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Article ; Online: Characterization of missense mutations in the NADPH oxidase partner p22

Kawai, Chikage / Kajikawa, Mizuho / Yamauchi, Akira / Okamoto, Shuichiro / Kuribayashi, Futoshi / Miyano, Kei

2023 Volume 67, Issue 4, Page(s) 194–200

Abstract: Defective superoxide production by NADPH oxidase 2 (Nox2) in phagocyte cells results in the development of chronic granulomatous disease (CGD), a hereditary disease characterized by recurrent and life-threatening infections. The partner protein ... ...

Abstract	Defective superoxide production by NADPH oxidase 2 (Nox2) in phagocyte cells results in the development of chronic granulomatous disease (CGD), a hereditary disease characterized by recurrent and life-threatening infections. The partner protein p22
MeSH term(s)	Cricetulus ; Animals ; Cell Line ; Humans ; NADPH Oxidases/chemistry ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Mutation, Missense ; NADPH Oxidase 2/metabolism
Chemical Substances	CYBA protein, human (EC 1.6.3.1) ; NADPH Oxidases (EC 1.6.3.-) ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-)
Language	English
Publishing date	2023-01-22
Publishing country	Australia
Document type	Journal Article
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.13051
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Article: Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers.

Aoki, Kaoru / Ideta, Hirokazu / Komatsu, Yukiko / Tanaka, Atsushi / Kito, Munehisa / Okamoto, Masanori / Takahashi, Jun / Suzuki, Shuichiro / Saito, Naoto

Bioengineering (Basel, Switzerland)

2024 Volume 11, Issue 2

Abstract: Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative ... ...

Abstract	Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative treatment options are available, such as joint arthroplasty, autologous bone grafting, and allogeneic bone grafting. Although various biodegradable polymers are also being developed as synthetic bone material in scaffolds for regenerative medicine, the clinical application of commercial synthetic bone products with comparable performance to that of calcium phosphate bioceramics have yet to be realized. This review discusses the status quo of bone-regeneration therapy using artificial bone composed of calcium phosphate bioceramics such as β-tricalcium phosphate (βTCP), carbonate apatite, and hydroxyapatite (HA), in addition to the recent use of calcium phosphate bioceramics, biodegradable polymers, and their composites. New research has introduced potential materials such as octacalcium phosphate (OCP), biologically derived polymers, and synthetic biodegradable polymers. The performance of artificial bone is intricately related to conditions such as the intrinsic material, degradability, composite materials, manufacturing method, structure, and signaling molecules such as growth factors and cells. The development of new scaffold materials may offer more efficient bone regeneration.
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering11020180
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Article ; Online: Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22

Miyano, Kei / Okamoto, Shuichiro / Kajikawa, Mizuho / Kiyohara, Takuya / Kawai, Chikage / Yamauchi, Akira / Kuribayashi, Futoshi

Redox biology

2022 Volume 56, Page(s) 102479

Abstract: The transmembrane protein ... ...

Abstract	The transmembrane protein p22
MeSH term(s)	Granulomatous Disease, Chronic ; Humans ; Membrane Proteins/metabolism ; Mutant Proteins ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Serine ; Sulfhydryl Compounds
Chemical Substances	DERL1 protein, human ; Membrane Proteins ; Mutant Proteins ; Reactive Oxygen Species ; Sulfhydryl Compounds ; Serine (452VLY9402) ; NADPH Oxidases (EC 1.6.3.-) ; CYBA protein, human (EC 1.6.3.1)
Language	English
Publishing date	2022-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2022.102479
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Article ; Online: Fine definition of the epitopes on the human gp91

Kawai, Chikage / Miyano, Kei / Okamoto, Shuichiro / Yamauchi, Akira / Kuribayashi, Futoshi

Journal of immunological methods

2021 Volume 501, Page(s) 113213

Abstract: Superoxide-producing NADPH oxidase, ... ...

Abstract	Superoxide-producing NADPH oxidase, gp91
MeSH term(s)	Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; CHO Cells ; COS Cells ; Chlorocebus aethiops ; Cricetulus ; Epitope Mapping ; Epitopes ; Glycosylation ; HL-60 Cells ; Humans ; Mice ; NADPH Oxidase 2/genetics ; NADPH Oxidase 2/immunology ; NADPH Oxidase 2/metabolism ; Protein Processing, Post-Translational ; RAW 264.7 Cells ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Superoxides/metabolism
Chemical Substances	Antibodies, Monoclonal ; Epitopes ; Pirb protein, mouse ; Receptors, Immunologic ; Superoxides (11062-77-4) ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-)
Language	English
Publishing date	2021-12-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2021.113213
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Zs.A 795: Show issues

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Article: Fine definition of the epitopes on the human gp91phox/NOX2 for the monoclonal antibodies CL-5 and 48

Kawai, Chikage / Miyano, Kei / Okamoto, Shuichiro / Yamauchi, Akira / Kuribayashi, Futoshi

Journal of immunological methods. 2022 Feb., v. 501

2022

Abstract: Superoxide-producing NADPH oxidase, gp91ᵖʰᵒˣ/NOX2, in phagocytes plays a critical role in the host defenses against pathogens. Moreover, gp91ᵖʰᵒˣ/NOX2 contributes to the oxidative stress in endothelial cells. Therefore, investigating the level of ... ...

Abstract	Superoxide-producing NADPH oxidase, gp91ᵖʰᵒˣ/NOX2, in phagocytes plays a critical role in the host defenses against pathogens. Moreover, gp91ᵖʰᵒˣ/NOX2 contributes to the oxidative stress in endothelial cells. Therefore, investigating the level of gp91ᵖʰᵒˣ/NOX2 with immunoblotting is important for estimating the amount of superoxide produced. Here, we showed that the epitopes in human gp91ᵖʰᵒˣ/NOX2 recognized by monoclonal antibodies (mAbs) CL-5 and 48 were in amino acids 132–147 and 136–144, respectively. Although the epitopes were close to the N-glycosylation sites, N-glycan maturation did not affect mAbs recognition. When Pro-136 was substituted with Arg, the corresponding mouse residue, human gp91ᵖʰᵒˣ/NOX2 was not recognized by mAbs CL-5 and 48; however, the substitution did not affect gp91ᵖʰᵒˣ/NOX2-based oxidase activity. This finding explains why these mAbs specifically recognize the human but not mouse gp91ᵖʰᵒˣ/NOX2. Hence, these mAbs are useful for investigating the level of gp91ᵖʰᵒˣ/NOX2 without amino acid substitutions in the epitopes.
Keywords	NAD(P)H oxidase (H2O2-forming) ; amino acids ; epitopes ; glycosylation ; humans ; immunoblotting ; mice ; oxidative stress
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2021.113213
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 795: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22

Miyano, Kei / Okamoto, Shuichiro / Yamauchi, Akira / Kawai, Chikage / Kajikawa, Mizuho / Kiyohara, Takuya / Itsumi, Momoe / Taura, Masahiko / Kuribayashi, Futoshi

Free radical research

2022 Volume 55, Issue 9-10, Page(s) 996–1004

Abstract: NADPH oxidase (Nox) 4 produces ... ...

Abstract	NADPH oxidase (Nox) 4 produces H
MeSH term(s)	Animals ; Humans ; Mice ; Down-Regulation ; Hemangioendothelioma ; Hydrogen Peroxide/metabolism ; Hypoxia/genetics ; NADPH Oxidase 4/genetics ; NADPH Oxidase 4/metabolism ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Protein Stability ; Reactive Oxygen Species/metabolism
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; NADPH Oxidase 4 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-) ; NOX4 protein, human (EC 1.6.3.-) ; Nox4 protein, mouse (EC 1.6.3.-) ; Reactive Oxygen Species
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2021.2009116
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Zs.A 2236: Show issues

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Article ; Online: The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells.

Okamoto, Shuichiro / Miyano, Kei / Kajikawa, Mizuho / Yamauchi, Akira / Kuribayashi, Futoshi

Bioscience, biotechnology, and biochemistry

2020 Volume 84, Issue 11, Page(s) 2319–2326

Abstract: Autophagy induced in cancer cells during chemotherapy is classified into two types, which differ depending on the kind of cells or anticancer drugs. The first type of autophagy contributes to the death of cells treated with drugs. In contrast, the second ...

Abstract	Autophagy induced in cancer cells during chemotherapy is classified into two types, which differ depending on the kind of cells or anticancer drugs. The first type of autophagy contributes to the death of cells treated with drugs. In contrast, the second type plays a crucial role in preventing anticancer drug-induced cell damages; the use of an autophagy inhibitor is considered effective in improving the efficacy of chemotherapy. Thus, it is important to determine which type of autophagy is induced during chemotherapy. Here, we showed that a novel inhibitor of RNA polymerase I, suppresses growth, induces cell cycle arrest and promotes apoptosis in leukemia cell lines. The number of apoptotic cells induced by co-treatment with CX-5461 and chloroquine, an autophagy inhibitor, increased compared with CX-5461 alone. Thus, the autophagy which may be induced by CX-5461 was the second type.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Autophagy/drug effects ; Benzothiazoles/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Leukemia/pathology ; Naphthyridines/pharmacology ; Protein Biosynthesis/drug effects ; RNA, Ribosomal/biosynthesis
Chemical Substances	Antineoplastic Agents ; Benzothiazoles ; CX 5461 ; Naphthyridines ; RNA, Ribosomal
Language	English
Publishing date	2020-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1080/09168451.2020.1801378
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Zs.A 4647: Show issues

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Article: Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

Okamoto, Shuichiro / Miyano, Kei / Kitakaze, Keisuke / Kato, Hitomi / Yamauchi, Akira / Kajikawa, Mizuho / Itsumi, Momoe / Kawai, Chikage / Kuribayashi, Futoshi

Biochemical and biophysical research communications. 2022 Jan. 08, v. 587

2022

Abstract: An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble ... ...

Abstract	An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble secretory proteins responsible for chemoresistance in a vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway–dependent manner. To further investigate the contribution of VEGF-A/VEGFR-2 signaling to the chemoresistance of AML cells, a biochemical assay system in which the AML cells were cocultured with human endothelial EA.hy926 cells in a monolayer was developed. By coculture with EA.hy926 cells, this study revealed that the AML cells resisted apoptosis induced by the anticancer drug cytarabine. SU4312, a VEGFR-2 inhibitor, attenuated VEGFR-2 phosphorylation and VEGF-A/VEGFR-2 signaling–dependent endothelial cell migration; thus, this inhibitor was observed to block VEGF-A/VEGFR-2 signaling. Interestingly, this inhibitor did not reverse the chemoresistance. When VEGFR-2 was knocked out in EA.hy926 cells using the CRISPR–Cas9 system, the cytarabine-induced apoptosis of AML cells did not significantly change compared with that of wild-type cells. Thus, coculture-induced chemoresistance appears to be independent of VEGF-A/VEGFR-2 signaling. When the transwell, a coculturing device, separated the AML cells from the EA.hy926 cells in a monolayer, the coculture-induced chemoresistance was inhibited. Given that the migration of VEGF-A/VEGFR-2 signaling–dependent endothelial cells is necessary for the endothelial niche formation in the bone marrow, VEGF-A/VEGFR-2 signaling contributes to chemoresistance by mediating the niche formation process, but not to the chemoresistance of AML cells in the niche.
Keywords	CRISPR-Cas systems ; antineoplastic agents ; apoptosis ; bone marrow ; cell movement ; coculture ; endothelial cells ; humans ; myeloid leukemia ; phosphorylation ; research ; vascular endothelial growth factor A ; vascular endothelial growth factor receptor-2
Language	English
Dates of publication	2022-0108
Size	p. 78-84.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2021.11.090
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Article ; Online: Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer.

Shiba, Shintaro / Miyasaka, Yuhei / Okamoto, Masahiko / Komatsu, Shuichiro / Okazaki, Shohei / Shibuya, Kei / Ohno, Tatsuya

Clinical and translational radiation oncology

2021 Volume 31, Page(s) 80–85

Abstract: Background and purpose: In radiotherapy (RT) for pancreatic cancer, the pancreas is considered an important organ at risk. However, there are insufficient reports on pancreatic function deterioration after X-ray RT as organ at risk, and there are no ... ...

Abstract	Background and purpose: In radiotherapy (RT) for pancreatic cancer, the pancreas is considered an important organ at risk. However, there are insufficient reports on pancreatic function deterioration after X-ray RT as organ at risk, and there are no reports on those after carbon ion (C-ion) RT. Here, we evaluated pancreatic exocrine insufficiency (PEI) after C-ion RT using dose-volume histogram (DVH) analysis. Materials and methods: Data were retrospectively collected from patients who had undergone C-ion RT for pancreatic cancer between July 2013 and June 2019. The prescribed C-ion doses were 55.2 Gy (relative biological effectiveness) in 12 fractions. Serum pancreatic amylase and lipase values were measured before and after C-ion RT. In DVH analysis, we assessed V Results: Thirty-three patients were included in the analysis. The median follow-up duration after the initiation of C-ion RT in these patients was 15.8 months (range, 4.3-64.8). During and after treatment, 57.6% of patients developed PEI within 13.6 months, defined as pancreatic amylase and lipase deficiencies. In DVH analysis, V Conclusion: We showed that pancreatic exocrine function declined after C-ion RT for pancreatic cancer and that PEI was initiated early in the course of C-ion RT. Additionally, a low dose of DVH parameters, such as V
Language	English
Publishing date	2021-10-03
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2021.09.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sleep and Skin Temperature in Preschool Children and Their Mothers.

Okamoto-Mizuno, Kazue / Mizuno, Koh / Shirakawa, Shuichiro

Behavioral sleep medicine

2018 Volume 16, Issue 1, Page(s) 64–78

Abstract: The purpose of this study was to investigate and compare sleep and skin temperature (Tsk) of preschool children with those of their mothers. The subjects included 18 pairs of preschool children and their mothers. The actigraphic measurement of sleep, Tsk, ...

Abstract	The purpose of this study was to investigate and compare sleep and skin temperature (Tsk) of preschool children with those of their mothers. The subjects included 18 pairs of preschool children and their mothers. The actigraphic measurement of sleep, Tsk, heart rate, bedroom climate, and the microclimate temperature and humidity (bed climate) were measured. Proximal and distal Tsk, the temperature gradient of distal and proximal Tsk (DPG), and bed climate temperature were significantly lower in the children. Approximately 70% of the children slept without bed covering. Heat dissipation during sleep in preschool children may primarily rely on the proximal Tsk. The lower Tsk than adults, and behavioral thermoregulation, may be important for sleep in preschoolers.
Language	English
Publishing date	2018-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2099743-7
ISSN	1540-2010 ; 1540-2002
ISSN (online)	1540-2010
ISSN	1540-2002
DOI	10.1080/15402002.2016.1173552
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