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Article ; Online: Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates.

Lim, Seong Gi / Seo, Sung Eun / Jo, Seongjae / Kim, Kyung Ho / Kim, Lina / Kwon, Oh Seok

ACS omega

2022 Volume 7, Issue 41, Page(s) 36441–36447

Abstract: Transient receptor potential vanilloid 1 (TRPV1) agonists that bind to the vanilloid pocket are being actively studied in the pharmaceutical industry to develop novel treatments for chronic pain and cancer. To discover synthetic vanilloids without the ... ...

Abstract	Transient receptor potential vanilloid 1 (TRPV1) agonists that bind to the vanilloid pocket are being actively studied in the pharmaceutical industry to develop novel treatments for chronic pain and cancer. To discover synthetic vanilloids without the side effect of capsaicin, a time-consuming process of drug candidate selection is essential to a myriad of chemical compounds. Herein, we propose a novel approach to field-effect transistors for the fast and facile screening of lead vanilloid compounds for the development of TRPV1-targeting medications. The graphene field-effect transistor was fabricated with human TRPV1 receptor protein as the bioprobe, and various analyses (SEM, Raman, and FT-IR) were utilized to verify successful manufacture. Simulations of TRPV1 with capsaicin, olvanil, and arvanil were conducted using AutoDock Vina/PyMOL to confirm the binding affinity. The interaction of the ligands with TRPV1 was detected via the fabricated platform, and the collected responses corresponded to the simulation analysis.
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c04202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrasensitive Gas Detection Based on Electrically Enhanced Nanoplasmonic Sensor with Graphene-Encased Gold Nanorod.

Kim, Kyung Ho / Jo, Seongjae / Seo, Sung Eun / Kim, Jaemin / Lee, Dae-Sik / Joo, Siyeon / Lee, Jiwon / Song, Hyun Seok / Lee, Hee Gu / Kwon, Oh Seok

ACS sensors

2023 Volume 8, Issue 6, Page(s) 2169–2178

Abstract: Nanoplasmonic sensors are a widely known concept and have been studied with various applications. Among them, gas detection is engaging attention in many fields. However, the analysis performance of nanoplasmonic sensors based on refractive index ... ...

Abstract	Nanoplasmonic sensors are a widely known concept and have been studied with various applications. Among them, gas detection is engaging attention in many fields. However, the analysis performance of nanoplasmonic sensors based on refractive index confined to the metal nanostructure characteristics causes challenges in gas detection. In this study, we develop a graphene-encased gold nanorod (AuNR)-based nanoplasmonic sensor to detect cadaverine gas. The graphene-encased AuNR (Gr@AuNR) presents an ultrasensitive peak wavelength shift even with tiny molecules. In addition, the external potential transmitted through graphene induces an additional shift. A chemical receptor is immobilized on Gr@AuNR (CR@Gr@AuNR) for selectively capturing cadaverine. The CR@Gr@AuNR achieves ultrasensitive detection of cadaverine gas, and the detection limit is increased to 15.99 ppb by applying a voltage to graphene. Furthermore, the experimental results of measuring cadaverine generated from spoiled pork show the practicality of CR@Gr@AuNR. The strategy of external-boosted nanoplasmonics provides new insight into plasmonic sensing and applications.
MeSH term(s)	Graphite/chemistry ; Gold/chemistry ; Cadaverine ; Nanotubes/chemistry
Chemical Substances	Graphite (7782-42-5) ; Gold (7440-57-5) ; Cadaverine (L90BEN6OLL)
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.2c02414
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recombinant protein embedded liposome on gold nanoparticle based on LSPR method to detect Corona virus.

Kim, Lina / Jo, Seongjae / Kim, Gyeong-Ji / Kim, Kyung Ho / Seo, Sung Eun / Ryu, Eunsu / Shin, Chan Jae / Kim, Yu Kyung / Choi, Jeong-Woo / Kwon, Oh Seok

Nano convergence

2023 Volume 10, Issue 1, Page(s) 51

Abstract: Antibody sensor to detect viruses has been widely used but has problems such as the difficulty of right direction control of the receptor site on solid substrate, and long time and high cost for design and production of antibodies to new emerging viruses. ...

Abstract	Antibody sensor to detect viruses has been widely used but has problems such as the difficulty of right direction control of the receptor site on solid substrate, and long time and high cost for design and production of antibodies to new emerging viruses. The virus detection sensor with a recombinant protein embedded liposome (R/Li) was newly developed to solve the above problems, in which R/Li was assembled on AuNPs (Au@R/Li) to increase the sensitivity using localized surface plasmon resonance (LSPR) method. Recombinant angiotensin-converting enzyme-2 (ACE2) was used as host receptors of SARS-CoV and SARS-CoV-2, and the direction of enzyme active site for virus attachment could be controlled by the integration with liposome. The recombinant protein embedded liposomes were assembled on AuNPs, and LSPR method was used for detection. With the sensor platform S1 protein of both viruses was detected with detection limit of 10 pg/ml and SARS-CoV-2 in clinical samples was detected with 10 ~ 35 Ct values. In the selectivity test, MERS-CoV did not show a signal due to no binding with Au@R/Li. The proposed sensor platform can be used as promising detection method with high sensitivity and selectivity for the early and simple diagnosis of new emerging viruses.
Language	English
Publishing date	2023-10-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2760386-6
ISSN	2196-5404 ; 2196-5404
ISSN (online)	2196-5404
ISSN	2196-5404
DOI	10.1186/s40580-023-00399-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recombinant protein embedded liposome on gold nanoparticle based on LSPR method to detect Corona virus

Lina Kim / Seongjae Jo / Gyeong-Ji Kim / Kyung Ho Kim / Sung Eun Seo / Eunsu Ryu / Chan Jae Shin / Yu Kyung Kim / Jeong-Woo Choi / Oh Seok Kwon

Nano Convergence, Vol 10, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract Antibody sensor to detect viruses has been widely used but has problems such as the difficulty of right direction control of the receptor site on solid substrate, and long time and high cost for design and production of antibodies to new ... ...

Abstract	Abstract Antibody sensor to detect viruses has been widely used but has problems such as the difficulty of right direction control of the receptor site on solid substrate, and long time and high cost for design and production of antibodies to new emerging viruses. The virus detection sensor with a recombinant protein embedded liposome (R/Li) was newly developed to solve the above problems, in which R/Li was assembled on AuNPs (Au@R/Li) to increase the sensitivity using localized surface plasmon resonance (LSPR) method. Recombinant angiotensin-converting enzyme-2 (ACE2) was used as host receptors of SARS-CoV and SARS-CoV-2, and the direction of enzyme active site for virus attachment could be controlled by the integration with liposome. The recombinant protein embedded liposomes were assembled on AuNPs, and LSPR method was used for detection. With the sensor platform S1 protein of both viruses was detected with detection limit of 10 pg/ml and SARS-CoV-2 in clinical samples was detected with 10 ~ 35 Ct values. In the selectivity test, MERS-CoV did not show a signal due to no binding with Au@R/Li. The proposed sensor platform can be used as promising detection method with high sensitivity and selectivity for the early and simple diagnosis of new emerging viruses. Graphical Abstract
Keywords	Virus sensor ; Protein embedded liposome ; Recombinant protein ; SARS-CoV-2 detection ; LSPR ; Technology ; T ; Chemical technology ; TP1-1185 ; Biotechnology ; TP248.13-248.65 ; Science ; Q ; Physics ; QC1-999
Subject code	500
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wide-range direct detection of 25-hydroxyvitamin D

Jo, Seongjae / Lee, Wonseok / Park, Joohyung / Park, Hyunjun / Kim, Minwoo / Kim, Woochang / Hong, Junghwa / Park, Jinsung

Biosensors & bioelectronics

2021 Volume 181, Page(s) 113118

Abstract: Vitamin D is associated with various diseases such as obesity, digestive problems, osteoporosis, depression, and infections, which has emerged as an interest in public healthcare. Recently, vitamin D has received more attention because of the potential ... ...

Abstract	Vitamin D is associated with various diseases such as obesity, digestive problems, osteoporosis, depression, and infections, which has emerged as an interest in public healthcare. Recently, vitamin D has received more attention because of the potential implication with coronavirus disease 2019. In this study, we developed a localized surface plasmon resonance (LSPR) aptasensor based on polyethylene-glycol(PEG)-free gold nanorods (AuNRs) for the wide-range and direct detection of 25-hydroxyvitamin D
MeSH term(s)	Aptamers, Nucleotide ; Biosensing Techniques ; COVID-19 ; Calcifediol ; Gold ; Humans ; Nanotubes ; Polyethylene Glycols ; Polyethylenes ; Surface Plasmon Resonance ; Vitamin D/analogs & derivatives ; Vitamin D/analysis
Chemical Substances	Aptamers, Nucleotide ; Polyethylenes ; Vitamin D (1406-16-2) ; Polyethylene Glycols (3WJQ0SDW1A) ; Gold (7440-57-5) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113118
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Article ; Online: Bio-inspired Ag nanovilli-based sandwich-type SERS aptasensor for ultrasensitive and selective detection of 25-hydroxy vitamin D

Kim, Woochang / Park, Joohyung / Kim, Woong / Jo, Seongjae / Kim, Minwoo / Kim, Chihyun / Park, Hyunjun / Bang, Doyeon / Lee, Wonseok / Park, Jinsung

Biosensors & bioelectronics

2021 Volume 188, Page(s) 113341

Abstract: Vitamin D has been identified as an essential biomarker for various diseases such as rheumatoid arthritis, cancer, and cardiovascular diseases. Recently, many reports have demonstrated a potential link between vitamin D and systemic infections, including ...

Abstract	Vitamin D has been identified as an essential biomarker for various diseases such as rheumatoid arthritis, cancer, and cardiovascular diseases. Recently, many reports have demonstrated a potential link between vitamin D and systemic infections, including coronavirus disease 2019. The villi of the small intestine increase the surface area of the intestinal walls, demonstrating exceptionally efficient absorption of nutrients in the lumen and adding digestive secretions. In this study, based on the villi structure, we developed a bio-inspired silver nanovilli-based sandwich-type surface enhanced Raman scattering aptasensor for the ultrasensitive and selective detection of 25-hydroxy vitamin D
MeSH term(s)	Aptamers, Nucleotide ; Biosensing Techniques ; COVID-19 ; Calcifediol ; Gold ; Humans ; Metal Nanoparticles ; Reproducibility of Results ; SARS-CoV-2 ; Silver ; Spectrum Analysis, Raman
Chemical Substances	Aptamers, Nucleotide ; Silver (3M4G523W1G) ; Gold (7440-57-5) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2021-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113341
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Article ; Online: High sensitive detection of copper II ions using D-penicillamine-coated gold nanorods based on localized surface plasmon resonance.

Hong, Yoochan / Jo, Seongjae / Park, Joohyung / Park, Jinsung / Yang, Jaemoon

Nanotechnology

2018 Volume 29, Issue 21, Page(s) 215501

Abstract: In this paper, we describe the development of a nanoplasmonic biosensor based on the localized surface plasmon resonance (LSPR) effect that enables a sensitive and selective recognition of copper II ions. First, we fabricated the nanoplasmonics as LSPR ... ...

Abstract	In this paper, we describe the development of a nanoplasmonic biosensor based on the localized surface plasmon resonance (LSPR) effect that enables a sensitive and selective recognition of copper II ions. First, we fabricated the nanoplasmonics as LSPR substrates using gold nanorods (GNR) and the nano-adsorption method. The LSPR sensitivity of the nanoplasmonics was evaluated using various solvents with different refractive indexes. Subsequently, D-penicillamine (DPA)-a chelating agent of copper II ions-was conjugated to the surface of the GNR. The limit of detection (LOD) for the DPA-conjugated nanoplasmonics was 100 pM. Furthermore, selectivity tests were conducted using various divalent cations, and sensitivity tests were conducted on the nanoplasmonics under blood-like environments. Finally, the developed nanoplasmonic biosensor based on GNR shows great potential for the effective recognition of copper II ions, even in human blood conditions.
Language	English
Publishing date	2018-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/aab4c4
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Article ; Online: Second Skin as Self-Protection Against γ-Hydroxybutyrate.

Kim, Gyeong-Ji / Park, Seon Joo / Kim, Lina / Kim, Kyung Ho / Kim, Soomin / An, Jai Eun / Shin, Chan Jae / Seo, Sung Eun / Jo, Seongjae / Kim, Jinyeong / Ha, Siyoung / Seo, Hwi Won / Rho, Mun-Chual / Kwon, Do Hyung / Kim, Woo-Keun / Jeong, Gugin / Ryu, Jae Chun / Kim, Jae Joon / Kwon, Oh Seok

ACS nano

2023 Volume 17, Issue 24, Page(s) 25405–25418

Abstract: γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated ... ...

Abstract	γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated sexual assault because it is tasteless, odorless, and colorless when dissolved in beverages. Generally, GHB detection methods are difficult to use promptly and secretly
MeSH term(s)	Sodium Oxybate ; Rape ; Ethanol
Chemical Substances	Sodium Oxybate (7G33012534) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c08840
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Article ; Online: Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function.

Park, Ye-Jin / Kim, Sungkyung / Shim, Hyeon-Pyo / Park, Jae H / Lee, Gyunghee / Kim, Tae-Yeop / Jo, Min-Cue / Kwon, Ah-Young / Lee, Mihwa / Lee, Seongjae / Yeo, Jiwon / Chung, Hyung-Lok / Bellen, Hugo J / Kwon, Seung-Hae / Jeon, Sang-Hak

iScience

2021 Volume 24, Issue 8, Page(s) 102899

Abstract: Phosphatidylserine (PS) is an integral component of eukaryotic cell membranes and organelles. ... ...

Abstract	Phosphatidylserine (PS) is an integral component of eukaryotic cell membranes and organelles. The
Language	English
Publishing date	2021-07-24
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.102899
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Article: Highly sensitive and wide-range nanoplasmonic detection of fibrinogen using erythrocyte membrane-blanketed nanoparticles

Jo, Seongjae / Insu Kim / Wonseok Lee / Minwoo Kim / Joohyung Park / Gyudo Lee / Dae Sung Yoon / Jinsung Park

Biosensors & bioelectronics. 2019 June 15, v. 135

2019

Abstract: Fibrinogen, which is a glycoprotein that circulates in the blood, plays various important biological roles, e.g., in blood coagulation, fibroblast proliferation, angiogenesis, and wound healing. Abnormal levels of fibrinogen in plasma have been ... ...

Abstract	Fibrinogen, which is a glycoprotein that circulates in the blood, plays various important biological roles, e.g., in blood coagulation, fibroblast proliferation, angiogenesis, and wound healing. Abnormal levels of fibrinogen in plasma have been identified as a key biomarker of a variety of disorders from cardiovascular diseases to hemophilia. Therefore, the development of a quantitative assay for fibrinogen in the blood has emerged as an important issue for the prevention and diagnosis of these diseases. Meanwhile, it is well known that erythrocytes can selectively capture fibrinogen because of the fibrinogen receptor expressed on their plasma membrane. Inspired by these biological interactions, herein, we devised an erythrocyte membrane (EM)-blanketed biosensor based on localized surface plasmon resonance (LSPR) for highly sensitive detection of fibrinogen. By placing the EM onto a nanoparticle-on-substrate, we enhanced the LSPR signal, achieving highly sensitive and selective detection of fibrinogen. We demonstrated that fibrinogen detection is possible over a wide concentration range, 0.001–5.000 mg/mL, which can cover normal and pathological blood fibrinogen levels. In addition, it was verified that the biosensor selectively detects fibrinogen in comparison with other human-blood-plasma components. The nanoplasmonic sensor blanketed with the EM opens up new opportunities for the development of a robust fibrinogen-sensing technology.
Keywords	angiogenesis ; biomarkers ; biosensors ; blood coagulation ; cardiovascular diseases ; erythrocyte membrane ; erythrocytes ; fibrinogen ; fibroblasts ; glycoproteins ; hemophilia ; nanoparticles ; plasma membrane ; surface plasmon resonance
Language	English
Dates of publication	2019-0615
Size	p. 216-223.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2019.04.030
Database	NAL-Catalogue (AGRICOLA)

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