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  1. Article ; Online: Judith Campisi (1948-2024).

    Desprez, Pierre-Yves / Kapahi, Pankaj

    Nature reviews. Cancer

    2024  Volume 24, Issue 5, Page(s) 291

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Neoplasms/history ; Neoplasms/genetics
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Historical Article ; Biography ; Journal Article ; Portrait ; Editorial
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-024-00687-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 24: Show issues

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  2. Article ; Online: Judith Campisi (1948-2024).

    Melov, Simon / Schilling, Birgit / Ellerby, Lisa M / Kapahi, Pankaj

    Nature cell biology

    2024  Volume 26, Issue 4, Page(s) 504–505

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-024-01396-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5169: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 12: Show issues

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  3. Article ; Online: Ketones to the rescue of the starving fly.

    Wilson, Kenneth A / Bar, Sudipta / Kapahi, Pankaj

    Nature metabolism

    2022  Volume 4, Issue 2, Page(s) 159–160

    Language English
    Publishing date 2022-02-17
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00527-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immune checkpoint inhibitors as senolytic agents.

    Singh, Parminder / Kapahi, Pankaj / van Deursen, Jan M

    Cell research

    2022  Volume 33, Issue 3, Page(s) 197–198

    MeSH term(s) Immune Checkpoint Inhibitors/pharmacology ; Senotherapeutics ; Cellular Senescence
    Chemical Substances Immune Checkpoint Inhibitors ; Senotherapeutics
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00761-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Haste makes waste: The significance of translation fidelity for development and longevity.

    Wilson, Kenneth A / Bar, Sudipta / Kapahi, Pankaj

    Molecular cell

    2021  Volume 81, Issue 18, Page(s) 3675–3676

    Abstract: We highlight Martinez-Miguel et al. (2021), which demonstrates that an amino acid substitution in RPS23 found in thermophilic archaea contributes to increased translation fidelity, lifespan, and stress response but slows development and reproduction in ... ...

    Abstract We highlight Martinez-Miguel et al. (2021), which demonstrates that an amino acid substitution in RPS23 found in thermophilic archaea contributes to increased translation fidelity, lifespan, and stress response but slows development and reproduction in other organisms.
    MeSH term(s) Longevity/genetics ; Reproduction
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.08.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Exonuclease EXD2 in mitochondrial translation.

    Zid, Brian M / Kapahi, Pankaj

    Nature cell biology

    2018  Volume 20, Issue 2, Page(s) 120–122

    MeSH term(s) Exonucleases/genetics ; Glucose/metabolism ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Protein Biosynthesis ; RNA, Messenger/genetics
    Chemical Substances RNA, Messenger ; Exonucleases (EC 3.1.-) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-017-0031-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 12: Show issues

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  7. Article ; Online: Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis.

    Sellegounder, Durai / Zafari, Parisa / Rajabinejad, Misagh / Taghadosi, Mahdi / Kapahi, Pankaj

    International immunopharmacology

    2021  Volume 98, Page(s) 107806

    Abstract: Coronavirus Disease 2019 (COVID-19), caused by the novel virus SARS-CoV-2, is often more severe in older adults. Besides age, other underlying conditions such as obesity, diabetes, high blood pressure, and malignancies, which are also associated with ... ...

    Abstract Coronavirus Disease 2019 (COVID-19), caused by the novel virus SARS-CoV-2, is often more severe in older adults. Besides age, other underlying conditions such as obesity, diabetes, high blood pressure, and malignancies, which are also associated with aging, have been considered risk factors for COVID-19 mortality. A rapidly expanding body of evidence has brought up various scenarios for these observations and hyperinflammatory reactions associated with COVID-19 pathogenesis. Advanced glycation end products (AGEs) generated upon glycation of proteins, DNA, or lipids play a crucial role in the pathogenesis of age-related diseases and all of the above-mentioned COVID-19 risk factors. Interestingly, the receptor for AGEs (RAGE) is mainly expressed by type 2 epithelial cells in the alveolar sac, which has a critical role in SARS-CoV-2-associated hyper inflammation and lung injury. Here we discuss our hypothesis that AGEs, through their interaction with RAGE amongst other molecules, modulates COVID-19 pathogenesis and related comorbidities, especially in the elderly.
    MeSH term(s) Age Factors ; Animals ; Anti-Inflammatory Agents/therapeutic use ; COVID-19/metabolism ; COVID-19/mortality ; COVID-19/virology ; Cellular Senescence ; Comorbidity ; Glycation End Products, Advanced ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Oxidative Stress ; Prognosis ; Receptor for Advanced Glycation End Products/metabolism ; Risk Assessment ; Risk Factors ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Signal Transduction ; COVID-19 Drug Treatment
    Chemical Substances AGER protein, human ; Anti-Inflammatory Agents ; Glycation End Products, Advanced ; Inflammation Mediators ; Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2021-05-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2021.107806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Haste makes waste: The significance of translation fidelity for development and longevity

    Wilson, Kenneth A. / Bar, Sudipta / Kapahi, Pankaj

    Molecular cell. 2021 Sept. 16, v. 81, no. 18

    2021  

    Abstract: We highlight Martinez-Miguel et al. (2021), which demonstrates that an amino acid substitution in RPS23 found in thermophilic archaea contributes to increased translation fidelity, lifespan, and stress response but slows development and reproduction in ... ...

    Abstract We highlight Martinez-Miguel et al. (2021), which demonstrates that an amino acid substitution in RPS23 found in thermophilic archaea contributes to increased translation fidelity, lifespan, and stress response but slows development and reproduction in other organisms.
    Keywords amino acid substitution ; longevity ; reproduction ; stress response ; thermophilic archaea ; wastes
    Language English
    Dates of publication 2021-0916
    Size p. 3675-3676.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.08.036
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/501: Show issues

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  9. Article: Protein synthesis and the antagonistic pleiotropy hypothesis of aging.

    Kapahi, Pankaj

    Advances in experimental medicine and biology

    2010  Volume 694, Page(s) 30–37

    Abstract: Growth and somatic maintenance are thought to be antagonistic piciotropic traits, but the molecular basis for this tradeoff is poorly understood. Here it is proposed that changes in protein synthesis mediate the tradeoffs that take place upon genetic and ...

    Abstract Growth and somatic maintenance are thought to be antagonistic piciotropic traits, but the molecular basis for this tradeoff is poorly understood. Here it is proposed that changes in protein synthesis mediate the tradeoffs that take place upon genetic and environmental manipulation in various model systems including yeast, worms, flies and mice. This hypothesis is supported by evidence that inhibition of the TOR (target of rapamycin) pathway and various translation factors that inhibit protein synthesis lead to slowing of growth and development but extend lifespan. Furthermore, dietary restriction (DR) that leads to antagonistic changes in growth and lifespan, also mediates this change by inhibiting protein synthesis. Direct screens to identify genes that extend lifespan from a subset of genes that are essential for growth and development have also uncovered a number of genes involved in protein synthesis. Given the conserved mechanisms of protein synthesis across species, I discuss potential mechanisms that mediate the lifespan extension by inhibition of protein synthesis that are likely to be important for aging and age-related disorders in humans.
    MeSH term(s) Aging/physiology ; Animals ; Caloric Restriction ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Protein Biosynthesis ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases
    Chemical Substances Intracellular Signaling Peptides and Proteins ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, mouse (EC 2.7.1.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2010-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4419-7002-2_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.

    Hilsabeck, Tyler A U / Narayan, Vikram P / Wilson, Kenneth A / Carrera, Enrique / Raftery, Daniel / Promislow, Daniel / Brem, Rachel B / Campisi, Judith / Kapahi, Pankaj

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Dietary restriction (DR) is a potent method to enhance lifespan and healthspan, but individual responses are influenced by genetic variations. Understanding how metabolism-related genetic differences impact longevity and healthspan are unclear. To ... ...

    Abstract Dietary restriction (DR) is a potent method to enhance lifespan and healthspan, but individual responses are influenced by genetic variations. Understanding how metabolism-related genetic differences impact longevity and healthspan are unclear. To investigate this, we used metabolites as markers to reveal how different genotypes respond to diet to influence longevity and healthspan traits. We analyzed data from
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.09.548232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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