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Article ; Online: Study on concordance of specific cytological diagnosis with histology in a teaching hospital

Akinfenwa Taoheed Atanda / Ramat Olayinka Faro-Tella

Sahel Medical Journal, Vol 24, Iss 3, Pp 111-

2021 Volume 116

Abstract: Background: Fine-needle aspiration cytology (FNAC), a cheap screening technique, has helped reduce the diagnostic turnaround time of palpable swellings from different anatomical sites. In light of the technique increasingly being used as a definitive ... ...

Abstract	Background: Fine-needle aspiration cytology (FNAC), a cheap screening technique, has helped reduce the diagnostic turnaround time of palpable swellings from different anatomical sites. In light of the technique increasingly being used as a definitive diagnostic tool, it is thus important to evaluate its accuracy in making specific diagnosis beyond just being a screening tool. Objective: To determine the concordance rate between cytological and histological diagnosis Materials and Methods: Cytology and corresponding histology reports for lesions from patients with maxillofacial, lymph node, and abdominal swellings, where both were available, were compared for the concordance of specific cytological diagnosis with final histological diagnosis. Results: In the 10-year (2006–2015) studied, there were 177 complete cases in which specific diagnoses were made on cytology; of these, 135 (75.3%) were in concordance with histological diagnoses. Concordance for intra-abdominal, maxillofacial, and lymph node aspirates was 90.2%, 85.5%, and 62.9%, respectively. Cytological concordance of specific diagnosis for benign and malignant lesions was 70.7% and 79.5%, respectively. Concordances for lymphomas, carcinomas, and sarcomas were 84.1%, 68.2%, and 66.7%, respectively. The specific cytologic diagnosis was enhanced by preaspirate ultrasound scan while the absence of immunocytochemistry hampered accuracy in specific diagnosis of nodal non-Hodgkin's and Hodgkin's lymphoma (66.7% and 42.9%), respectively. Conclusion: This study concludes that FNAC is a simple technique with fairly reliable utility in proffering specific diagnosis on suitable lesions. However, in developing countries where repertoire of antibodies for immunocytochemistry may be limited, the accuracy will be improved by good clinical history and preaspirate ultrasound where necessary.
Keywords	concordance ; diagnosis ; fine-needle aspiration cytology ; specific ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Renal cell carcinoma in Nigeria

Akinfenwa Taoheed Atanda / Muhammad Sanusi Haruna

Sahel Medical Journal, Vol 20, Iss 4, Pp 137-

A systematic review

2017 Volume 142

Abstract: Literature on renal cell carcinoma (RCC) in Nigeria is characterized by lacunae in several important areas with resultant incomprehensiveness of data. This requires a review of the literature so as to streamline the data. Using internet search engines, ... ...

Abstract	Literature on renal cell carcinoma (RCC) in Nigeria is characterized by lacunae in several important areas with resultant incomprehensiveness of data. This requires a review of the literature so as to streamline the data. Using internet search engines, data were extracted from a total of twelve studies reported in peer reviewed journals between 2000 and 2015 from various states of Nigeria including Kano. These were subsequently collated, analyzed, and then compared with those from other parts of the world. There is relatively low incidence rate of 0.3/100,000 population; slight male preponderance and affectation of younger age groups with average age at diagnosis of 45 ± 4 years. Significant smoking history, exposure to industrial dye, family history, and HIV associated immunodeficiency are major risk factors of RCC in Nigeria. A significant number of cases presented with triad of loin pain, hematuria, and loin mass; advanced disease and bulky tumors of up to 3.8 kg and 56 cm. The predominant histological subtypes were clear cell carcinoma 60%–85.7% and papillary carcinoma 23.8%–46.2%. In general, there has been poor overall outcome for RCC bearing patients in the country. RCC in Nigeria is characterized by earlier age at onset and poor outcome, thus necessitating more aggressive case identification at early stages so as to improve prognosis.
Keywords	Clear cell ; Nigeria ; renal cell carcinoma ; Medicine ; R
Subject code	616
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Perceived and Real Histopathology Turnaround Time: A Teaching Hospital Experience.

Atanda, Akinfenwa Taoheed / Yusuf, Ibrahim / Haruna, Muhammad Sanusi

Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society

2017 Volume 23, Issue 2, Page(s) 98–101

Abstract: Background: This study aims to audit analytic turnaround time (TAT) in a histopathology laboratory with a view to assessing the timeliness of its reports, identify causes of delay in its TAT, and compare this with client perception of its performance.!## ...

Abstract	Background: This study aims to audit analytic turnaround time (TAT) in a histopathology laboratory with a view to assessing the timeliness of its reports, identify causes of delay in its TAT, and compare this with client perception of its performance. Materials and methods: Records of 1440 batches of specimens processed over a 5-year period in the histopathology laboratory of a teaching hospital were retrieved from archives. From these, median and mean TATs were calculated and causes of delay identified. Questionnaires were also deployed to assess physicians' perception of the laboratory's performance. Results: Analytic TAT was 3.6 ± 2 days, with 86.7% of reports being ready within 5 working days. The delays in timeliness of report generation were due mainly to residency training-related factors; tissue processing-related factors, and inadequate clinical information among others. Client perception of TAT rated the laboratory below average by 18.4%; average by 57.5%; good by 20.7%, and excellent in its performance by 3.4% of respondents. Conclusion: Even though physicians perceived the laboratory's TAT to be just average, its analytic TAT for reports is within acceptable international standards but with room for improvement in its performance.
Language	English
Publishing date	2017-11-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2641743-1
ISSN	2278-7100 ; 1117-6806
ISSN (online)	2278-7100
ISSN	1117-6806
DOI	10.4103/njs.NJS_4_17
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Wilms′ tumour in African children

Lofty-John Chukwuemeka Anyanwu / Akinfenwa Taoheed Atanda / Jareenat Oladoyin Atanda

African Journal of Paediatric Surgery, Vol 12, Iss 1, Pp 7-

Can an institutional approach improve outcome?

2015 Volume 11

Abstract: Background: The poor outcome for patients with Wilms′ tumour (WT) in developing countries has been predicated on late presentation, poverty and low rate of chemotherapeutic access. This study aims to evaluate the effects of an institutionalised approach ... ...

Abstract	Background: The poor outcome for patients with Wilms′ tumour (WT) in developing countries has been predicated on late presentation, poverty and low rate of chemotherapeutic access. This study aims to evaluate the effects of an institutionalised approach to improving outcome for patients managed in a tertiary hospital in Nigeria. Materials and Methods: Oncology records of children diagnosed with WT between 2009 and 2013 were analysed for therapy completion and other prognostic parameters. Ensuing data were then compared with those from other centres in Africa. Results: Compared with results from some local and African studies, the therapy completion rate was higher (60%) with a survival rate among this group being between 1 and 4 years. No patient was lost to follow-up because of unavailability or unaffordability of cytotoxic agents. Conclusion: This study shows that an institutionalised approach can help to improve access to anti-cancer drugs, reduce the rate of loss to follow-up and thus improve outcome. There is however need to improve on patient-doctor communication, form support groups and establish a WT registry.
Keywords	Chemotherapy ; follow-up ; outcome ; survival ; Wilms ; Pediatrics ; RJ1-570 ; Medicine ; R ; Surgery ; RD1-811
Subject code	616
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wilms′ tumour in African children

Lofty-John Chukwuemeka Anyanwu / Akinfenwa Taoheed Atanda / Jareenat Oladoyin Atanda

African Journal of Paediatric Surgery, Vol 12, Iss 1, Pp 7-

Can an institutional approach improve outcome?

2015 Volume 11

Abstract	Background: The poor outcome for patients with Wilms′ tumour (WT) in developing countries has been predicated on late presentation, poverty and low rate of chemotherapeutic access. This study aims to evaluate the effects of an institutionalised approach to improving outcome for patients managed in a tertiary hospital in Nigeria. Materials and Methods: Oncology records of children diagnosed with WT between 2009 and 2013 were analysed for therapy completion and other prognostic parameters. Ensuing data were then compared with those from other centres in Africa. Results: Compared with results from some local and African studies, the therapy completion rate was higher (60%) with a survival rate among this group being between 1 and 4 years. No patient was lost to follow-up because of unavailability or unaffordability of cytotoxic agents. Conclusion: This study shows that an institutionalised approach can help to improve access to anti-cancer drugs, reduce the rate of loss to follow-up and thus improve outcome. There is however need to improve on patient-doctor communication, form support groups and establish a WT registry.
Keywords	Chemotherapy ; follow-up ; outcome ; survival ; Wilms ; Pediatrics ; RJ1-570 ; Medicine ; R ; Surgery ; RD1-811
Subject code	616
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Autopsy and religion

Akinfenwa Taoheed Atanda / Ali Bala Umar / Ibrahim Yusuf / Mohammed Ibrahim Imam / Alfa Alhaji Sule

Sahel Medical Journal, Vol 19, Iss 3, Pp 119-

A review of the literature

2016 Volume 124

Abstract: In spite of immense benefits derivable from carrying out autopsy on the dead, its practice has been very limited in northern Nigeria. One of the reasons for this is the perception that religion opposes the practice of autopsy. Using online search engines ...

Abstract	In spite of immense benefits derivable from carrying out autopsy on the dead, its practice has been very limited in northern Nigeria. One of the reasons for this is the perception that religion opposes the practice of autopsy. Using online search engines and religious doctrinal literature including the Qur'an, Bible and Talmud, a review of their teachings regarding autopsies was conducted. Findings were then harmonized with the practice of autopsy in its present form. Available literature reveals that the religious impediments include the permissibility or otherwise of the procedure, timing, opposite sexes seeing the corpse's nakedness, body mutilation, exhumation of the dead and retention of organs or tissues for teaching purposes. This study concludes that no religion expressly condemns the practice of autopsying the dead, and that the meeting points for various religions and the practice of autopsy is the need for learning and dispensation of justice. However, there is also a common agreement on the need for the procedure to be done promptly and to maintain the dignity of the dead during the procedure.
Keywords	Autopsy ; postmortem ; religion ; Medicine ; R
Subject code	290
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wilms' tumour in African children: Can an institutional approach improve outcome?

Anyanwu, Lofty-John Chukwuemeka / Anyanwa, Lofty-John Chukwuemeka / Atanda, Akinfenwa Taoheed / Atanda, Jareenat Oladoyin

African journal of paediatric surgery : AJPS

2015 Volume 12, Issue 1, Page(s) 7–11

Abstract: Background: The poor outcome for patients with Wilms' tumour (WT) in developing countries has been predicated on late presentation, poverty and low rate of chemotherapeutic access. This study aims to evaluate the effects of an institutionalised approach ...

Abstract	Background: The poor outcome for patients with Wilms' tumour (WT) in developing countries has been predicated on late presentation, poverty and low rate of chemotherapeutic access. This study aims to evaluate the effects of an institutionalised approach to improving outcome for patients managed in a tertiary hospital in Nigeria. Materials and methods: Oncology records of children diagnosed with WT between 2009 and 2013 were analysed for therapy completion and other prognostic parameters. Ensuing data were then compared with those from other centres in Africa. Results: Compared with results from some local and African studies, the therapy completion rate was higher (60%) with a survival rate among this group being between 1 and 4 years. No patient was lost to follow-up because of unavailability or unaffordability of cytotoxic agents. Conclusion: This study shows that an institutionalised approach can help to improve access to anti-cancer drugs, reduce the rate of loss to follow-up and thus improve outcome. There is however need to improve on patient-doctor communication, form support groups and establish a WT registry.
MeSH term(s)	Arabidopsis Proteins ; Biopsy ; Child, Preschool ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/therapy ; Lost to Follow-Up ; Male ; Neoplasm Staging ; Nigeria/epidemiology ; Prognosis ; Retrospective Studies ; Survival Rate/trends ; Transcription Factors ; Treatment Outcome ; Wilms Tumor/diagnosis ; Wilms Tumor/epidemiology ; Wilms Tumor/therapy
Chemical Substances	Arabidopsis Proteins ; TOC1 protein, Arabidopsis ; Transcription Factors
Language	English
Publishing date	2015-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2392865-7
ISSN	0974-5998 ; 0189-6725
ISSN (online)	0974-5998
ISSN	0189-6725
DOI	10.4103/0189-6725.150926
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incidence and risk factors of cervical dysplasia among human immune deficiency virus positive and human immune deficiency virus negative women at Aminu Kano Teaching Hospital

Zakari Muhammad / Iman Haruna Usman / Zainab Ahmed Datti / Attah Rapheal Avidime / Shuaibu Adavuruku Danjuma / Atanda Akinfenwa Taoheed / Aisha Abdullahi Suleiman

Sahel Medical Journal, Vol 20, Iss 4, Pp 160-

2017 Volume 167

Abstract: Background: HIV infection is a risk factor for cervical cancer and both diseases are prevalent in Nigeria. HIV positive women are at greater risk of cervical dysplasia than HIV negative women which may be as a result of immunosupression, hence adding ... ...

Abstract	>Background: HIV infection is a risk factor for cervical cancer and both diseases are prevalent in Nigeria. HIV positive women are at greater risk of cervical dysplasia than HIV negative women which may be as a result of immunosupression, hence adding more burdens to their already worsening health condition. It has become relevant to screen these women early and refer for appropriate and effective therapeutic intervention.Objective: To compare the incidence and risk factors of cervical dysplasia among HIV positive and HIV negative women at Aminu Kano Teaching Hospital, Kano.Methods: This was a comparative cross sectional studyl, which involved HIV positive women attending HIV clinic and HIV negative women attending the gynecological clinic at Aminu Kano Teaching Hospital. A cohort of 150 consenting HIV- positive women not on HAART and 150 HIV- negative women, selected by systematic random sampling were sent for Pap smear examination. On the same day blood samples were taken from antecubital vein and sent for both CD4 count and viral load among the HIV positive group. A pretested questionnaire was administered to the women of both groups on same day to determine the presence or absence of risk factors of cervical dysplasia in them. The results obtained were recorded using proforma and analyses of risk factors of cervical dysplasia was done using Chi square test and Fisher exact test to compare variables between those with normal and abnormal smears and student t test to determine the relationship of lesions with CD4count and viral load among the HIV positive women.Results: The incidence of cervical dysplasia among HIV- positive women was 49 (32.7%) and was significantly higher than 12(8%) found among the HIV- negative. Age ≥ 35years and parity ≥5, early coitarche, multiple sexual partners, low-socioeconomic status, cigarette smoking did confer some risk of dysplasia however. This study also showed that among the HIV positive group, CD4 count was inversely associated with risk of cervical dysplasia and women ...
Keywords	Aminu Kano Teaching Hospital-Kano ; cervical dysplasia ; human immune deficiency virus-positive women ; incidence ; risk factors ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Causes of maxillofacial patients mortality in a Nigerian tertiary hospital

Kelvin Uchenna Omeje / Ibiyinka Olushola Amole / Otasowie Daniel Osunde / Akinwale Adeyemi Efunkoya / Akinfenwa Taoheed Atanda

South Sudan Medical Journal, Vol 9, Iss 1, Pp 4-

2016 Volume 7

Abstract: Background. An analysis of maxillofacial mortality was done in a Nigerian tertiary health care centre to determine the major causes of mortality and identify possible predisposing factors in our environment. Materials and methods. A retrospective ... ...

Abstract	Background. An analysis of maxillofacial mortality was done in a Nigerian tertiary health care centre to determine the major causes of mortality and identify possible predisposing factors in our environment. Materials and methods. A retrospective analysis of mortality in maxillofacial surgery department of Aminu Kano Teaching Hospital from January 2005 to December 2014 was done. Data were analyzed using statistical package for social sciences (SPSS) version 15.0 (SPSS Inc, Chicago, IL). Results. A mortality rate of 1.8% (46 deaths from 2,540 admissions) was recorded. There were 35 males (76.1%) and 11 (23.9%) females. The mean age of the deceased patients was 40.0±13.0years. Orofacial infections (41.3%) and advanced (stage IV) orofacial malignancies (28.3%) accounted for most deaths. Conclusion. Fascial space infections and orofacial malignancies contribute largely to mortality in our setting. Late presentation was a major factor predisposing to mortality.
Keywords	Audit ; Maxillofacial patient ; Mortality ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	South Sudan Doctors' Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wilms' tumour: Determinants of prognosis in an African setting.

Atanda, Akinfenwa Taoheed / Anyanwu, Lofty-John Chuhwuemeka / Atanda, Oladoyin Jareenat / Mohammad, Aminu Mohammad / Abdullahi, Lawal Barau / Farinyaro, Aliyu Umar

African journal of paediatric surgery : AJPS

2015 Volume 12, Issue 3, Page(s) 171–176

Abstract: Background: The few studies available in the literature on Wilms' tumour (WT) from sub-Saharan Africa have reported a dismal outcome for children with the tumour. This study evaluated the risk factors that have been correlated with outcome in the ... ...

Abstract	Background: The few studies available in the literature on Wilms' tumour (WT) from sub-Saharan Africa have reported a dismal outcome for children with the tumour. This study evaluated the risk factors that have been correlated with outcome in the literature and compare these with outcome among our patients. Materials and methods: Cases of histologically confirmed WT between 2009 and 2013 in a tertiary hospital in Northwestern Nigeria were evaluated for gender, age, laterality, symptoms, duration before presentation, stage at presentation, histologic subtype and p53 mutation. These were then correlated with outcome. Results: Totally, 30 cases of WT were diagnosed with mean age of 4.8 ± 1.9 years; and male:female ratio of 2:1. No statistically significant relationship with outcome was found for gender (P = 0.138) or histologic subtype (P = 0.671). The most significant variables which positively influenced the outcome were presentation at earlier stages (P = 0.007) and completion of therapy (P = 0.0007). p53 mutation was seen in 3 (16.7%) of 18 cases and was not associated with a poor outcome (P = 0.089). However, 2 of the 3 cases presented in Stage IV and none of them survived the 1 st year. Conclusion: This study shows that even though p53 mutation was associated with a more aggressive phenotype, the most significant determinants of a good outcome among patients in a developing country like ours is non-blastemal dominant histologic subtype, early stage at presentation and completion of therapy.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/surgery ; Male ; Morbidity/trends ; Nephrectomy/methods ; Nigeria/epidemiology ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate/trends ; Treatment Outcome ; Wilms Tumor/diagnosis ; Wilms Tumor/epidemiology ; Wilms Tumor/surgery
Language	English
Publishing date	2015-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2392865-7
ISSN	0974-5998 ; 0189-6725
ISSN (online)	0974-5998
ISSN	0189-6725
DOI	10.4103/0189-6725.170185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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