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  1. Book ; Online: Breast Cancer Biology

    Afroze, Dil / Rah, Bilal / Ali, Shazia / Shehjar, Faheem / Ishaq Dar, Mohd / Chauhan, Shailender S. / Thakur, Natasha

    2020  

    Keywords Biomedical engineering ; Prosthetics
    Size 1 electronic resource (126 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049580
    ISBN 9781789858839 ; 1789858836
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A novel and ultrasensitive electrochemical immunosensor based on nanocellulose-Ti

    Kareem, Faheem / Mohd-Naim, Noor Faizah / Ahmed, Minhaz Uddin

    International journal of biological macromolecules

    2023  Volume 257, Issue Pt 2, Page(s) 128657

    Abstract: A versatile and highly sensitive sensing platform based on nanocellulose/MXene/ ... ...

    Abstract A versatile and highly sensitive sensing platform based on nanocellulose/MXene/ZrO
    MeSH term(s) Ovalbumin ; Immunoassay ; Biosensing Techniques ; Reproducibility of Results ; Titanium ; Electrochemical Techniques ; Limit of Detection ; Gold/chemistry ; Nitrites ; Transition Elements
    Chemical Substances Ovalbumin (9006-59-1) ; MXene ; Titanium (D1JT611TNE) ; Gold (7440-57-5) ; Nitrites ; Transition Elements
    Language English
    Publishing date 2023-12-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  3. Article ; Online: Nitroreduction of flutamide by

    Khan, Mohd Faheem / Murphy, Cormac D

    Biochemistry and biophysics reports

    2022  Volume 29, Page(s) 101209

    Abstract: The microbial model of mammalian drug metabolism, ...

    Abstract The microbial model of mammalian drug metabolism,
    Language English
    Publishing date 2022-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2022.101209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fluorotelomer alcohols are efficiently biotransformed by Cunninghamella elegans.

    Khan, Mohd Faheem / Murphy, Cormac D

    Environmental science and pollution research international

    2022  Volume 30, Issue 9, Page(s) 23613–23623

    Abstract: Cunninghamella elegans is a well-studied fungus that biotransforms a range of xenobiotics owing to impressive cytochrome P450 (CYP) activity. In this paper, we report the biotransformation of 6:2 fluorotelomer alcohol (6:2 FTOH) by the fungus, yielding a ...

    Abstract Cunninghamella elegans is a well-studied fungus that biotransforms a range of xenobiotics owing to impressive cytochrome P450 (CYP) activity. In this paper, we report the biotransformation of 6:2 fluorotelomer alcohol (6:2 FTOH) by the fungus, yielding a range of fluorinated products that were detectable by fluorine-19 nuclear magnetic resonance spectroscopy (
    MeSH term(s) Fluorocarbons/metabolism ; Cunninghamella/metabolism ; Cytochrome P-450 Enzyme System/metabolism
    Chemical Substances fluorotelomer alcohols ; Fluorocarbons ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-11-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-23901-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Biotransformation of fluorinated drugs and xenobiotics by the model fungus Cunninghamella elegans.

    Khan, Mohd Faheem / Hof, Carina / Niemcova, Patricie / Murphy, Cormac D

    Methods in enzymology

    2024  Volume 696, Page(s) 251–285

    Abstract: Some species of the genus Cunninghamella (C. elegans, C. echinulata and C. blaskesleeana) produce the same phase I and phase II metabolites when incubated with xenobiotics as mammals, and thus are considered microbial models of mammalian metabolism. This ...

    Abstract Some species of the genus Cunninghamella (C. elegans, C. echinulata and C. blaskesleeana) produce the same phase I and phase II metabolites when incubated with xenobiotics as mammals, and thus are considered microbial models of mammalian metabolism. This had made these fungi attractive for metabolism studies with drugs, pesticides and environmental pollutants. As a substantial proportion of pharmaceuticals and agrochemicals are fluorinated, their biotransformation has been studied in Cunninghamella fungi and C. elegans in particular. This article details the methods employed for cultivating the fungi in planktonic and biofilm cultures, and extraction and analysis of fluorinated metabolites. Furthermore, protocols for the heterologous expression of Cunninghamella cytochromes P450 (CYPs), which are the enzymes associated with phase I metabolism, are described.
    MeSH term(s) Cunninghamella/metabolism ; Xenobiotics/metabolism ; Biotransformation ; Cytochrome P-450 Enzyme System/metabolism ; Halogenation ; Biofilms ; Pharmaceutical Preparations/metabolism ; Animals
    Chemical Substances Xenobiotics ; Cytochrome P-450 Enzyme System (9035-51-2) ; Pharmaceutical Preparations
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Withdrawal Notice: Recent Discovery for Inhibitors Targeting in SARS-CoV-2 and Developed anti-NCP

    Faheem, Mohd / Singh, Vinay K

    Mini reviews in medicinal chemistry

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557520666200807134619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5891: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cytochrome P450 5208A3 is a promiscuous xenobiotic biotransforming enzyme in Cunninghamella elegans.

    Khan, Mohd Faheem / Murphy, Cormac D

    Enzyme and microbial technology

    2022  Volume 161, Page(s) 110102

    Abstract: Cunninghamella elegans is a long-established microbial model of mammalian drug and xenobiotic metabolism enabled by the actions of cytochrome P450 enzymes that are poorly characterised. In this paper we describe the identification of a new cytochrome ... ...

    Abstract Cunninghamella elegans is a long-established microbial model of mammalian drug and xenobiotic metabolism enabled by the actions of cytochrome P450 enzymes that are poorly characterised. In this paper we describe the identification of a new cytochrome P450 (CYP) monooxygenase in the fungus that catalyses the biotransformation of a range of structurally distinct xenobiotic substrates. The fungal enzyme was heterologously expressed in the yeast Pichia pastoris X-33 alone and in combination with previously identified C. elegans CYP reductases (CPRs A, B and C). Enzyme activity was assessed against a panel of drugs (flurbiprofen, diclofenac and ibuprofen), pesticides (transfluthrin, β-cyfluthrin and λ-cyhalothrin) and a perfluoroalkyl substance (6:2 fluorotelomer alcohol) that were incubated with whole yeast cells expressing CYP5208A3. The biotransformation products were determined by gas chromatography-mass spectrometry (GC-MS) revealing the same metabolites that had been previously observed in the fungus. Co-expression of the CPRs improved metabolite production and the degree of improvement depended on the substrate and the CYP/CPR combination. Optimal pyrethroid biotransformation was achieved with CYP/CPR_C, whereas the best combination for non-steroidal anti-inflammatory drug hydroxylation was CYP/CPR_A; fluorotelomer alcohol oxidation was only observed with CYP/CPR_B. The change in substrate specificity observed with CYP5208A3 in combination with the different CPRs might help explain how C. elegans can biotransform such a broad spectrum of xenobiotics.
    MeSH term(s) Biotransformation ; Cunninghamella/genetics ; Cunninghamella/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Xenobiotics/metabolism
    Chemical Substances Xenobiotics ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2182: Show issues Location:
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  8. Article: Mechanical and Durability Analysis of Fly Ash Based Geopolymer with Various Compositions for Rigid Pavement Applications.

    Tahir, Muhammad Faheem Mohd / Abdullah, Mohd Mustafa Al Bakri / Rahim, Shayfull Zamree Abd / Mohd Hasan, Mohd Rosli / Sandu, Andrei Victor / Vizureanu, Petrica / Ghazali, Che Mohd Ruzaidi / Kadir, Aeslina Abdul

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 10

    Abstract: Ordinary Portland cement (OPC) is a conventional material used to construct rigid pavement that emits large amounts of carbon dioxide ( ... ...

    Abstract Ordinary Portland cement (OPC) is a conventional material used to construct rigid pavement that emits large amounts of carbon dioxide (CO
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15103458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Induction of p53 mediated mitochondrial apoptosis and cell cycle arrest in human breast cancer cells by plant mediated synthesis of silver nanoparticles from Bergenia ligulata (Whole plant).

    Mohd Faheem, Mir / Bhagat, Madhulika / Sharma, Pooja / Anand, Rythem

    International journal of pharmaceutics

    2022  Volume 619, Page(s) 121710

    Abstract: The biological synthesis of nanoparticles is a growing research trend because it has numerous pharmaceutical and biomedical applications. The present study describes the preparation, characterization and anti-cancer evaluation of silver nanoparticles ... ...

    Abstract The biological synthesis of nanoparticles is a growing research trend because it has numerous pharmaceutical and biomedical applications. The present study describes the preparation, characterization and anti-cancer evaluation of silver nanoparticles synthesized using an aqueous extract of Bergenia ligulata whole plant as a reducing agent. The physiochemical properties of the Bergenia ligulata silver nanoparticles (BgAgNPs) were measured by ultraviolet-visible spectrophotometry, Fourier transform infrared spectrophotmetry (FTIR), X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM) analysis for identifying functional groups, crystallinity, structural and morphological features, respectively. Further, BgAgNps, along with the Bergenia ligulata aqueous extract (BgAE), were investigated for their effects on cell proliferation and apoptosis through MTT, colony-forming assay, wound-healing assay and flow cytometry-based approaches. The cytotoxic effects were more pronounced in cells treated with BgAgNps in comparison to BgAE. These effects were evidenced by the decreasing cell viability, migration capacity and loss of characteristic morphological features. In addition, BgAgNps unveiled significant induction of apoptosis in human breast cancer (MCF-7) cells, possibly through oxidative stress-mediated reactive oxygen species (ROS) generation and loss of mitochondrial membrane potential (MMP). Moreover, molecular mechanism-based studies revealed that BgAgNps robustly augmented p53 levels and pro-apoptotic downstream targets of p53 like Bax and cleaved caspase 3 in MCF-7 cells. Of note, BgAgNps had little or no cytotoxic effect on p53-deficient cancer cells (Mda-mb-231 and SW-620). These findings confirm that the BgAgNPs exhibited superior anti-cancer potential and could be exploited as a promising, cost-effective, and environmentally benign strategy in treating this disease in the future.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Cycle Checkpoints ; Female ; Humans ; MCF-7 Cells ; Metal Nanoparticles/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Silver/chemistry ; Tumor Suppressor Protein p53
    Chemical Substances Antineoplastic Agents ; Plant Extracts ; Tumor Suppressor Protein p53 ; Silver (3M4G523W1G)
    Language English
    Publishing date 2022-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.121710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Endogenous production of 2-phenylethanol by Cunninghamella echinulata inhibits biofilm growth of the fungus.

    Hof, Carina / Khan, Mohd Faheem / Murphy, Cormac D

    Fungal biology

    2023  Volume 127, Issue 10-11, Page(s) 1384–1388

    Abstract: The filamentous fungus Cunninghamella echinulata is a model of mammalian xenobiotic metabolism. Under certain conditions it grows as a biofilm, which is a natural form of immobilisation and enables the fungus to catalyse repeated biotransformations. ... ...

    Abstract The filamentous fungus Cunninghamella echinulata is a model of mammalian xenobiotic metabolism. Under certain conditions it grows as a biofilm, which is a natural form of immobilisation and enables the fungus to catalyse repeated biotransformations. Putative signalling molecules produced by other Cunninghamella spp., such as 3-hydroxytyrosol and tyrosol, do not affect the biofilm growth of C. echinulata, suggesting that it employs a different molecule to regulate biofilm growth. In this paper we report that 2-phenylethanol is produced in higher concentrations in planktonic cultures of C. echinulata than when the fungus is grown as a biofilm. We demonstrate that exogenously added 2-phenylethanol inhibits biofilm growth of C. echinulata but has no effect on planktonic growth. Furthermore, we show that addition of 2-phenylethanol to established C. echinulata biofilm causes detachment. Therefore, we conclude that this molecule is produced by the fungus to regulate biofilm growth.
    MeSH term(s) Animals ; Cunninghamella/metabolism ; Phenylethyl Alcohol/pharmacology ; Biotransformation ; Biofilms ; Mammals
    Chemical Substances Phenylethyl Alcohol (ML9LGA7468)
    Language English
    Publishing date 2023-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2532164-X
    ISSN 1878-6162 ; 1878-6146
    ISSN (online) 1878-6162
    ISSN 1878-6146
    DOI 10.1016/j.funbio.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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