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Article: Porous Materials Based on Poly(methylvinylsiloxane) Cross-Linked with 1,3,5,7-Tetramethylcyclotetrasiloxane in High Internal Phase Emulsion as Precursors to Si-C-O and Si-C-O/Pd Ceramics.

Mrówka, Jan / Partyka, Janusz / Hasik, Magdalena

2021 Volume 14, Issue 19

Abstract: Polysiloxane networks were prepared by hydrosilylation of poly(methylvinylsiloxane) ( ... ...

Abstract	Polysiloxane networks were prepared by hydrosilylation of poly(methylvinylsiloxane) (V
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14195661
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design and in vitro evaluation of electrospun shape memory polyurethanes for self-fitting tissue engineering grafts and drug delivery systems.

Bil, Monika / Kijeńska-Gawrońska, Ewa / Głodkowska-Mrówka, Eliza / Manda-Handzlik, Aneta / Mrówka, Piotr

Materials science & engineering. C, Materials for biological applications

2020 Volume 110, Page(s) 110675

Abstract: Integration of multiple features including shape memory, biodegradation, and sustained drug delivery in a single material offers the opportunity to significantly improve the abilities of implantable devices for cardiovascular system regeneration. Two ... ...

Abstract	Integration of multiple features including shape memory, biodegradation, and sustained drug delivery in a single material offers the opportunity to significantly improve the abilities of implantable devices for cardiovascular system regeneration. Two types of shape memory polyurethanes (SMPUs): PU-PLGA and PU-PLLA/PEG differing in soft segments composition that comprising blends of various biodegradable polyols, i.e. D,l-lactide-co-glycolide diol (o-PLGA), poly(e-caprolactone) diols (o-PCL) with various molecular weights, poly-l-lactide diol (o-PLLA), polyethylene glycol (o-PEG) were synthesized and further utilized to electrospun nanofibrous - rapamycin (Rap) delivery system. Structure characterization by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DCS) and hydrophilicity measurements were performed to gain more insights on the influence of the particular units of the softs segments on the transition temperature (T
MeSH term(s)	Biocompatible Materials/chemistry ; Calorimetry, Differential Scanning ; Cell Survival ; Crystallization ; Drug Delivery Systems ; Drug Liberation ; Fibroblasts/cytology ; Humans ; Kinetics ; Lactates ; Molecular Weight ; Polyesters ; Polyethylene Glycols ; Polyurethanes/chemistry ; Smart Materials/chemistry ; Spectroscopy, Fourier Transform Infrared ; Temperature ; Tensile Strength ; Tissue Engineering
Chemical Substances	Biocompatible Materials ; Lactates ; Polyesters ; Polyurethanes ; Smart Materials ; poly(lactic acid-ethylene glycol) ; Polyethylene Glycols (3WJQ0SDW1A) ; poly(lactide) (459TN2L5F5)
Language	English
Publishing date	2020-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.110675
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Article: Thermostability of Organobentonite Modified with Poly(acrylic acid).

Grabowska, Beata / Cukrowicz, Sylwia / Kaczmarska, Karolina / Żymankowska-Kumon, Sylwia / Bobrowski, Artur / Tyliszczak, Bożena / Mrówka, Natalia Maria

Materials (Basel, Switzerland)

2023 Volume 16, Issue 10

Abstract: ... at temperatures in the ranges of 20-100 °C (related to evaporation of solvent water) and 100-230 °C (related ... to intermolecular dehydration). The decomposition of PAA chains occurs between 230 and 300 °C, while complete ... decomposition of PAA and formation of organic decomposition products takes place at 300-500 °C. Dehydroxylation ...

Abstract	A new type of organobentonite foundry binder composed of a composite of bentonite (SN) and poly(acrylic acid) (PAA) was analyzed using thermal analysis (TG-DTG-DSC) and pyrolysis gas chromatography mass spectrometry (Py-GC/MS). The temperature range in which the composite retains its binding properties was identified using thermal analysis of the composite and its components. Results showed that the thermal decomposition process is complex and involves physicochemical transformations that are mainly reversible at temperatures in the ranges of 20-100 °C (related to evaporation of solvent water) and 100-230 °C (related to intermolecular dehydration). The decomposition of PAA chains occurs between 230 and 300 °C, while complete decomposition of PAA and formation of organic decomposition products takes place at 300-500 °C. Dehydroxylation of montmorillonite (MMT) in bentonite begins at about 500 °C, which leads to a drastic structural transformation. An endothermic effect associated with the remodeling of the mineral structure was observed on the DSC curve in the range of 500-750 °C. The produced SN/PAA composite was found to be thermostable during degradation in both oxidative and inert atmosphere, similar to the starting bentonite, and even maintained over a relatively higher and wider temperature range compared to organic binding materials used. At the given temperatures of 300 °C and 800 °C, only CO
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16103626
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Article: Investigation of Damage to Multilayer Optics in X-Ray Laser Cavities: W/C, WRe/C, WC/C, Stainless-Steel/C, and Cr3C2/C Mirrors.

Macgowan, B J / Mrowka, S / Barbee, T W / da Silva, L B / Eder, D C / Koch, J A / Pan, L S / Turner, J A / Underwood, J H / Young, P E

Journal of X-ray science and technology

1992 Volume 3, Issue 4, Page(s) 231–282

Abstract: ... incidence reflectivity was time resolved for W/C, WRe/C, WC/C, 303-stainless-steel/C, and Cr3C2/C ... multilayers. The damage thresholds of the different mirrors were compared, and the Cr3C2/C mirrors were found ...

Abstract	In many applications, multilayer mirrors are exposed to damaging fluences of x rays. In x-ray laser cavities intense optical and broad-band x radiation, from the x-ray laser plasma amplifier, can damage multilayer mirrors on time scales of hundreds of picoseconds. We describe experiments using short duration (500 ps) bursts of soft x rays from a laser produced gold plasma to damage multilayer mirrors designed to reflect wavelengths close to 45 Å at normal incidence. The effect of the damaging x-ray flux on normal incidence reflectivity was time resolved for W/C, WRe/C, WC/C, 303-stainless-steel/C, and Cr3C2/C multilayers. The damage thresholds of the different mirrors were compared, and the Cr3C2/C mirrors were found to be the most resilient. The outer layers of the multilayers were observed to expand slowly as x rays were absorbed, and a more rapid expansion then preceded the total loss of reflectivity, at temperatures well below the melting temperature of the mirror components. It is believed that the dominant expansion mechanism is a change in the amorphous carbon layers to a more graphitic structure. The data are fit quite well by a model that assumes expansion of up to 25% in the thickness of the outermost carbon layers, followed by intermixing of the hotter layers. The rapid expansion has been observed to occur in times from 40 to 150 ps and may be the fastest resolution to date of the phenomenon of graphitization. The integrated reflectivity of the mirrors was observed to increase by up to a factor of 2.5 as they damaged; this reflectivity increase may be consistent with a reduction in the layer roughness.
Language	English
Publishing date	1992-01-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012019-9
ISSN	1095-9114 ; 0895-3996
ISSN (online)	1095-9114
ISSN	0895-3996
DOI	10.3233/XST-1992-3401
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Article ; Online: Multi-Camera Vehicle Tracking Using Edge Computing and Low-Power Communication.

Nikodem, Maciej / Słabicki, Mariusz / Surmacz, Tomasz / Mrówka, Paweł / Dołęga, Cezary

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 11

Abstract: Typical approaches to visual vehicle tracking across large area require several cameras and complex algorithms to detect, identify and track the vehicle route. Due to memory requirements, computational complexity and hardware constrains, the video images ...

Abstract	Typical approaches to visual vehicle tracking across large area require several cameras and complex algorithms to detect, identify and track the vehicle route. Due to memory requirements, computational complexity and hardware constrains, the video images are transmitted to a dedicated workstation equipped with powerful graphic processing units. However, this requires large volumes of data to be transmitted and may raise privacy issues. This paper presents a dedicated deep learning detection and tracking algorithms that can be run directly on the camera's embedded system. This method significantly reduces the stream of data from the cameras, reduces the required communication bandwidth and expands the range of communication technologies to use. Consequently, it allows to use short-range radio communication to transmit vehicle-related information directly between the cameras, and implement the multi-camera tracking directly in the cameras. The proposed solution includes detection and tracking algorithms, and a dedicated low-power short-range communication for multi-target multi-camera tracking systems that can be applied in parking and intersection scenarios. System components were evaluated in various scenarios including different environmental and weather conditions.
Language	English
Publishing date	2020-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20113334
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Book ; Thesis: Paroxysmales Vorhofflimmern

Mrowka, Christian

klinische Charakterisierung von 100 Patienten

1991

Author's details	vorgelegt von Christian Mrowka
Size	100 S. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 1991
HBZ-ID	HT004241409
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
92 D 3105	order for loan	Magazin

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Article ; Online: Influence of Macitentan on the Vascular Tone and Recruitment of Finger Capillaries Under Hypobaric Hypoxia in High Altitude.

Betge, Stefan / Drinda, Stefan / Neumann, Thomas / Bäz, Laura / Pfeil, Alexander / Schulze, Christian / Mrowka, Ralf / Jung, Christian / Franz, Marcus

High altitude medicine & biology

2020 Volume 21, Issue 4, Page(s) 336–345

Abstract: ... Mrowka, Christian Jung, and Marcus Franz. Influence of macitentan on the vascular tone and recruitment ...

Abstract	Betge, Stefan, Stefan Drinda, Thomas Neumann, Laura Bäz, Alexander Pfeil, Christian Schulze, Ralf Mrowka, Christian Jung, and Marcus Franz. Influence of macitentan on the vascular tone and recruitment of finger capillaries under hypobaric hypoxia in high altitude.
MeSH term(s)	Altitude ; Capillaries ; Humans ; Hypoxia ; Oxygen ; Pyrimidines ; Sulfonamides
Chemical Substances	Pyrimidines ; Sulfonamides ; Oxygen (S88TT14065) ; macitentan (Z9K9Y9WMVL)
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2076262-8
ISSN	1557-8682 ; 1527-0297
ISSN (online)	1557-8682
ISSN	1527-0297
DOI	10.1089/ham.2019.0120
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Zs.A 5674: Show issues

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Article: Terapia genowa w leczeniu chorych z glejakami mózgu.

Słowiński, Jerzy / Mrówka, Ryszard

Neurologia i neurochirurgia polska

2004 Volume 38, Issue 1, Page(s) 45–50

Abstract: The prognosis of patients with brain gliomas remains poor despite the use of advanced surgical techniques, radio- and chemotherapy. In this respect, gene engineering techniques altering the glioma genome in order to regulate the function of key genes ... ...

Title translation	Gene therapy for the treatment of patients with brain gliomas.
Abstract	The prognosis of patients with brain gliomas remains poor despite the use of advanced surgical techniques, radio- and chemotherapy. In this respect, gene engineering techniques altering the glioma genome in order to regulate the function of key genes involved in cancerogenesis seem to be promising. The premise for applying a gene therapy in patients with brain gliomas is described, together with basic strategies and results of hitherto performed experimental and clinical studies, mostly with the use of virus vectors. The rapid progress in molecular techniques may enable to overcome methodological problems related to the introduction of the therapeutic gene into the target cell, and thus to improve so far unsatisfactory results of glioma gene therapy. The important role of a neurosurgeon in the process of precise gene vector application to the tumour area should not be underestimated.
MeSH term(s)	Brain Neoplasms/genetics ; Carrier Proteins/genetics ; Epidermal Growth Factor/genetics ; Genetic Therapy/methods ; Glioma/genetics ; Humans ; Intercellular Signaling Peptides and Proteins ; Molecular Biology/methods ; Protein Kinase C/genetics ; Proteins/genetics ; Receptors, Platelet-Derived Growth Factor/genetics ; Transforming Growth Factor beta/genetics ; Vascular Endothelial Growth Factor A/genetics
Chemical Substances	Carrier Proteins ; Intercellular Signaling Peptides and Proteins ; Proteins ; Transforming Growth Factor beta ; Vascular Endothelial Growth Factor A ; caspase-activated DNase inhibitor ; FGFBP1 protein, human (139946-12-6) ; Epidermal Growth Factor (62229-50-9) ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1) ; Protein Kinase C (EC 2.7.11.13)
Language	Polish
Publishing date	2004-08-12
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
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Article ; Online: Discovery of 5-naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines.

Tilekar, Kalpana / Upadhyay, Neha / Jänsch, Niklas / Schweipert, Markus / Mrowka, Piotr / Meyer-Almes, F J / Ramaa, C S

Bioorganic chemistry

2019 Volume 95, Page(s) 103522

Abstract: Histone deacetylases (HDACs) are being explored as a therapeutic target for interventions in different types of cancer. HDAC8 is a class I HDAC that is implicated as a therapeutic target in various indication areas, including different types of cancer ... ...

Abstract	Histone deacetylases (HDACs) are being explored as a therapeutic target for interventions in different types of cancer. HDAC8 is a class I HDAC that is implicated as a therapeutic target in various indication areas, including different types of cancer and particularly childhood neuroblastoma. Most previously described HDAC8-selective inhibitors contain a hydroxamate function as zinc binding group (ZBG) to confer potency. However, hydroxamate class HDAC inhibitors have raised increasing concerns about their mutagenic character. Therefore, non-hydroxamate based inhibitors could prove to be safer than hydroxamates. In the present work, a series of novel 5-naphthylidene-2,4-thiazolidinedione was designed and evaluated as potential antiproliferative agents targeting selectively HDAC8 enzyme. Eleven novel derivatives were synthesized, purified and characterized by spectroscopic techniques. Compounds 3k and 3h was found to be most potent selective inhibitors of HDAC8 with IC
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Discovery ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Histone Deacetylases ; Humans ; Molecular Docking Simulation ; Repressor Proteins/antagonists & inhibitors ; Structure-Activity Relationship ; Thiazolidinediones/chemistry ; Thiazolidinediones/pharmacology
Chemical Substances	Antineoplastic Agents ; Enzyme Inhibitors ; Repressor Proteins ; Thiazolidinediones ; 2,4-thiazolidinedione (AA68LXK93C) ; HDAC8 protein, human (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2019-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2019.103522
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Article ; Online: Slow NMDA-Mediated Excitation Accelerates Offset-Response Latencies Generated via a Post-Inhibitory Rebound Mechanism.

Rajaram, Ezhilarasan / Kaltenbach, Carina / Fischl, Matthew J / Mrowka, Leander / Alexandrova, Olga / Grothe, Benedikt / Hennig, Matthias H / Kopp-Scheinpflug, Conny

eNeuro

2019 Volume 6, Issue 3

Abstract: In neural circuits, action potentials (spikes) are conventionally caused by excitatory inputs whereas inhibitory inputs reduce or modulate neuronal excitability. We previously showed that neurons in the superior paraolivary nucleus (SPN) require solely ... ...

Abstract	In neural circuits, action potentials (spikes) are conventionally caused by excitatory inputs whereas inhibitory inputs reduce or modulate neuronal excitability. We previously showed that neurons in the superior paraolivary nucleus (SPN) require solely synaptic inhibition to generate their hallmark offset response, a burst of spikes at the end of a sound stimulus, via a post-inhibitory rebound mechanism. In addition SPN neurons receive excitatory inputs, but their functional significance is not yet known. Here we used mice of both sexes to demonstrate that in SPN neurons, the classical roles for excitation and inhibition are switched, with inhibitory inputs driving spike firing and excitatory inputs modulating this response. Hodgkin-Huxley modeling suggests that a slow, NMDA receptor (NMDAR)-mediated excitation would accelerate the offset response. We find corroborating evidence from
MeSH term(s)	Acoustic Stimulation ; Action Potentials/physiology ; Animals ; Auditory Perception/physiology ; Excitatory Postsynaptic Potentials ; Female ; Inhibitory Postsynaptic Potentials ; Male ; Mice, Inbred C57BL ; Neurons/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Superior Olivary Complex/physiology
Chemical Substances	Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2019-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0106-19.2019
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