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Book ; Online ; E-Book: Environmental contamination and climate change

Gautam, Vandana / Kapoor, Dhriti / Bhardwaj, Renu

effect on plants and remedial strategies

(Climate change and its causes, effects and prediction)

2021

Author's details	Vandana Gautam, Dhriti Kapoor and Renu Bhardwaj, editors
Series title	Climate change and its causes, effects and prediction
Keywords	Plants / Effect of stress on ; Plants / Effect of pollution on ; Vegetation and climate ; Plants / Effect of pesticides on
Language	English
Size	1 Online-Ressource (xii, 204 Seiten), Illustrationen
Publisher	Nova Science Publishers
Publishing place	New York
Publishing country	United States
Document type	Book ; Online ; E-Book
Note	Includes bibliographical references and index
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021070188
ISBN	978-1-5361-9732-7 ; 9781536196672 ; 1-5361-9732-7 ; 1536196673
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Compare the Combined Diagnostic Accuracy of Transient Elastography and Visual Liver Score in Assessing Non-Alcoholic Fatty Liver Disease (NAFLD) and Compare it with Liver Biopsy in Morbidly Obese Patients Undergoing Bariatric Surgery: An Observational Study.

Sharma, Deborshi / Anand, Gautam / Meena, Sanjay / Bhardwaj, Vaishali

Obesity surgery

2024 Volume 34, Issue 4, Page(s) 1247–1256

Abstract: Introduction: A liver biopsy is the gold standard for the diagnosis of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Here, we combine preoperative transient elastography (TE) and intraoperative standardized visual ... ...

Abstract	Introduction: A liver biopsy is the gold standard for the diagnosis of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Here, we combine preoperative transient elastography (TE) and intraoperative standardized visual liver score (VLS) which is compared with intraoperative liver biopsy for prediction of NAFLD and NASH in patients undergoing bariatric surgery. Aim: Evaluate the combined diagnostic accuracy of TE and VLS in assessing NAFLD or NASH and compare it with liver biopsy in patients undergoing bariatric surgery. Methods: In a prospective cohort of 70 morbidly obese undergoing bariatric surgery, preoperative TE and intraoperative VLS were calculated. Findings of TE and VLS were compared with histology from intraoperative liver biopsy. Results: Histologically, 44 (62.85%) had NAFLD (≥ S1). Significant steatosis was seen in 20 (28.57%) while significant fibrosis was visible in 18 (25.71%). Area Under the Receiver Operating Characteristics (AUROC) TE for diagnosis of NAFLD was excellent (0.844, p = 0.001). At the optimal cutoff of 8.1, the positive predictive value (PPV) was 92.9%, and diagnostic accuracy was 90.6%. VLS had a sensitivity of 90.9% for NAFLD. The combined sensitivity of TE + VLS was 95.5% for ruling out NAFLD. Fourteen (20%) had NASH. VLS had a diagnostic accuracy of 97% in identifying NASH in comparison to TE. AUROC-VLS was 0.987, p ≤ 0.001, and a sensitivity of 100%. The overall sensitivity of combined TE and VLS was 100% with a negative predictive value (NPV) of 100%. Conclusion: TE when combined with intraoperative VLS is comparable to liver biopsy and can be used for the diagnosis of NAFLD and NASH in patients undergoing bariatric surgery.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Elasticity Imaging Techniques ; Obesity, Morbid/surgery ; Prospective Studies ; Liver/pathology ; Liver Cirrhosis/pathology ; Bariatric Surgery ; Biopsy
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-024-07106-7
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Zs.A 3381: Show issues

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Article ; Online: Lost and found: foreign body in submandibular gland.

Bhardwaj, Viny / Gautam, Vimmi / Verma, Hitesh / Bhutada, Mayank Dilip

BMJ case reports

2023 Volume 16, Issue 11

Abstract: A young adult male patient presented with the history of a retained foreign body in the oral cavity. The object in question was a stapler pin that got accidentally lodged while the patient tried removing food particles from his mouth 28 days earlier. ... ...

Abstract	A young adult male patient presented with the history of a retained foreign body in the oral cavity. The object in question was a stapler pin that got accidentally lodged while the patient tried removing food particles from his mouth 28 days earlier. Aside from intermittent pain upon digital palpation on the right side of the floor of his mouth, he was asymptomatic. Clinical examination was unremarkable. Plain radiography and a computed tomogram revealed a linear foreign body in the right submandibular gland. The patient underwent a submandibular gland excision, during which a 2 cm long stapler pin was retrieved. This case highlights that not all foreign bodies cause inflammatory reactions as a telltale sign of their presence.
MeSH term(s)	Young Adult ; Humans ; Male ; Submandibular Gland/diagnostic imaging ; Submandibular Gland/surgery ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Head ; Face
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-257564
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New ring-A modified cycloartane triterpenoids from Dysoxylum malabaricum bark: Isolation, structure elucidation and their cytotoxicity.

Bhardwaj, Nivedita / Gupta, Priyamvada / Tripathi, Nancy / Chakrabarty, Sanheeta / Verma, Ashish / Kumari, Sanju / Gautam, Vibhav / Ravikanth, G / Jain, Shreyans K

Steroids

2024 Volume 205, Page(s) 109390

Abstract: The Genus Dysoxylum (Meliaceae) consists of approximately 80 species that are abundant in structurally diverse triterpenoids. The present study focused on isolating new triterpenoids from the bark of Dysoxylum malabaricum, one of the predominant species ... ...

Abstract	The Genus Dysoxylum (Meliaceae) consists of approximately 80 species that are abundant in structurally diverse triterpenoids. The present study focused on isolating new triterpenoids from the bark of Dysoxylum malabaricum, one of the predominant species of Dysoxylum present in India. The methanol-dichloromethane bark extract was subjected to LCMS profiling followed by silica gel column chromatography and HPLC analysis to target new compounds. Two new ring A-modified cycloartane-type triterpenoids (1 and 2) were isolated from the bark extract. Spectroscopic methods like NMR, HRESIMS data, and electronic circular dichroism calculations elucidated the structuresandabsolute configurations of the isolated compounds. These compounds were evaluated for their cytotoxic potential against breast cancer cells and displayed notable cytotoxicity. Compound 1 exhibited the highest cytotoxicity against the MDA-MB-231 cells and induced apoptotic cell death. Also, it was able to inhibit glucose uptake and increase nitric oxide production in breast cancer cells.
MeSH term(s)	Humans ; Female ; Molecular Structure ; Plant Bark/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Triterpenes/pharmacology ; Triterpenes/chemistry ; Meliaceae/chemistry ; Plant Extracts/chemistry ; Breast Neoplasms
Chemical Substances	cycloartane (511-64-8) ; Antineoplastic Agents, Phytogenic ; Triterpenes ; Plant Extracts
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2024.109390
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Zs.A 87: Show issues

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Article ; Online: ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.

Bhardwaj, Neha / Rohilla, Manish / Gautam, Upasana / Trehan, Amita / Bansal, Deepak / Kakkar, Nandita / Srinivasan, Radhika

American journal of clinical pathology

2023 Volume 159, Issue 4, Page(s) 407–415

Abstract: Objectives: The protein ALK is targeted for therapy in neuroblastoma, and ALK mutation confers a poor prognosis. We evaluated ALK in a cohort of patients with advanced neuroblastoma diagnosed by fine-needle aspiration biopsy (FNAB).: Methods: Fifty- ... ...

Abstract	Objectives: The protein ALK is targeted for therapy in neuroblastoma, and ALK mutation confers a poor prognosis. We evaluated ALK in a cohort of patients with advanced neuroblastoma diagnosed by fine-needle aspiration biopsy (FNAB). Methods: Fifty-four cases of neuroblastoma were evaluated for ALK protein expression by immunocytochemistry and ALK gene mutation by next-generation sequencing. MYCN amplification by fluorescence in situ hybridization, International Neuroblastoma Risk Group (INRG) staging, and risk assignment was performed, and patients were managed accordingly. All parameters were correlated with overall survival (OS). Results: ALK protein showed cytoplasmic expression in 65% cases and did not correlate with MYCN amplification (P = .35), INRG groups (P = .52), and OS (P = .2); however, ALK-positive, poorly differentiated neuroblastoma showed better prognosis (P = .02). ALK negativity was associated with poor outcome by Cox proportional hazard model (hazard ratio, 2.36). Two patients showed ALK gene F1174L mutation with 8% and 54% allele frequency and high ALK protein expression; they died of disease 1 and 17 months following diagnosis, respectively. A novel IDH1 exon 4 mutation was also detected. Conclusions: ALK expression is a promising prognostic and predictive marker in advanced neuroblastoma that can be evaluated in cell blocks from FNAB samples along with traditional prognostic parameters. ALK gene mutation confers a poor prognosis for patients with this disease.
MeSH term(s)	Humans ; Anaplastic Lymphoma Kinase/genetics ; Biopsy, Fine-Needle ; In Situ Hybridization, Fluorescence ; Mutation ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Prognosis ; Receptor Protein-Tyrosine Kinases/genetics ; Risk Assessment
Chemical Substances	Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; N-Myc Proto-Oncogene Protein ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; ALK protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqac172
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Ud II Zs.91: Show issues

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Article ; Online: Salvo of Ventricular Premature Complexes in Ischemic Heart Disease

Gautam Jesrani / Samiksha Gupta / Arshia Bhardwaj / Harsheel Gupta

APIK Journal of Internal Medicine, Vol 10, Iss 3, Pp 213-

2022 Volume 215

Abstract: Nonsustained ventricular tachycardia can be observed in various cardiac conditions, which can be benign or life-threatening, and is commonly encountered in patients with underlying structural heart disease. Hemodynamic instability in this rhythm ... ...

Abstract	Nonsustained ventricular tachycardia can be observed in various cardiac conditions, which can be benign or life-threatening, and is commonly encountered in patients with underlying structural heart disease. Hemodynamic instability in this rhythm abnormality is uncommon, but emergency management is warranted for unstable patients to mitigate dire consequences.
Keywords	ischemic heart disease ; nonsustained ventricular tachycardia ; ventricular couplets ; ventricular premature complex ; Internal medicine ; RC31-1245
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative transcriptomics of stem rust resistance in wheat NILs mediated by Sr24 rust resistance gene

Gautam Vishwakarma / Ajay Saini / Subhash Chander Bhardwaj / Satish Kumar / Bikram Kishore Das

PLoS ONE, Vol 18, Iss

2023 Volume 12

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Withdrawal Notice: S.A.R.S Covid-19 A Medicinal Chemistry Approach

Bhardwaj, Gautam / Tonk, Rajiv Kumar / Garg, Harish / Bhalla, Vijay

Mini reviews in medicinal chemistry

2021

Language	English
Publishing date	2021-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557521666210126125633
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Zs.A 5891: Show issues

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Article ; Online: Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits.

Kapoor, Bharat / Kapoor, Dhriti / Gautam, Shristy / Singh, Rahul / Bhardwaj, Savita

Current nutrition reports

2021 Volume 10, Issue 3, Page(s) 232–242

Abstract: Purpose of review: Polyunsaturated fatty acids (PUFAs) are obtained from various sources, which can be incorporated in the routine diet to maintain the health. They provide protection from several diseases like osteoarthritis, cancer, and autoimmune ... ...

Abstract	Purpose of review: Polyunsaturated fatty acids (PUFAs) are obtained from various sources, which can be incorporated in the routine diet to maintain the health. They provide protection from several diseases like osteoarthritis, cancer, and autoimmune disorders. Major focus is given to the PUFAs omega-3 (ω-3) and omega-6 (ω-6) fatty acids which are available in both terrestrial and in the marine environment. The main concern of this article is to review the key scientific reports in context with the human health consequences and advantages of the food sources of ω-3 and ω-6 fatty acids. Recent findings: ω-3 and ω-6 fatty acids are consumed by the population globally in the form of foods that are rich in fatty acids. Their nutritional effects have the capability to improve the physical functioning and metabolic rate of the body. These PUFAs contribute in various cellular activities like cell signaling, structural integrity and fluidity of cell membrane, the regulation of blood pressure, glucose level, the nervous system, inflammatory reactions, and hematic clotting. Animal and cell-based models represent that ω-3 and ω-6 PUFAs can regulate the skeletal muscle metabolism. The main concern of this article is to review the key scientific reports in context with the human health consequences and advantages of the food sources of ω-3 and ω-6 fatty acids.
MeSH term(s)	Animals ; Diet ; Fatty Acids ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated ; Humans
Chemical Substances	Fatty Acids ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2161-3311
ISSN (online)	2161-3311
DOI	10.1007/s13668-021-00363-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Challenges in implementation of mother milk banks in Rajasthan: A situational analysis.

Mantri, Neha / Goel, Akhil D / Joshi, Nitin K / Bhardwaj, Pankaj / Gautam, Vaishali / Gupta, Manoj K

Journal of mother and child

2022 Volume 25, Issue 2, Page(s) 86–94

Abstract: Background: Breastmilk is the baby's "first vaccine". Donated human milk (DHM) is the next best alternative when a mother's milk is not available, as recommended by WHO- UNICEF. DHM as a nutritional source provides similar immune protection and may ... ...

Abstract	Background: Breastmilk is the baby's "first vaccine". Donated human milk (DHM) is the next best alternative when a mother's milk is not available, as recommended by WHO- UNICEF. DHM as a nutritional source provides similar immune protection and may prove revolutionary in reducing neonatal morbidity and mortality. The study aimed to explore the challenges in the implementation of selected Mother Milk Banks (MMBs) of Rajasthan. Material and methods: A qualitative in-depth interview of key stakeholders was conducted to know the various facets of the challenges in milk banking practices using the Root Cause Analysis framework. Results: The system challenges identified in the functioning of AMMBs were lack of recurring funds, dedicated lactational counselors, and trained technicians. Databases for demand-supply estimates were also lacking. The community challenges were low acceptance of DHM due to safety concerns, risk of disease transmission, and quality of donated milk. Moreover, the religious stigma and cultural beliefs regarding the transfer of heredity traits and decrease in mother-child affection act as barriers in donating milk. Conclusion: For acceptance and availability of DHM, Social Behavior Communication Change (SBCC) interventions must be incorporated early during the antenatal check-up period. Our study highlighted the role of education; motivation by healthcare providers has a major influence on infant feeding choices. In a developing country such as India, where the frameworks concerning the development of mother milk banks are still maturing, our study findings provide baseline information to address the barriers in the implementation of mother milk banks in India.
MeSH term(s)	Female ; Humans ; India ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Milk Banks ; Milk, Human ; Mothers ; Pregnancy
Language	English
Publishing date	2022-04-01
Publishing country	Poland
Document type	Journal Article
ISSN	2719-535X
ISSN (online)	2719-535X
DOI	10.34763/jmotherandchild.20212502.d-21-00009
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