- and tri-snRNPs are present at reduced levels. Our results also reveal the existence of 3'-extended snRNA transcripts in patients' cells. Moreover, we show that the mutant cells have alterations in splicing of INTS7 and INTS10 minor introns, contain lower levels of the INTS7 and INTS10 proteins and display changes in the assembly of Integrator subunits. Altogether, our results show that compound heterozygous g.108_126del;g.111G>A mutations induce splicing defects and affect the homeostasis and function of the Integrator complex.
MeSH term(s)	Spliceosomes/genetics ; Spliceosomes/metabolism ; Ribonucleoproteins, Small Nuclear/genetics ; Mutation ; Introns/genetics ; RNA Splicing/genetics ; RNA, Small Nuclear/metabolism ; Homeostasis/genetics
Chemical Substances	Ribonucleoproteins, Small Nuclear ; RNA, Small Nuclear
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac1182
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