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Article: A Case of Eagle Syndrome in a Chiropractic Patient.

Vernon, Leonard F

2023 Volume 15, Issue 5, Page(s) e38426

Abstract: Eagle syndrome is a rare condition that is characterized by, among other things, pain in the face and neck, with the majority of cases being unilateral and isolated to the lower jaw. It is not uncommon for the pain to radiate to the ear. Symptoms can be ... ...

Abstract	Eagle syndrome is a rare condition that is characterized by, among other things, pain in the face and neck, with the majority of cases being unilateral and isolated to the lower jaw. It is not uncommon for the pain to radiate to the ear. Symptoms can be constant or intermittent and may increase with yawning or rotation of the head, causing Eagle syndrome to be frequently misdiagnosed. The objective of this report is to summarize the symptoms, diagnostic workup, necessary imaging, and management of Eagle syndrome.
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: J. Marion Sims, MD: Why He and His Accomplishments Need to Continue to be Recognized a Commentary and Historical Review.

Vernon, Leonard F

Journal of the National Medical Association

2019 Volume 111, Issue 4, Page(s) 436–446

Abstract: This review provides a fresh perspective on the work of J. Marion Sims, an Antebellum era physician who invented the vaginally speculum that bears his name. His accent to become the "Father of Modern Gynecology" was his groundbreaking development of the ... ...

Abstract	This review provides a fresh perspective on the work of J. Marion Sims, an Antebellum era physician who invented the vaginally speculum that bears his name. His accent to become the "Father of Modern Gynecology" was his groundbreaking development of the surgical techniques for the repair for vesicovaginal fistula. Recent scholarship, however, has pointed to the dark side of Sims in that his techniques were perfected through his use of Black slave women as his research subjects. In addition, he has been criticized for his failure to use anesthesia during his research operations. This article argues that Sims's work needs to be understood in a broader historical context and within the broader framework of other forms of human experimentation that took place in the nineteenth and twentieth centuries. There is a strong argument that recent attempts to remove Sims from history also have the unintended consequence of removing the contributions of not only the Black slave women who were his subjects in the development of modern obstetrical medicine, but the important role Blacks played in the development of other medical procedures.
MeSH term(s)	African Americans/history ; Anesthesia/history ; Female ; Gynecology/history ; History, 19th Century ; Human Experimentation/ethics ; Human Experimentation/history ; Humans ; Southeastern United States ; Vesicovaginal Fistula/history ; Vesicovaginal Fistula/surgery
Language	English
Publishing date	2019-03-07
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Review
ZDB-ID	419737-9
ISSN	1943-4693 ; 0027-9684
ISSN (online)	1943-4693
ISSN	0027-9684
DOI	10.1016/j.jnma.2019.02.002
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Article: William Bradley Coley, MD, and the phenomenon of spontaneous regression.

Vernon, Leonard F

ImmunoTargets and therapy

2018 Volume 7, Page(s) 29–34

Abstract: The standard definition of spontaneous regression (SR) of cancer is as follows, "…when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on ...

Abstract	The standard definition of spontaneous regression (SR) of cancer is as follows, "…when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease." SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]-1345, exact date is unknown), who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected. The available treatment for this condition was limited to amputation. Historical records report that on the day of surgery, physicians found that the tumor had disappeared and reportedly never returned. To date, the medical literature consists only of individual case studies and overviews of this phenomenon. The most cited work on the subject was done by surgeons Tilden Everson and Warren Cole who reviewed 176 published cases of SR from 1900 to 1960. While a percentage of these were found not to be cases of SR, there remained a number of unexplained cases. A frequent theme in many cases of SR is the co-occurrence of infection. Given the current interest in immunotherapy in the treatment of cancer, this article discusses one of the very early pioneers of this theory, William Bradley Coley, MD, a surgeon who was clearly ahead of his time. Ostracized by colleagues for his belief that stimulation of the immune system could in fact produce a regression of cancer, Coley remained convinced that his theory was right and, while he was not familiar with cytokines such as tumor necrosis factor (TNF), interferons, and streptokinase, he knew instinctively that an innate immune response was taking place.
Language	English
Publishing date	2018-04-23
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	2253-1556
ISSN	2253-1556
DOI	10.2147/ITT.S163924
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Book: Jersey City Medical Center

Vernon, Leonard F

(Images of America)

2004

Abstract: Publisher-supplied data) The history of healthcare in Jersey City dates back to the early nineteenth century, when the city operated a variety of public facilities for the poor. Jersey City Medical Center was originally located in a part of the city ... ...

Institution	Jersey City Medical Center (N.J.)
Author's details	Leonard F. Vernon ; foreword by Jonathan M. Metsch
Series title	Images of America
Abstract	(Publisher-supplied data) The history of healthcare in Jersey City dates back to the early nineteenth century, when the city operated a variety of public facilities for the poor. Jersey City Medical Center was originally located in a part of the city called Paulus Hook and was known as the Jersey City Charity Hospital. The hospital gradually stopped accepting charity patients and, in 1885, dropped the word "charity" from its name. When Mayor Frank Hague began an aggressive building campaign with the help of federal funds, an average city hospital was transformed into a comprehensive medical facility.
MeSH term(s)	Hospitals, Municipal/history ; History, 19th Century ; History, 20th Century ; History, 21st Century
Keywords	New Jersey
Language	English
Size	128 p. :, ill., ports., ;, 24 cm.
Publisher	Arcadia
Publishing place	Charleston, SC
Document type	Book
ISBN	9780738536644 ; 0738536644
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Intractable nausea caused by zolpidem withdrawal: a case report.

Baruch, Edward / Vernon, Leonard F / Hasbun, Rafael J

Journal of addiction medicine

2007 Volume 1, Issue 1, Page(s) 48–50

Abstract: First launched in France in 1988, zolpidem (Ambien®) is a short-acting hypnotic agent. Early studies reported that that the development of physical dependence and tolerance to sedative-hypnotic drugs, such as the depressant and anticonvulsant effects ... ...

Abstract	First launched in France in 1988, zolpidem (Ambien®) is a short-acting hypnotic agent. Early studies reported that that the development of physical dependence and tolerance to sedative-hypnotic drugs, such as the depressant and anticonvulsant effects evidenced with benzodiazepines, is not found with zolpidem. Direct to consumer advertising by the manufacturer continues to state that the risk for dependency is low; however, recent publications seem to contradict this. Additionally, adverse drug reactions affecting the central nervous system, gastrointestinal tract, and respiratory system have been reported. Other studies have examined the interactions of selective serotonin reuptake inhibitors and zolpidem as a possible cause of hallucinations. With continued physician marketing efforts touting the safety and efficacy of zolpidem, there is a high likelihood to overlook the risk of dependency and the symptoms related to zolpidem withdrawal. We report a case of a 41-year-old female who developed a dependency to zolpidem, who on her own decided to decrease her dosage, resulting in intractable nausea requiring hospitalization. Reported cases of zolpidem withdrawal have occurred with doses in excess of 160 mg per day, none of these have reported with intractable nausea as the sole symptom. In our reported case, although exceeding recommended dosage withdrawal phenomenon seemed to be severe after withdrawal from a comparatively low dose of zolpidem. Before zolpidem is prescribed, patient education should include warnings about the potential problems associated with dependency and abrupt discontinuation. Education about this common and likely underrecognized clinical phenomenon will help prevent future episodes and minimize the risk of misdiagnosis.
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Journal Article
ISSN	1932-0620
ISSN	1932-0620
DOI	10.1097/ADM.0b013e31804259cb
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metrics and Science Monograph Collections at the Marston Science Library, University of Florida

Stephanie C. Haas / Michelle F. Leonard / Vernon N. Kisling

Issues in Science and Technology Librarianship : a quarterly publication of the Science and Technology Section, Association of College and Research Libraries, Iss 62, p A

2010 Volume 1

Abstract: As academic libraries are increasingly supported by a matrix of database functions, the use of data mining and visualization techniques offer significant potential for future collection development and service initiatives based on quantifiable data. ... ...

Abstract	As academic libraries are increasingly supported by a matrix of database functions, the use of data mining and visualization techniques offer significant potential for future collection development and service initiatives based on quantifiable data. While data collection techniques are still not standardized and results may be skewed because of granularity problems, faulty algorithms, and a host of other factors, useful baseline data is extractable and broad trends can be identified.The purpose of the current study is to provide an initial assessment of data associated with science monograph collection at the Marston Science Library (MSL), University of Florida. These sciences fall within the major Library of Congress Classification schedules of Q, S, and T, excluding TR, TT, and TX. The Rs are also excluded as these subjects are the responsibility of the Health Science Center Library which is connected with the medical school and the teaching hospital. The overall strategy of this project is to look at the potential science audiences within the university community and analyze data related to purchasing and circulation patterns, e-book usage, and interlibrary loan (ILL) statistics. This paper presents the results from the academic year July 1, 2008 to June 30, 2009, because all data reservoirs needed were available for the circulation and ILL data. The Springer e-book study is based on 2009 data. The research team consisted of both librarians and technical support staff from MSL, the Acquisitions Department, the Cataloging Department, and the IT Department.
Keywords	Bibliography. Library science. Information resources ; Z
Subject code	027
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Association of College and Research Libraries
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Pulmonary Metastasectomy in Colorectal Cancer cohort study: Analysis of case selection, risk factors and survival in a prospective observational study of 512 patients.

Treasure, Tom / Farewell, Vernon / Macbeth, Fergus / Batchelor, Tim / Milošević, Mišel / King, Juliet / Zheng, Yan / Leonard, Pauline / Williams, Norman R / Brew-Graves, Chris / Fallowfield, Lesley

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1793–1803

Abstract: Aim: We wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or are not resected.: Methods: Teams participating in the study of Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) identified ... ...

Abstract	Aim: We wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or are not resected. Methods: Teams participating in the study of Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) identified potential candidates for lung metastasectomy and invited their consent to join Stage 1. Baseline data related to CRC and fitness for surgery were collected. Eligible patients were invited to consent for randomization in the PulMiCC randomized controlled trial (Stage 2). Sites were provided with case report forms for non-randomized patients to record adverse events and death at any time. They were all reviewed at 1 year. Baseline and survival data were analysed for the full cohort. Results: Twenty-five clinical sites recruited 512 patients from October 2010 to January 2017. Data collection closed in October 2020. Before analysis, 28 patients with non-CRC lung lesions were excluded and three had withdrawn consent leaving 481. The date of death was known for 292 patients, 136 were alive in 2020 and 53 at earlier time points. Baseline factors and 5-year survival were analysed in three strata: 128 non-randomized patients did not have metastasectomy; 263 had elective metastasectomy; 90 were from the randomized trial. The proportions of solitary metastases for electively operated and non-operated patients were 69% and 35%. Their respective 5-year survivals were 47% and 22%. Conclusion: Survival without metastasectomy was greater than widely presumed. Difference in survival appeared to be largely related to selection. No inference can be drawn about the effect of metastasectomy on survival in this observational study.
MeSH term(s)	Cohort Studies ; Colorectal Neoplasms ; Humans ; Lung Neoplasms/surgery ; Metastasectomy ; Risk Factors
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article ; Observational Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15651
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Case studies in chiropractic MRI

Kent, Christopher / Vernon, Leonard F

1998

Title variant	Chiropractic MRI
Author's details	Christopher Kent, Leonard F. Vernon
MeSH term(s)	Chiropractic/methods ; Magnetic Resonance Imaging/methods ; Spinal Injuries/diagnosis ; Musculoskeletal Diseases/diagnosis
Language	English
Size	v, 147 p. :, ill., 28 cm.
Edition	1st ed.
Publisher	International Chiropractors Association
Publishing place	Arlington, Va
Document type	Book
ISBN	9781886190023 ; 188619002X
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.

Ortega, Victor E / Daya, Michelle / Szefler, Stanley J / Bleecker, Eugene R / Chinchilli, Vernon M / Phipatanakul, Wanda / Mauger, Dave / Martinez, Fernando D / Herrera-Luis, Esther / Pino-Yanes, Maria / Hawkins, Gregory A / Ampleford, Elizabeth J / Kunselman, Susan J / Cox, Corey / Bacharier, Leonard B / Cabana, Michael D / Cardet, Juan Carlos / Castro, Mario / Denlinger, Loren C /

Eng, Celeste / Fitzpatrick, Anne M / Holguin, Fernando / Hu, Donglei / Jackson, Daniel J / Jarjour, Nizar / Kraft, Monica / Krishnan, Jerry A / Lazarus, Stephen C / Lemanske, Robert F / Lima, John J / Lugogo, Njira / Mak, Angel / Moore, Wendy C / Naureckas, Edward T / Peters, Stephen P / Pongracic, Jacqueline A / Sajuthi, Satria P / Seibold, Max A / Smith, Lewis J / Solway, Julian / Sorkness, Christine A / Wenzel, Sally / White, Steven R / Burchard, Esteban G / Barnes, Kathleen / Meyers, Deborah A / Israel, Elliot / Wechsler, Michael E

The Lancet. Child & adolescent health

2021 Volume 5, Issue 12, Page(s) 862–872

Abstract: Background: Pharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from ... ...

Abstract	Background: Pharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from different ancestral backgrounds respond to long-acting beta agonist (LABA) and ICSs. Therefore, we sought to understand the pharmacogenetic mechanisms regulating therapeutic responsiveness in individuals of African descent. Methods: We did ancestry-based pharmacogenetic studies of children (aged 5-11 years) and adolescents and adults (aged 12-69 years) from the Best African Response to Drug (BARD) trials, in which participants with asthma uncontrolled with low-dose ICS (fluticasone propionate 50 μg in children, 100 μg in adolescents and adults) received different step-up combination therapies. The hierarchal composite outcome of pairwise superior responsiveness in BARD was based on asthma exacerbations, a 31-day difference in annualised asthma-control days, or a 5% difference in percentage predicted FEV Findings: We included 249 unrelated children and 267 unrelated adolescents and adults in the BARD pharmacogenetic analysis. In children, we identified a significant admixture mapping peak for superior responsiveness to 5 × ICS versus 100 μg fluticasone plus salmeterol on chromosome 12 (odds ratio [OR Interpretation: BARD is the first genome-wide pharmacogenetic study of LABA and ICS response in clinical trials of individuals of African descent to detect and replicate genome-wide significant loci. Admixture mapping of the composite BARD trial outcome enabled the identification of novel pharmacogenetic variation accounting for differential therapeutic responses in people of African descent with asthma. Funding: National Institutes of Health, National Heart, Lung, and Blood Institute.
MeSH term(s)	Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/drug therapy ; Asthma/ethnology ; Black People ; Bronchodilator Agents/therapeutic use ; Child ; Drug Therapy, Combination ; Female ; Fluticasone/therapeutic use ; Humans ; Male ; Middle Aged ; Pharmacogenomic Testing ; Salmeterol Xinafoate/therapeutic use ; United States ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Bronchodilator Agents ; Salmeterol Xinafoate (6EW8Q962A5) ; Fluticasone (CUT2W21N7U)
Language	English
Publishing date	2021-11-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2352-4650
ISSN (online)	2352-4650
DOI	10.1016/S2352-4642(21)00268-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.

Shook, Brian C / Chakravarty, Devraj / Barbay, J Kent / Wang, Aihua / Leonard, Kristi / Alford, Vernon / Powell, Mark T / Rassnick, Stefanie / Scannevin, Robert H / Carroll, Karen / Wallace, Nathaniel / Crooke, Jeffrey / Ault, Mark / Lampron, Lisa / Westover, Lori / Rhodes, Kenneth / Jackson, Paul F

Bioorganic & medicinal chemistry letters

2013 Volume 23, Issue 9, Page(s) 2688–2691

Abstract: A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse ... ...

Abstract	A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.
MeSH term(s)	Adenosine A2 Receptor Antagonists/chemistry ; Adenosine A2 Receptor Antagonists/pharmacokinetics ; Adenosine A2 Receptor Antagonists/therapeutic use ; Animals ; Brain/metabolism ; Catalepsy/drug therapy ; Half-Life ; Humans ; Kinetics ; Mice ; Protein Binding ; Pyrimidines/chemistry ; Pyrimidines/pharmacokinetics ; Pyrimidines/therapeutic use ; Rats ; Receptor, Adenosine A2A/chemistry ; Receptor, Adenosine A2A/metabolism
Chemical Substances	Adenosine A2 Receptor Antagonists ; Pyrimidines ; Receptor, Adenosine A2A
Language	English
Publishing date	2013-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2013.02.078
Database	MEDical Literature Analysis and Retrieval System OnLINE

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