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  1. Book ; Online ; E-Book: Beyond the virus

    Germain, Sabrina / Yong, Adrienne

    multidisciplinary and international perspectives on inequalities raised by COVID-19

    (Bristol studies in law and social justice)

    2023  

    Author's details edited by Sabrina Germain and Adrienne Yong
    Series title Bristol studies in law and social justice
    Keywords Equality ; COVID-19 Pandemic, 2020- / Influence ; COVID-19 Pandemic, 2020- / Social aspects
    Language English
    Size 1 Online-Ressource (xvii, 200 Seiten), Diagramme
    Publisher Bristol University Press
    Publishing place Bristol
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030021677
    ISBN 978-1-5292-2126-8 ; 978-1-5292-2125-1 ; 9781529221237 ; 1-5292-2126-9 ; 1-5292-2125-0 ; 1529221234
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Will COVID-19 Mark the End of an Egalitarian National Health Service?

    GERMAIN, Sabrina

    European Journal of Risk Regulation

    2020  Volume 11, Issue 2, Page(s) 358–365

    Keywords Safety Research ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2600871-3
    ISSN 2190-8249 ; 1867-299X
    ISSN (online) 2190-8249
    ISSN 1867-299X
    DOI 10.1017/err.2020.33
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 Highlighting Inequalities in Access to Healthcare in England: A Case Study of Ethnic Minority and Migrant Women.

    Germain, Sabrina / Yong, Adrienne

    Feminist legal studies

    2020  Volume 28, Issue 3, Page(s) 301–310

    Abstract: Our commentary aims to show that the COVID-19 pandemic has amplified existing barriers to healthcare in England for ethnic minority and migrant women. We expose how the pandemic has affected the allocation of healthcare resources leading to the ... ...

    Abstract Our commentary aims to show that the COVID-19 pandemic has amplified existing barriers to healthcare in England for ethnic minority and migrant women. We expose how the pandemic has affected the allocation of healthcare resources leading to the prioritisation of COVID-19 patients and suspending the equal access to healthcare services approach. We argue that we must look beyond this disruption in provision by examining existing barriers to access that have been amplified by the pandemic in order to understand the poorer health outcomes for women in ethnic minority and migrant communities. The reflection focuses on racialised medical perceptions, gendered cultural norms including information barriers and stigma, and specific legal barriers.
    Keywords covid19
    Language English
    Publishing date 2020-10-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2015451-3
    ISSN 1572-8455 ; 0966-3622
    ISSN (online) 1572-8455
    ISSN 0966-3622
    DOI 10.1007/s10691-020-09437-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: COVID-19 Highlighting Inequalities in Access to Healthcare in England: A Case Study of Ethnic Minority and Migrant Women

    Germain, Sabrina / Yong, Adrienne

    Fem Leg Stud

    Abstract: Our commentary aims to show that the COVID-19 pandemic has amplified existing barriers to healthcare in England for ethnic minority and migrant women. We expose how the pandemic has affected the allocation of healthcare resources leading to the ... ...

    Abstract Our commentary aims to show that the COVID-19 pandemic has amplified existing barriers to healthcare in England for ethnic minority and migrant women. We expose how the pandemic has affected the allocation of healthcare resources leading to the prioritisation of COVID-19 patients and suspending the equal access to healthcare services approach. We argue that we must look beyond this disruption in provision by examining existing barriers to access that have been amplified by the pandemic in order to understand the poorer health outcomes for women in ethnic minority and migrant communities. The reflection focuses on racialised medical perceptions, gendered cultural norms including information barriers and stigma, and specific legal barriers.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #871512
    Database COVID19

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  6. Article ; Online: Immune genotypes, immune responses, and survival in a wild bird population.

    Nelson-Flower, Martha J / Grieves, Leanne A / Reid, Jane M / Germain, Ryan R / Lazic, Savo / Taylor, Sabrina S / MacDougall-Shackleton, Elizabeth A / Arcese, Peter

    Molecular ecology

    2023  Volume 32, Issue 12, Page(s) 3044–3059

    Abstract: Individuals vary in their immune genotype, inbreeding coefficient f, immune responses, survival to adulthood, and adult longevity. However, whether immune genes predict survival or longevity, whether such relationships are mediated through immune ... ...

    Abstract Individuals vary in their immune genotype, inbreeding coefficient f, immune responses, survival to adulthood, and adult longevity. However, whether immune genes predict survival or longevity, whether such relationships are mediated through immune responses, and how f affects immune genotype remain unclear. We use a wild song sparrow (Melospiza melodia) population in which survival to adulthood, adult longevity, and f were measured precisely, and in which immune responses have previously been assessed. We investigate four toll-like receptor (TLR) and the major histocompatibility complex (MHC) class IIB exon 2 genes. We test whether immune genes predict fitness (survival to adulthood or adult longevity); whether immune genes predict immune response; whether immune response predicts fitness and whether fitness, immune responses, or immune genotypes are correlated with f. We find that survival to adulthood is not associated with immune gene variation, but adult longevity is decreased by high MHC allele diversity (especially in birds that were relatively outbred), and by the presence of a specific MHC supertype. Immune responses were affected by specific immune genotypes. Survival to adulthood and adult longevity were not predicted by immune response, implying caution in the use of immune response as a predictor for fitness. We also found no relationship between f and immune genotype. This finding indicates that immune gene associations with longevity and immune response are not artefacts of f, and suggests that pathogen-mediated selection at functional loci can slow the loss of genetic variation arising from genetic drift and small population size.
    MeSH term(s) Humans ; Animals ; Genetic Variation ; Genotype ; Inbreeding ; Passeriformes ; Histocompatibility Antigens Class II ; Alleles ; Immunity ; Selection, Genetic
    Chemical Substances Histocompatibility Antigens Class II
    Language English
    Publishing date 2023-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.16923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 2005/723: Show issues

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  7. Article: Mid-Atlantic Big Brown and Eastern Red Bats: Relationships between Acoustic Activity and Reproductive Phenology.

    Deeley, Sabrina / Ford, W Mark / Kalen, Nicholas J / Freeze, Samuel R / St Germain, Michael / Muthersbaugh, Michael / Barr, Elaine / Kniowski, Andrew / Silvis, Alexander / De La Cruz, Jesse

    Diversity

    2022  Volume 14, Issue 5, Page(s) 319

    Abstract: Acoustic data are often used to describe bat activity, including habitat use within the summer reproductive period. These data inform management activities that potentially impact bats, currently a taxa of high conservation concern. To understand the ... ...

    Abstract Acoustic data are often used to describe bat activity, including habitat use within the summer reproductive period. These data inform management activities that potentially impact bats, currently a taxa of high conservation concern. To understand the relationship between acoustic and reproductive timing, we sampled big brown bats (
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518137-3
    ISSN 1424-2818
    ISSN 1424-2818
    DOI 10.3390/d14050319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immune genotypes, immune responses, and survival in a wild bird population

    Nelson‐Flower, Martha J. / Grieves, Leanne A. / Reid, Jane M. / Germain, Ryan R. / Lazic, Savo / Taylor, Sabrina S. / MacDougall‐Shackleton, Elizabeth A. / Arcese, Peter

    Molecular Ecology. 2023 June, v. 32, no. 12 p.3044-3059

    2023  

    Abstract: Individuals vary in their immune genotype, inbreeding coefficient f, immune responses, survival to adulthood, and adult longevity. However, whether immune genes predict survival or longevity, whether such relationships are mediated through immune ... ...

    Abstract Individuals vary in their immune genotype, inbreeding coefficient f, immune responses, survival to adulthood, and adult longevity. However, whether immune genes predict survival or longevity, whether such relationships are mediated through immune responses, and how f affects immune genotype remain unclear. We use a wild song sparrow (Melospiza melodia) population in which survival to adulthood, adult longevity, and f were measured precisely, and in which immune responses have previously been assessed. We investigate four toll‐like receptor (TLR) and the major histocompatibility complex (MHC) class IIB exon 2 genes. We test whether immune genes predict fitness (survival to adulthood or adult longevity); whether immune genes predict immune response; whether immune response predicts fitness and whether fitness, immune responses, or immune genotypes are correlated with f. We find that survival to adulthood is not associated with immune gene variation, but adult longevity is decreased by high MHC allele diversity (especially in birds that were relatively outbred), and by the presence of a specific MHC supertype. Immune responses were affected by specific immune genotypes. Survival to adulthood and adult longevity were not predicted by immune response, implying caution in the use of immune response as a predictor for fitness. We also found no relationship between f and immune genotype. This finding indicates that immune gene associations with longevity and immune response are not artefacts of f, and suggests that pathogen‐mediated selection at functional loci can slow the loss of genetic variation arising from genetic drift and small population size.
    Keywords Melospiza melodia ; Toll-like receptors ; adulthood ; adults ; allelic variation ; exons ; genetic drift ; genotype ; immune response ; longevity ; major histocompatibility complex ; population size ; wild birds
    Language English
    Dates of publication 2023-06
    Size p. 3044-3059.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.16923
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Immunogenicity, safety, and tolerability of a recombinant measles-vectored Lassa fever vaccine: a randomised, placebo-controlled, first-in-human trial.

    Tschismarov, Roland / Van Damme, Pierre / Germain, Clara / De Coster, Ilse / Mateo, Mathieu / Reynard, Stephanie / Journeaux, Alexandra / Tomberger, Yvonne / Withanage, Kanchanamala / Haslwanter, Denise / Terler, Katherine / Schrauf, Sabrina / Müllner, Matthias / Tauber, Erich / Ramsauer, Katrin / Baize, Sylvain

    Lancet (London, England)

    2023  Volume 401, Issue 10384, Page(s) 1267–1276

    Abstract: Background: Lassa fever is a substantial health burden in west Africa. We evaluated the safety, tolerability, and immunogenicity of a recombinant, live-attenuated, measles-vectored Lassa fever vaccine candidate (MV-LASV).: Methods: This first-in- ... ...

    Abstract Background: Lassa fever is a substantial health burden in west Africa. We evaluated the safety, tolerability, and immunogenicity of a recombinant, live-attenuated, measles-vectored Lassa fever vaccine candidate (MV-LASV).
    Methods: This first-in-human phase 1 trial-consisting of an open-label dose-escalation stage and an observer-blinded, randomised, placebo-controlled treatment stage-was conducted at a single site at the University of Antwerp, Antwerp, Belgium, and involved healthy adults aged 18-55 years. Participants in the dose-escalation stage were sequentially assigned to a low-dose group (two intramuscular doses of MV-LASV at 2 × 10
    Findings: Between Sept 26, 2019, and Jan 20, 2020, 60 participants were enrolled and assigned to receive placebo (n=12) or MV-LASV (n=48). All 60 participants received at least one study treatment. Most adverse events occurred during the treatment phase, and frequencies of total solicited or unsolicited adverse events were similar between treatment groups, with 96% of participants in the low-dose group, 100% of those in the high-dose group, and 92% of those in the placebo group having any solicited adverse event (p=0·6751) and 76% of those in the low-dose group, 70% of those in the high-dose group, and 100% of those in the placebo group having any unsolicited adverse event (p=0·1047). The only significant difference related to local solicited adverse events, with higher frequencies observed in groups receiving MV-LASV (24 [96%] of 25 participants in the low-dose group; all 23 [100%] participants in the high-dose group) than in the placebo group (6 [50%] of 12 participants; p=0·0001, Fisher-Freeman-Halton test). Adverse events were mostly of mild or moderate severity, and no serious adverse events were observed. MV-LASV also induced substantial concentrations of LASV-specific IgG (geometric mean titre 62·9 EU/ml in the low-dose group and 145·9 EU/ml in the high-dose group on day 42).
    Interpretation: MV-LASV showed an acceptable safety and tolerability profile, and immunogenicity seemed to be unaffected by pre-existing immunity against the vector. MV-LASV is therefore a promising candidate for further development.
    Funding: Coalition for Epidemic Preparedness Innovations.
    MeSH term(s) Adult ; Humans ; Measles Vaccine ; Lassa Fever ; Vaccines, Synthetic ; Vaccines, Attenuated ; Measles ; Double-Blind Method ; Antibodies, Viral
    Chemical Substances Measles Vaccine ; Vaccines, Synthetic ; Vaccines, Attenuated ; Antibodies, Viral
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00048-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  10. Article ; Online: Mid-Atlantic Big Brown and Eastern Red Bats

    Sabrina Deeley / W. Mark Ford / Nicholas J. Kalen / Samuel R. Freeze / Michael St. Germain / Michael Muthersbaugh / Elaine Barr / Andrew Kniowski / Alexander Silvis / Jesse De La Cruz

    Diversity, Vol 14, Iss 319, p

    Relationships between Acoustic Activity and Reproductive Phenology

    2022  Volume 319

    Abstract: Acoustic data are often used to describe bat activity, including habitat use within the summer reproductive period. These data inform management activities that potentially impact bats, currently a taxa of high conservation concern. To understand the ... ...

    Abstract Acoustic data are often used to describe bat activity, including habitat use within the summer reproductive period. These data inform management activities that potentially impact bats, currently a taxa of high conservation concern. To understand the relationship between acoustic and reproductive timing, we sampled big brown bats ( Eptesicus fuscus ) and eastern red bats ( Lasiurus borealis ) on 482 mist-netting and 35,410 passive acoustic sampling nights within the District of Columbia, Maryland, Pennsylvania, Virginia, and West Virginia, 2015–2018. We documented the proportion of female, pregnant, lactating, and juvenile big brown and eastern red bats within each mist-net sampling event and calculated locally estimated non-parametric scatterplot smoothing (LOESS) lines for each reproductive and acoustic dataset. We compared the peak in acoustic activity with the peaks of each reproductive condition. We determined that the highest levels of acoustic activity within the maternity season were most associated with the period wherein we captured the highest proportions of lactating bats, not juvenile bats, as often assumed.
    Keywords acoustic sampling ; bats ; big brown bats ; eastern red bats ; Eptesicus fuscus ; Lasiurus borealis ; Biology (General) ; QH301-705.5
    Subject code 551
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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