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Article ; Online: Targeting the Main Protease (M

Altincekic, Nadide / Jores, Nathalie / Löhr, Frank / Richter, Christian / Ehrhardt, Claus / Blommers, Marcel J J / Berg, Hannes / Öztürk, Sare / Gande, Santosh L / Linhard, Verena / Orts, Julien / Abi Saad, Marie Jose / Bütikofer, Matthias / Kaderli, Janina / Karlsson, B Göran / Brath, Ulrika / Hedenström, Mattias / Gröbner, Gerhard / Sauer, Uwe H /

Perrakis, Anastassis / Langer, Julian / Banci, Lucia / Cantini, Francesca / Fragai, Marco / Grifagni, Deborah / Barthel, Tatjana / Wollenhaupt, Jan / Weiss, Manfred S / Robertson, Angus / Bax, Adriaan / Sreeramulu, Sridhar / Schwalbe, Harald

ACS chemical biology

2024 Volume 19, Issue 2, Page(s) 563–574

Abstract: The main protease M ...

Abstract	The main protease M
MeSH term(s)	Drug Discovery/methods ; SARS-CoV-2/metabolism ; Catalytic Domain ; Magnetic Resonance Spectroscopy ; Peptide Hydrolases/metabolism ; Protease Inhibitors/metabolism ; Antiviral Agents/pharmacology ; Molecular Docking Simulation
Chemical Substances	Peptide Hydrolases (EC 3.4.-) ; Protease Inhibitors ; Antiviral Agents
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.3c00720
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Biochemistry / [Hauptbd.] / Jeremy M. Berg ; John L. Tymoczko ; Lubert Stryer with Gregory J. Gatto

Berg, Jeremy M. / Tymoczko, John L. / Stryer, Lubert

2012

Collection	Biochemistry
Language	English
Size	Getr. Zählung : Ill., graph. Darst.
Edition	Internat. 7. ed., 1. print.
Publisher	Freeman u.a.
Publishing place	New York
Publishing country	United States
Document type	Book
Note	Hier auch später erschienene, unveränderte Nachdrucke
HBZ-ID	HT016791419
ISBN	978-1-4292-7635-1 ; 1-4292-7635-5
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Article: Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

Abud, A Abed / Abi, B / Acciarri, R / Acero, M A / Adames, M R / Adamov, G / Adamowski, M / Adams, D / Adinolfi, M / Aduszkiewicz, A / Aguilar, J / Ahmad, Z / Ahmed, J / Aimard, B / Ali-Mohammadzadeh, B / Alion, T / Allison, K / Monsalve, S Alonso / AlRashed, M /

Alt, C / Alton, A / Alvarez, R / Amedo, P / Anderson, J / Andreopoulos, C / Andreotti, M / Andrews, M / Andrianala, F / Andringa, S / Anfimov, N / Ankowski, A / Antoniassi, M / Antonova, M / Antoshkin, A / Antusch, S / Aranda-Fernandez, A / Arellano, L / Arnold, L O / Arroyave, M A / Asaadi, J / Asquith, L / Aurisano, A / Aushev, V / Autiero, D / Lara, V Ayala / Ayala-Torres, M / Azfar, F / Back, A / Back, H / Back, J J / Backhouse, C / Bagaturia, I / Bagby, L / Balashov, N / Balasubramanian, S / Baldi, P / Baller, B / Bambah, B / Barao, F / Barenboim, G / Alzas, P Barham / Barker, G / Barkhouse, W / Barnes, C / Barr, G / Monarca, J Barranco / Barros, A / Barros, N / Barrow, J L / Basharina-Freshville, A / Bashyal, A / Basque, V / Batchelor, C / Chagas, E Batista das / Battat, J B R / Battisti, F / Bay, F / Bazetto, M C Q / Alba, J L L Bazo / Beacom, J F / Bechetoille, E / Behera, B / Beigbeder, C / Bellantoni, L / Bellettini, G / Bellini, V / Beltramello, O / Benekos, N / Montiel, C Benitez / Neves, F Bento / Berger, J / Berkman, S / Bernardini, P / Berner, R M / Bersani, A / Bertolucci, S / Betancourt, M / Rodríguez, A Betancur / Bevan, A / Bezawada, Y / Bezerra, T J C / Bhardwaj, A / Bhatnagar, V / Bhattacharjee, M / Bhattarai, D / Bhuller, S / Bhuyan, B / Biagi, S / Bian, J / Biassoni, M / Biery, K / Bilki, B / Bishai, M / Bitadze, A / Blake, A / Blaszczyk, F / Blazey, G C / Blucher, E / Boissevain, J / Bolognesi, S / Bolton, T / Bomben, L / Bonesini, M / Bongrand, M / Bonilla-Diaz, C / Bonini, F / Booth, A / Boran, F / Bordoni, S / Borkum, A / Bostan, N / Bour, P / Bourgeois, C / Boyden, D / Bracinik, J / Braga, D / Brailsford, D / Branca, A / Brandt, A / Bremer, J / Breton, D / Brew, C / Brice, S J / Brizzolari, C / Bromberg, C / Brooke, J / Bross, A / Brunetti, G / Brunetti, M / Buchanan, N / Budd, H / Butorov, I / Cagnoli, I / Cai, T / Caiulo, D / Calabrese, R / Calafiura, P / Calcutt, J / Calin, M / Calvez, S / Calvo, E / Caminata, A / Campanelli, M / Caratelli, D / Carber, D / Carceller, J C / Carini, G / Carlus, B / Carneiro, M F / Carniti, P / Terrazas, I Caro / Carranza, H / Carroll, T / Forero, J F Castaño / Castillo, A / Castromonte, C / Catano-Mur, E / Cattadori, C / Cavalier, F / Cavallaro, G / Cavanna, F / Centro, S / Cerati, G / Cervelli, A / Villanueva, A Cervera / Chalifour, M / Chappell, A / Chardonnet, E / Charitonidis, N / Chatterjee, A / Chattopadhyay, S / Neyra, M S S Chavarry / Chen, H / Chen, M / Chen, Y / Chen, Z / Chen-Wishart, Z / Cheon, Y / Cherdack, D / Chi, C / Childress, S / Chirco, R / Chiriacescu, A / Chisnall, G / Cho, K / Choate, S / Chokheli, D / Chong, P S / Christensen, A / Christian, D / Christodoulou, G / Chukanov, A / Chung, M / Church, E / Cicero, V / Clarke, P / Cline, G / Coan, T E / Cocco, A G / Coelho, J A B / Colton, N / Conley, E / Conley, R / Conrad, J / Convery, M / Copello, S / Cova, P / Cremaldi, L / Cremonesi, L / Crespo-Anadón, J I / Crisler, M / Cristaldo, E / Crnkovic, J / Cross, R / Cudd, A / Cuesta, C / Cui, Y / Cussans, D / Dalager, O / da Motta, H / Da Silva Peres, L / David, C / David, Q / Davies, G S / Davini, S / Dawson, J / De, K / De, S / Debbins, P / De Bonis, I / Decowski, M P / De Gouvêa, A / De Holanda, P C / De Icaza Astiz, I L / Deisting, A / De Jong, P / Delbart, A / Delepine, D / Delgado, M / Dell'Acqua, A / Delmonte, N / De Lurgio, P / de Mello Neto, J R T / DeMuth, D M / Dennis, S / Densham, C / Deptuch, G W / De Roeck, A / De Romeri, V / De Souza, G / Devi, R / Dharmapalan, R / Dias, M / Diaz, F / Díaz, J S / Domizio, S Di / Giulio, L Di / Ding, P / Noto, L Di / Dirkx, G / Distefano, C / Diurba, R / Diwan, M / Djurcic, Z / Doering, D / Dolan, S / Dolek, F / Dolinski, M / Domine, L / Donon, Y / Douglas, D / Douillet, D / Dragone, A / Drake, G / Drielsma, F / Duarte, L / Duchesneau, D / Duffy, K / Dunne, P / Dutta, B / Duyang, H / Dvornikov, O / Dwyer, D / Dyshkant, A / Eads, M / Earle, A / Edmunds, D / Eisch, J / Emberger, L / Emery, S / Englezos, P / Ereditato, A / Erjavec, T / Escobar, C / Eurin, G / Evans, J J / Ewart, E / Ezeribe, A C / Fahey, K / Falcone, A / Fani', M / Farnese, C / Farzan, Y / Fedoseev, D / Felix, J / Feng, Y / Fernandez-Martinez, E / Menendez, P Fernandez / Morales, M Fernandez / Ferraro, F / Fields, L / Filip, P / Filthaut, F / Fiorini, M / Fischer, V / Fitzpatrick, R S / Flanagan, W / Fleming, B / Flight, R / Fogarty, S / Foreman, W / Fowler, J / Fox, W / Franc, J / Francis, K / Franco, D / Freeman, J / Freestone, J / Fried, J / Friedland, A / Robayo, F Fuentes / Fuess, S / Furic, I K / Furman, K / Furmanski, A P / Gabrielli, A / Gago, A / Gallagher, H / Gallas, A / Gallego-Ros, A / Gallice, N / Galymov, V / Gamberini, E / Gamble, T / Ganacim, F / Gandhi, R / Gandrajula, R / Gao, F / Gao, S / Garcia-Gamez, D / García-Peris, M Á / Gardiner, S / Gastler, D / Gauvreau, J / Ge, G / Geffroy, N / Gelli, B / Gendotti, A / Gent, S / Ghorbani-Moghaddam, Z / Giammaria, P / Giammaria, T / Giangiacomi, N / Gibin, D / Gil-Botella, I / Gilligan, S / Girerd, C / Giri, A K / Gnani, D / Gogota, O / Gold, M / Gollapinni, S / Gollwitzer, K / Gomes, R A / Bermeo, L V Gomez / Fajardo, L S Gomez / Gonnella, F / Gonzalez-Diaz, D / Gonzalez-Lopez, M / Goodman, M C / Goodwin, O / Goswami, S / Gotti, C / Goudzovski, E / Grace, C / Gran, R / Granados, E / Granger, P / Grant, A / Grant, C / Gratieri, D / Green, P / Greenler, L / Greer, J / Grenard, J / Griffith, W C / Groh, M / Grudzinski, J / Grzelak, K / Gu, W / Guardincerri, E / Guarino, V / Guarise, M / Guenette, R / Guerard, E / Guerzoni, M / Guffanti, D / Guglielmi, A / Guo, B / Gupta, A / Gupta, V / Guthikonda, K K / Gutierrez, R / Guzowski, P / Guzzo, M M / Gwon, S / Ha, C / Haaf, K / Habig, A / Hadavand, H / Haenni, R / Hahn, A / Haiston, J / Hamacher-Baumann, P / Hamernik, T / Hamilton, P / Han, J / Harris, D A / Hartnell, J / Hartnett, T / Harton, J / Hasegawa, T / Hasnip, C / Hatcher, R / Hatfield, K W / Hatzikoutelis, A / Hayes, C / Hayrapetyan, K / Hays, J / Hazen, E / He, M / Heavey, A / Heeger, K M / Heise, J / Henry, S / Morquecho, M A Hernandez / Herner, K / Hewes, J / Hilgenberg, C / Hill, T / Hillier, S J / Himmel, A / Hinkle, E / Hirsch, L R / Ho, J / Hoff, J / Holin, A / Hoppe, E / Horton-Smith, G A / Hostert, M / Hourlier, A / Howard, B / Howell, R / Hoyos, J / Hristova, I / Hronek, M S / Huang, J / Hulcher, Z / Iles, G / Ilic, N / Iliescu, A M / Illingworth, R / Ingratta, G / Ioannisian, A / Irwin, B / Isenhower, L / Itay, R / Jackson, C M / Jain, V / James, E / Jang, W / Jargowsky, B / Jediny, F / Jena, D / Jeong, Y S / Jesús-Valls, C / Ji, X / Jiang, L / Jiménez, S / Jipa, A / Johnson, R / Johnson, W / Johnston, N / Jones, B / Jones, S / Judah, M / Jung, C K / Junk, T / Jwa, Y / Kabirnezhad, M / Kaboth, A / Kadenko, I / Kakorin, I / Kalitkina, A / Kalra, D / Kamiya, F / Kaneshige, N / Kaplan, D M / Karagiorgi, G / Karaman, G / Karcher, A / Karolak, M / Karyotakis, Y / Kasai, S / Kasetti, S P / Kashur, L / Kazaryan, N / Kearns, E / Keener, P / Kelly, K J / Kemp, E / Kemularia, O / Ketchum, W / Kettell, S H / Khabibullin, M / Khotjantsev, A / Khvedelidze, A / Kim, D / King, B / Kirby, B / Kirby, M / Klein, J / Klustova, A / Kobilarcik, T / Koehler, K / Koerner, L W / Koh, D H / Kohn, S / Koller, P P / Kolupaeva, L / Korablev, D / Kordosky, M / Kosc, T / Kose, U / Kostelecký, V A / Kothekar, K / Kralik, R / Kreczko, L / Krennrich, F / Kreslo, I / Kropp, W / Kroupova, T / Kubota, S / Kudenko, Y / Kudryavtsev, V A / Kulagin, S / Kumar, J / Kumar, P / Kunze, P / Kurita, N / Kuruppu, C / Kus, V / Kutter, T / Kvasnicka, J / Kwak, D / Lambert, A / Land, B / Lane, C E / Lang, K / Langford, T / Langstaff, M / Larkin, J / Lasorak, P / Last, D / Laundrie, A / Laurenti, G / Lawrence, A / Lazanu, I / LaZur, R / Lazzaroni, M / Le, T / Leardini, S / Learned, J / LeBrun, P / LeCompte, T / Lee, C / Lee, S Y / Miotto, G Lehmann / Lehnert, R / de Oliveira, M A Leigui / Leitner, M / Lepin, L M / Li, S W / Li, Y / Liao, H / Lin, C S / Lin, Q / Lin, S / Lineros, R A / Ling, J / Lister, A / Littlejohn, B R / Liu, J / Liu, Y / Lockwitz, S / Loew, T / Lokajicek, M / Lomidze, I / Long, K / Lord, T / LoSecco, J M / Louis, W C / Lu, X-G / Luk, K B / Lunday, B / Luo, X / Luppi, E / Lux, T / Luzio, V P / Maalmi, J / MacFarlane, D / Machado, A A / Machado, P / Macias, C T / Macier, J R / Maddalena, A / Madera, A / Madigan, P / Magill, S / Mahn, K / Maio, A / Major, A / Maloney, J A / Mandrioli, G / Mandujano, R C / Maneira, J / Manenti, L / Manly, S / Mann, A / Manolopoulos, K / Plata, M Manrique / Manyam, V N / Manzanillas, L / Marchan, M / Marchionni, A / Marciano, W / Marfatia, D / Mariani, C / Maricic, J / Marie, R / Marinho, F / Marino, A D / Marsden, D / Marshak, M / Marshall, C / Marshall, J / Marteau, J / Martín-Albo, J / Martinez, N / Caicedo, D A Martinez / Miravé, P Martínez / Martynenko, S / Mascagna, V / Mason, K / Mastbaum, A / Matichard, F / Matsuno, S / Matthews, J / Mauger, C / Mauri, N / Mavrokoridis, K / Mawby, I / Mazza, R / Mazzacane, A / Mazzucato, E / McAskill, T / McCluskey, E / McConkey, N / McFarland, K S / McGrew, C / McNab, A / Mefodiev, A / Mehta, P / Melas, P / Mena, O / Mendez, H / Mendez, P / Méndez, D P / Menegolli, A / Meng, G / Messier, M D / Metcalf, W / Mettler, T / Mewes, M / Meyer, H / Miao, T / Michna, G / Miedema, T / Mikola, V / Milincic, R / Miller, G / Miller, W / Mills, J / Mineev, O / Minotti, A / Miranda, O G / Miryala, S / Mishra, C S / Mishra, S R / Mislivec, A / Mitchell, M / Mladenov, D / Mocioiu, I / Moffat, K / Moggi, N / Mohanta, R / Mohayai, T A / Mokhov, N / Molina, J / Bueno, L Molina / Montagna, E / Montanari, A / Montanari, C / Montanari, D / Zetina, L M Montañno / Moon, S H / Mooney, M / Moor, A F / Moreno, D / Moretti, D / Morris, C / Mossey, C / Mote, M / Motuk, E / Moura, C A / Mousseau, J / Mouster, G / Mu, W / Mualem, L / Mueller, J / Muether, M / Mufson, S / Muheim, F / Muir, A / Mulhearn, M / Munford, D / Muramatsu, H / Murphy, S / Musser, J / Nachtman, J / Nagu, S / Nalbandyan, M / Nandakumar, R / Naples, D / Narita, S / Nath, A / Navrer-Agasson, A / Nayak, N / Nebot-Guinot, M / Negishi, K / Nelson, J K / Nesbit, J / Nessi, M / Newbold, D / Newcomer, M / Newton, H / Nichol, R / Nicolas-Arnaldos, F / Nikolica, A / Niner, E / Nishimura, K / Norman, A / Norrick, A / Northrop, R / Novella, P / Nowak, J A / Oberling, M / Ochoa-Ricoux, J / Olivier, A / Olshevskiy, A / Onel, Y / Onishchuk, Y / Ott, J / Pagani, L / Palacio, G / Palamara, O / Palestini, S / Paley, J M / Pallavicini, M / Palomares, C / Vazquez, W Panduro / Pantic, E / Paolone, V / Papadimitriou, V / Papaleo, R / Papanestis, A / Paramesvaran, S / Parke, S / Parozzi, E / Parsa, Z / Parvu, M / Pascoli, S / Pasqualini, L / Pasternak, J / Pater, J / Patrick, C / Patrizii, L / Patterson, R B / Patton, S J / Patzak, T / Paudel, A / Paulos, B / Paulucci, L / Pavlovic, Z / Pawloski, G / Payne, D / Pec, V / Peeters, S J M / Perez, A Pena / Pennacchio, E / Penzo, A / Peres, O L G / Perry, J / Pershey, D / Pessina, G / Petrillo, G / Petta, C / Petti, R / Pia, V / Piastra, F / Pickering, L / Pietropaolo, F / Pimentel, V L / Pinaroli, G / Plows, K / Plunkett, R / Poling, R / Pompa, F / Pons, X / Poonthottathil, N / Poppi, F / Pordes, S / Porter, J / Potekhin, M / Potenza, R / Potukuchi, B V K S / Pozimski, J / Pozzato, M / Prakash, S / Prakash, T / Prest, M / Prince, S / Psihas, F / Pugnere, D / Qian, X / Raaf, J L / Radeka, V / Rademacker, J / Radics, B / Rafique, A / Raguzin, E / Rai, M / Rajaoalisoa, M / Rakhno, I / Rakotonandrasana, A / Rakotondravohitra, L / Rameika, R / Delgado, M A Ramirez / Ramson, B / Rappoldi, A / Raselli, G / Ratoff, P / Raut, S / Razakamiandra, R F / Rea, E M / Real, J S / Rebel, B / Rechenmacher, R / Reggiani-Guzzo, M / Reichenbacher, J / Reitzner, S D / Sfar, H Rejeb / Renshaw, A / Rescia, S / Resnati, F / Ribas, M / Riboldi, S / Riccio, C / Riccobene, G / Rice, L C J / Ricol, J S / Rigamonti, A / Rigaut, Y / Rincón, E V / Ritchie-Yates, H / Rivera, D / Robert, A / Rochester, L / Roda, M / Rodrigues, P / Alonso, M J Rodriguez / Bonilla, E Rodriguez / Rondon, J Rodriguez / Rosauro-Alcaraz, S / Rosenberg, M / Rosier, P / Roskovec, B / Rossella, M / Rossi, M / Rout, J / Roy, P / Rubbia, A / Rubbia, C / Russell, B / Ruterbories, D / Rybnikov, A / Saa-Hernandez, A / Saakyan, R / Sacerdoti, S / Safford, T / Sahu, N / Sakashita, K / Sala, P / Samios, N / Samoylov, O / Sanchez, M C / Sandberg, V / Sanders, D A / Sankey, D / Santana, S / Santos-Maldonado, M / Saoulidou, N / Sapienza, P / Sarasty, C / Sarcevic, I / Savage, G / Savinov, V / Scaramelli, A / Scarff, A / Scarpelli, A / Schefke, T / Schellman, H / Schifano, S / Schlabach, P / Schmitz, D / Schneider, A W / Scholberg, K / Schukraft, A / Segreto, E / Selyunin, A / Senise, C R / Sensenig, J / Sergi, A / Sgalaberna, D / Shaevitz, M H / Shafaq, S / Shaker, F / Shamma, M / Sharankova, R / Sharma, H R / Sharma, R / Sharma, R K / Shaw, T / Shchablo, K / Shepherd-Themistocleous, C / Sheshukov, A / Shin, S / Shoemaker, I / Shooltz, D / Shrock, R / Siegel, H / Simard, L / Sinclair, J / Sinev, G / Singh, J / Singh, L / Singh, P / Singh, V / Sipos, R / Sippach, F W / Sirri, G / Sitraka, A / Siyeon, K / Skarpaas, K / Smith, A / Smith, E / Smith, P / Smolik, J / Smy, M / Snider, E / Snopok, P / Snowden-Ifft, D / Nunes, M Soares / Sobel, H / Soderberg, M / Sokolov, S / Salinas, C J Solano / Söldner-Rembold, S / Soleti, S R / Solomey, N / Solovov, V / Sondheim, W E / Sorel, M / Sotnikov, A / Soto-Oton, J / Ugaldi, F A Soto / Sousa, A / Soustruznik, K / Spagliardi, F / Spanu, M / Spitz, J / Spooner, N J C / Spurgeon, K / Stancari, M / Stanco, L / Stanford, C / Stein, R / Steiner, H M / Lisbôa, A F Steklain / Stewart, J / Stillwell, B / Stock, J / Stocker, F / Stokes, T / Strait, M / Strauss, T / Strigari, L / Stuart, A / Suarez, J G / Sunción, J M Suárez / Sullivan, H / Summers, D / Surdo, A / Susic, V / Suter, L / Sutera, C M / Svoboda, R / Szczerbinska, B / Szelc, A M / Tanaka, H / Tang, S / Tapia, A / Oregui, B Tapia / Tapper, A / Tariq, S / Tarpara, E / Tata, N / Tatar, E / Tayloe, R / Teklu, A M / Tennessen, P / Tenti, M / Terao, K / Ternes, C A / Terranova, F / Testera, G / Thakore, T / Thea, A / Thompson, J L / Thorn, C / Timm, S C / Tishchenko, V / Tomassetti, L / Tonazzo, A / Torbunov, D / Torti, M / Tortola, M / Tortorici, F / Tosi, N / Totani, D / Toups, M / Touramanis, C / Travaglini, R / Trevor, J / Trilov, S / Trzaska, W H / Tsai, Y / Tsai, Y-T / Tsamalaidze, Z / Tsang, K V / Tsverava, N / Tufanli, S / Tull, C / Tyley, E / Tzanov, M / Uboldi, L / Uchida, M A / Urheim, J / Usher, T / Uzunyan, S / Vagins, M R / Vahle, P / Valder, S / Valdiviesso, G D A / Valencia, E / Valentim, R / Vallari, Z / Vallazza, E / Valle, J W F / Vallecorsa, S / Berg, R Van / de Water, R G Van / Forero, D Vanegas / Vannerom, D / Varanini, F / Oliva, D Vargas / Varner, G / Vasel, J / Vasina, S / Vasseur, G / Vaughan, N / Vaziri, K / Ventura, S / Verdugo, A / Vergani, S / Vermeulen, M A / Verzocchi, M / Vicenzi, M / de Souza, H Vieira / Vignoli, C / Vilela, C / Viren, B / Vrba, T / Wachala, T / Waldron, A V / Wallbank, M / Wallis, C / Wang, H / Wang, J / Wang, L / Wang, M H L S / Wang, X / Wang, Y / Warburton, K / Warner, D / Wascko, M O / Waters, D / Watson, A / Wawrowska, K / Weatherly, P / Weber, A / Weber, M / Wei, H / Weinstein, A / Wenman, D / Wetstein, M / White, A / Whitehead, L H / Whittington, D / Wilking, M J / Wilkinson, A / Wilkinson, C / Williams, Z / Wilson, F / Wilson, R J / Wisniewski, W / Wolcott, J / Wongjirad, T / Wood, A / Wood, K / Worcester, E / Worcester, M / Wresilo, K / Wret, C / Wu, W / Xiao, Y / Xie, F / Yaeggy, B / Yandel, E / Yang, G / Yang, K / Yang, T / Yankelevich, A / Yershov, N / Yonehara, K / Yoon, Y S / Young, T / Yu, B / Yu, H / Yu, J / Yu, Y / Yuan, W / Zaki, R / Zalesak, J / Zambelli, L / Zamorano, B / Zani, A / Zazueta, L / Zeller, G P / Zennamo, J / Zeug, K / Zhang, C / Zhang, S / Zhang, Y / Zhao, M / Zhivun, E / Zhu, G / Zimmerman, E D / Zucchelli, S / Zuklin, J / Zutshi, V / Zwaska, R

The European physical journal. C, Particles and fields

2022 Volume 82, Issue 7, Page(s) 618

Abstract: DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a ... ...

Abstract	DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6
Language	English
Publishing date	2022-07-16
Publishing country	France
Document type	Journal Article
ZDB-ID	1459069-4
ISSN	1434-6052 ; 1434-6044
ISSN (online)	1434-6052
ISSN	1434-6044
DOI	10.1140/epjc/s10052-022-10549-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Asymmetrically Substituted m-Terphenyl Phosphates Inhibit the Transcription Factor STAT5a.

Müller-Klieser, Daniel / Berg, Thorsten

Chembiochem : a European journal of chemical biology

2021 Volume 23, Issue 4, Page(s) e202100603

Abstract: ... of symmetrically substituted m-terphenyl phosphates, binds to the interface between the SH2 domain and the linker ... domain of STAT5a. Here, we outline a synthetic strategy for the synthesis of asymmetrically substituted m ... specific manner. The asymmetrically substituted m-terphenyl phosphate with the highest activity against ...

Abstract	We recently presented Stafia-1 as the first chemical entity that inhibits the transcription factor STAT5a with selectivity over the highly homologous STAT5b. Stafia-1, which was identified from a series of symmetrically substituted m-terphenyl phosphates, binds to the interface between the SH2 domain and the linker domain of STAT5a. Here, we outline a synthetic strategy for the synthesis of asymmetrically substituted m-terphenyl phosphates, which can be tailored to address their asymmetric STAT5a binding site in a more specific manner. The asymmetrically substituted m-terphenyl phosphate with the highest activity against STAT5a was converted to a phosphatase-stable monofluoromethylene phosphonate. The synthetic methodology and activity analysis described here provide first insights into the structure-activity relationships of m-terphenyl phosphates for use as selective STAT5a inhibitors.
MeSH term(s)	Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Organophosphorus Compounds/chemical synthesis ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/pharmacology ; STAT5 Transcription Factor/antagonists & inhibitors ; STAT5 Transcription Factor/metabolism ; Structure-Activity Relationship ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Organophosphorus Compounds ; STAT5 Transcription Factor ; STAT5A protein, human ; Tumor Suppressor Proteins
Language	English
Publishing date	2021-12-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202100603
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings: PriVileG-M Umsetzbarkeit der Telemedizin für psychisch labile Schwangere und junge Mütter

Gloystein, Simone / Stentzel, Ulrike / Pfitzner, Stefanie / Neumann, Alexandra / Bethke, Bedriska / Greffin, Klara / Mühlan, Holger / Schmidt, Silke / van den Berg, Neeltje

2023 , Page(s) 23dkvf113

Event/congress	22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-10-02
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dkvf113
Database	German Medical Science

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Article ; Online: Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis.

Buskila, Yossi / Kékesi, Orsolya / Bellot-Saez, Alba / Seah, Winston / Berg, Tracey / Trpceski, Michael / Yerbury, Justin J / Ooi, Lezanne

Cell death & disease

2019 Volume 10, Issue 4, Page(s) 310

Abstract: Amyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND) in which humans lose motor functions due to progressive loss of motoneurons in the cortex, brainstem, and spinal cord. In patients and in animal models of MND it has been ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND) in which humans lose motor functions due to progressive loss of motoneurons in the cortex, brainstem, and spinal cord. In patients and in animal models of MND it has been observed that there is a change in the properties of motoneurons, termed neuronal hyperexcitability, which is an exaggerated response of the neurons to a stimulus. Previous studies suggested neuronal excitability is one of the leading causes for neuronal loss, however the factors that instigate excitability in neurons over the course of disease onset and progression are not well understood, as these studies have looked mainly at embryonic or early postnatal stages (pre-symptomatic). As hyperexcitability is not a static phenomenon, the aim of this study was to assess the overall excitability of upper motoneurons during disease progression, specifically focusing on their oscillatory behavior and capabilities to fire repetitively. Our results suggest that increases in the intrinsic excitability of motoneurons are a global phenomenon of aging, however the cellular mechanisms that underlie this hyperexcitability are distinct in SOD1
MeSH term(s)	Aging/metabolism ; Aging/pathology ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/physiopathology ; Animals ; Cortical Excitability/drug effects ; Cortical Excitability/genetics ; Disease Models, Animal ; Disease Progression ; Female ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; KCNQ Potassium Channels/genetics ; KCNQ Potassium Channels/metabolism ; Male ; Membrane Potentials/drug effects ; Membrane Potentials/genetics ; Membrane Potentials/physiology ; Mice ; Mice, Transgenic ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Motor Neurons/physiology ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism
Chemical Substances	Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; KCNQ Potassium Channels ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2019-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-019-1538-9
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Article ; Online: S.F. Berg and A.M.R. Strand respond.

Berg, Siri Fuglem / Strand, Anne Mari Røsting

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2019 Volume 139, Issue 3

Title translation	S.F. Berg og A.M.R. Strand svarer.
MeSH term(s)	Grief ; Saline Solution
Chemical Substances	Saline Solution
Language	Norwegian
Publishing date	2019-02-11
Publishing country	Norway
Document type	Journal Article ; Comment
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.19.0064
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Article: Save the children by treating their mothers (PriVileG-M-study)-study protocol

Bischoff, M. / Howland, V. / Klinger-König, J. / Tomczyk, S. / Schmidt, S. / Zygmunt, M. / Heckmann, M. / van den Berg, N. / Bethke, B. / Corleis, J. / Günther, S. / Liutkus, K. / Stentzel, U. / Neumann, A. / Penndorf, P. / Ludwig, T. / Hammer, E. / Winter, T. / Grabe, H. J.

BMC Psychiatry

A sequentially randomized controlled trial of individualized psychotherapy and telemedicine to reduce mental stress in pregnant women and young mothers and to improve child's health

2019 Volume 19, Issue 1, Page(s) No

Abstract: Background: As early as pregnancy, maternal mental stress impinges on the child's development and health. Thus, this may cause enhanced risk for premature birth, lowered fetal growth, and lower fetal birth weight as well as enhanced levels of the stress ... ...

Title translation	Rettet die Kinder durch die Behandlung der Mütter (PriVileG-M-Studie)-Studienprotokoll: Eine sequentiell randomisierte, kontrollierte Studie mit individualisierter Psychotherapie und Telemedizin zur Verringerung der psychischen Belastung bei Schwangeren und jungen Müttern und zur Verbesserung der Gesundheit des Kindes
Abstract	Background: As early as pregnancy, maternal mental stress impinges on the child's development and health. Thus, this may cause enhanced risk for premature birth, lowered fetal growth, and lower fetal birth weight as well as enhanced levels of the stress hormone cortisol and lowered levels of the bonding hormone oxytocin. Maternal stress further reduces maternal sensitivity for the child's needs which impairs the mother-child-interaction and bonding. Therefore, prevention and intervention studies on mental stress are necessary, beginning prenatally and applying rigorous research methodology, such as randomized controlled trials, to ensure high validity. Methods: A randomized controlled trial is used to assess the impact of psychotherapy and telemedicine on maternal mental stress and the child's mental and physical health. Mentally stressed pregnant women are randomized to an intervention (IG) and a not intervened control group. The IG receives an individualized psychotherapy starting prenatal and lasting for 10 months. Afterwards, a second randomization is used to investigate whether the use of telemedicine can stabilize the therapeutic effects. Using ecological momentary assessments and video recordings, the transfer into daily life, maternal sensitivity and mother-child-bonding are assessed. Psycho-biologically, the synchronicity of cortisol and oxytocin levels between mother and child are assessed as well as the peptidome of the colostrum and breast milk, which are assumed to be essential for the adaptation to the extra-uterine environment. All assessments are compared to an additional control group of healthy women. Finally, the results of the study will lead to the development of a qualification measure for health professionals to detect mental stress, to treat it with low-level interventions and to refer those women with high stress levels to mental health professionals. Discussion: The study aims to prevent the transgenerational transfer of psychiatric and somatic disorders from the mother to her child. The effects of the psychotherapy will be stabilized through telemedicine and long-term impacts on the child's and mothers' mental health are enhanced. The combination of psychotherapy, telemedicine and methodologies of ecological momentary assessment, video recording and bio banking are new in content-related and methodological manner.
Keywords	Ecological Momentary Assessment ; Expectant Mothers ; Intervention ; Mother Child Relations ; Mutter-Kind-Beziehungen ; Pregnancy ; Prenatal Care ; Prenatal Development ; Prenatal Exposure ; Pränatale Entwicklung ; Pränatale Gesundheitsrisiken ; Pränatale Versorgung ; Schwangerschaft ; Stress ; Telemedicine ; Telemedizin ; Werdende Mütter
Language	English
Document type	Article
ZDB-ID	2050438-X
ISSN	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-019-2279-0
Database	PSYNDEX

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Article: Comparison of Mitochondrial Respiration in M. triceps brachii and M. vastus lateralis Between Elite Cross-Country Skiers and Physically Active Controls.

Berg, Jonathan / Undebakke, Vidar / Rasch-Halvorsen, Øystein / Aakerøy, Lars / Sandbakk, Øyvind / Tjønna, Arnt Erik

Frontiers in physiology

2019 Volume 10, Page(s) 365

Abstract: Rationale: The main purposes of this study were to compare mitochondrial respiration in M. triceps ... brachii and M. vastus lateralis between elite cross-country (XC) skiers and physically active controls ... Results: XC skiers had generally higher mitochondrial respiration in M. triceps brachii compared to CON ...

Abstract	Rationale: The main purposes of this study were to compare mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country (XC) skiers and physically active controls (CON), and to explore the associations between mitochondrial respiration in these muscles and peak oxygen uptake ( Methods: Thirteen male elite XC skiers (age: 25 ± 4; peak oxygen uptake ( Results: XC skiers had generally higher mitochondrial respiration in M. triceps brachii compared to CON ( Conclusion: The higher mitochondrial respiration found in M. triceps brachii compared to M. vastus lateralis among our elite XC skiers demonstrates the potential for the arm muscles to adapt to aerobic endurance training. The opposite pattern found in CON, clearly showed lower mitochondrial respiration in M. triceps brachii compared to XC skiers, whereas respiration in M. vastus lateralis did not differ between groups. The strong positive correlation between mitochondrial respiration in M. triceps brachii and
Language	English
Publishing date	2019-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2019.00365
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Article ; Online: Mifepristone followed by misoprostol compared with placebo followed by misoprostol as medical treatment for early pregnancy loss (the Triple M trial): A double-blind placebo-controlled randomised trial.

Hamel, Charlotte / Coppus, Sjors / van den Berg, Joyce / Hink, Esther / van Seeters, Jacoba / van Kesteren, Paul / Merién, Ashley / Torrenga, Bas / van de Laar, Rafli / Terwisscha van Scheltinga, Josien / Gaugler-Senden, Ingrid / Graziosi, Peppino / van Rumste, Minouche / Nelissen, Ewka / Vandenbussche, Frank / Snijders, Marcus

EClinicalMedicine

2021 Volume 32, Page(s) 100716

Abstract: Background: Worldwide, millions of women seek treatment for early pregnancy loss (EPL) annually. Medical management with misoprostol is widely used, but only effective 60% of the time. Pre-treatment with mifepristone prior to misoprostol might improve ... ...

Abstract	Background: Worldwide, millions of women seek treatment for early pregnancy loss (EPL) annually. Medical management with misoprostol is widely used, but only effective 60% of the time. Pre-treatment with mifepristone prior to misoprostol might improve the success rate of medical management. Methods: This was a multi-centre, double-blind, placebo-controlled randomised trial in 17 Dutch hospitals. Women with a non-viable pregnancy between 6 and 14 weeks of gestation were eligible for inclusion after at least one week of expectant management. Participants were randomised (1:1) between oral mifepristone 600 mg or an oral placebo tablet. Participants took 400 μg misoprostol orally, repeated after four hours on day two and, if necessary, day three. Primary outcome was expulsion of gestational sac and endometrial thickness <15 mm after 6-8 weeks. Analyses were done according to intention-to-treat principles. This trial is registered with ClinicalTrials.gov, NCT03212352. Findings: Between June 28th 2018 and January 8th 2020, 175 women were randomised to mifepristone and 176 to placebo, including 344 in the intention-to-treat analysis. In the mifepristone group 136 (79•1%) of 172 participants reached complete evacuation compared to 101 (58•7%) of 172 participants in the placebo group ( Interpretation: Pre-treatment with mifepristone prior to misoprostol was more effective than misoprostol alone in managing EPL. Funding: Healthcare Insurers Innovation Foundation, Radboud University Medical Centre, Canisius Wilhelmina Hospital.
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2020.100716
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