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Article: Unilateral branch retinal artery occlusion in association with COVID-19: a case report.

Hirosawa, Kunihiko / Inomata, Takenori / Sung, Jaemyoung / Morooka, Yuki / Huang, Tianxiang / Akasaki, Yasutsugu / Okumura, Yuichi / Nagino, Ken / Omori, Kaho / Nakao, Shintaro

International journal of ophthalmology

2024 Volume 17, Issue 4, Page(s) 777–782

Language	English
Publishing date	2024-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2024.04.25
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Article ; Online: Gas Bubbles in the Anterior Chamber.

Nakao, Shintaro / Sonoda, Koh-Hei

JAMA ophthalmology

2020 Volume 138, Issue 11, Page(s) e202049

MeSH term(s)	Adult ; Anterior Chamber/pathology ; Endotamponade ; Eye Diseases/etiology ; Eye Diseases/physiopathology ; Fluorocarbons ; Head Movements ; Humans ; Lens, Crystalline/surgery ; Male ; Microbubbles ; Retinal Detachment/surgery ; Slit Lamp Microscopy ; Vitrectomy
Chemical Substances	Fluorocarbons ; perflutren (CK0N3WH0SR)
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2020.2049
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Article ; Online: Removal of MIRAgel scleral buckle implants using Yankauer suction catheter with adjusted diameter.

Nakao, Shintaro / Nishida, Takashi / Sonoda, Koh-Hei

American journal of ophthalmology case reports

2022 Volume 26, Page(s) 101470

Abstract: Purpose: A variety of removal methods have been reported for cases wherein MIRAgel-associated complications have occurred. Recently, Santorum et al. reported an aspiration method using a metal microcannula. Herein, we report a novel alternative approach ...

Abstract	Purpose: A variety of removal methods have been reported for cases wherein MIRAgel-associated complications have occurred. Recently, Santorum et al. reported an aspiration method using a metal microcannula. Herein, we report a novel alternative approach using Yankauer suction catheter based on Santorum et al.'s method. Observations: This retrospective case involved a 40-year-old Caucasian man with MIRAgel implant-associated swelling-related complications (strabismus and disfiguring mass effect), who underwent suction-assisted implant removal in January 2020 at Kyushu University Hospital. Surgery was conducted under general anesthesia with an incision made in the superior quadrant, and the degraded MIRAgel implant was aspirated using a Yankauer suction catheter instrument with its diameter adjusted to the space. At the one-month follow-up, there were no early postsurgical complications, and the retina remained completely attached. Conclusions: Yankauer suction catheter is a useful instrument for removal of MIRAgel scleral buckle implants. It is made up of polyvinyl chloride, which is safer and cheaper, and can be cut to adjust the instrument's diameter according to the surgical field.
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2022.101470
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Article ; Online: Five cases of endoscopically noted esophageal stenosis due to abnormal aortic angiogenesis.

Iwanaga, Shintaro / Inomata, Hiroko / Tabuchi, Maiko / Sasaki, Ryu / Yamaguchi, Naoyuki / Nakao, Kazuhiko

Clinical journal of gastroenterology

2023 Volume 16, Issue 3, Page(s) 325–329

Abstract: Right aortic arch is caused by a malformation of the aorta while Kommerell's diverticulum is a saccular aneurysm arising at the origin of the subclavian artery. Both diseases are caused by malformations during embryonic development and can subsequently ... ...

Abstract	Right aortic arch is caused by a malformation of the aorta while Kommerell's diverticulum is a saccular aneurysm arising at the origin of the subclavian artery. Both diseases are caused by malformations during embryonic development and can subsequently cause compression of the esophagus and trachea due to abnormal arterial migration. Here, we report five cases of esophageal stenosis due to aortic angiogenesis anomalies. Three of the five cases had aortic running abnormalities, noted on computed tomography (CT). However, until it was observed for the first time, esophageal stricture was not recognized as an esophagogastroduodenoscopy (EGD) finding due to the lack of knowledge of diseases such as Kommerell's diverticulum even when EGD was performed during regular follow-up after treatment for esophageal cancer or other conditions. Symptoms include dysphagia and dyspnea due to stenosis of the esophagus and trachea, however, regardless of symptomatic presentation, the presence of esophageal stenosis on EGD should be considered as an effect of aortic travel abnormality or Kommerell's diverticulum. Although there have been no reports of Kommerell's diverticulum rupture due to endoscopic manipulation, gastroenterologists should consider the possibility of Kommerell's diverticulum during clinical decision making.
MeSH term(s)	Humans ; Esophageal Stenosis/diagnostic imaging ; Esophageal Stenosis/etiology ; Aorta, Thoracic/diagnostic imaging ; Aneurysm ; Tomography, X-Ray Computed ; Diverticulum
Language	English
Publishing date	2023-02-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-023-01773-2
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Article ; Online: A case report of hydrocephalus due to diffuse villous hyperplasia of the choroid plexus: surgical treatment by combination a flexible videoscope with a rigid endoscope.

Nakajima, Shintaro / Murofushi, Keisuke / Matsuda, Shinpei / Shimada, Shino / Shimoji, Kazuaki / Nakao, Yasuaki / Yamamoto, Takuji

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2023 Volume 39, Issue 8, Page(s) 2045–2051

Abstract: Purpose: Diffuse villous hyperplasia of the choroid plexus (DVHCP) and choroid plexus papilloma (CPP) are rare benign tumors usually diagnosed as a result of progressive hydrocephalus, especially in childhood. We present the case of a Japanese boy ... ...

Abstract	Purpose: Diffuse villous hyperplasia of the choroid plexus (DVHCP) and choroid plexus papilloma (CPP) are rare benign tumors usually diagnosed as a result of progressive hydrocephalus, especially in childhood. We present the case of a Japanese boy diagnosed with progressive hydrocephalus due to DVHCP. Methods: Case: A 2-year and 3-month-old Japanese boy was found to have delayed motor development (equivalent to 1 year and 2 months old), an enlarged head circumference of 51 cm within + 1.5 standard deviation (S.D.), and incomplete closure of the anterior fontanel. The magnetic resonance imaging (MRI) showed lobular enlargement of the bilateral choroid plexuses extending from the trigone to the body and inferior horn of the lateral ventricle. The endoscopic choroid plexus coagulation surgery was performed to reduce the CSF formation rate. Results: DVHCP was diagnosed both pathologically and clinically. Postoperatively, the patient progressed without complications, such as cerebrospinal fluid leakage. Although ventricular enlargement persisted, the anterior fontanel recessed, and the expansion of the head circumference stopped. Conclusion: Few cases of bilateral DVHCP and CPP have been reported in the literature. We encountered a case in which effective choroid plexus coagulation was performed for hydrocephalus due to DVHCP using less invasive endoscopic technique. It also represented an association between DVHCP and the gain of chromosome 9p.
MeSH term(s)	Humans ; Infant ; Male ; Choroid Plexus/diagnostic imaging ; Choroid Plexus/surgery ; Choroid Plexus/pathology ; Endoscopes ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/etiology ; Hydrocephalus/surgery ; Hyperplasia/complications ; Hyperplasia/pathology ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-07-01
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-06012-0
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Article ; Online: Real-time fundus reconstruction and intraocular mapping using an ophthalmic endoscope.

Zhou, Dongbo / Takeyama, Hayato / Nakao, Shintaro / Sonoda, Koh-Hei / Tadano, Kotaro

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 Volume 19, Issue 3, Page(s) e2496

Abstract: Background: Robotic ophthalmic endoscope holders allow surgeons to execute dual-hand operations in eye surgery. To prevent needle-like endoscopes from invading the retina when moving, surgeons expect visual and real-time information about the relative ... ...

Abstract	Background: Robotic ophthalmic endoscope holders allow surgeons to execute dual-hand operations in eye surgery. To prevent needle-like endoscopes from invading the retina when moving, surgeons expect visual and real-time information about the relative special relationship between the endoscope and fundus. Methods: This study develops a real-time fundus reconstruction method. First, using deep learning, the method estimates the distance between the fundus part corresponding to every pixel of the RGB endoscopic image and the endoscope. Then, by combining the estimated distance with the kinematics of a robotic holder, the point cloud representing the present fundus area is generated, and by which the size and position of the eyeball are estimated. Results: This method shows a real-time frequency of 10 Hz, which is robust to eyeball movement. The error of fundus reconstruction is about 0.5 mm, and the error of eyeball estimation is about 1 mm. Conclusion: Using this fundus reconstruction method can map the position of the endoscope inside the eyeball when using a robotic endoscope holder in eye surgery. The overall accuracy level meets the ophthalmologists' accuracy requirements of ophthalmologists.
MeSH term(s)	Humans ; Endoscopes ; Endoscopy/methods ; Robotics/methods ; Surgery, Computer-Assisted/methods ; Equipment Design
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2496
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Article ; Online: Correction to: Persistence of vascular empty sleeves in choroidal neovascularization after anti-VEGF therapy in both animal models and humans.

Wada, Iori / Nakao, Shintaro / Fukuda, Yosuke / Shiose, Satomi / Takeda, Atsunobu / Kannan, Ram / Sonoda, Koh-Hei

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 261, Issue 10, Page(s) 3047

Language	English
Publishing date	2023-08-22
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06214-x
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Article: Retinal neurovascular alteration in type 2 diabetes with renal impairment in association with systemic arterial stiffness.

Ari Widjaja, Sauli / Mieler, William F / Sasono, Wimbo / Soelistijo, Soebagijo A / Kartasasmita, Arief S / Murakami, Akira / Nakao, Shintaro

International journal of retina and vitreous

2024 Volume 10, Issue 1, Page(s) 2

Abstract: Background: Diabetic retinopathy (DR) patients should be alert for subclinical macroangiopathy. We aimed to investigate the association between retinal neurovascular alteration and systemic arterial stiffness in type 2 diabetes mellitus (type 2 DM) ... ...

Abstract	Background: Diabetic retinopathy (DR) patients should be alert for subclinical macroangiopathy. We aimed to investigate the association between retinal neurovascular alteration and systemic arterial stiffness in type 2 diabetes mellitus (type 2 DM) patients with varying degrees of renal impairment. Methods: The study included 170 patients with confirmed diagnosis of type 2 DM aged ≥18 years old. Renal function was assessed by estimated glomerular filtration rate (eGFR). Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). Retinal neurovascular parameters were derived from Optical Coherence Tomography (OCT)/OCT-Angiography, represented by vessel density (VD Central, Inner, Outer, Full), foveal avascular zone (FAZ area and FAZ perimeter) of the superficial capillary plexus, the average of macular ganglion cell-inner plexiform layer thickness (ave mGC-IPLt) and the average of retinal nerve fiber layer thickness (aveRNFLt). The association between variables among the groups (according to renal function, diabetic retinopathy (DR) severity, and arterial stiffness categories) were analyzed by regression analysis with multiple hypothesis testing commands. Results: Out of the 265 eyes, the mean DM duration and HbA1c were 6.21 ± 6.37 years and 8.44 ± 2.06% respectively. While the mean of eGFR, baPWV and ABI were 66.78 ± 32.80 ml/min/1.73m2, 15.49 ± 3.07 m/s, and 1.05 ± 0.12, respectively. Patients with more severe renal impairment demonstrated longer DM duration (p < 0.001), higher baPWV (p < 0.0001), and retinal vascular alteration. Proliverative DR group showed the lowest eGFR (p < 0.0001), highest baPWV (p < 0.0001), and retinal neurovascular changes. Significantly lower eGFR and retinal vascular alteration were found in the baPWV > 14 group. Some neurovascular parameters were significantly negatively correlated with baPWV; moreover, retinal neurovascular changes were also noted in the abnormal ABI group. Conclusions: The strong association between changes in the retinal neurovascular system, DR severity, renal impairment, and arterial stiffness in type 2 DM was confirmed. Patients with more severe renal impairment had higher levels of arterial stiffness, more severe DR and retinal neurovascular alteration. Retinal neurovascular changes seen in OCT/OCTA might mimic renal microvascular alteration and systemic arterial stiffness. Therefore, assessment of baPWV and OCT/OCTA should be integrated in DR screening to enhance cardiovascular risk stratification and prognosis as well as to provide clinically useful early identification of subclinical micro- and macrovascular alterations.
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2836254-8
ISSN	2056-9920
ISSN	2056-9920
DOI	10.1186/s40942-023-00521-5
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Article ; Online: Characterization of tick-borne encephalitis virus isolated from tick infesting dog in central Hokkaido in 2018.

Takahashi, Yuji / Kobayashi, Shintaro / Nakao, Ryo / Kariwa, Hiroaki / Yoshii, Kentaro

Ticks and tick-borne diseases

2022 Volume 13, Issue 2, Page(s) 101900

Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic virus belonging to the genus Flavivirus of the family Flaviviridae, causing meningitis or meningoencephalitis in humans. TBEV is widely distributed across the Eurasian northern regions, including Japan. ... ...

Abstract	Tick-borne encephalitis virus (TBEV) is a zoonotic virus belonging to the genus Flavivirus of the family Flaviviridae, causing meningitis or meningoencephalitis in humans. TBEV is widely distributed across the Eurasian northern regions, including Japan. Dogs have been reported to be sentinel hosts of TBEV in endemic areas, but studies of ticks infesting dogs are limited in Japan. This study isolated a novel TBEV strain from a tick (Ixodes ovatus) collected on a dog from central Hokkaido. Whole-genome sequencing revealed that the isolated strain belonged to the Far Eastern subtype of TBEV and was classified under a different subcluster of other Japanese isolates. Nanporo-18-44 showed growth properties similar to those of Oshima 5-10 both in vitro and in vivo. The pathogenicity of both viruses was similar in mice infected intracerebrally, however they showed a distinct distribution in the infected neurons of the mouse brain. Our results suggest that infections of humans and animals by unknown strains of TBEV exist in other areas of Japan. Further surveys including those conducted outside of Hokkaido, are required to elucidate the epidemiological risk of TBEV in Japan.
MeSH term(s)	Animals ; Dogs ; Encephalitis Viruses, Tick-Borne ; Encephalitis, Tick-Borne/epidemiology ; Encephalitis, Tick-Borne/veterinary ; Ixodes ; Japan/epidemiology ; Mice ; Virulence
Language	English
Publishing date	2022-01-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2022.101900
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Article: [Impact of anti-VEGF therapy on the cellular microenvironment in retinal angiogenesis].

Nakao, Shintaro

Nippon Ganka Gakkai zasshi

2014 Volume 118, Issue 11, Page(s) 943–952

Abstract: Various large-scale studies show the efficacy of anti-vascular endothelial growth factor (VEGF) therapy in treatment of retinal diseases. Based on the evidence, it is expected that this therapeutic strategy will be used widely for various retinal ... ...

Abstract	Various large-scale studies show the efficacy of anti-vascular endothelial growth factor (VEGF) therapy in treatment of retinal diseases. Based on the evidence, it is expected that this therapeutic strategy will be used widely for various retinal vascular diseases including diabetic retinopathy and retinal vein occlusion. Leukocyte infiltration is an important step that occurs during angiogenesis in inflammatory diseases. Various studies report that infiltrated leukocytes are a prerequisite for retinal angiogenesis, including diabetic retinopathy. Furthermore, the fibrovascular membrane (FVM) microenvironment consists of stromal components (extracellular matrix, myofibroblasts and leukocytes) supported by angiogenesis (endothelial cells and pericytes). The activity of proliferative diabetic retinopathy (PDR) is thought to be determined by the angiogenesis-assisted FVM microenvironment status. Recently, we investigated whether intravitreal anti-VEGF therapy modulates leukocyte infiltration in retinal angiogenesis using the surgically obtained FVM in pars plana vitrectomy with or without pretreatment with bevacizumab. The effect of anti-VEGF therapy on leukocyte infiltration was also examined with a mouse model of oxygen-induced retinopathy. Moreover, the impact of anti-VEGF therapy on endothelial cells, pericytes and myofibroblasts was also examined using the FVM. We could observe that anti-VEGF therapy blocked leukocyte infiltration as well as re-entry from the retina. The therapy also could induce the contraction of blood vessels, increasing the pericyte ratio and transforming growth factor-β expression in the FVM. Our data indicate anti-VEGF therapy could attain anti-inflammation, vessel contraction and vessel maturation, resulting in the resolution of retinal edema as well as the prevention of intraoperative hemorrhage.
MeSH term(s)	Animals ; Cellular Microenvironment/drug effects ; Humans ; Leukocytes ; Neovascularization, Pathologic/drug therapy ; Retinal Diseases/drug therapy ; Retinal Diseases/metabolism ; Retinal Vessels/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Chemical Substances	Vascular Endothelial Growth Factor A
Language	Japanese
Publishing date	2014-11
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	82001-5
ISSN	0029-0203 ; 0300-9203
ISSN	0029-0203 ; 0300-9203
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